-
1
-
-
0020534965
-
Somatic generation of antibody diversity
-
Tonegawa, S. 1983. Somatic generation of antibody diversity. Nature 302:575.
-
(1983)
Nature
, vol.302
, pp. 575
-
-
Tonegawa, S.1
-
2
-
-
0021885386
-
DNA elements are asymmetrically joined during the site-specific recombination of kappa immunoglobulin genes
-
Lewis, S., Gifford, A. and Baltimore, D. 1985. DNA elements are asymmetrically joined during the site-specific recombination of kappa immunoglobulin genes. Science 228:677.
-
(1985)
Science
, vol.228
, pp. 677
-
-
Lewis, S.1
Gifford, A.2
Baltimore, D.3
-
3
-
-
0023475193
-
Two pairs of recombination signals are sufficient to cause immunoglobulin V(D)J joining
-
Akira, S., Okazaki, K. and Sakano, H. 1987. Two pairs of recombination signals are sufficient to cause immunoglobulin V(D)J joining. Science 238:1134.
-
(1987)
Science
, vol.238
, pp. 1134
-
-
Akira, S.1
Okazaki, K.2
Sakano, H.3
-
4
-
-
0020663062
-
A severe combined immunodeficiency mutation in the mouse
-
Bosma, G. C., Custer, R. P. and Bosma, M. J. 1983. A severe combined immunodeficiency mutation in the mouse. Nature 301:527.
-
(1983)
Nature
, vol.301
, pp. 527
-
-
Bosma, G.C.1
Custer, R.P.2
Bosma, M.J.3
-
5
-
-
0024042733
-
Transcription of unrearranged antigen receptor genes in scid mice
-
Schuler, W. Schuler, A., Lennon, G. G., Bosma, G. C. and Bosma, M. J. 1988. Transcription of unrearranged antigen receptor genes in scid mice EMBO J. 7:2019.
-
(1988)
EMBO J.
, vol.7
, pp. 2019
-
-
Schuler, W.1
Schuler, A.2
Lennon, G.G.3
Bosma, G.C.4
Bosma, M.J.5
-
6
-
-
0023026643
-
Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency
-
Schuler, W., Weiler, I. J., Schuler, A., Phillips, R. A., Rosenberg, N., Mak, T. W. Kearney, J. F., Perry, R. P. and Bosma, M. 1986. Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell 46:963
-
(1986)
Cell
, vol.46
, pp. 963
-
-
Schuler, W.1
Weiler, I.J.2
Schuler, A.3
Phillips, R.A.4
Rosenberg, N.5
Mak, T.W.6
Kearney, J.F.7
Perry, R.P.8
Bosma, M.9
-
7
-
-
0024052153
-
The scid gene encodes a trans-acting factor that mediates the rejoining event of Ig gene rearrangement
-
Hendrikson, E. A., Schatz, D. G. and Weaver, D. T. 1988. The scid gene encodes a trans-acting factor that mediates the rejoining event of Ig gene rearrangement. Genes Dev. 2:817
-
(1988)
Genes Dev.
, vol.2
, pp. 817
-
-
Hendrikson, E.A.1
Schatz, D.G.2
Weaver, D.T.3
-
8
-
-
0023719292
-
Abnormal recombination of Igh D and J segments in transformed pre-B cells of scid mice
-
Kim, M. G., Schuler, W., Bosma, M. J. and Marcu, K. B. 1988. Abnormal recombination of Igh D and J segments in transformed pre-B cells of scid mice. J. Immunol. 141:1341.
-
(1988)
J. Immunol.
, vol.141
, pp. 1341
-
-
Kim, M.G.1
Schuler, W.2
Bosma, M.J.3
Marcu, K.B.4
-
9
-
-
0023792756
-
The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism
-
Malynn, B. A., Blackwell, T. K., Fulop, G. M., Rathbun, O. A., Furley, A. J. W., Ferrier, P., Heinke, L. B., Phillips, R. A., Yancopoulos, G. D. and Alt, F. W. 1988. The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism. Cell 54:453.
-
(1988)
Cell
, vol.54
, pp. 453
-
-
Malynn, B.A.1
Blackwell, T.K.2
Fulop, G.M.3
Rathbun, O.A.4
Furley, A.J.W.5
Ferrier, P.6
Heinke, L.B.7
Phillips, R.A.8
Yancopoulos, G.D.9
Alt, F.W.10
-
10
-
-
0023801361
-
Aberrant immunoglobulin gene rearrangement in scid mouse bone marrow cells
-
Okazaki, K., Nishikawa, S. I. and Sakano, H. 1988. Aberrant immunoglobulin gene rearrangement in scid mouse bone marrow cells. J. Immunol. 141:1348.
-
(1988)
J. Immunol.
, vol.141
, pp. 1348
-
-
Okazaki, K.1
Nishikawa, S.I.2
Sakano, H.3
-
11
-
-
0024422692
-
Isolation of scid preB cells that rearrange kappa light chain genes: Formation of normal signal and abnormal coding joints
-
Blackwell, T. K., Malynn, B. A., Pollack, R. R., Ferrier, P., Covey, L. R., Fulop, G. M., Phillips, R. A., Yancopoulos, G. D. and Alt, F. W. 1989. Isolation of scid preB cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joints. EMBO J. 8:735.
-
(1989)
EMBO J.
, vol.8
, pp. 735
-
-
Blackwell, T.K.1
Malynn, B.A.2
Pollack, R.R.3
Ferrier, P.4
Covey, L.R.5
Fulop, G.M.6
Phillips, R.A.7
Yancopoulos, G.D.8
Alt, F.W.9
-
12
-
-
0025319851
-
Defective V-to-J recombination of T cell receptor γ genes in scid mice
-
Schuler, W., Schuler, A. and Bosma, M. J. 1990. Defective V-to-J recombination of T cell receptor γ genes in scid mice. Eur. J. Immunol. 20:545.
-
(1990)
Eur. J. Immunol.
, vol.20
, pp. 545
-
-
Schuler, W.1
Schuler, A.2
Bosma, M.J.3
-
13
-
-
0026087635
-
Coding joint formation of endogenous T cell receptor genes in lymphoid cells from scid mice: Unusual P-nucleotide additions in VJ coding joints
-
Schuler, W., Reutsch, N. R., Amsler, M. and Bosma, M. J. 1991. Coding joint formation of endogenous T cell receptor genes in lymphoid cells from scid mice: unusual P-nucleotide additions in VJ coding joints. Eur. J. Immunol. 21:589.
-
(1991)
Eur. J. Immunol.
, vol.21
, pp. 589
-
-
Schuler, W.1
Reutsch, N.R.2
Amsler, M.3
Bosma, M.J.4
-
14
-
-
0026018228
-
T-lymphocyte development in scid is arrested shortly after the initiation of T-cell receptor δ gene recombination
-
Carroll, A. M. and Bosma, M. J. 1991. T-lymphocyte development in scid is arrested shortly after the initiation of T-cell receptor δ gene recombination. Genes Dev. 5:1357
-
(1991)
Genes Dev.
, vol.5
, pp. 1357
-
-
Carroll, A.M.1
Bosma, M.J.2
-
15
-
-
0026331952
-
T cell receptor γ and δ gene rearrangement in scid thymocytes similarity to those in normal thymocytes
-
Kienker, L. J., Kuzeil, W. A., Garni-Wagner, B. A., Kumar, V. and Tucker, P. W. 1991. T cell receptor γ and δ gene rearrangement in scid thymocytes similarity to those in normal thymocytes J. Immunol. 147:4351.
-
(1991)
J. Immunol.
, vol.147
, pp. 4351
-
-
Kienker, L.J.1
Kuzeil, W.A.2
Garni-Wagner, B.A.3
Kumar, V.4
Tucker, P.W.5
-
17
-
-
0027171959
-
Human chromosome 8 (p12 → q22) complements radiosensitivity in severe combined immune deficiency (SCID) mouse
-
Itoh, M., Hamatani, K., Komatsu, K., Araki, R., Takayama, K. and Abe, M. 1993. Human chromosome 8 (p12 → q22) complements radiosensitivity in severe combined immune deficiency (SCID) mouse. Red. Res., 134:364.
-
(1993)
Red. Res.
, vol.134
, pp. 364
-
-
Itoh, M.1
Hamatani, K.2
Komatsu, K.3
Araki, R.4
Takayama, K.5
Abe, M.6
-
18
-
-
0009482260
-
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
-
Towbin, H., Staehelin, B. J. and Gordon, J. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl Acad. Sci. USA 76:4350.
-
(1979)
Proc. Natl Acad. Sci. USA
, vol.76
, pp. 4350
-
-
Towbin, H.1
Staehelin, B.J.2
Gordon, J.3
-
19
-
-
0004032583
-
-
Public Health Service, NIH, Bethesda, MD
-
Kabat, E. A., Wu, T. T., Reid-Miller, M., Perry, H. M. and Gottesman, K. S. 1987. Sequences of Proteins of Immunological Interest, 4th edn. Public Health Service, NIH, Bethesda, MD.
-
(1987)
Sequences of Proteins of Immunological Interest, 4th Edn.
-
-
Kabat, E.A.1
Wu, T.T.2
Reid-Miller, M.3
Perry, H.M.4
Gottesman, K.S.5
-
20
-
-
0026555338
-
Three lymphoid-specific factors account for all junctional diversity characteristic of somatic assembly of T-cell receptor and immunoglobulin genes
-
Kallenbach, S., Doyen, N., D'Andon, M. F. and Rougeon, F. 1992. Three lymphoid-specific factors account for all junctional diversity characteristic of somatic assembly of T-cell receptor and immunoglobulin genes. Proc. Natl Acad. Sci. USA 89:2799.
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 2799
-
-
Kallenbach, S.1
Doyen, N.2
D'Andon, M.F.3
Rougeon, F.4
-
21
-
-
0027369562
-
Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes
-
Komori, T., Okada, A., Stewart, V. and Alt, F. 1993. Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes. Science 261:1171
-
(1993)
Science
, vol.261
, pp. 1171
-
-
Komori, T.1
Okada, A.2
Stewart, V.3
Alt, F.4
-
22
-
-
0027452074
-
Mice lacking TdT: Mature animals with an immature lymphocyte repertoire
-
Gilfillan, S., Dierich, A., Lemeur, M., Benoist, C. and Mathis, D. 1993. Mice lacking TdT: mature animals with an immature lymphocyte repertoire. Science 261:1175.
-
(1993)
Science
, vol.261
, pp. 1175
-
-
Gilfillan, S.1
Dierich, A.2
Lemeur, M.3
Benoist, C.4
Mathis, D.5
-
23
-
-
0019888320
-
Terminal deoxynucleotidyl transferase of 60,000 daltons from mouse, rat, and calf thymus
-
Nakamura, H., Tanabe, K., Yoshida, S. and Morita, T. 1981. Terminal deoxynucleotidyl transferase of 60,000 daltons from mouse, rat, and calf thymus. J. Biol. Chem. 256:8745.
-
(1981)
J. Biol. Chem.
, vol.256
, pp. 8745
-
-
Nakamura, H.1
Tanabe, K.2
Yoshida, S.3
Morita, T.4
-
24
-
-
0023605091
-
T cell receptor δ gene rearrangements in early thymocytes
-
Chien, Y. H., Iwashima, M., Weltstein, D. A., Kaplan, K. B., Elliot, J. F., Born, W. and Davis, M. M. 1987. T cell receptor δ gene rearrangements in early thymocytes. Nature 330:722
-
(1987)
Nature
, vol.330
, pp. 722
-
-
Chien, Y.H.1
Iwashima, M.2
Weltstein, D.A.3
Kaplan, K.B.4
Elliot, J.F.5
Born, W.6
Davis, M.M.7
-
26
-
-
0024791338
-
Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining
-
Lafaille, J. J., DeCloux, A., Bonneville, M., Takagaki, Y. and Tonegawa, S. 1989. Junctional sequences of T cell receptor γδ genes: implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining. Cell 59:859.
-
(1989)
Cell
, vol.59
, pp. 859
-
-
Lafaille, J.J.1
DeCloux, A.2
Bonneville, M.3
Takagaki, Y.4
Tonegawa, S.5
-
27
-
-
0025184095
-
Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences
-
Feeney, A. J. 1990. Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences. J. Exp. Med. 172:1377.
-
(1990)
J. Exp. Med.
, vol.172
, pp. 1377
-
-
Feeney, A.J.1
-
28
-
-
0020041687
-
Organization, structure and assembly of immunoglobulin heavy chain diversity segments
-
Kurosawa, Y. and Tonegawa, S. 1982. Organization, structure and assembly of immunoglobulin heavy chain diversity segments. J. Exp. Med. 155:201.
-
(1982)
J. Exp. Med.
, vol.155
, pp. 201
-
-
Kurosawa, Y.1
Tonegawa, S.2
-
29
-
-
0022976432
-
Nonhomologous recombination in mammalian cells: Role for short sequence homologies in the joining reaction
-
Roth, D. B. and Wilson, J. W. 1986. Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction. Mol. Cell. Biol. 6:4295.
-
(1986)
Mol. Cell. Biol.
, vol.6
, pp. 4295
-
-
Roth, D.B.1
Wilson, J.W.2
-
30
-
-
0024473375
-
Only DFL16, DSP2 and DQ52 gene families exist in mouse immunoglobulin heavy chain diversity loci, of which DFL16 and DSP2 originate from the same primordial gene
-
Ichihara, Y., Hayashida, H., Miyazawa, S. and Kurosawa, Y. 1989. Only DFL16, DSP2 and DQ52 gene families exist in mouse immunoglobulin heavy chain diversity loci, of which DFL16 and DSP2 originate from the same primordial gene. Eur. J. Immunol. 19:1849.
-
(1989)
Eur. J. Immunol.
, vol.19
, pp. 1849
-
-
Ichihara, Y.1
Hayashida, H.2
Miyazawa, S.3
Kurosawa, Y.4
-
31
-
-
0025335392
-
H joining: Implications for the joining mechanism and the ontogenic timing of Ly1 B cell and B-CLL progenitor generation
-
H joining: implications for the joining mechanism and the ontogenic timing of Ly1 B cell and B-CLL progenitor generation. EMBO J. 9:2133.
-
(1990)
EMBO J.
, vol.9
, pp. 2133
-
-
Gu, H.1
Forster, I.2
Rajewsky, K.3
-
32
-
-
0026610950
-
H junctions occurring at sites of short sequence homology results in limited junctional diversity in neonatal antibodies
-
H junctions occurring at sites of short sequence homology results in limited junctional diversity in neonatal antibodies. J. Immunol. 149:222.
-
(1992)
J. Immunol.
, vol.149
, pp. 222
-
-
Feeney, A.J.1
-
33
-
-
0024846088
-
The V(D)J recombination activating gene, RAG-1
-
Schatz, D. G., Oettinger, M. A. and Baltimore, D. 1989. The V(D)J recombination activating gene, RAG-1. Cell 59:1035.
-
(1989)
Cell
, vol.59
, pp. 1035
-
-
Schatz, D.G.1
Oettinger, M.A.2
Baltimore, D.3
-
34
-
-
0025301095
-
RAG-2, adjacent genes that synergistically activate V(D)J recombination
-
Oettinger, M. A., Schatz, D. G., Gorka, C. and Baltimore, D. 1990. RAG-2, adjacent genes that synergistically activate V(D)J recombination, Science 248:1517.
-
(1990)
Science
, vol.248
, pp. 1517
-
-
Oettinger, M.A.1
Schatz, D.G.2
Gorka, C.3
Baltimore, D.4
-
35
-
-
0027275497
-
The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver
-
Li, Y-S., Hayakawa, K. and Hardy, R. R. 1993. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178:951.
-
(1993)
J. Exp. Med.
, vol.178
, pp. 951
-
-
Li, Y.-S.1
Hayakawa, K.2
Hardy, R.R.3
-
36
-
-
0023901043
-
Evidence of functional lymphocytes in some (leaky) scid mice
-
Bosma, G. C., Fried, M., Custer, R. P., Carroll, A., Gibson, D. M. and Bosma, M. J. 1988. Evidence of functional lymphocytes in some (leaky) scid mice J. Exp. Med. 167:1016.
-
(1988)
J. Exp. Med.
, vol.167
, pp. 1016
-
-
Bosma, G.C.1
Fried, M.2
Custer, R.P.3
Carroll, A.4
Gibson, D.M.5
Bosma, M.J.6
-
38
-
-
0024202730
-
Detection and characterization of functional T cells in mice with severe combined immune deficiency
-
Carroll, A. M. and Bosma, M. J. 1988. Detection and characterization of functional T cells in mice with severe combined immune deficiency. Eur. J. Immunol. 18:1965.
-
(1988)
Eur. J. Immunol.
, vol.18
, pp. 1965
-
-
Carroll, A.M.1
Bosma, M.J.2
-
39
-
-
0024351336
-
Limited clonal diversity of serum immunoglobulin in leaky scid mice
-
Gibson, D., Bosma, G. C. and Bosma, M. J. 1989. Limited clonal diversity of serum immunoglobulin in leaky scid mice. Curr. Top. Microbiol. Immunol. 152:125.
-
(1989)
Curr. Top. Microbiol. Immunol.
, vol.152
, pp. 125
-
-
Gibson, D.1
Bosma, G.C.2
Bosma, M.J.3
-
40
-
-
0025363051
-
Normal recombination substrate Vh to DJh rearrangements in pre-B cell lines from scid mice
-
Ferrier, P., Covey, L. R., Li, S. C., Suh, H., Malynn, B. A. Blackwell, T. K., Morrow, M. A. and Alt, F. W. 1990. Normal recombination substrate Vh to DJh rearrangements in pre-B cell lines from scid mice. J. Exp. Med. 171:1909.
-
(1990)
J. Exp. Med.
, vol.171
, pp. 1909
-
-
Ferrier, P.1
Covey, L.R.2
Li, S.C.3
Suh, H.4
Malynn, B.A.5
Blackwell, T.K.6
Morrow, M.A.7
Alt, F.W.8
-
42
-
-
0025294780
-
T-cell receptor gene rearrangements in functional T-cell clones from severe combined immune deficient (scid) mice: Reversion of the scid phenotype in individual lymphocyte progenitors
-
Petrini, J. H.-J., Carrol, A. M. and Bosma, M. J. 1990. T-cell receptor gene rearrangements in functional T-cell clones from severe combined immune deficient (scid) mice: reversion of the scid phenotype in individual lymphocyte progenitors. Proc. Natl Acad. Sci. USA 87:3450.
-
(1990)
Proc. Natl Acad. Sci. USA
, vol.87
, pp. 3450
-
-
Petrini, J.H.-J.1
Carrol, A.M.2
Bosma, M.J.3
-
43
-
-
0027315271
-
Scid mouse pre-B cells with intracellular μ chains: Analysis of recombinase activity and IgH rearrangements
-
Kotloff, D. B., Bosma, M. J. and Ruetsch, N. R. 1993. Scid mouse pre-B cells with intracellular μ chains: analysis of recombinase activity and IgH rearrangements. Int. Immunol. 5:383.
-
(1993)
Int. Immunol.
, vol.5
, pp. 383
-
-
Kotloff, D.B.1
Bosma, M.J.2
Ruetsch, N.R.3
-
44
-
-
0027524734
-
V(D)J recombination in peritoneal B cells of leaky scid mice
-
Kotloff, D. B. Bosma, M. J. and Ruetsch, N. R. 1993. V(D)J recombination in peritoneal B cells of leaky scid mice J. Exp. Med. 178:1981.
-
(1993)
J. Exp. Med.
, vol.178
, pp. 1981
-
-
Kotloff, D.B.1
Bosma, M.J.2
Ruetsch, N.R.3
-
45
-
-
0028960511
-
Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation
-
Blunt, T., Finnie, N. J. Taccioli, G. E., Smith, G. C. M., Demengeot, J., Gottlieb, T. M., Muzita, R., Varghese, A. J., Alt, F. W., Jeggo, P. A. and Jackson, S. P. 1995. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80:813.
-
(1995)
Cell
, vol.80
, pp. 813
-
-
Blunt, T.1
Finnie, N.J.2
Taccioli, G.E.3
Smith, G.C.M.4
Demengeot, J.5
Gottlieb, T.M.6
Muzita, R.7
Varghese, A.J.8
Alt, F.W.9
Jeggo, P.A.10
Jackson, S.P.11
-
46
-
-
0028953951
-
DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect
-
Kirchgessher, C. U., Patil, C. K., Evans, J. W., Cuomo, C. A., Fried, L. M., Carter, T., Oettinger, M. A. and Brown, J. M. 1995. DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science 267:1178.
-
(1995)
Science
, vol.267
, pp. 1178
-
-
Kirchgessher, C.U.1
Patil, C.K.2
Evans, J.W.3
Cuomo, C.A.4
Fried, L.M.5
Carter, T.6
Oettinger, M.A.7
Brown, J.M.8
-
47
-
-
0041646843
-
Joining of immunoglobulin heavy chain gene segments: Implication from a chromosome with evidence of three D-JH fusions
-
Alt, F. W. and Baltimore, D. 1982. Joining of immunoglobulin heavy chain gene segments: implication from a chromosome with evidence of three D-JH fusions. Proc. Natl Acad. Sci. USA 79:4118.
-
(1982)
Proc. Natl Acad. Sci. USA
, vol.79
, pp. 4118
-
-
Alt, F.W.1
Baltimore, D.2
-
48
-
-
0028912817
-
Imaging and quantitation of chemiluminescence using photoexcitable storage phosphor screen
-
Nguyen, Q. and Heffelfinger, D. M. 1995. Imaging and quantitation of chemiluminescence using photoexcitable storage phosphor screen. Anal. Biochem. 226:59.
-
(1995)
Anal. Biochem.
, vol.226
, pp. 59
-
-
Nguyen, Q.1
Heffelfinger, D.M.2
-
49
-
-
0028911114
-
Estimation of extremely low amounts of single mRNAs by quantitative noncompetitive reverse transcription-polymerase chain reaction assay in biological specimens from normal and neoplastic cells
-
Pane, F., Salera, A., Mostarda, I., Slvatore, F. and Sacchetti, L. 1995. Estimation of extremely low amounts of single mRNAs by quantitative noncompetitive reverse transcription-polymerase chain reaction assay in biological specimens from normal and neoplastic cells. Anal. Biochem. 225:362.
-
(1995)
Anal. Biochem.
, vol.225
, pp. 362
-
-
Pane, F.1
Salera, A.2
Mostarda, I.3
Slvatore, F.4
Sacchetti, L.5
|