Canonical VH CDR1 nucleotide sequences are conserved in all jawed vertebrates

International Immunology

Volumn 8, Issue 6, 1996, Pages 847-854

  Hsu, Ellen ^a  

^a NEW YORK UNIVERSITY   (United States)

Author keywords

Antibodies; Evolution; Genes; VH

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; GENETICS; HAGFISH; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; LAMPREY; MAMMAL; MOLECULAR CLONING; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; VERTEBRATE; XENOPUS; ANIMAL CELL; ANTIBODY COMBINING SITE; ANTIBODY STRUCTURE; DNA DETERMINATION; GENETIC SELECTION; JAW; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOTTING, SOUTHERN; CLONING, MOLECULAR; CONSERVED SEQUENCE; GENES, IMMUNOGLOBULIN; HAGFISHES; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; LAMPREYS; MAMMALS; MICE; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; VERTEBRATES; XENOPUS;

EID: 0029658935     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.6.847     Document Type: Article

References (25)

1. Davies, D. R., Padlan, E. A. and Sheriff, S. 1990. Antibody-antigen complexes. Annu. Rev. Biochem 59: 439.
2. Wu, T, T. and Kabat, E. A 1970. An analysis of the sequences of the variable regions of Bence-Jones proteins and myeloma light chains and their implication for antibody complementarity. J. Exp. Med. 132: 211.
3. Kabat, E. A. and Wu, T. T. 1971. Attempts to locate complementarity-determining residues in the variable positions of light and heavy chains. Ann. NY Acad. Sci. 190: 382.
4. Kabat E. A., Wu, T. T., Perry, H. M., Gottesman, K. S. and Foeller, C. 1991. Sequences of Proteins of Immunological Interest, 5th edn. US Department of Health and Human Services, Washington, DC.
5. Turchin, A., Desravines, S. and Hsu, E. 1995, Isolating any vertebrate immunoglobulin heavy chain variable region by polymerase chain reaction In Lefkovits, I. and Pernis, B , eds, Immunological Methods IV. Academic Press, New York, in press
6. Lee. A. and Hsu, E. 1994. Isolation and characterization of the Xenopus terminal deoxynucleotidyl transferase. J. Immunol. 152;4500.
7. Altschul, S. F., Gish, W., Miller, W., Myers, E. W. and Lipman, D. J. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403.
8. Hsu E., Schwager, J. and Alt, F. W. 1989. Evolution of immunoglobulin genes: VH families in the amphibian Xenopus. Proc. Natl Acad. Sci. USA 86:8010.
9. Gyllensten, U. 1992. Direct sequencing of in vitro amplified DNA In Erlich, H. A., ed., PCR Technology, p. 45. W H. Freeman, New York.
10. Wilson, M., Hsu, E., Marcuz, A., Courtet, M., Du Pasquier, L. and Steinberg, C. 1992, What limits affinity maturation of antibodies in Xenopus - the rate of somatic mutation or the ability to select mutants? EMBO J. 11:4337.
11. Schwager J., Buerckert, N., Courtet, M, and Du Pasquier, L 1989. Genetic basis of the antibody repertoire in Xenopus: analysis of the VH diversity. EMBO J. 8:2989.
12. Haire, R. N., Amemiya, C. T., Suzuki, D, and Litman, G. W. 1990. Eleven distinct VH gene families and additional patterns of sequence variation suggest a high degree of immunoglobulin gene complexity in a lower vertebrate, Xenopus laevis J. Exp. Med. 171:1721.
13. Livant, D., Blatt, C. and Hood, L. 1986. One heavy chain variable gene subfamily in the BALB/c mouse contains 500-1000 or more members. Cell 47:461.
14. Brodeur, P. H. and Riblet, R. 1984. The immunoglobulin heavy chain variable region (Igh-V) locus in the mouse. I. One hundred Igh-V genes comprise seven families of homologous genes. Eur. J. Immunol. 14:922.
15. Wilson M., Marcuz, A., Courtet, M. and Du Pasquier, L 1992, Sequences of Cμ and the VH1 family of LG7, a clonable strain of Xenopus, homozygous for the immunoglobulin loci. Dev. Immunol. 3:13.
16. Ota, T. and Nei, M. 1994. Divergent evolution and evolution by the birth-and-death process in the immunoglobulin VH gene family. Mol. Biol. Evol. 11:469.
17. Schroeder, H. W., Hillson, J. L. and Perlmutter, R. M. 1990. Structure and evolution of mammalian VH families. Int. Immunol. 20:41.
18. Sparrow, A. H., Price, H. J. and Underbrink, A. G. 1972. A survey of DNA content per cell and per chromosome of prokaryotic and eukaryotic organisms: some evolutionary considerations. Brookhaven Symp. Biol. 23:451.
19. Tomlinson, I. M., Walter, G., Marks, J. D., Llewelyn, M. B. and Winter, G. 1992. The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops. J. Mol. Biol. 227:776.
20. Padlan, E. A. 1994. Anatomy of the antibody molecule. Mol. Immunol. 31:169.
21. Padlan, E. A. 1990. On the nature of antibody combining sites: unusual structural features that may confer on these sites an enhanced capacity for binding ligands. Proteins: Struct. Fund. Genet. 7:112.
22. Rogozin, I. B. and Kolchanov, N. A. 1992. Somatic hypermutagenesis in immunoglobulin genes. II. influence of neighbouring base sequences on mutagenesis. Biochim. Biophys. Acta 1171:11.
23. Betz, A. G., Rada, C., Panell, R., Milstein, C. and Neuberger, M. S. 1993. Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proc. Natl Acad. Sci. USA 90:2385.
24. Betz, A. G., Neuberger, M. S. and Milstein, C. 1993. Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes, Immunol. Today 14:405.
25. Reynaud, C.-A., Dahan, A., Anquez, V. and Weill, J,-C. 1989. Somatic hyperconversion diversifies the single VH gene of the chicken with a high incidence in the D region. Cell 59:171.