Hyper insulinism and decreased insulin sensitivity in nonobese healthy offspring of conjugal diabetic parents and individuals with IGT and NIDDM

Indian Journal of Physiology and Pharmacology

Volumn 40, Issue 2, 1996, Pages 139-144

  Rao, Chippada Appa ^a   Snehalatha, C ^b  

^a SRI VENKATESWARA UNIVERSITY   (India)

^b Diabetes Research Centre Tamil Nadu   (India)

Author keywords

Hyperinsulinism; Insulin resistance; Insulin sensitivity; Insulin tolerance test

Indexed keywords

C PEPTIDE; INSULIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FAMILIAL DISEASE; FEMALE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; BLOOD; BODY WEIGHT; CLINICAL TRIAL; GENETICS; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HYPERINSULINISM; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADULT; BLOOD GLUCOSE; BODY WEIGHT; C-PEPTIDE; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HUMANS; HYPERINSULINISM; INSULIN; INSULIN RESISTANCE; MALE;

EID: 0029658897     PISSN: 00195499     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Reaven GM, Bernstein R, Davis B, Olefsky JM. Non-ketotic diabetes mellitus, insulin deficiency or insulin resistance, Am J Med 1976; 60 : 80-88.
2. Olefsky JM, Kolterman OG. Mechanism of insulin resistance in obesity and non-insulin dependent (type II) diabetes. In : Diabetes mellitus, Ed. Jay. S. Skyler, George F, Cahill. Yorke Medical Books, U.S.A., 1981, p 73-89.
3. Steinberg AG. Heredity in diabetes mellitus. Diabetes 1961; 10 : 269-274.
4. Viswanathan M, Mohan V, Snehalatha C, Ramachandran A. High prevalence of Type II (non-insulin dependent) diabetes among the offspring of conjugal type II diabetic parents in India. Diabetologia 1985; 28 : 907-910.
5. Johnston C, Ward WK, Beard JC, McKnight B, Porter D. Islet function and insulin sensitivity in the non-diabetic offspring of conjugal type II diabetic parents. Diabetic Med 1990; 7 : 2: 119-125.
6. Leslie RDG, Ganesh A, Volkmann JP, Alberti KGMM. Insensitivity to insulin in offspring of non-insulin dependent diabetic patients. Diabetes Nutr Metab 1988; 3 : 235-237.
7. WHO study group, 1985; Diabetes Mellitus. Techn Rep Series 727; WHO; Geneva.
8. Hyvarinen A, Nikkila EA. Specific determination of blood glucose with orthotoluidine. Clin Chim Acta 1962; 7 : 140-143.
9. Herbert V, Lau KS, Gottlieb CW, Bleicher SJ. Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab 1965; 25 : 1375-1384.
10. Heding LG. Radiommunological determination of human C-peptide in serum. Diabetologia 1975; 11 : 541-548.
11. Alford FP, Martin FIR, Pearson MJ. Significance and interpretation of mildly abnormal oral glucose tolerance test. Diabetologia 1971; 7 : 173-180.
12. Lundbaek K. Intravenous glucose tolerance as a tool in definition and diagnosis of diabetes mellitus. Brit Med J 1962; 1 : 1507-1513.
13. Rahinowitz D. Some endocrine and metabolic aspects of obesity. Annu. Rev Med 1970; 21 : 241-258.
14. Reaven GM, Olefsky JM. The role of insulin resistance in the pathogenesis of diabetes mellitus. Adv Metab Disord 1978; 9 : 313-331.
15. Bonora E, Zavarani I, Coscelli C, Butturini U. Decreased hepatic insulin extraction in subjects with mild glucose intolerance. Metabolism 1983; 32 : 438-444.
16. Gliemann J, Sonne O. Binding and receptor mediated degradation of insulin in adipocytes. J Biol Chem 1978; 243 : 7857-7863.
17. Olefsky JM. Insulin resistance and insulin action. An in vitro and in vivo perspective. Diabetes 1981; 30 : 118-162.
18. Coscelli C, Bonora E, Butturini U. Circulating insulin and C-peptide after oral glucose in situations of glucose intolerence. In : Recent advances in obesity and diabetes research. Ed. Melchionda, N et al. Raven Press, New York, 1984; p 63-76.
19. Bergman RN, Finegood DT, Ader M. Assessment of insulin sensitivity in vivo. Endocrin Rev 1985; 6 : 45-86.
20. Prato SD, Ferrannini E, Defronzo RA. Evaluation of insulin sensitivity in man. In : Methods in diabetes research, Vol 2. Clinical Methods. Ed. William L. Clarke, Joseph Larner, Stephen L. Pohl. John Wiley and Sons, New York, 1986; 36-76.
21. Kahn C. Insulin resistance, insulin sensitivity and insulin unresponsiveness, a necessary distinction, Metabolism 1978; 27 (Suppl. 2) : 1893-1902,
22. Olefsky JM. The insulin receptor, its role in insulin resistance of obesity and diabetes. Diabetes 1976; 25 : 1154-1164.
23. Crettaz M, Jeanrenand B. Post-receptor alterations in the states of insulin resistance. Metabolism 1980; 29 : 467-473.
24. Haffner SM, Stern MP, Hazuda HP, Mitchell BD, Patterson JK. Increased insulin concentrations in non-diabetic offspring of diabetic parents. N Engl J Med 1988; 319 : 1297-1301.
25. Ramachandran A. Clinical, biochemical and hormonal studies in offspring of conjugal type II (NIDDM) diabetic parents in Asian Indians. Ph.D. Thesis, Madras University; 1987.