Biodistribution of 111indium-labeled engineered human antibody CTMO1 in ovarian cancer patients: Influence of protein dose

Cancer Research

Volumn 56, Issue 22, 1996, Pages 5179-5185

  Van Hof, Arjan C ^a   Molthoff, Carla F M ^a   Davies, Quentin ^b   Perkins, Alan C ^b   Verheijen, René H M ^a   Kenemans, Peter ^a   Hollander, Wim Den ^a   Wilhelm, Abraham J ^a   Baker, Terry S ^c   Sopwith, Mark ^c   Frier, Malcolm ^b   Symonds, E Malcolm ^b   Roos, Jan C ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b QUEEN S MEDICAL CENTRE   (United Kingdom)

^c UCB PHARMA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CA 15-3 ANTIGEN; CALICHEAMICIN; CANCER ANTIBODY; DRUG CARRIER; IMMUNOGLOBULIN G; INDIUM 111; MONOCLONAL ANTIBODY; INDIUM;

ADULT; AGED; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CLINICAL ARTICLE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG UPTAKE; DRUG URINE LEVEL; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; OVARY CARCINOMA; PRIORITY JOURNAL; TISSUE DISTRIBUTION; HALF LIFE TIME; IMMUNOLOGY; METABOLISM; MIDDLE AGED; OVARY TUMOR; SCINTISCANNING;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; CA-15-3 ANTIGEN; FEMALE; HALF-LIFE; HUMANS; INDIUM RADIOISOTOPES; MIDDLE AGED; OVARIAN NEOPLASMS; TISSUE DISTRIBUTION;

EID: 0029658878     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Venesmaa, P Epithelial ovarian cancer: impact of surgery and chemotherapy on survival during 1977-1990. Obstet. Gynecol., 84 8-11, 1994.
2. Krommer, C. F., and Szalai, J. P. A. Review of 28 years of treating advanced ovarian cancer. Anticancer Res., 13: 817-826, 1993
3. Trimble, E. L., Adams, I. D., Vena, D., Hawkins, M. J, Friedman, M. A., Fisherman, J. S., Christian, M C, Canetta, R, Onetto, N., Hayn, R., and Arbuck, S. G. Paclitaxel for platinum-refractory ovarian cancer: results from the first 1,000 patients registered to National Cancer Institute treatment referral center 9103. J. Clin. Oncol., 11: 2405-2410, 1993.
4. Massuger, L. F. A. G., Kenemans, P., Claessens, R. A. M. J., Verheijen, R. H. M, and Corstens, F. H. M. Detection and localization of ovarian cancer with radiolabeled monoclonal antibodies. Eur. J. Obstet. Gynecol. Reprod. Biol., 41: 47-63, 1991.
5. Rubin, S. C. Monoclonal antibodies in the management of ovarian cancer. Cancer (Phila.), 71: 1602-1612, 1993.
6. Riethmuller, G., Schneidergadicke, E, and Johnson, J. P. Monoclonal antibodies in cancer therapy. Curr. Opin. Immunol., 5: 732-739, 1993.
7. Tashiro, Y, Yonezawa, S., Kim, Y. S, and Sato, E. Immunohistochemical study of mucin carbohydrates and core proteins in human ovarian tumors. Hum Pathol, 25: 364-372, 1994.
8. Zotter, S, Hageman, P. C., Lossnitzer, A., Mooi, W. J., and Hilgers, J. Tissue and tumor distribution of human polymorphic epithelial mucin. Cancer Rev, 11-12: 55-101, 1988.
9. Buist, M., and Kenemans, P. Imaging and radioimmunotargeting of ovarian cancer. Tumor Targeting, 1: 149-162, 1995.
10. Molthoff, C. F. M., Pinedo, H. M., Schluper, H. M. M, Rutgers, D H., and Boven, E. Comparison of I-131 labeled anti-episialin 139H2 with cisplatin, cyclophosphamide or external-beam radiation for anti-tumor efficacy in human ovarian cancer xenografts. Int. J. Cancer. 51: 108-115, 1992.
11. Maraveyas, A., and Epenetos, A. A. Targeted immunotherapy an update with special emphasis on ovarian cancer. Acta Oncol., 32: 741-746, 1993.
12. Hilkens, J, Ligtenberg, M J. L., Vos, H. L., and Litvinov, S. V. Cell membrane-associated mucins and their adhesion-modulation properties. Trends Biochem. Sci., 17: 359-363, 1992
13. Litvinov, S. V., and Hilkens, J. The epithelial sialomucin, episialin, is sialylated during recycling. J Biol. Chem., 268: 21364-21371, 1993
14. Bon, G G., Kenemans, P., van Kamp, G J, Yedema, C. A., and Hilgers, J. Review on the clinical value of polymorphic epithelial mucin tumor markers for the management of carcinoma patients. J. Nucl Med. Allied. Sci, 34: 151-162, 1990.
15. Aboud-Pirak, E., Sergent, T., Otte-Slachmuylder, C., Abarca, J., Trouet, A., and Schneider, Y. J Binding and endocytosis of a monoclonal antibody to a high molecular weight human milk fat globule membrane-associated antigen by cultured MCF-7 breast carcinoma cells. Cancer Res., 48: 3188-3196, 1988
16. Hinman, L. M., Hamann, P. R, Wallace, R., Menendez, A. T., Durr, F. E., and Upeslacis, J. Preparation and characterization of monoclonal antibody conjugates of the calicheamicins: a novel and potent family of antitumor antibiotics. Cancer Res., 53 3336-3342, 1993.
17. Baker, T. S., Bose, C. C., Caskey-Finney, H. M., King, D. J., Lawson, A. D. G., Lyons, A., Mountain, A, Owens, R. J., Rolfe, M R., Sehdev, M, Yarranton, G T., and Adair, J. R. Humanization of an anti-mucin antibody for breast and ovarian cancer therapy In: R. L. Ceriani (ed.), Antigen and Antibody Molecular Engineering in Breast Cancer Diagnosis and Treatment, pp 61-82 New York: Plenum Press, 1994
18. Turner, A., King, D. J., Farnsworth, A. P H, Rhind, S. K., Pedley, R. B., Boden, J, Boden, R., Millican, T. A., Millar, K., Boyce, B, Beeley, N. R. A., Eaton, M A. W., and Parker, D Comparative biodistributions of indium-111-labeled macrocycle chimeric B72.3 antibody conjugates in tumor-bearing mice. Br. J. Cancer, 70: 35-41, 1994
19. Buist, M. R, Kenemans, P., den Hollander, W., Vermorken, J. B., Molthoff, C. F M, Burger, C. W., Helmerhorst, T. J M., Baak, J P A., and Roos, J. C Kinetics and tissue distribution of the radiolabeled chimeric monoclonal antibody MOv18 and F(ab')2 fragments in ovarian carcinoma patients. Cancer Res, 53 5413-5418, 1993.
20. Granowska, M, Britton, K. E., Mather, S. J, Lowe, D. G., Ellison, D., Bomanji, J., Burchell, J., Taylor-Papadimitriou, J, Hudson, C. R., and Shepherd, J. H. Radioimmunoscintigraphy with technetium-99m-labeled monoclonal antibody. SM3, in gynaecological cancer. Eur J. Nucl Med., 20: 483-489, 1993.
21. Ind, T. E. J., Granowska, M., Britton, K. E., Morris, G, Lowe, D G., Hudson, C N., and Shepherd, J. H Perioperative radioimmunodetection of ovarian carcinoma using a hand held gamma detection probe. Br. J. Cancer, 70: 1263-1266, 1994.
22. 111In-NCRC48) defining a polymorphic epithelial mucin (PEM) epitope. Nucl Med. Commun., 14: 578-586, 1993.
23. Ward, B. G, Mather, S. J, Hawkins, L. R, Crowther, M. E, Shepherd, J. H., Granowska, M, Britton, K E, and Slevin, M. L. Localization of radioiodine conjugated to the monoclonal antibody HMFG2 in human ovarian carcinoma, assessment of intravenous and intraperitoneal routes of administration. Cancer Res., 47: 4719-4723, 1987.
24. Epenetos, A. A., Snook, D., Durbin, H., Johnson, P. M., and Taylor-Papadimitriou, J. Limitations of radiolabeled monoclonal antibodies for localizations of human neoplasms. Cancer Res., 46: 3183-3191, 1986.
25. Worlock, A. J., Zalutsky, M. R., and Metzgar, R S. Radiolocalization of human pancreatic tumors in athymic mice by monoclonal antibody DU-PAN 1. Cancer Res., 50: 7246-7251, 1990.
26. Taylor, A., Milton, W., Eyre, H., Christian, P, Wu, F, Hagan, P., Alazraki, N., Datz, L., and Unger, M Radioimmunodetection of human melanoma with indium-111-labeled monoclonal antibody. J Nucl. Med., 29: 329-337, 1988.
27. Boerman, O. C., Sharkey, R. M., Wong, G. Y, Blumenthal, R. D, Aninipot, R. L., and Goldenberg, D. M. Influence of antibody protein dose on therapeutic efficacy of radioiodinated antibodies in nude mice bearing GW-39 human tumor. Cancer Immunol. Immunother., 35: 127-134, 1992.
28. Patt, Y. Z., Lamki, L. M., Haynie, T. P., Unger, M. W., Rosenblum, M. G, Shirkhoda, A., and Murray, J. L. Improved tumor localization with increasing dose of indium-111-labeled anti-carcinoembryonic antigen monoclonal antibody ZCE-025 in metastatic colorectal cancer. J. Clin. Oncol., 6: 1220-1230, 1988.
29. Rosenblum, M G, Levin, B., Roh, M., Hohn, D., McCabe, R., Thompson, L., Cheung, L, and Murray, J. L. Clinical pharmacology and tissue disposition studies of I-131-labeled anticolorectal carcinoma human monoclonal antibody LiCO 16,88, Cancer Immunol. Immunother., 39 397-400, 1994.
30. Fujimori, K., Covell, D G., Fletcher, J. E., and Weinstein, J N. Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab′)2, and Fab in tumors. Cancer Res., 49 5656-5663, 1989.
31. Thomas, G. D., Chappell, M J., Dykes, P. W, Ramsden, D. B, Godfrey, K. R., Ellis, J. R. M, and Bradwell, A. R Effect of dose, molecular size, affinity, and protein binding on tumor uptake of antibody or ligand: a biomathematical model. Cancer Res, 49 3290-3296, 1989
32. Hagan, P. L., Halpern, S. E., Chen, A., Krishnan, L, Frinke, J, Bartholomew, R M., David, G. S, and Carlo, D. In vivo kinetics of radiolabeled monoclonal anti-CEA antibodies in animal models. J. Nucl. Med., 26: 1418-1423, 1985
33. Mach, J. P., Buchegger, F., Forni, M., Ritschard, J., Berche, C, Lumbroso, J D., Schreyer, M., Girardet, C., Accolla, R. S., and Carrel, S Use of radiolabeled monoclonal anti-CEA antibodies for the detection of human carcinomas by external photoscanning and tomoscintigraphy. Immunol. Today, 239-249, 1981
34. Bosslet, K., Steinstrasser, A, Schwarz, A., Harthus, H. P, Luben, G, Kuhlmann, L., and Sedlacek, H H. Quantitative considerations supporting the irrelevance of circulating serum CEA for the immunoscintigraphic visualization of CEA expressing carcinomas. Eur. J. Nucl. Med., 14: 523-528, 1988.
35. Colcher, D., Milenic, D E, Ferrom, P., Carrasquillo, J. A., Reynolds, J. C, Roselli, M, Larson, S M, and Schlom, J. In vivo fate of monoclonal antibody B72.3 in patients with colorectal cancer. J. Nucl. Med, 31: 133-1142, 1990.
36. Carrasquillo, J A, Abrams, P G., Schroff, R W., Reynolds, J. C., Woodhouse, C. S., Morgan, A. C., Keenan, A M, Foon, K. A., Perentesis, P., Marshall, S, Horowitz, M, Szymendera, J, Englert, J, Oldham, R. K., and Larson, S. M Effect of antibody dose on the imaging and biodistribution of indium-111 9.2 27 anti-melanoma monoclonal antibody J. Nucl. Med., 29: 39-47, 1988
37. 111In-labeled anticarcinoembryonic antigen monoclonal antibody in nude mice bearing human colon, cancer xenografts. Cancer Res., 49: 1587-1594, 1989.
38. Himmelsbach, M., and Wahl, R L. Studies on the metabolic fate of 111-indium-labeled antibodies Nucl. Med. Biol., 16: 839-845, 1989.
39. Buijs, W. C. A M., Massuger, L. F. A G., Claessens, R. A. M J, Kenemans, P, and Corstens, F. H M Dosimetric evaluation of immunoscintigraphy using indium-111-labeled monoclonal antibody fragments in patients with ovarian cancer J. Nucl. Med., 33 1113-1120, 1992.
40. Lamki, L. M., Murray, J L, and Rosenblum, M. G. Effect of unlabeled moab on biodistribution of indium-111 labeled moab. Nucl Med Commun, 9: 553-564, 1988.