Roles of calcitonin gen: Related peptide (CGRP) in hyperpnea-induced constriction in guinea pigs

American Journal of Respiratory and Critical Care Medicine

Volumn 154, Issue 5, 1996, Pages 1551-1556

  Nagase, Takahide ^a   Ohga, Eijiro ^a   Katayama, Hirofumi ^a   Sudo, Eiichi ^a   Aoki, Tomoko ^a   Matsuse, Takeshi ^a   Ouchi, Yasuyoshi ^a   Fukuchi, Yoshinosuke ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; BRONCHODILATING AGENT; CALCITONIN GENE RELATED PEPTIDE (8 37); CALCITONIN GENE-RELATED PEPTIDE (8-37); INDOLE DERIVATIVE; LEUKOTRIENE D4; LIPOXYGENASE INHIBITOR; MIOTIC AGENT; PEPTIDE FRAGMENT; PROPIONIC ACID DERIVATIVE; QUINOLINE DERIVATIVE; VERLUKAST;

AIRWAY PRESSURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSISTED VENTILATION; ASTHMA; BRONCHOSPASM; GUINEA PIG; HYPERPNEA; LUNG PRESSURE; LUNG RESISTANCE; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; ANIMAL; ARTIFICIAL VENTILATION; BIOLOGICAL MODEL; DRUG ANTAGONISM; DRUG EFFECT; DRUG INTERACTION; EXERCISE INDUCED ASTHMA; HYPERVENTILATION; PHYSIOLOGY; POSITIVE END EXPIRATORY PRESSURE;

ANIMALS; ASTHMA, EXERCISE-INDUCED; BRONCHOCONSTRICTION; BRONCHODILATOR AGENTS; CALCITONIN GENE-RELATED PEPTIDE; DRUG INTERACTIONS; GUINEA PIGS; HYPERVENTILATION; INDOLES; LEUKOTRIENE D4; LIPOXYGENASE INHIBITORS; MALE; MIOTICS; MODELS, BIOLOGICAL; PEPTIDE FRAGMENTS; POSITIVE-PRESSURE RESPIRATION; PROPIONATES; QUINOLINES; RESPIRATION, ARTIFICIAL;

EID: 0029658877     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.154.5.8912779     Document Type: Article

References (33)

1. Ray, D. W., C. Hernandez, N. Munoz, A. R. Leff, and J. Solway. 1988. Bronchoconstriction elicited by isocapnic hyperpnea in guinea pigs. J. Appl. Physiol. 65:934-939.
2. Blackie, S. P., C. Hilliam, R. Village, and P. D. Paré. 1990. The time course of bronchoconstriction in asthmatics during and after isocapnic hyperventilation. Am. Rev. Respir. Dis. 142:1133-1136.
3. McFadden, E. R., Jr., and B. M. Pichurko. 1985. Intraairway thermal profiles during exercise and hyperventilation in normal man. J. Clin. Invest. 76:1007-1010.
4. McFadden, E. R., Jr., K. A. M. Lenner, and K. P. Strohl. 1986. Postexertional airway rewarming and thermally induced asthma: new insights into pathophysiology and possible pathogenesis. J. Clin. Invest. 78: 18-25.
5. Ray, D. W., A. Garland, C. Hernandez, S. Eappen, L. Alger, and J. Solway. 1991. Time course of bronchoconstriction induced by dry gas hyperpnea in guinea pigs. J. Appl. Physiol. 70:504-510.
6. Ray, D. W., C. Hernandez, A. R. Leff, J. M. Drazen, and J. Solway. 1989. Tachykinins mediate bronchoconstriction elicited by isocapnic hypernea in guinea pigs. J. Appl. Physiol. 63:1108-1112.
7. Garland, A., J. E. Jordan, D. W. Ray, S. M. Spaethe, L. Alger, and J. Solway. 1993. Role of eicosanoids in hyperpnea-induced airway responses in guinea pigs. J. Appl. Physiol. 75:2797-2804.
8. Merighi, A., J. M. Polack, S. J. Gibson, S. Gulbenkian, K. L. Valentino, and S. M. Peirone. 1988. Ultrastructural studies on calcitonin gene-related peptide-, tachykinins-, and somatostatin-immunoreactive neurons in rat dorsal root ganglia: evidence for the colocalization of different peptides in single secretory granules. Cell Tissue Res. 254: 101-109.
9. Di Marzo, V., J. R. Tippins, and H. R. Morris. 1986. The effect of vasoactive intestinal peptide and calcitonin gene-related peptide on peptidoleukotriene release from platelet activating factor stimulated rat lung and ionophore stimulated guinea pig lungs. Biochem. Int. 13:933-942.
10. Raud, J., T. Lundeberg, G. Brodda-Jansen, E. Theodorsson, and P. Hedqvist. 1991. Potent anti-inflammatory action of calcitonin gene-related peptide. Biochem. Biophys. Res. Commun. 180:1429-1435.
11. Chiba, T., A. Yamaguchi, T. Yamatani, A. Nakamura, T. Morishita, T. Inui, M. Fukase, T. Noda, and T. Fujita. 1989. Calcitonin gene-related peptide receptor antagonist human CGRP-(8-37). Am. J. Physiol. 256(Endrocrinol. Metab. 19):E331-E335.
12. 4 receptor antagonist. Can. J. Physiol. Pharmacol. 67:17-28.
13. Gillard, J., A. W. Ford-Hutchinson, C. Chan, S. Charleson, D. Denis, A. Foster, R. Fortin, S. Leger, C. S. McFarlane, H. Morton, H. Piechuta, D. Reindeau, C. A. Rouzer, J. Rokach, R. Young, D. E. MacIntyre, L. Peterson, T. Bach, G. Eiermann, S. Hopple, J. Humes, L. Hupe, S. Luell, J. Metzger, R. Meurer, D. K. Miller, E. Opas, and S. Pacholok. 1989. L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2- dimenthlpropanoic acid), a novel, orally active leukotirene biosynthesis inhibitor. Can. J. Physiol. Pharmacol. 67:456-464.
14. Ludwig, M. S., I. Dreshaj, J. Solway, A. Munoz, and R. H. Ingram Jr. 1987. Partitioning of pulmonary resistance during constriction in the dog: effects of volume history. J. Appl. Physiol. 62:807-815.
15. Ludwig, M. S., P. V. Romero, and J. H. T. Bates. 1989. A comparison of the dose-response behaviour of canine airways and parenchyma. J. Appl. Physiol. 67:1220-1225.
16. Ingenito, E. P., B. Davison, and J. J. Fredberg. 1993. Tissue resistance in the guinea pig at baseline and during methacholine constriction. J. Appl. Physiol. 75:2541-2548.
17. Nagase, T., T. Ito, M. Yanai, J. G. Martin, and M. S. Ludwig. 1993. Responsiveness of and interactions between airways and tissue in guinea pigs during induced constriction. J. Appl. Physiol. 74:2848-2854.
18. Nagase, T., A. Moretto, M. J. Dallaire, D. H. Eidelman, J. G. Martin, and M. S. Ludwig. 1994. Airway and tissue responses to antigen challenge in sensitized Brown-Norway rats. Am. J. Respir. Crit. Care Med. 150:218-226.
19. Nagase, T., Y. Fukuchi, S. Teramoto, T. Matsuse, and H. Orimo. 1994. Mechanical interdependence in relation to age: effects of lung volume on airway resitance in rats. J. Appl. Physiol. 77:1172-1177.
20. Nagase, T., M. J. Dallaire, and M. S. Ludwig. 1994. Airway and tissue responses during hyperpnea-induced constriction in guinea pigs. Am. J. Respir. Crit. Care Med. 149:1342-1347.
21. 4. Am. J. Respir. Crit. Care Med. 152:81-86.
22. Fredberg, J. J., D. H. Keefe, G. M. Glass, R. G. Castile, and I. D. Frantz, III. 1984. Alveolar pressure nonhomogeneity during small amplitude high frequency oscillation. J. Appl. Physiol. 57:788-800.
23. James, A. L., J. C. Hogg, L. A. Dunn, and P. D. Paré. 1988. The use of the internal perimeter to compare airway size and to calculate smooth muscle shortening. Am. Rev. Respir. Dis. 138:136-139.
24. Thurlbeck, W. M. 1967. The internal surface area of nonemphysematous lungs. Am. Rev. Respir. Dis. 95:765-773.
25. Solway, J., and A. R. Leff. 1991. Sensory neuropeptides and airway function. J. Appl. Physiol. 71:2077-2087.
26. Brian, S. D., T. J. Williams, J. R. Tippins, H. R. Morris, and I. MacIntyre. 1985. Calcitonin gene-related peptide is a potent vasodilator. Nature 313:54-56.
27. Janssen, P. L., and A. Tucker. 1994. Calcitonin gene-related peptide modulates pulmonary vascular reactivity in isolated rat lungs. J. Appl. Physiol. 77:142-146.
28. McCormack, D., J. Mak, M. Coupe, and P. J. Barnes. 1989. Calcitonin gene-related peptide vasodilation of human pulmonary vessels. J. Appl. Physiol. 67:1265-1270.
29. Ray, D. W., S. Eappen, C. Hernandez, M. Jackson, A. R. Leff, and J. Solway. 1990. Distribution of airway narrowing during hyperpnea-induced bronchoconstriction in guinea-pigs. J. Appl. Physiol. 69: 1323-1329.
30. 4-receptor antagonist. N. Engl. J. Med. 323:1736-1739.
31. Israel, E. R., Dermarkarian, M. Rosenberg, R. Sperling, G. Taylor, P. Rubin, and J. M. Drazen. 1990. The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air. N. Engl. J. Med. 323: 1740-1744.
32. 4. Int. Arch. Allergy Immunol. 103: 286-292.
33. Zaidi, M., B. Moonga, B. J. Bevis, Z. Bascal, and L. Breimer. 1990. The calcitonin gene peptides: biological and clinical relevance. Crit. Rev. Clin. Lab. Sci. 28:109-174.