Reduction of 123i-iomazenil uptake in haemodynamically and metabolically impaired brain areas in patients with cerebrovascular disease

Nuclear Medicine Communications

Volumn 17, Issue 8, 1996, Pages 701-705

  Hayashida, K ^a   Hirose, Y ^a   Ishida, Y ^a   Miyake, Y ^a   Tanaka, Y ^b   Miyashita, K ^b   Nishimura, T ^c  

^a Department of Radiology ^*  (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^c OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

IOMAZENIL I 123; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID A RECEPTOR; DIAGNOSTIC AGENT; DRUG DERIVATIVE; FLUMAZENIL; IOMAZENIL; LIGAND; RADIOACTIVE IODINE;

ADULT; AGED; ARTICLE; BRAIN METABOLISM; CEREBROVASCULAR DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; POSITRON EMISSION TOMOGRAPHY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; BRAIN CIRCULATION; COMPARATIVE STUDY; COMPUTER ASSISTED EMISSION TOMOGRAPHY; METABOLISM; MIDDLE AGED; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; SCINTISCANNING;

AGED; CEREBROVASCULAR CIRCULATION; CEREBROVASCULAR DISORDERS; FLUMAZENIL; HUMANS; IODINE RADIOISOTOPES; LIGANDS; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; RECEPTORS, GABA-A; TOMOGRAPHY, EMISSION-COMPUTED; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0029658640     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1080/00006231-199608000-00010     Document Type: Article

References (13)

1. Benavides J, Serrano A, Duval D et al Autoradiographic detection and quantification of traumatic brain lesion in the rat w3 site radioligands. In: Krieglstein J, Oberpichler H, eds. Pharmacology of cerebral ischemia. Stuttgart: Wis-senschaftliche Verlagsgesellschaft mbH Stuttgart, 1990: 39-15.
2. Hantraye P, Kaijima M, Prenant C et al Central type benzodiazepine binding sites: A positron emission tomography study in the baboon’s brain. Neurosci Lett 1984; 48; 115-120.
3. Innis R, Al-Tikriti M, Zohgbi S et al. SPECT imaging of the benzodiazepine receptor: Feasibility of in vivo potency measurements from stepwise displacement curve. J Nucl Med 1991; 32: 1654-1661.
4. Schubiger PA, Hasler PH, Beer-Wohlfahrt H et al. Evaluation of a multicenter study with iomazenil: A benzodiazepine receptor ligand. Nucl Med Cotnmun 1991; 12: 569-582.
5. Aquilonius S, Eckernas A. A colour atlas of the human brain. New York: Raven Press, 1980.
6. Frackowiak RSJ, Lenzi GL, Jones T, Heather JD. Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 0-15 and positron emission tomography: Theory, procedure, and normal values. JCAT 1980; 4: 727-736.
7. Powers WJ, Grubb RL, Raichle ME. Physiologic response to focal cerebral ischemia in humans. Ann Neurol 1984; 16: 546-552.
8. Hirano T, Minematsu K, Hasegawa Y, Tanaka, Y, Haya-shida K, Yamaguchi T. Acetazolamide reactivity on I-123-IMP single photon emission computed tomography in patients with major cerebral artery occlusive disease: Correlation with positron emission tomography parameters. J Cereb Blood Flow Metab 1994; 14: 763-770.
9. Sette G, Baron JC, Young AR et al. In vivo mapping of brain benzodiazepine receptor changes by positron emission tomography after focal ischemia in the anesthetized baboon. Stroke 1993; 24: 2046-2058.
10. Johnson EW, de Lanerolle NC, Kim JH et al. Central and peripheral benzodiazepine receptors: Opposite changes in human epileptogenic tissue. Neurology 1992: 42: 811-815.
11. Odano I, Miyashita K, Minoshima S et al. A potential use of a I-123-labelled benzodiazepine receptor antagonist as a predictor of neuronal cell viability: Comparisons with C-14 labelled 2-deoxyglucose autoradiography and histopatho-logical examination. Nucl Med Cotnmun 1995; 16: 443-446.
12. Yonekura Y, Nishizawa S, Tanaka F et al Phase 1 clinical study of 123I-iomazenil: A new probe to evaluate central-type benzodiazepine receptors with SPECT. Kakuigaku (Jpn J Nucl Med) 1995; 32: 89-97.
13. Torizuka K, Uemura K, Tohru M et al. Phase 2 clinical study of 123I-iomazenil in various cerebral diseases: (Part 2) Clinical evaluation of central-type benzodiazepine receptor imaging with 123I-iomazenil SPECT. Kakuigaku (Jpn J Nucl Med) (submitted).