Prostaglandin E2 acts via the hypothalamus to stimulate ACTH secretion in the fetal sheep

Journal of Neuroendocrinology

Volumn 8, Issue 9, 1996, Pages 713-720

  Young, I Ross ^a   Loose, Jan M ^a   Kleftogiannis, Fotini ^a   Canny, Benedict J ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

ACTH; Cortisol; Fetus; HPA axis; PGE2

Indexed keywords

CORTICOTROPIN; HYDROCORTISONE; PROSTAGLANDIN E2; TETRACOSACTIDE; ADRENOCORTICOTROPIN ZINC;

ADRENAL GLAND; ANIMAL EXPERIMENT; ARTICLE; CHILDBIRTH; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; CORTICOTROPIN RELEASE; FETUS; FETUS CIRCULATION; GESTATIONAL AGE; HYDROCORTISONE BLOOD LEVEL; HYPOPHYSIS; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MATURATION; NONHUMAN; PRIORITY JOURNAL; SHEEP; ANIMAL; DRUG EFFECT; FEMALE; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MALE; PHYSIOLOGY; PREGNANCY; PRENATAL DEVELOPMENT; SECRETION;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; COSYNTROPIN; DINOPROSTONE; FEMALE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; HYPOTHALAMUS; MALE; PITUITARY-ADRENAL SYSTEM; PREGNANCY; SHEEP;

EID: 0029658625     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2826.1996.tb00708.x     Document Type: Article

References (31)

1. 2. J Physiol 1991; 443: 431-439.
2. 2, corticotropinreleasing factor, and arginine vasopressin in several hypothalamic areas of freely moving rats: Estimation by push-pull perfusion. Neuroendocrinology 1994; 60: 8-15.
3. 2 release. Am J Physiol 1995; 268: G404-G409.
4. 2) on the corticotropin-releasing hormone (CRH)-induced ACTH release in healthy men. Horm. Metab. Res 1992; 24: 336-338.
5. 2 is a positive regulator of adrenocorticotropin receptors, 3β-hydroxysteroid dehydrogenase, and 17α-hydroxylase expression in bovine adrenocortical cells. Endocrinology 1991; 129: 1333-1339.
6. Challis JRG, Dilley SR, Robinson JS et al. Prostaglandins in the circulation of the fetal lamb. Prostaglandins 1976; 11: 1041-1052.
7. Evans CA, Kennedy TG, Challis JRG. Gestational changes in prostanoid concentrations in intrauterine tissues and fetal fluids from pregnant sheep, and the relation to prostanoid output in vitro. Biol. Reprod 1982; 27: 1-11.
8. 1α in the utero-ovarian venous plasma of non-pregnant and early pregnant ewes. Biol. Reprod 1984; 30: 936-944.
9. Fowden AL, Harding R, Ralph MM et al. The nutritional regulation of prostaglandin E concentrations in the fetus and pregnant ewe during late gestation. J Physiol 1987; 394: 1-12.
10. Burgess KM, Ralph MM, Jenkin G et al. Effect of oxytocin and estradiol on uterine prostaglandin release in nonpregnant and early pregnant ewes. Biol. Reprod 1990; 42: 822-833.
11. 2. Nature 1976; 264: 797-799.
12. 2 infusion in the fetal lamb on fetal plasma ACTH. prolactin and Cortisol concentrations. Prostaglandins 1979; 18: 101-116.
13. 2, Prostacyclin and 1-24 adrenocorticotrophin on plasma cortisol levels of fetal sheep. J Endocrinol 1982; 95: 153-162.
14. 2 stimulates adrenocorticotrophin and cortisol secretion via a hypothalamic site of action in fetal sheep. J Dev Physiol 1992; 18: 173-177.
15. Antolovich GC, Clarke IJ, McMillen IC et al. Hypothalamo-pituitary disconnection in the fetal sheep. Neuroendocrinology 1990; 51: 1-9.
16. Antolovich GC, McMillen IC, Robinson PM et al. The effect of hypothalamo- pituitary disconnection on the functional and morphologic development of the pituitary-adrenal axis in the fetal sheep in the last third of gestation. Neuroendocrinology 1991; 54: 254-261.
17. Antolovich GC, McMillen IC, Robinson PM et al. Effect of cortisol infusion on the pituitary-adrenal axis of the hypothalamo-pituitary disconnected fetal sheep. Neuroendocrinology 1992; 56: 312-319.
18. Deayton JM, Young IR, Hollingworth SA et al. Effect of late hypothalamo-pituitary disconnection on the development of the HPA axis in the ovine fetus and the initiation of parturition. J Neuroendocrinol 1994; 6: 25-31.
19. Jones SA, Adamson SL, Bishai I et al. Eicosanoids in third ventricular cerebrospinal fluid of fetal and newborn sheep. Am J Physiol 1993; 264: R135-R142.
20. Ozolins IZ, Young IR, McMillen IC. Surgical disconnection of the hypothalamus from the fetal pituitary abolishes the corticotrophic response to intrauterine hypoglycemia or hypoxemia in the sheep during late gestation. Endocrinology 1992; 130: 2438-2445.
21. Cudd TA, Castro MI, Wood CE. Content, in vivo release, and bioactivity of fetal pulmonary immunoreactive adrenocorticotropin. Am J Physiol 1993; 265: E667-E672.
22. Cudd TA, Wood CE. Secretion and clearance of immunoreactive ACTH by fetal lung. Am J Physiol 1995; 268: E845-E848.
23. Liggins GC, Kennedy PC. Effects of electrocoagulation of the foetal lamb hypophysis on growth and development. J Endocrinol 1968; 40: 371-381.
24. Deayton JM, Young IR, Thorburn GD. Early hypophysectomy of sheep fetuses: effects on growth, placental steroidogenesis and prostaglandin production. J Reprod Fertil 1993; 97: 513-520.
25. Ozolins IZ, Young IR, McMillen IC. Effect of cortisol infusion on basal and corticotropin-releasing factor (CRF)-stimulated plasma ACTH concentrations in the sheep fetus after surgical isolation of the pituitary. Endocrinology 1990; 127: 1833-1840.
26. Hennessy DP, Coghlan JP, Hardy KJ et al. Development of the pituitary-adrenal axis in chronically cannulated ovine fetuses. J Dev Physiol 1982; 4: 339-352.
27. Magyar DM, Fridshal D, Elsner CW et al. Time-trend analysis of plasma Cortisol concentrations in the fetal sheep in relation to parturition. Endocrinology 1980; 107: 155-159.
28. Phillips ID, Ross JT, Owens JA et al. ACTHI-39, adrenal growth and steroidogenic enzyme mRNA levels after disconnection of the fetal hypothalamus and pituitary. J. Physiol. 1996; 491; 871-879.
29. Bocking AD, McMillen IC, Harding R et al. Effect of reduced uterine blood flow on fetal and maternal cortisol. J Dev Physiol 1986; 8: 237-245.
30. McMillen IC, Antolovich GC, Mercer JE et al. Proopiomelanocortin messenger RNA levels are increased in the anterior pituitary of the sheep fetus after adrenalectomy in late gestation. Neuroendocrinology 1990; 52: 297-302.
31. 2 administered to fetal sheep increases the plasma concentrations of adrenocorticotropin and the proportion of ACTH in low molecular weight forms. Endocrinology 1995; 136: 1233-1240.