Regulation of antigen processing and presentation to class I MHC restricted CD8+T lymphocytes

Immunological Reviews

Volumn , Issue 151, 1996, Pages 31-49

  Hahn, Young S ^a,b   Yang, Bing ^a,b   Braciale, Thomas J ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALNEXIN; CD8 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEASOME; HLA ANTIGEN CLASS 1;

AMINO ACID SEQUENCE; ANTIGEN PRESENTATION; CARBOXY TERMINAL SEQUENCE; CYTOPLASM; CYTOTOXIC T LYMPHOCYTE; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN TRANSPORT; REVIEW; T LYMPHOCYTE; ANIMAL; CD8+ T LYMPHOCYTE; HUMAN; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; ANIMALS; ANTIGEN PRESENTATION; CD8-POSITIVE T-LYMPHOCYTES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MOLECULAR SEQUENCE DATA;

EID: 0029658574     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-065x.1996.tb00702.x     Document Type: Review

References (35)

1. Androlewicz, M. & Cresswell, P. (1994) Human transporters associated with antigen processing possess a promiscuous peptide-binding site. Immunity 1, 7.
2. Braciale, T. J. (1992) Antigen processing for presentation by MHC class I molecules. Curr. Opin. Immunol. 4, 59.
3. Brown, M. G., Driscoll, J. & Monaco, J. J. (1991) Structural and serological similarity of MHC-linked LMP and proteosome (multocatalytic proteinase) complexes. Nature 353, 355.
4. Degen, E. & Williams, D. B. (1991) Participation of a novel 88-kD protein in the biogenesis of murine class I histocompatibility molecules. J. Cell. Biol. 112, 1099.
5. Del, V. M., Schlicht, H. J., Ruppert, T., Reddehase, M. J. & Koszinowski, U. H. (1991) Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein. Cell 66, 1145.
6. Eisenlohr, L. C., Yewdell, J. W. & Bennink, J. R. (1992) Flanking sequences influence the presentation of an endogenously synthesized peptide to cytotoxic T lymphocytes. J. Exp. Med. 175, 481.
7. Elliott, T., Willis, A., Cerundolo, V. & Townsend, A. (1995) Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum. J. Exp. Med. 181, 1481.
8. Falk, K., Roetzschke, O., Stevanovic, S., Jung, G. & Rammensee, H. G. (1991) Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351, 290.
9. Gaczynska, M., Rock, K. L. & Goldberg, A. L. (1993) Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes. Nature 365, 264.
10. Glynne, R., Powis, S. H., Beck, S., Kelly, A., Kerr, L. A. & Trowsdale, J. (1991) A proteasome-related gene between the two APC transporter loci in the class II region of the human MHC. Nature 353, 357.
11. + T cell recognition of an endogenously processed epitope is regulated primarily by residues within the epitope. J. Exp. Med. 176, 1335.
12. Heemels, M. T., Schumacher, T. N., Wonigeit, K. & Ploegh, H. L. (1993) Peptide translocation by variants of the transporter associated with antigen processing. Science 262, 2059.
13. Hochstenbach, F., David, V., Watkins, S. & Brenner, M. B. (1992) Endoplasmic reticulum resident protein of 90 kilodaltons associates with the T cell and B cell antigen receptors and major histocompatibility complex antigens during their assembly. Proc. Natl. Acad. Sci. USA 89, 4734.
14. Jackson, M., Cohen-Doyle, M., Peterson, P. & Williams, D. (1994) Regulation of MHC class I transport by the molecular chaperone, calnexin (p88, IP90). Science 263, 384.
15. Kelly, A., Powis, S. H., Glynne, R., Radley, E., Beck, S. & Trowsdale, J. (1991) Second proteasome-related gene in the human MHC class II region. Nature 353, 667.
16. Kelly, A., Powis, S. H., Kerr, L. A., Mockridge, I., Elliott, T., Bastin, J., Uchanska, Z. B., Ziegler, A., Trowsdale, J. & Townsend, A. (1992) Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex. Nature 355, 641.
17. Livingstone, A. M., Powis, S. J., Diamond, A.G., Butcher, G.W. & Howard, J.C. (1989) A trans-acting major hislocompatability complex-linked gene whose alleles determine gain and loss changes in the antigenic structure of a classical class I molecule. J. Exp. Med. 170, 777.
18. Martinez, C. K. & Monaco, J. J. (1991) Homology of proteasoine subunits to a major histocompatibility complex-linked LMP gene. Nature 353, 664.
19. Maryanski, J. L., Verdini, A. S., Weber, P. C., Salemme, F. R. & Corradin, G. (1990) Competitor analogs for defined T cell antigens: Peptides incorporating a putative binding motif and polyproline or polyglycine spacers. Cell 60, 63.
20. Momburg, F. Roelse, J., Howard, J. C., Butcher, G. W., Hammerling, G. J. & Neefjes, J. J. (1994) Selectivity of MHC-encoded peptide transporters from human, mouse and rat. Nature 367, 648.
21. Nuchtern, J. G., Bonifacino, J. S., Biddison, W. E. & Klausner, R. D. (1989) Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation. Nature 339, 223.
22. Palombella, V. J., Rando, O. J., Goldberg, A. L. & Maniatis, T. (1994) The ubiquitin-proteasonie pathway is required for processing the NF-kappa BI precursor protein and the activation of NF-kappa B. Cell 78, 773.
23. Powis, S. J., Deverson, E.V., Coadwell, W. J., Ciruela, A., Huskisson, N.S., Smith, H., Butcher, G.W., Howard, J.C. (1992) Effect of poyporphism of an MHC-linked transporter on the peptides assembled in a class I molecules. Nature 357, 211.
24. Rajagopalan, S. & Brenner, M. (1994) Calnexin retains unassembled major histocompatibility complex class I free heavy chains in the endoplasmic reticulum. J. Exp. Med. 180, 407.
25. Rammensee, H. G., Falk, K. & Rotzschke, O. (1993) Peptides naturally presented by MHC class 1 molecules. Annu. Rev. Immunol 11, 213.
26. Rock, K. L., Gramm, C., Rothstein, L., Clark, K., Stein, R., Dick, L., Hwang, D. & Goldberg, A. L. (1994) Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78, 761.
27. Schumacher, T. N., Kantesaria, D. V., Heemels, M. T., Ashton, R. P., Shepherd, J. C., Fruh, K., Yang, Y., Peterson, P. A., Tonegawa, S. & Ploegh, H. L. (1994) Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator. J. Exp. Med. 179, 533.
28. Shepherd, J. C., Schumacher, T. N., Ashton, R. P., Imaeda, S., Ploegh, H. L., Janeway, C. J. & Tonegawa, S. (1993) TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective. Cell 74, 577.
29. Spies, T. & DeMars, R. (1991) Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter. Nature 351, 323.
30. Sweetser, M. T., Braciale, V. L. & Braciale, T. J. (1989) Class I major histocompatibility complex-restricted T lymphocyte recognition of the influenza hemagglutinin. Overlap between class I cytotoxic T lymphocytes and antibody sites. J. Exp. Med. 170, 1357.
31. Townsend, A., Elliott, T., Cerundolo, V., Foster, L., Barber, B. & Tse, A. (1990) Assembly of MHC class I molecules analysed in vitro. Cell 62, 285.
32. Townsend, A. R. M., Rothbard, J., Gotch, F. M., Bahadur, G., Wraith, D. & McMichael, A. J. (1986) The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell 44, 959.
33. Yang, B. & Braciale, T. J. (1995) Characteristics of ATP-dependent peptide transport in isolated microsomes. J. Immunol. 155, 3889.
34. Yang, B., Hahn, Y. S., Hahn, C. S. & Braciale, T. J. The requirement for proteasome activity in class I MHC antigen presentation is dictated by the length of pre-processed antigen. In press.
35. Yewdell, J. W. & Bennink, J. R. (1989) Brefeldin A specifically inhibits presentation of protein antigens to cytotoxic T lymphocytes. Science 244, 1072.