Association between the PI*M3 allele of α1-antitrypsin and Alzheimer's disease? A preliminary report

Human Genetics

Volumn 98, Issue 6, 1996, Pages 744-746

  Kowalska, Anna ^a   Danker Hopfe, Heidi ^b   Wender, Mieczyslaw ^c   Florczak, Jolanta ^c   Walter, Hubert ^b  

^a INSTITUTE OF HUMAN GENETICS   (Poland)

^b UNIVERSITY OF BREMEN   (Germany)

^c POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; SERINE PROTEINASE INHIBITOR;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE FREQUENCY; HUMAN; PHENOTYPE; PRIORITY JOURNAL; ALLELE; GENETICS; MIDDLE AGED;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; ALPHA 1-ANTITRYPSIN; ALZHEIMER DISEASE; HUMANS; MIDDLE AGED; PHENOTYPE; SERPINS;

EID: 0029658540     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004390050297     Document Type: Article

References (15)

1. Alzheimer's Disease Collaborative Group (1995) The structure of the preselinin 1 (S182) gene and identification of six novel mutations in early onset AD families. Nat Genet 11:219-222
2. Bassett ML, Bradbear RA, Kerlin P (1986) α1-Antitrypsin phenotypes in chronic active hepatitis. J Gastroenterol Hepatol 1: 207-211
3. Brantly M, Nukiwa T, Crystal RG (1988) Molecular basis of alpha-1-antitrypsin deficiency. Am J Med 84 (suppl 6A): 13-31
4. Ho GJ, Smirnova IV, Akaaboune M, Hantai D, Festoff BW (1994) Serine proteases and their serpin inhibitors in Alzheimer's disease. Biomed Pharmacother 48:296-304
5. Kamboh ML (1995) Apolipoprotein E polymorphism and susceptibility to Alzheimer's disease. Hum.Biol 67:195-215
6. Kamboh ML, Sanghera DK, Ferrell RE, DeKosky ST (1995) ApoE*4-associated Alzheimer's disease risk is modified by α1-antichymotrypsin polymorphism. Nat Genet 10:486-488
7. McCombe PA, Clark P, Frith JA, Hammond SR, Steward GJ, Pollard JD, McLeod JG (1985) Alpha-1 antitrypsin phenotypes in demyelinating disease; an association between demyelinating disease and the allele P1M3. Ann Neurol 18:514-516
8. Muir A, Whitfield JB (1990) Alpha-1-antitrypsin (protease inhibitor) phenotypes and longevity. Hum Hered 40:22-28
9. NINCDS, ADRDA (1984) Report of the NINCDS and ADRDA work group under the auspices of Department of Health and Human Services task force on Alzheimer's disease. Neurology 34:939-946
10. Rao CR (1952) Advanced statistical methods in biometric research. Wiley, New York
11. Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD (1993) Apolipoprotein E: high-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 90:1977-1981
12. Terry RD (1983) Senile dementia of the Alzheimer type. Ann Neurol 14:497-506
13. Titenko-Holland NV, Kowalska A (1992) Alpha-1-antitrypsin (PI) subtypes in Russians and Poles. Hum Hered 42:384-386
14. Van Broeckhoven C (1995) Presenilins and Alzheimer disease. Nat Genet 11:230-232
15. Weidinger S, Cujnik F, Schwarzfisher F (1985) Alpha-1-antitrypsin: evidence for a fifth PIM subtype and a new deficiency allele PI* Z Augsburg. Hum Genet 71:27-29