Complexity of the regulation of K(ir)2.1 K+ channels

Neuropharmacology

Volumn 35, Issue 7, 1996, Pages 887-893

  Ruppersberg, J P ^a   Fakler, B ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

DTT; GTP S; Inward rectifier K+ channel; Run down

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; CYANOGINOSIN; DITHIOTHREITOL; ENZYME INHIBITOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; POTASSIUM CHANNEL; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); INWARDLY RECTIFYING POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; GENE EXPRESSION; ION CURRENT; MEMBRANE POTENTIAL; MOLECULAR CLONING; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SECOND MESSENGER; XENOPUS; ANIMAL; BIOSYNTHESIS; DOWN REGULATION; DRUG EFFECT; DRUG INTERACTION; METABOLISM; PATCH CLAMP; UPREGULATION;

ANIMALS; ANTIOXIDANTS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DITHIOTHREITOL; DOWN-REGULATION; DRUG INTERACTIONS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; UP-REGULATION; XENOPUS;

EID: 0029658460     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(96)00092-5     Document Type: Article

References (18)

1. Aguilar-Bryan L., Nichols C.G., Wechsler S.W., Clement J.P., Boyd A.E., Gonzalez G., Herrera-Sosa H., Nguy K., Bryan J., Nelson D.A. Cloning of the β cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science. 268:1995;423-426.
2. - channel gating to an ATP hydrolysis cycle. Neuron. 12:1994;473-482.
3. ir1.1 channels. J. Biol. Chem. 271:1996;17261-17266.
4. Fabiato A. Computer programs for calculating total from specified free or free from specified total concentrations in aqueous solutions containing multiple metals and ligands. Meth. Enzym. 157:1988;378-417.
5. Fakler B., Brändle U., Glowatzki E., König C., Bond C., Adelman J.P., Zenner H.-P., Ruppersberg J.P. A structural determinant of differential sensitivity of cloned inward rectifier channels to intracellular spermine. FEBS Lett. 356:1988;199-203.
6. + channels is caused by intracellular spermine. Cell. 80:1995;149-154.
7. + channels are regulated independently by protein kinases and ATP hydrolysis. Neuron. 13:1994;1413-1420.
8. Fakler B., Schultz J.H., Yang J., Schulte U., Brändle U., Zenner H.P., Jan L.Y., Ruppersberg J.P. Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels (ROMK) to intracellular pH. EMBO. 15(16):1996;4093-4099.
9. + channels. Science. 266:1994;1068-1072.
10. 2+ exchanger. Nature. 352:1991;715-718.
11. Hille B. (1992). Ionic Channels in Excitable Membranes, pp. 127-130. Sinauer, Sunderland, MA.
12. KATP: An inward rectifier subunit plus the sulfonylurea receptor. Science. 270:1995;1166-1169.
13. Inagaki N., Tsuura Y., Namba N., Msauda K., Gonoi T., Horie M., Seino Y., Mizuta M., Seino S. Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart. J. Biol. Chem. 270:1995;5691-5694.
14. +-channel proteins. Nature. 374:1995;135-141.
15. Kubo Y., Baldwin T.J., Jan Y.N., Jan L.Y. Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature. 362:1993;127-133.
16. Lopatin A.N., Makhina E.H., Nichols C.G. Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature. 372:1994;366-369.
17. + channel activity involves phosphorylation processes. Proc. Natn Acad. Sci. U.S.A. A 91: 8077-8081.
18. Nilius B., Schwarz G., Droogmans G. Modulation by histamine of an inwardly rectifying potassium channel in human endothelial cells. J. Physiol. 472:1993;359-371.