Incorporation of 3H-arachidonic acid into platelet phospholipids of patients with schizophrenia

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 55, Issue 1-2, 1996, Pages 21-26

  Yao, J K ^a   Van Kammen, D P ^b  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL; HALOPERIDOL; MEMBRANE PHOSPHOLIPID; PHOSPHATIDIC ACID; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; PHOSPHOLIPASE C; THROMBIN; ARACHIDONIC ACID DERIVATIVE; MEMBRANE LIPID; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; POLYPHOSPHOINOSITIDE; TRITIUM;

ARACHIDONIC ACID METABOLISM; CONFERENCE PAPER; CONTROLLED STUDY; CYTOCHEMISTRY; DRUG WITHDRAWAL; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOTOPE LABELING; PRIORITY JOURNAL; SCHIZOPHRENIA; THROMBOCYTE; THROMBOCYTE ACTIVATION; ARTICLE; BIOSYNTHESIS; COMPARATIVE STUDY; ENZYME ACTIVATION; MALE; METABOLISM; THIN LAYER CHROMATOGRAPHY; TIME;

ARACHIDONIC ACIDS; BLOOD PLATELETS; CHROMATOGRAPHY, THIN LAYER; ENZYME ACTIVATION; HUMANS; MALE; MEMBRANE LIPIDS; PHOSPHATIDIC ACIDS; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHATIDYLSERINES; PHOSPHOLIPIDS; SCHIZOPHRENIA; THROMBIN; TIME FACTORS; TRITIUM;

EID: 0029658390     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-3278(96)90141-6     Document Type: Conference Paper

References (32)

1. Nestler E. J., Duman R. S. G proteins and cyclic nucleotides in the nervous system. In: Siegel G. J., Agranoff B. W., Albers R. W., Molinoff P. B., eds. Basic Neurochemistry. 5th edn. New York: Raven Press, 1994: pp 429-448.
2. Berridge M. J., Irvine, R. F. Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 1984; 312: 315-321.
3. Nishizuka Y. Turnover of inositol phospholipids and signal transduction. Science 1984; 225: 1365-1379.
4. Kishimoto A., Takai Y., Mori T., Kikkawa U., Nishizuka Y. Activation of calcium and phospholipid-dependent protein kinase by diacyl-glycerol, its possible relation to phosphatidylinositol turnover. J Biol Chem 1980; 255: 2273-2276.
5. Siess W. Molecular mechanism of platelet activation. Physiol Rev 1989; 69(1):58-141.
6. Das I., Essali M. A., deBelleroche J., Hirch S. R. Inositol phoslipid turnover in platelet of schizophrenic patients. Prostaglandins Leukot Essent Fatty Acids 1992; 46: 65-66.
7. Essali M. A., Das I., Belleroche J., Hirsch S. R. The platelet phosphoinositide system in schizophrenia: The effects of neuroleptic treatment. Biol Psychiatr 1990; 28: 475-487.
8. Yao J. Y., Yasei P., van Kammen D. P. Increased turnover of platelet phosphatidylinositol in schizophrenia. Prostaglandins Leukotr Essent Fatty Acids 1992; 46: 39-46.
9. Zilberman-Kaufman M., Agam G., Moscovitz L., Livne A. A., Belmaker R. H. Elevated inositol monophosphatase activity in schizophrenic patients. Clin Chem Acta 1992; 209: 89-93.
10. Levine J., Umansky R., Ezrielev G., Belmaker R. H. Lack of effect of inositol treatment in chronic schizophrenia. Biol Psychiatr 1993; 33: 673-675.
11. Kaiya H., Nishida A., Imai A., Nakashima S., Nozawa Y. Accumulation of diacylglycerol in platelet phosphoinositide turnover in schizophrenia: A biological marker of good prognosis? Biol Psychiatr 1989 26: 669-676.
12. Yao J. K., van Kammen D. P., Gurklis J. A. Abnormal incorporation of arachidonic acid into platelets of drug-free patients with schizophrenia. Psychiatr Res 1996; in press.
13. Csernansky J. G., Poscher M., Faull K. F. Serotonin in schizophrenia. In: Coccaro E. F., Murphy D. L., eds. Serotonin in Major Psychiatric Disorders. Washington DC: American Psychiatric Press, 1990, pp 211-230.
14. 2-adrenergic receptor populations on phosphoinositide hydrolysis. Life Sci 1991; 50: 169-180.
15. van Kammen D. P., Peters J., van Kammen W. B. et al. Elevated CSF NE and relapse in schizophrenia. Biol Psychiatr 1989; 26: 178-188.
16. Bunney W. E. Jr., Hamburg D. A. Methods for reliable longitudinal observation of behavior. Arch Gen Psychiatr 1963; 9: 280-294.
17. Overall J. E., Gorham D. R. The brief psychiatric rating scale. Psychol Res 1962; 10: 799-812.
18. Andreasen N. C. Negative symptoms in schizophrenia: Definition and reliability. Arch Gen Psychiatr 1982; 39: 784-794.
19. Siess W., Cuatrecasas P., Lapetina E. G. A role for cyclooxygenase products in the formation of phosphatidic acid in stimulated human platelets. J Biol Chem 1983; 258: 4683-4686.
20. Vargas J. R., Radomski M., Moncada S. The use of prostacyclin in the separation from plasma and washing of human platelets. Prostaglandins 1982; 23: 929-945.
21. Watson S. P., McConnell R. T., Lapetina E. G. The rapid formation of inositol phosphates in human platelets by thrombin is inhibited by prostacyclin. J Biol Chem 1984; 259: 13199-13202.
22. Billah M. M., Lapetina E. G. Rapid decrease of phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets. J Biol Chem 1982; 257: 12705-12708.
23. Yao J. K., Rastetter G. M. Microanalysis of complex lipids by high-performance thin-layer chromatography. Anal Biochem 1985; 150: 111-116.
24. Rittenhouse-Simmons S. Production of diglyceride from phosphatidyl-inositol in activated human platelets. Clin Invest 1979; 63: 580-587.
25. Bell R. L., Majerus P. W. Thrombin-induced hydrolysis of phosphatidyl-inositol in human platelets. J Biol Chem 1980; 255: 1790-1792.
26. Lapetina E. G., Hawthorne J. N. The diglyceride kinase of rat cerebral cortex. Biochemistry 1971; 122: 171-179.
27. Billah M. M., Lapetina E. G., Cuatrecasas P. Phosphatidylinositol-specific phospholipase C of platelets: Association with 1,2-diacylglycerol kinase and inhibition by cyclic AMP. Biochem Biophys Res Commun 1979; 90: 92-98.
28. Wakatabe H., Tsukahara T., Ishigooka J., Miura S. Effects of chlorpromazine on phosphatidylinositol turnover following thrombin stimulation of human platelets. Biol Psychiatr 1991; 29: 965-978.
29. Hokin L. E., Hokin M. R. Diglyceride kinase and other pathways for phosphatidic acid synthesis in the erythrocyte membrane. Biochim Biophys Acta 1963; 67: 470-484.
30. Demisch L., Heinz K., Gerbaldo H., Kirsten R. Increased concentrations of phosphatidylinositol (PI) and decreased esterification of arachidonic acid into phospholipids in platelets from patients with schizoaffective disorders or atypic phasic psychoses. Prostaglandins Leukot Essent Fatty Acids 1992; 46: 47-52.
31. Demisch L., Gerbaldo H. Gibt es biologische Pradiktoren fur den Verlauf endogener Psychosen? Untersuchungen zum Einbau von Arachidonsaure in Blutplattchenphospholipide. In: Beckmann H., Laux Hrsg G., eds. Biologische Psychiatrie Springer. Berlin: 1987: pp 126.
32. Gerbaldo H., Demisch L., Bochnik H. J. Phasic and process psychosis: A polydiagnostic comparison among the Frankfurt Classification System, DSM III, RDC, Feighner Criteria and ICD-9. Psychopath 1989; 22: 14-27.