DNA ploidy and MYC DNA amplification in ovarian carcinomas. Correlation with p53 and bcl-2 expression, proliferative activity and prognosis

Virchows Archiv

Volumn 429, Issue 4-5, 1996, Pages 221-227

  Diebold, Joachim ^a   Suchy, Bernhard ^a   Baretton, Gustavo Bruno ^a   Blasenbreu, Sabine ^a   Meier, Werner ^a   Schmidt, Michael ^a   Rabes, Hartmut ^a   Löhrs, Udo ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

DNA ploidy; Multiplex PCR; MYC amplification; Ovarian carcinoma; Prognosis

Indexed keywords

DNA; MONOCLONAL ANTIBODY KI 67; PROTEIN BCL 2; PROTEIN P53; KI 67 ANTIGEN;

ADULT; ARTICLE; CANCER GENETICS; CANCER GRADING; CELL PROLIFERATION; ENDOMETRIOID CARCINOMA; FEMALE; FLOW CYTOMETRY; GENE AMPLIFICATION; GENE EXPRESSION; GENE NUMBER; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MUCINOUS CARCINOMA; ONCOGENE MYC; OVARY CARCINOMA; PLOIDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TREATMENT OUTCOME; UNDIFFERENTIATED CARCINOMA; AGED; BIOSYNTHESIS; CARCINOMA; CHEMISTRY; GENETICS; IMAGE CYTOMETRY; METHODOLOGY; MIDDLE AGED; OVARY TUMOR;

AGED; CARCINOMA; DNA, NEOPLASM; FEMALE; FLOW CYTOMETRY; GENE AMPLIFICATION; GENES, MYC; HUMANS; IMAGE CYTOMETRY; KI-67 ANTIGEN; MIDDLE AGED; OVARIAN NEOPLASMS; PLOIDIES; POLYMERASE CHAIN REACTION; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0029658373     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Baker VV, Borst MR Dixon D, Hatch KD, Shingleton HM, Miller D (1990) c-myc amplification in ovarian cancer. Gynecol Oncol 38:340-342
2. Baretton G, Diebold J, DePascale T, Bussar-Maatz, R, Weissbach L, Löhrs U (1994) Deoxyribonucleic acid ploidy in seminomas with and without syncytiotrophoblastic cells. J Urol 151:67-71
3. Bauknecht T, Angel P, Kohler M, Kommoss F, Birmelin G, Pfleiderer A, Wagner E (1993) Gene structure and expression analysis of the epidermal growth factor receptor, transforming growth factor-alpha, myc, jun, and metallothionein in human ovarian carcinomas. Classification of malignant phenotypes. Cancer 71:419-429
4. Bell DA (1994) Flow cytometry. In: Kurman RJ (ed) Blaustein's pathology of the female genital tract. Springer, Berlin Heidelberg New York, pp 1161-1171
5. Berchuck A, Kohler MF, Hopkins MP, Humphrey PA, Robboy SJ, Rodriguez, GC, Soper JT, Clarke Pearson DL, Bast RC (1994) Overexpression of p53 is not a feature of benign and early-stage borderline epithelial ovarian tumours. Gynaecol Oncol 52:232-236
6. Berns EM, Klijn JG, Henzen Logmans SC, Rodenburg CJ, Burg ME van der, Foekens JA (1992) Receptors for hormones and growth factors and (onco)-gene amplification in human ovarian cancer. Int J Cancer 52:218-224
7. Bosari S, Viale G, Radaelli U, Bossi P, Bonoldi E, Coggi G (1993) p53 Accumulation in ovarian carcinomas and its prognostic implications. Hum Pathol 24:1175-1179
8. Braly PS, Klevecz RR (1993) Flow cytometric evaluation of ovarian cancer. Cancer 71:1621-1628
9. Brescia RJ, Barakat RA, Beller U, Frederickson G, Suhrland MJ, Dubin N, Demopoulos RI (1990) The prognostic significance of nuclear DNA content in malignant epithelial tumours of the ovary. Cancer 65:141-147
10. Brison O (1993) Gene amplification and tumour progression. Biochim Biophys Acta 1155:25-41
11. Cawkwell L, Lewis FA, Quirke P (1994) Frequency of allele loss of DCC, p53, RBI, WT1, NF1, NM23 and APC/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction. Br J Cancer 70:813-818
12. Christodoulou K, Ioannou P, Middleton L (1994) Molecular genetic detection of Xp21 muscular dystrophy carriers in Cyprus. Biomed Pharmacother 48:355-358
13. Diebold J, Baretton G, Felchner M, Meier W, Dopfer K, Schmidt M, Löhrs U (1996) Bcl-2 expression, p53 accumulation and apoptosis in ovarian carcinomas. Am J Clin Pathol 105:341-349
14. Erba E, Ubezio P, Pepe S, Vaghi M, Marsoni S, Torri W, Mangioni C, Landoni F, D'Incalci M (1989) Flow cytometric analysis of DNA content in human ovarian cancers. Br J Cancer 60:45-50
15. Gajewski WH, Fuller AF Jr, Pastel Ley C, Flotte TJ, Bell DA (1994) Prognostic significance of DNA content in epithelial ovarian cancer. Gynecol Oncol 53:5-12
16. Garte SJ (1993) The c-myc oncogene in tumour progression. Crit Rev Oncog 4:435-449
17. Gilbert J, Norris MD, Haber M, Kavallaris M, Marshall GM, Stewart BW (1993) Determination of N-myc gene amplification in neuroblastoma by differential polymerase chain reaction. Mol Cell Probes 7:227-234
18. Haapasalo H, Atkin NB, Collan Y, Pesonen E, Paljarvi L (1991) Tumour ploidy, morphometry, histological grading and clinical features in ovarian carcinoma: mutual relations. Anal Cell Pathol 3:261-271
19. Hartmann LC, Podratz KC, Keeney GL, Kamel NA, Edmonson JH, Grill JP, Su JQ, Katzmann JA, Roche PC (1994) Prognostic significance of p53 immunostaining in epithelial ovarian cancer. J Clin Oncol 12:64-69
20. Hedley DW, Friedlander ML, Taylor IW, Rugg CA, Musgrove EA (1983) Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. J Histochem Cytochem 31:1333-1335
21. Katsaros D, Theillet C, Zola P, Louason G, Sanfilippo B, Isaia E, Arisio R, Giardina G, Sismondi P (1995) Concurrent abnormal expression of erbB-2, myc and ras genes is associated with poor outcome of ovarian cancer patients. Anticancer Res 15:1501-1510
22. Kohler MF, Marks JR, Wiseman RW, Jacobs IJ, Davidoff AM, Clarke Pearson DL, Soper JT, Bast RC Jr, Berchuck A (1993) Spectrum of mutation and frequency of allelic deletion of the p53 gene in ovarian cancer. J Natl Cancer Inst 85:1513-1519
23. Koskinen PJ, Makela TP, Vastrik I, Alitalo K (1993) Myc amplification: regulation of myc function. Clin Chim Acta 217:57-62
24. Kupryjanczyk J, Thor AD, Beauchamp R, Merritt V, Edgerton SM, Bell DA, Yandell DW (1993) p53 Gene mutations and protein accumulation in human ovarian cancer. Proc Natl Acad Sci USA 90:4961-4965
25. Lane DP (1992) p53, guardian of the genome. Nature 358:15-16
26. Lane DP (1993) A death in the life of p53. Nature 362:786-787
27. Liehr T, Atanasov N, Tulusan HT, Gebhart E (1993) Amplification of proto-oncogenes in human ovarian carcinomas. Int J Oncol 2:155-160
28. Ljungberg B, Forsslund G, Stenling R, Zetterberg A (1986) Prognostic significance of the DNA content in renal cell carcinoma. J Urol 135:422-426
29. Marks JR, Davidoff AM, Kerns BJ, Humphrey PA, Pence JC, Dodge RK, Clarke Pearson DL, Iglehart JD, Bast RC Jr, Berchuck A (1991) Overexpression and mutation of p53 in epithelial ovarian cancer. Cancer Res 51:2979-2984
30. Okamoto A, Sameshima Y, Yokoyama S, Terashima Y, Sugimura T, Terada M, Yokota J (1991) Frequent allelic losses and mutations of the p53 gene in human ovarian cancer. Cancer Res 51:5171-5176
31. Padberg BC, Arps H, Franke U, Thiedemann C, Rehpenning W, Stegner HE, Lietz H, Schröder S, Dietel M (1992) DNA cytophotometry and prognosis in ovarian tumours of borderline malignancy. A clinicomorphologic study of 80 cases. Cancer 69:2510-2514
32. Petersson F (1988) Annual report on gynecological cancer of FIGO, vol 20. Panorama Press, Stockholm
33. Rodenburg CJ, Cornelisse CJ, Heintz PA, Hermans J, Fleuren GJ (1987) Tumour ploidy as a major prognostic factor in advanced ovarian cancer. Cancer 59:317-323
34. Rodenburg CJ, Ploem Zaaijer JJ, Cornelisse CJ, Mesker WE, Hermans J, Heintz PA, Ploem JS, Fleuren GJ (1987) Use of DNA image cytometry in addition to flow cytometry for the study of patients with advanced ovarian cancer. Cancer Res 47:3938-3941
35. Ryan JJ, Prochownik E, Gottlieb CA, Apel IJ, Merino R, Nunez G, Clarke MF (1994) c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle. Proc Natl Acad Sci USA 91:5878-5882
36. Saiki RK, Scharf S, Faloona F, Mullis KB, Horn GT, Erlich HA, Arnheim N (1985) Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230:1350-1354
37. Sasano H, Garrett CT, Wilkinson DS, Silverberg S, Comerford J, Hyde J (1990) Protooncogene amplification and tumour ploidy in human ovarian neoplasms. Hum Pathol 21:382-391
38. Schreiber G, Dubeau L (1990) C-myc proto-oncogene amplification detected by polymerase chain reaction in archival human ovarian carcinomas. Am J Pathol 137:653-658
39. Stewart BW (1994) Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators. J Natl Cancer Inst 86:1286-1296
40. Tashiro H, Miyazaki K, Okamura H, Iwai A, Fukumoto M (1992) c-myc over-expression in human primary ovarian tumours: its relevance to tumour progression. Int J Cancer 50:828-833
41. Trope C, Kaern J (1994) DNA ploidy in epithelial ovarian cancer: a new independent prognostic factor? Gynecol Oncol 53:1-4
42. Vaux DL, Cory S, Adams JM (1988) Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440-142
43. Zhou DJ, Gonzalez Cadavid N, Ahuja H, Battifora H, Moore GE, Cline MJ (1988) A unique pattern of proto-oncogene abnormalities in ovarian adenocarcinomas. Cancer 62:1573-1576