Bcl-x(S) enhances adenoviral vector-induced apoptosis in neuroblastoma cells

Cancer Research

Volumn 56, Issue 24, 1996, Pages 5734-5740

  Dole, Mukund G ^a   Clarke, Michael F ^a   Holman, Peter ^a   Benedict, Mary ^a   Lu, Jingyi ^a   Jasty, Rama ^a   Eipers, Peter ^a   Thompson, Craig B ^b   Rode, Christopher ^a   Bloch, Craig ^a   Nuñez, Gabriel ^a   Castle, Valerie P ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS VECTOR; BCL2L1 PROTEIN, HUMAN; DNA; DNA FRAGMENT; ONCOPROTEIN; PROTEIN BCL 2; PROTEIN BCL X;

ADENOVIRUS; APOPTOSIS; ARTICLE; GENE EXPRESSION; HUMAN; HUMAN CELL; NEUROBLASTOMA; PRIORITY JOURNAL; RNA SPLICING; CELL CULTURE; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOLOGY; PROTO ONCOGENE;

ADENOVIRIDAE; APOPTOSIS; BCL-X PROTEIN; DNA FRAGMENTATION; DNA, NEOPLASM; GENES, BCL-2; GENETIC VECTORS; HUMANS; NEUROBLASTOMA; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0029658337     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Wyllie, A. Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview. Cancer Metastasis Rev., 11: 95-103, 1992.
2. Canman, C., Tang, H., Normolle, D , Lawrence, T , and Maybaum, J. Variations in patterns of DNA damage induced in human colo-rectal tumor cells by 5-fluorode-oxyuridine: implications for mechanisms of resistance and cytotoxicity. Proc. Natl. Acad. Sci USA, 98: 10474-10478, 1992.
3. Oberhammer, F., Wilson, J., Dive, C , Morris, I., Hickman, J , Wakeling, A , Walker, P., and Sikorska, M Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J , 12: 3679-3684, 1993.
4. Tsujimoto, Y., Cossman, J , Jaffe, E , and Croce, C. Involvement of the bcl-2 oncogene in human follicular lymphoma. Science (Washington DC), 228: 1440-1443, 1985
5. Vaux, D , Cory, S., and Adams, J Bcl-2 promotes the survival of hematopoietic cells and cooperates with c-myc to immortalize pre-B cells. Nature (Lond), 335: 440-442, 1988.
6. Hockenbery, D M., Nuñez, G., Milliman, C., Schreiber, R. D., and Korsmeyer, S. J. Bcl-2 is an inner mitochondrial membrane protein that blocks PCD Nature (Lond.), 348: 334-336, 1990
7. Tsujimoto, Y. Stress-resistance conferred by high level of Bcl-2 protein in human B lymphoblastoid cell line. Oncogene, 4: 1331-1336, 1989
8. Sentman, C., Shutter, J., Hockenbery, D., Kanagawa, O., and Korsmeyer, S. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes Cell, 67: 879-888, 1992
9. Miyashita, T., and Reed, J. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood, 81: 151-157, 1993.
10. Boise, L., Gonzalez-Garcia, M., Postema, C , Ding, L., Linsten, T , Turka, L., Mao, X , Nuñez, G., and Thompson, C. bcl-x, a bcl-2 related gene that functions as a dominant regulator or apoptotic cell death. Cell, 74: 597-608, 1993.
11. Nuñez, G., and Clarke, M The Bcl-2 family of proteins: regulators of cell death and survival. Trends Cell Biol., 4: 399-403, 1994.
12. Sato, T , Hanada, M , Bodrug, S., Irie, S., Iwama, N., Boise, L , Thompson, C , Golemis, E , Fong, L , Wang, H., and Reed, J. Interactions among members of the Bcl-2 protein family with a yeast two hybrid system Proc. Natl. Acad Sci USA, 91: 9238-9242, 1994.
13. Krajewski, S., Krajewska, M., Shabaik, A., Wang, H., Ine, S , Fong, L , and Reed, J Immunohistochemical analysis of in vivo patterns of Bcl-x expression Cancer Res., 54: 5501-5507, 1994.
14. L is the major mRNA form expressed during murine development and its product localizes to the mitochondria. Development (Camb ), 120: 3033-3042, 1994
15. Krajewski, S , Bodrug , S , Gascoyne, R , Beran, K , Krajewska, M., and Reed, J Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes. Am. J Pathol., 145: 515-525, 1994.
16. Heermeier, K., Benedict, M., Minglin, L , Furth, P , Nuñez, G., and Hennighausen, L. Bax and Bcl-xS are induced at the onset of apoptosis in involuting mammary epithelial cells Mech Dev., 56: 197-207, 1996
17. L is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis. Cancer Res , 55: 2576-2582, 1995.
18. Dole, M., Nuñez, G., Merchant, A , Maybaum, J., Rode, C., Bloch, C., and Castle, V. Bcl-2 inhibits chemotherapy-induced apoptosis in neuroblastoma. Cancer Res., 54: 3253-3259, 1994.
19. S adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells Proc. Natl. Acad. Sci. USA, 92. 11024-11028, 1995
20. Yang, Y., Nunes, F., Berencsi, K., Furth, E., Gonczol, E , and Wilson, J. Cellular immunity to viral antigens limits El-deleted adenoviruses for gene therapy Proc. Natl. Acad. Sci USA, 91: 4407-4411, 1994.
21. Gottschalk, A., Boise, L , Thompson, C , and Quintans, J. Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2. Proc. Natl. Acad. Sci. USA, 91: 7350-7354, 1994.
22. Hansen, M., Nielson, S., and Berg, K. Re-examination and further development of a precise and rapid dye method for measuring cell growth and cell kill. J Immunol. Methods, 119: 203-210, 1989.
23. Nicoletti, I., Migliorati, G., Pagliacci, M., Grignani, F , and Riccardi, C A rapid and simple method for measuring thymocyte apoptosis by propidium iodide and flow cytometry J. Immunol. Methods, 139: 271-279, 1991.
24. Fraker, P., King, L., Lill-Elghanian, D., and Telford, W Quantification of apoptotic events in pure and heterogeneous populations of cells using the flow cytometer. Methods Cell Biol., 46: 57-76, 1995.
25. Walker, P , Kokileva, L , LeBlanc, J., and Sikorska, M. Detection of the initial stages of DNA fragmentation in apoptosis Biotechniques, 15: 1032-1040, 1993.
26. Ellis, R., Yuan, J., and Horvitz, H. Mechanisms and functions of cell death Annu. Rev. Cell Biol., 7: 663-698, 1991.
27. S sensitizes MCF-7 cells to chemotherapy-induced apoptosis. Cancer Res., 55: 2507-2510, 1995.
28. Walker, P., and Sikorska, M Endonuclease activities, chromatin structure and DNA degradation in apoptosis. Biochem. Cell Biol., 72: 615-623, 1994.
29. 2+ alone. FEBS Lett , 349: 385-391, 1994.
30. Filipski, J., LeBlanc, J., Youdale, T., Sikorska, M., and Walker, R. Periodicity of DNA folding in higher order chromatin structures. EMBO J., 9: 1319-1327, 1990.
31. Laemmli, U., Das, E , Poljak, L., and Adachi, Y. Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains. Curr. Opin Genet. Dev., 2: 275-285, 1992
32. Garrard, W. Chromosomal loop organization in eukaryotic genomes. In: F. Eckstein and D. Lilley (eds.), Nucleic Acids and Molecular Biology, pp 163-175 Berlin: Springer-Verlag, 1990.
33. Gasser, S., Amati, B , Cardenas, M., and Hofmann, J. Studies on scaffold attachment sites and their relation to genome function. Int. Rev. Cytol., 119: 57-96, 1989.
34. Zlatanova, J., and van Holde, E. Chromatin loops and transcriptional regulation. Crit. Rev Eukaryotic Gene Expr., 2: 211-224, 1992.