Mouse cerebellar GABA(B) participation in the expression of acute ethanol-induced ataxia and in its modulation by the cerebellar adenosinergic A1 system

Brain Research Bulletin

Volumn 41, Issue 1, 1996, Pages 53-59

  Dar, M Saeed ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Baclofen; Cyclohexyladenosine; Intracerebellar mice; Motor impairment; Pertussis toxin; Phaclophen

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 AMINOBUTYRIC ACID B RECEPTOR; 8 CYCLOPENTYLTHEOPHYLLINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A1 RECEPTOR; ADENYLATE CYCLASE; ALCOHOL; BACLOFEN; CYCLOHEXYLADENOSINE; MUSCIMOL; PERTUSSIS TOXIN; PHACLOFEN; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ADENOSINE; ADENOSINE RECEPTOR; ADENYLATE CYCLASE TOXIN; BORDETELLA VIRULENCE FACTOR; DRUG DERIVATIVE; GUANINE NUCLEOTIDE BINDING PROTEIN; N(6) CYCLOHEXYLADENOSINE; N(6)-CYCLOHEXYLADENOSINE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBELLAR ATAXIA; CONTROLLED STUDY; ENZYME ACTIVE SITE; GRANULE CELL; MALE; MOTOR COORDINATION; MOTOR DYSFUNCTION; MOUSE; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; ANIMAL; ANIMAL BEHAVIOR; ATAXIA; CEREBELLUM; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; MICROINJECTION; MOTOR ACTIVITY; MOUSE STRAIN; PHYSIOLOGY;

ADENOSINE; ADENYLATE CYCLASE TOXIN; ANIMALS; ATAXIA; BACLOFEN; BEHAVIOR, ANIMAL; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; GABA AGONISTS; GTP-BINDING PROTEINS; MALE; MICE; MICE, INBRED STRAINS; MICROINJECTIONS; MOTOR ACTIVITY; MUSCIMOL; PERTUSSIS TOXIN; RECEPTORS, GABA-B; RECEPTORS, PURINERGIC P1; VIRULENCE FACTORS, BORDETELLA;

EID: 0029658273     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(96)00172-4     Document Type: Article

References (23)

1. 1. Becker, H. C. (1988) Effects of the imidazobenzodiazepine Ro15-4513 on the stimulant and depressant actions of ethanol on spontaneous locomotor activity. Life Sci. 43:643-650.
2. 2. Hoffman, P. L.; Tabakoff, B.; Szabo, G.; Suzdak, P. D.; Paul, S. M. (1987) Effect of an imidazobenzodiazepine, Ro15-4513, on the incoordination and hypothermia produced by ethanol and pentobarbital. Life Sci. 41:611-619.
3. 3. Dar, M. S. (1992) Selective antagonism of acute ethanol-induced motor disturbances by centrally administered Ro15-4513 in mice. Pharmacol. Biochem. Behav. 42:473-479.
4. 4. Polc, P. (1985) Interactions of partial inverse benzodiazepine agonists Ro15-4513 and FG-7142 with ethanol in rats and cats. Br. J. Pharmacol. 86:465P.
5. 5. Bonetti, E. P.; Burkard, W. P.; Gabl, M.; Mohler, H. (1985) The partial inverse benzodiazepine agonist Ro15-4513 antagonizes acute ethanol effects in mice and rats. Br. J. Pharmacol. 86:463P.
6. 6. Suzdak, P. D.; Glowe, J. R.; Crawley, J. N.; Schwartz, R. D.; Skol-Nick, P.; Paul, S. M. (1986) A selective imidazobenzodiazepine antagonist of ethanol in the rat. Science (Washington, D.C.) 234:1243-1247.
7. 7. Dar, M. S. (1995) Antagonism by intracerebellar Ro15-4513 of acute ethanol-induced motor incoordination in mice. Pharmacol. Biochem. Behav. 52:217-223.
8. 3H] Ro15-4513 binding in intact cultured cerebellar granule cells. Eur. J. Pharmacol. 169:53-60.
9. 9. Simantov, R.; Oster-Granite, M. L.; Nerndon, R. M.; Snyder, S. H. (1976) Gamma-aminobutyric acid receptor binding selectively by viral-induced granule cell in hamster cerebellum. Brain Res. 105:365-371.
10. B) receptors of cerebellum may share a common adenylate cyclase catalytic unit. J. Pharmacol. Exp. Ther. 232:62-66.
11. 11. Pacheco, M. A.; Ward, S. J.; Childers, S. R. (1993) Identification of cannabinoid receptors in cultures of rat cerebellar granule cells. Brain Res. 603:102-110.
12. 12. Bowery, N. G.; Doble, A.; Hill, D. R.; Hudson, A. L.; Shaw, J. S.; Turnbull, M. J.; Warrington, R. (1981) Bicuculline-insensitive GABA receptors on peripheral autonomic nerve terminals. Eur. J. Pharmacol. 294:584-587.
13. 13. Dietrich, R. A.; Dunwiddie, T. V.; Harris, R. A.; Erwin, V. G. (1989) Mechanism of action of ethanol: Initial central nervous system actions. Pharmacol. Rev. 41:357-489.
14. A receptor operated chloride channels: II chronic effects of ethanol. J. Pharmacol. Exp. Ther. 253:713-719.
15. 15. Allan, A. M.; Harris, R. A. (1989) A new alcohol antagonist: Phaclofen. Life Sci. 45:1771-1779.
16. B receptors in mediating the locomotor stimulatory effects of ethanol in mice. Psychopharmacology (Berlin) 111:219-224.
17. 17. Dar, M. S.; Mustafa, S. J.; Wooles, W. R. (1983) Possible role of adenosine in the CNS effects of ethanol. Life Sci. 33:1363-1374.
18. 18. Dar, M. S. (1990) Central adenosinergic system involvement in ethanol-induced motor incoordination in mice. J. Pharmacol. Exp. Ther. 255:1202-1209.
19. 19. Dar, M. S.; Bowman, E. R.; Li, C. (1994) Intracerebellar nicotinic-cholinergic participation in the cerebellar adenosinergic modulation of ethanol-induced motor incoordination in mice. Brain Res. 644:117-127.
20. 20. Meng, Z. H.; Dar, M. S. (1994) Intrastriatal Ro15-4513 functionally antagonizes ethanol-induced motor incoordination and striatal adenosinergic modulation of ethanol-induced in rats. J. Pharmacol. Exp. Ther. 271:524-534.
21. 21. Slotnick, B. M.; Leonard, C. M. (1975) A stereotaxic atlas of albino mouse forebrain. Washington, D.C.: U.S. Government Printing Office.
22. 22. Sidman, R. L.; Augerine, J. B.; Jr.; Pierce, E. T. (1971) Atlas of the mouse brain and spinal cord. Cambridge, MA: Harvard University Press.
23. B receptors involved in the pharmacological effects of ethanol? Eur. J. Pharmacology 182:473-480.