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Volumn 192, Issue 7, 1996, Pages 658-668

P21(ras) in carcinogenesis

Author keywords

Apoptosis; Carcinogenesis; Cell cycle regulation; p21(ras) on oncogenes

Indexed keywords

GROWTH FACTOR; GROWTH FACTOR RECEPTOR; ONCOPROTEIN; PROTEIN P21; RAS PROTEIN; CARCINOGEN; HRAS PROTEIN, HUMAN;

EID: 0029658248     PISSN: 03440338     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0344-0338(96)80087-2     Document Type: Article
Times cited : (17)

References (139)
  • 1
    • 0025720735 scopus 로고
    • The role of Jun, Fos, and the AP-1 complex in cell-proliferation and transformation
    • Angel P, Karin M (1991 ) The role of Jun, Fos, and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1072: 129-157
    • (1991) Biochim Biophys Acta , vol.1072 , pp. 129-157
    • Angel, P.1    Karin, M.2
  • 2
    • 0027515642 scopus 로고
    • Susceptibility to apoptosis is differentially regulated by c-myc and mutated Ha-ras oncogenes and is associated with endonuclease availability
    • Arends MJ, McGregor AH, Toft NJ, Brown EJH, Wyllie AH (1993) Susceptibility to apoptosis is differentially regulated by c-myc and mutated Ha-ras oncogenes and is associated with endonuclease availability. Br J Cancer 68: 1127-1133
    • (1993) Br J Cancer , vol.68 , pp. 1127-1133
    • Arends, M.J.1    McGregor, A.H.2    Toft, N.J.3    Brown, E.J.H.4    Wyllie, A.H.5
  • 3
    • 0028231893 scopus 로고
    • Apoptosis is inversely related to necrosis and determines net growth in tumors bearing constitutively expressed myc, ras, and HPV oncogenes
    • Arends MJ, McGregor AH, Wyllie AH (1994) Apoptosis is inversely related to necrosis and determines net growth in tumors bearing constitutively expressed myc, ras, and HPV oncogenes. Am J Pathol 144: 1045-1057
    • (1994) Am J Pathol , vol.144 , pp. 1045-1057
    • Arends, M.J.1    McGregor, A.H.2    Wyllie, A.H.3
  • 4
    • 0027931640 scopus 로고
    • Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway
    • Aronheim A, Engelberg D, Li N, Al-Alawi N, Schlessinger J, Karin M (1994) Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. Cell 78: 949-961
    • (1994) Cell , vol.78 , pp. 949-961
    • Aronheim, A.1    Engelberg, D.2    Li, N.3    Al-Alawi, N.4    Schlessinger, J.5    Karin, M.6
  • 6
    • 0026521070 scopus 로고
    • Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients
    • Basu TN, Gutmann DH, Fletcher JA, Glover TW, Collins FS, Downward J (1992) Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients. Nature 356: 713-715
    • (1992) Nature , vol.356 , pp. 713-715
    • Basu, T.N.1    Gutmann, D.H.2    Fletcher, J.A.3    Glover, T.W.4    Collins, F.S.5    Downward, J.6
  • 7
    • 0029126877 scopus 로고
    • Neurofibromatosis type 1 and Ras-mediated signaling: Filling in the GAPs
    • Bernards A (1995) Neurofibromatosis type 1 and Ras-mediated signaling: Filling in the GAPs. Biochim Biophys Acta 1242: 43-59
    • (1995) Biochim Biophys Acta , vol.1242 , pp. 43-59
    • Bernards, A.1
  • 8
    • 0027732538 scopus 로고
    • Proteins regulating Ras and its relatives
    • Boguski MS, McCormick F (1993) Proteins regulating Ras and its relatives. Nature 366: 643-654
    • (1993) Nature , vol.366 , pp. 643-654
    • Boguski, M.S.1    McCormick, F.2
  • 9
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos JL (1989) Ras oncogenes in human cancer: A review. Cancer Res 49: 4682-4689
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 10
    • 0026026818 scopus 로고
    • The GTPase superfamily: Conserved structure and molecular mechanism
    • Bourne HR, Sanders DA, McCormick F (1991) The GTPase superfamily: conserved structure and molecular mechanism. Nature 349: 117-127
    • (1991) Nature , vol.349 , pp. 117-127
    • Bourne, H.R.1    Sanders, D.A.2    McCormick, F.3
  • 11
    • 0028917954 scopus 로고
    • Regulation of Ras-mediated signalling: More than one way to skin a cat
    • Burgering BMT, Bos JL (1995) Regulation of Ras-mediated signalling: more than one way to skin a cat. TIBS 20: 18-22
    • (1995) TIBS , vol.20 , pp. 18-22
    • Burgering, B.M.T.1    Bos, J.L.2
  • 12
    • 0029160069 scopus 로고
    • Protein kinase B (c-Akt) in phosphatidyhnositol-3-OH kinase signal transduktion
    • Burgering MT, Coffer PJ (1995) Protein kinase B (c-Akt) in phosphatidyhnositol-3-OH kinase signal transduktion. Nature 376: 599-602
    • (1995) Nature , vol.376 , pp. 599-602
    • Burgering, M.T.1    Coffer, P.J.2
  • 14
    • 0029153801 scopus 로고
    • Src regulates the simultaneous rearrangement of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation
    • Chang J-H, Gill S, Settleman J, Parsons SJ (1995) c-Src regulates the simultaneous rearrangement of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation. J Cell Biol 130: 355-368
    • (1995) J Cell Biol , vol.130 , pp. 355-368
    • Chang, J.-H.1    Gill, S.2    Settleman, J.3    Parsons, S.J.4
  • 15
    • 0028915743 scopus 로고
    • GTPase cascades choreographing cellular behavior: Movement, morphogenesis, and more
    • Chant J, Stowers L (1995) GTPase cascades choreographing cellular behavior: Movement, morphogenesis, and more. Cell 81: 1-4
    • (1995) Cell , vol.81 , pp. 1-4
    • Chant, J.1    Stowers, L.2
  • 16
    • 0027938510 scopus 로고
    • Phosphorylation of the Ras nucleotide exchange factor Son of sevenless by Mitogen-activated protein kinase
    • Cherniack AD, Klarlund JK, Czech MP (1994) Phosphorylation of the Ras nucleotide exchange factor Son of sevenless by Mitogen-activated protein kinase. J Biol Chem 269: 4717-4720
    • (1994) J Biol Chem , vol.269 , pp. 4717-4720
    • Cherniack, A.D.1    Klarlund, J.K.2    Czech, M.P.3
  • 17
    • 0027956706 scopus 로고
    • Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues
    • Chuang E, Barnard D, Hettich L, Zhang X-F, Avruch J, Marshall MS (1994) Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues. Mol Cell Biol 14: 5318-5325
    • (1994) Mol Cell Biol , vol.14 , pp. 5318-5325
    • Chuang, E.1    Barnard, D.2    Hettich, L.3    Zhang, X.-F.4    Avruch, J.5    Marshall, M.S.6
  • 19
    • 0028589148 scopus 로고
    • Platelet-derived growth factor receptor signals
    • Claesson-Welsh L (1994) Platelet-derived growth factor receptor signals. J Biol Chem 269: 32023-32026
    • (1994) J Biol Chem , vol.269 , pp. 32023-32026
    • Claesson-Welsh, L.1
  • 20
    • 0027716596 scopus 로고
    • Inhibition by cAMP of Ras-dependent activation of Raf
    • Cook SJ, McCormick F (1993) Inhibition by cAMP of Ras-dependent activation of Raf. Science 262: 1069-1072
    • (1993) Science , vol.262 , pp. 1069-1072
    • Cook, S.J.1    McCormick, F.2
  • 21
    • 0029055812 scopus 로고
    • The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
    • Coso OA, Ciariello M, Yu Y-C, Teramoto H, Crespo P, Xu N, Miki T, Gutkind JS (1995) The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81: 1137-1146
    • (1995) Cell , vol.81 , pp. 1137-1146
    • Coso, O.A.1    Ciariello, M.2    Yu, Y.-C.3    Teramoto, H.4    Crespo, P.5    Xu, N.6    Miki, T.7    Gutkind, J.S.8
  • 22
    • 0028228616 scopus 로고
    • Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
    • Cowley S, Paterson H, Kemp P, Marshall CJ (1994) Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77: 841-852
    • (1994) Cell , vol.77 , pp. 841-852
    • Cowley, S.1    Paterson, H.2    Kemp, P.3    Marshall, C.J.4
  • 23
    • 0026539931 scopus 로고
    • The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product
    • Crews CM, Alessandrini A, Erikson RL (1992) The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science 258: 478-480
    • (1992) Science , vol.258 , pp. 478-480
    • Crews, C.M.1    Alessandrini, A.2    Erikson, R.L.3
  • 24
    • 0027943249 scopus 로고
    • Myc induces cyclin D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle
    • Daksis JI, Lu RY, Facchini LM, Marhin WW, Penn LJZ (1994) Myc induces cyclin D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle. Oncogene 9: 3635-3645
    • (1994) Oncogene , vol.9 , pp. 3635-3645
    • Daksis, J.I.1    Lu, R.Y.2    Facchini, L.M.3    Marhin, W.W.4    Penn, L.J.Z.5
  • 26
    • 0027165150 scopus 로고
    • The mitogen-activated protein kinase signal transduction pathway
    • Davis RJ (1993) The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 268: 14553-14556
    • (1993) J Biol Chem , vol.268 , pp. 14553-14556
    • Davis, R.J.1
  • 27
    • 0028338927 scopus 로고
    • The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle
    • Denko NC, Giaccia AJ, Stringer JR, Stambrook PJ (1994) The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle. Proc Natl Acad Sci USA 91: 5124-5128
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5124-5128
    • Denko, N.C.1    Giaccia, A.J.2    Stringer, J.R.3    Stambrook, P.J.4
  • 28
    • 0027957728 scopus 로고
    • The GRB2/Sem-5 adaptor protein
    • Downward J (1994) The GRB2/Sem-5 adaptor protein. FEBS Letters 338: 113-117
    • (1994) FEBS Letters , vol.338 , pp. 113-117
    • Downward, J.1
  • 29
  • 30
    • 0027910431 scopus 로고
    • Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation
    • Egan SE, Giddings BW, Brooks MW, Buday L, Sizeland AM, Weinberg RA (1993) Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature 363: 45-51
    • (1993) Nature , vol.363 , pp. 45-51
    • Egan, S.E.1    Giddings, B.W.2    Brooks, M.W.3    Buday, L.4    Sizeland, A.M.5    Weinberg, R.A.6
  • 31
    • 0023124104 scopus 로고
    • Expression of H-ras correlates with metastatic potential: Evidence for direct regulation of the metastatic phenotype in 10T1/2 and NIH 3T3 cells
    • Egan SE, McClarty GA, Jarolim L, Wright JA, Spiro I, Hager G, Greenberg AH (1987) Expression of H-ras correlates with metastatic potential: evidence for direct regulation of the metastatic phenotype in 10T1/2 and NIH 3T3 cells. Mol Cell Biol 7: 830-837
    • (1987) Mol Cell Biol , vol.7 , pp. 830-837
    • Egan, S.E.1    McClarty, G.A.2    Jarolim, L.3    Wright, J.A.4    Spiro, I.5    Hager, G.6    Greenberg, A.H.7
  • 36
    • 0023715225 scopus 로고
    • Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP
    • Feig LA, Cooper GM (1988) Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol Cell Biol 8: 3235-3243
    • (1988) Mol Cell Biol , vol.8 , pp. 3235-3243
    • Feig, L.A.1    Cooper, G.M.2
  • 37
    • 0021719520 scopus 로고
    • Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells
    • Feramisco JR, Gross M, Kamata T, Rosenberg M, Sweet RW (1984) Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells. Cell 38: 109-117
    • (1984) Cell , vol.38 , pp. 109-117
    • Feramisco, J.R.1    Gross, M.2    Kamata, T.3    Rosenberg, M.4    Sweet, R.W.5
  • 38
    • 0027440568 scopus 로고
    • Bcl-2 associates with the ras-related protein R-ras p23
    • Fernandez-Sarabla MJ, Bisschoff JR (1993) Bcl-2 associates with the ras-related protein R-ras p23. Nature 366: 274-275
    • (1993) Nature , vol.366 , pp. 274-275
    • Fernandez-Sarabla, M.J.1    Bisschoff, J.R.2
  • 40
    • 0023158728 scopus 로고
    • Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes
    • Flier JS, Mueckler MM, Usher P, Lodish HF (1987) Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science 235: 1492-1495
    • (1987) Science , vol.235 , pp. 1492-1495
    • Flier, J.S.1    Mueckler, M.M.2    Usher, P.3    Lodish, H.F.4
  • 41
  • 42
    • 0027420730 scopus 로고
    • The glucose transporter family: Structure, function, and tissue-specific expression
    • Gould GW, Holman GD (1993) The glucose transporter family: Structure, function, and tissue-specific expression. Biochem J 295: 329-341
    • (1993) Biochem J , vol.295 , pp. 329-341
    • Gould, G.W.1    Holman, G.D.2
  • 45
    • 0028021882 scopus 로고
    • Pleckstrin homology domains bind to phosphatidylinositol-4,5-biphosphate
    • Harlan JE, Hajduk PJ, Yoon NS, Fesik SW (1994) Pleckstrin homology domains bind to phosphatidylinositol-4,5-biphosphate. Nature 371: 168-170
    • (1994) Nature , vol.371 , pp. 168-170
    • Harlan, J.E.1    Hajduk, P.J.2    Yoon, N.S.3    Fesik, S.W.4
  • 46
    • 0026452949 scopus 로고
    • Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells
    • Hartwell L (1992) Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell 71: 543-546
    • (1992) Cell , vol.71 , pp. 543-546
    • Hartwell, L.1
  • 47
    • 0016374648 scopus 로고
    • Transport of sugars in tumor cell membranes
    • Hatanaka M (1974) Transport of sugars in tumor cell membranes. Biochim Biophys Acta 355: 77-104
    • (1974) Biochim Biophys Acta , vol.355 , pp. 77-104
    • Hatanaka, M.1
  • 48
    • 0028168827 scopus 로고
    • Role of p21 ras in insulin-stimulated glucose transport in 3T3-L1 adipocytes
    • Hausdorff SF, Frangioni JV, Birnbaum MJ (1994) Role of p21 ras in insulin-stimulated glucose transport in 3T3-L1 adipocytes. J Biol Chem 269: 21391-21394
    • (1994) J Biol Chem , vol.269 , pp. 21391-21394
    • Hausdorff, S.F.1    Frangioni, J.V.2    Birnbaum, M.J.3
  • 50
    • 0028171968 scopus 로고
    • Mediation of c-Myc-induced apoptosis by p53
    • Hermeking H, Eick D (1994) Mediation of c-Myc-induced apoptosis by p53. Science 265: 2091-2093
    • (1994) Science , vol.265 , pp. 2091-2093
    • Hermeking, H.1    Eick, D.2
  • 51
    • 0026698173 scopus 로고
    • Apoptosis induced by anticancer drugs
    • Hickman JA (1992) Apoptosis induced by anticancer drugs. Cancer Metastasis Rev 11: 121-139
    • (1992) Cancer Metastasis Rev , vol.11 , pp. 121-139
    • Hickman, J.A.1
  • 53
    • 0026802989 scopus 로고
    • Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
    • Hinds PW, Mittnacht S, Dulic V, Arnold A, Reed SI, Weinberg RA (1992) Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70: 993-1006
    • (1992) Cell , vol.70 , pp. 993-1006
    • Hinds, P.W.1    Mittnacht, S.2    Dulic, V.3    Arnold, A.4    Reed, S.I.5    Weinberg, R.A.6
  • 54
    • 0028222129 scopus 로고
    • Molecular cloning and tissue distribution of PHAS-I, an intracellular target for insulin and growth factors
    • Hu C, Pang S, Kong X, Velleca M, Lawrence Jr JC (1994) Molecular cloning and tissue distribution of PHAS-I, an intracellular target for insulin and growth factors. Proc Natl Acad Sci USA 91: 3730-3734
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3730-3734
    • Hu, C.1    Pang, S.2    Kong, X.3    Velleca, M.4    Lawrence Jr., J.C.5
  • 55
    • 0027428530 scopus 로고
    • Raf-1 forms a stable complex with MEK1 and activates MEK1 by serine phosphorylation
    • Huang W, Allessandrini A, Crews CM, Erikson RL (1993) Raf-1 forms a stable complex with MEK1 and activates MEK1 by serine phosphorylation. Proc Natl Acad Sci USA 90: 10947-10951
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10947-10951
    • Huang, W.1    Allessandrini, A.2    Crews, C.M.3    Erikson, R.L.4
  • 56
    • 0027938209 scopus 로고
    • Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
    • Hunter T, Pines J (1994) Cyclins and cancer II: Cyclin D and CDK inhibitors come of age. Cell 79: 573-582
    • (1994) Cell , vol.79 , pp. 573-582
    • Hunter, T.1    Pines, J.2
  • 57
    • 0025745484 scopus 로고
    • H-ras expression, genetic instability, and acquisition of metastatic ability by rat prostatic cancer cells following v-H-ras oncogene transaction
    • Ichikawa T, Schalken JA, Ichikawa Y, Steinberg GD, Isaacs JT (1991) H-ras expression, genetic instability, and acquisition of metastatic ability by rat prostatic cancer cells following v-H-ras oncogene transaction. Prostate 18: 163-172
    • (1991) Prostate , vol.18 , pp. 163-172
    • Ichikawa, T.1    Schalken, J.A.2    Ichikawa, Y.3    Steinberg, G.D.4    Isaacs, J.T.5
  • 58
    • 0027494864 scopus 로고
    • Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression
    • Jiang W, Kahn SM, Zhou P, Zhang YJ, Cacace AM, Infante AS, Doi S, Santella RM, Weinstein IB (1993) Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression. Oncogene 8: 3447-3457
    • (1993) Oncogene , vol.8 , pp. 3447-3457
    • Jiang, W.1    Kahn, S.M.2    Zhou, P.3    Zhang, Y.J.4    Cacace, A.M.5    Infante, A.S.6    Doi, S.7    Santella, R.M.8    Weinstein, I.B.9
  • 59
    • 0025252220 scopus 로고
    • PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex
    • Kaplan DR, Morrison DK, Wong G, McCormick F, Williams LT (1990) PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex. Cell 61: 125-133
    • (1990) Cell , vol.61 , pp. 125-133
    • Kaplan, D.R.1    Morrison, D.K.2    Wong, G.3    McCormick, F.4    Williams, L.T.5
  • 61
    • 0023443072 scopus 로고
    • Immortalization by c-myc, H-ras, and Ela oncogenes induces differential cellular gene expression and growth factor responses
    • Kelekar A, Cole MD (1987) Immortalization by c-myc, H-ras, and Ela oncogenes induces differential cellular gene expression and growth factor responses. Mol Cell Biol 7: 3899-3907
    • (1987) Mol Cell Biol , vol.7 , pp. 3899-3907
    • Kelekar, A.1    Cole, M.D.2
  • 64
    • 0028272507 scopus 로고
    • Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
    • Leevers SJ, Paterson HF, Marshall CJ (1994) Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature 369: 411-414
    • (1994) Nature , vol.369 , pp. 411-414
    • Leevers, S.J.1    Paterson, H.F.2    Marshall, C.J.3
  • 65
    • 0028204538 scopus 로고
    • The 1993 Walter Hubert Lecture: The role of the p53 tumour-suppressor gene in tumorigenesis
    • Levine AJ, Perry ME, Chang A, Silver A, Dittmer D, Wu M, Welsh D (1994) The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis. Br J Cancer 69: 409-416
    • (1994) Br J Cancer , vol.69 , pp. 409-416
    • Levine, A.J.1    Perry, M.E.2    Chang, A.3    Silver, A.4    Dittmer, D.5    Wu, M.6    Welsh, D.7
  • 67
    • 0025773554 scopus 로고
    • Mutator phenotype may be required for multistage carcinogenesis
    • LoebLA (1991) Mutator phenotype may be required for multistage carcinogenesis. Cancer Res 57: 3075-3079
    • (1991) Cancer Res , vol.57 , pp. 3075-3079
    • Loeb, L.A.1
  • 68
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe SW, Ruley HE, Jacks T (1993) p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74: 957-967
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3
  • 69
    • 0029006126 scopus 로고
    • Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation
    • Marais R, Light Y, Paterson HE, Marshall CJ (1995) Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation. The EMBO Journal 14: 3136-3145
    • (1995) The EMBO Journal , vol.14 , pp. 3136-3145
    • Marais, R.1    Light, Y.2    Paterson, H.E.3    Marshall, C.J.4
  • 70
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
    • Marshall CJ (1995) Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation. Cell 80: 179-185
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 72
    • 0026567562 scopus 로고
    • GAP domains responsible for Ras p21-dependent inhibition of muscarinic atrial K+ channel currents
    • Martin GA, Yatani A, Clark R, Conroy L, Polakis P, Brown AM, McCormick F (1992) GAP domains responsible for Ras p21-dependent inhibition of muscarinic atrial K+ channel currents. Science 255: 192-194
    • (1992) Science , vol.255 , pp. 192-194
    • Martin, G.A.1    Yatani, A.2    Clark, R.3    Conroy, L.4    Polakis, P.5    Brown, A.M.6    McCormick, F.7
  • 73
    • 0028049248 scopus 로고
    • How cells cycle towards cancer
    • Marx J (1994) How cells cycle towards cancer. Science 263: 319-321
    • (1994) Science , vol.263 , pp. 319-321
    • Marx, J.1
  • 75
    • 0026778344 scopus 로고
    • GTPase-activating protein SH2-SH3 domains induce gene expression in a Ras-dependent fashion
    • Medema RH, de-Laat WL, Martin GA, McCormick F, Bos JL (1992) GTPase-activating protein SH2-SH3 domains induce gene expression in a Ras-dependent fashion. Mol Cell Biol 12: 3425-3430
    • (1992) Mol Cell Biol , vol.12 , pp. 3425-3430
    • Medema, R.H.1    De-Laat, W.L.2    Martin, G.A.3    McCormick, F.4    Bos, J.L.5
  • 76
    • 0027772521 scopus 로고
    • Growth factors, mitogens, oncogenes and the regulation of glucose transport
    • Merral NW, Plevin R, Gould GW (1993) Growth factors, mitogens, oncogenes and the regulation of glucose transport. Cell Signalling 5: 667-675
    • (1993) Cell Signalling , vol.5 , pp. 667-675
    • Merral, N.W.1    Plevin, R.2    Gould, G.W.3
  • 77
    • 0028363749 scopus 로고
    • Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases
    • Milne DM, Campbell DG, Caudwell FB, Meek DW (1994) Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases. J Biol Chem 269: 9253-9260
    • (1994) J Biol Chem , vol.269 , pp. 9253-9260
    • Milne, D.M.1    Campbell, D.G.2    Caudwell, F.B.3    Meek, D.W.4
  • 79
    • 0028931265 scopus 로고
    • Principles of CDK regulation
    • Morgan DO (1995) Principles of CDK regulation. Nature 374: 131-134
    • (1995) Nature , vol.374 , pp. 131-134
    • Morgan, D.O.1
  • 80
    • 0021970413 scopus 로고
    • Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells
    • Mulcahy LS, Smith MR, Stacey DW (1985) Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells. Nature 313: 241-243
    • (1985) Nature , vol.313 , pp. 241-243
    • Mulcahy, L.S.1    Smith, M.R.2    Stacey, D.W.3
  • 81
    • 0026526437 scopus 로고
    • E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
    • Nevins JR (1992) E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258: 424-429
    • (1992) Science , vol.258 , pp. 424-429
    • Nevins, J.R.1
  • 82
    • 0027210447 scopus 로고
    • Posttranslational processing of the ras superfamily of small GTP-binding proteins
    • Newman CM, Magee AI (1993) Posttranslational processing of the ras superfamily of small GTP-binding proteins. Biochim Biophys Acta 1155: 79-96
    • (1993) Biochim Biophys Acta , vol.1155 , pp. 79-96
    • Newman, C.M.1    Magee, A.I.2
  • 83
    • 0028837170 scopus 로고
    • Activation of the small GTP-binding proteins rho and rac by growth factor receptors
    • Noves CD, Hawkins P, Stephens L, Hall A (1995) Activation of the small GTP-binding proteins rho and rac by growth factor receptors. J Cell Sci 108: 225-233
    • (1995) J Cell Sci , vol.108 , pp. 225-233
    • Noves, C.D.1    Hawkins, P.2    Stephens, L.3    Hall, A.4
  • 84
    • 0028124189 scopus 로고
    • Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes
    • Okada T, Kawano Y, Sakakibara T, Hazeki O, Ui M (1994) Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. J Biol Chem 269: 3568-3573
    • (1994) J Biol Chem , vol.269 , pp. 3568-3573
    • Okada, T.1    Kawano, Y.2    Sakakibara, T.3    Hazeki, O.4    Ui, M.5
  • 85
    • 0028034233 scopus 로고
    • Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function
    • Pause A, Belsham GJ, Gingras A-C, Donze O, Lin T-A, Lawrence JC, Sonenberg N (1994) Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature 371: 762-767
    • (1994) Nature , vol.371 , pp. 762-767
    • Pause, A.1    Belsham, G.J.2    Gingras, A.-C.3    Donze, O.4    Lin, T.-A.5    Lawrence, J.C.6    Sonenberg, N.7
  • 86
    • 0028859279 scopus 로고
    • Protein modules and signalling networks
    • Pawson T (1995) Protein modules and signalling networks. Nature 373: 573-580
    • (1995) Nature , vol.373 , pp. 573-580
    • Pawson, T.1
  • 89
    • 0028072520 scopus 로고
    • Joining the complex: Cyclin-dependent kinase inhibitory proteins and the cell cycle
    • 88a Peter M, Herskowitz I (1994) Joining the complex: Cyclin-dependent kinase inhibitory proteins and the cell cycle. Cell 79: 181-184
    • (1994) Cell , vol.79 , pp. 181-184
    • Peter, M.1    Herskowitz, I.2
  • 90
    • 0028670126 scopus 로고
    • ras in receptor tyrosine kinase signalling
    • ras in receptor tyrosine kinase signalling. Biochim Biophys Acta 1198: 131-147
    • (1994) Biochim Biophys Acta , vol.1198 , pp. 131-147
    • Pronk, G.J.1    Bos, J.L.2
  • 92
    • 0028114771 scopus 로고
    • Turned on by insulin
    • Proud CG (1994) Turned on by insulin. Nature 371: 747-748
    • (1994) Nature , vol.371 , pp. 747-748
    • Proud, C.G.1
  • 93
    • 0007625884 scopus 로고
    • Oncogenes in human tumor cell lines: Molecular cloning of a transforming gene from human bladder carcinoma cells
    • Pulciani S, Santos E, Lauver AV, Long LK, Robbins KC, Barbacid M (1982) Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells. Proc Natl Acad Sci USA 79: 2845-2849
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 2845-2849
    • Pulciani, S.1    Santos, E.2    Lauver, A.V.3    Long, L.K.4    Robbins, K.C.5    Barbacid, M.6
  • 94
    • 0027463545 scopus 로고
    • Growth factors: Regulation of normal and neoplastic growth
    • Pusztai L, Lewis CE, Lorenzen J, McGee JO'D (1993) Growth factors: Regulation of normal and neoplastic growth. J Pathol 169: 191-201
    • (1993) J Pathol , vol.169 , pp. 191-201
    • Pusztai, L.1    Lewis, C.E.2    Lorenzen, J.3    McGee, J.O'D.4
  • 95
  • 96
    • 0026046509 scopus 로고
    • Metastatic behavior of human melanoma cell lines in nude mice correlates with urokinase-type plasminogen activator, its type-1 inhibitor, and urokinase mediated matrix degradation
    • Quax PHA, van Muijen GNP, Weening-Verhoeff EJD, Lund LR, Dano K, Ruiter DJ, Verheijen JH (1991) Metastatic behavior of human melanoma cell lines in nude mice correlates with urokinase-type plasminogen activator, its type-1 inhibitor, and urokinase mediated matrix degradation. J Cell Biol 115: 191-199
    • (1991) J Cell Biol , vol.115 , pp. 191-199
    • Quax, P.H.A.1    Van Muijen, G.N.P.2    Weening-Verhoeff, E.J.D.3    Lund, L.R.4    Dano, K.5    Ruiter, D.J.6    Verheijen, J.H.7
  • 97
    • 0028040019 scopus 로고
    • Bcl-2 and the regulation of programmed cell death
    • Reed JC (1994) Bcl-2 and the regulation of programmed cell death. J Cell Biol 224: 1-6
    • (1994) J Cell Biol , vol.224 , pp. 1-6
    • Reed, J.C.1
  • 98
    • 0027408247 scopus 로고
    • Identification of a ten-amino acid Proline-rich SH3 binding site
    • Ren R, Mayer BJ, Cicchetti P, Baltimore D (1993) Identification of a ten-amino acid Proline-rich SH3 binding site. Science 259: 1157-1161
    • (1993) Science , vol.259 , pp. 1157-1161
    • Ren, R.1    Mayer, B.J.2    Cicchetti, P.3    Baltimore, D.4
  • 101
    • 0028144704 scopus 로고
    • R-ras interacts with rasGAP, neurofibromin and c-Raf but does not regulate cell growth or differentiation
    • Rey I, Taylor-Harris P, van Erp H, Hall A (1994) R-ras interacts with rasGAP, neurofibromin and c-Raf but does not regulate cell growth or differentiation. Oncogene 9: 685-692
    • (1994) Oncogene , vol.9 , pp. 685-692
    • Rey, I.1    Taylor-Harris, P.2    Van Erp, H.3    Hall, A.4
  • 102
    • 0028947757 scopus 로고
    • Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma 1
    • Richard S, Yu D, Blumer KJ, Hausladen D, Olszowy MW, Connelly PA, Shaw AS (1995) Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma 1. Mol Cell Biol 25: 186-197
    • (1995) Mol Cell Biol , vol.25 , pp. 186-197
    • Richard, S.1    Yu, D.2    Blumer, K.J.3    Hausladen, D.4    Olszowy, M.W.5    Connelly, P.A.6    Shaw, A.S.7
  • 103
    • 0026778133 scopus 로고
    • The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    • Ridley AJ, Hall A (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70: 389-399
    • (1992) Cell , vol.70 , pp. 389-399
    • Ridley, A.J.1    Hall, A.2
  • 104
    • 0026654125 scopus 로고
    • The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
    • Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A (1992) The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70: 401-410
    • (1992) Cell , vol.70 , pp. 401-410
    • Ridley, A.J.1    Paterson, H.F.2    Johnston, C.L.3    Diekmann, D.4    Hall, A.5
  • 106
    • 0025966709 scopus 로고
    • Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases
    • Rogge RD, Karlovich CA, Banerjee U (1991) Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases. Cell 64: 39-48
    • (1991) Cell , vol.64 , pp. 39-48
    • Rogge, R.D.1    Karlovich, C.A.2    Banerjee, U.3
  • 107
    • 0027365517 scopus 로고
    • Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E
    • Rosenwald IB, Lazaris-Karatzas A, Sonenberg N, Schmidt EV (1993) Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E. Mol Cell Biol 13: 7358-7363
    • (1993) Mol Cell Biol , vol.13 , pp. 7358-7363
    • Rosenwald, I.B.1    Lazaris-Karatzas, A.2    Sonenberg, N.3    Schmidt, E.V.4
  • 108
    • 0141611211 scopus 로고
    • Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase
    • Rossomando AJ, Payne DM, Weber MJ, Sturgill TW (1989) Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase. Proc Natl Acad Sci USA 86: 6940-6943
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 6940-6943
    • Rossomando, A.J.1    Payne, D.M.2    Weber, M.J.3    Sturgill, T.W.4
  • 110
    • 0025736034 scopus 로고
    • The inhibition of the GTPase activating protein-Ha-ras interaction by acidic lipids is due to physical association of the C-terminal domain of the GTPase activating protein with micellar structures
    • Serth J, Lautwein A, Frech M, Wittinghofer A, Pingoud A (1991) The inhibition of the GTPase activating protein-Ha-ras interaction by acidic lipids is due to physical association of the C-terminal domain of the GTPase activating protein with micellar structures. The EMBO Journal 10: 1325-1330
    • (1991) The EMBO Journal , vol.10 , pp. 1325-1330
    • Serth, J.1    Lautwein, A.2    Frech, M.3    Wittinghofer, A.4    Pingoud, A.5
  • 111
    • 0026740716 scopus 로고
    • Molecular cloning of cDNAs encoding the GAP-associated protein p190: Implications for a signaling pathway from ras to the nucleus
    • Settleman J, Narasimhan V, Foster LC, Weinberg RA (1992) Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus. Cell 69: 539-549
    • (1992) Cell , vol.69 , pp. 539-549
    • Settleman, J.1    Narasimhan, V.2    Foster, L.C.3    Weinberg, R.A.4
  • 112
    • 0028171292 scopus 로고
    • G1 phase progression: Cycling on cue
    • Sherr CJ (1994) G1 phase progression: Cycling on cue. Cell 79: 551-555
    • (1994) Cell , vol.79 , pp. 551-555
    • Sherr, C.J.1
  • 113
    • 0029071657 scopus 로고
    • D-type cyclins
    • Sherr CJ (1995) D-type cyclins. TIBS 20: 187-190
    • (1995) TIBS , vol.20 , pp. 187-190
    • Sherr, C.J.1
  • 114
    • 0019474922 scopus 로고
    • Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts
    • Shih C, Padhy LC, Murray M, Weinberg RA (1981) Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts. Nature 290: 261-264
    • (1981) Nature , vol.290 , pp. 261-264
    • Shih, C.1    Padhy, L.C.2    Murray, M.3    Weinberg, R.A.4
  • 115
    • 0027404990 scopus 로고
    • ras1 activation and binds to sevenless and sos proteins in vitro
    • ras1 activation and binds to sevenless and sos proteins in vitro. Cell 73: 169-177
    • (1993) Cell , vol.73 , pp. 169-177
    • Simon, M.A.1    Dodson, G.S.2    Rubin, G.M.3
  • 118
    • 0028175939 scopus 로고
    • The Ras-related protein R-ras interacts directly with Raf-1 in a GTP-dependent manner
    • Spaargaren M, Martin GA, McCormick F, Fernandez-Sarabia, Bischoff JR (1994) The Ras-related protein R-ras interacts directly with Raf-1 in a GTP-dependent manner. Biochem J 300: 303-307
    • (1994) Biochem J , vol.300 , pp. 303-307
    • Spaargaren, M.1    Martin, G.A.2    McCormick, F.3    Fernandez-Sarabia4    Bischoff, J.R.5
  • 119
    • 0021184853 scopus 로고
    • Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein
    • Stacey DW, Kung H-F (1984) Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein. Nature 310: 508-511
    • (1984) Nature , vol.310 , pp. 508-511
    • Stacey, D.W.1    Kung, H.-F.2
  • 120
    • 0023619575 scopus 로고
    • A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants
    • Trahey M, McCormick F (1987) A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science 238: 542-545
    • (1987) Science , vol.238 , pp. 542-545
    • Trahey, M.1    McCormick, F.2
  • 121
    • 0029118603 scopus 로고
    • Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase
    • Ui M, Okada T, Hazeki K, Hazeki O (1995) Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. TIBS 20: 303-307
    • (1995) TIBS , vol.20 , pp. 303-307
    • Ui, M.1    Okada, T.2    Hazeki, K.3    Hazeki, O.4
  • 122
    • 0025343230 scopus 로고
    • Signal transduction by receptors with tyrosine kinase activity
    • Ullrich A, Schlessinger J (1990) Signal transduction by receptors with tyrosine kinase activity. Cell 61: 203-212
    • (1990) Cell , vol.61 , pp. 203-212
    • Ullrich, A.1    Schlessinger, J.2
  • 123
    • 0027211693 scopus 로고
    • Phospholipase C-gamma1 and phosphatidylinoskol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal
    • Valius M, Kazlauskas A (1993) Phospholipase C-gamma1 and phosphatidylinoskol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell 73: 321-334
    • (1993) Cell , vol.73 , pp. 321-334
    • Valius, M.1    Kazlauskas, A.2
  • 125
    • 0026669469 scopus 로고
    • p53 function and dysfunction
    • Vogelstein B, Kinzler KW (1992) p53 function and dysfunction. Cell 70: 523-526
    • (1992) Cell , vol.70 , pp. 523-526
    • Vogelstein, B.1    Kinzler, K.W.2
  • 126
    • 0027250250 scopus 로고
    • Mammalian Ras interacts directly with the serine/threonine kinase Raf
    • Vojtek AB, Hollenberg SM, Cooper JA (1993) Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74: 205-214
    • (1993) Cell , vol.74 , pp. 205-214
    • Vojtek, A.B.1    Hollenberg, S.M.2    Cooper, J.A.3
  • 128
    • 0029029743 scopus 로고
    • R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism
    • Wang H-G, Millan JA, Cox AD, Der CJ, Rapp UR, Beck T, Zha H, Reed JC (1995) R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism. J Cell Biol 129: 1103-1114
    • (1995) J Cell Biol , vol.129 , pp. 1103-1114
    • Wang, H.-G.1    Millan, J.A.2    Cox, A.D.3    Der, C.J.4    Rapp, U.R.5    Beck, T.6    Zha, H.7    Reed, J.C.8
  • 130
    • 0027200883 scopus 로고
    • Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro
    • Warns PH, Viclana PR, Downward J (1993) Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro. Nature 364: 352-355
    • (1993) Nature , vol.364 , pp. 352-355
    • Warns, P.H.1    Viclana, P.R.2    Downward, J.3
  • 132
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81: 323-330
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 133
    • 0028999052 scopus 로고
    • Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation
    • Weng Q-P, Andrabi K, Klippel A, Kozlowski MT, Williams LT, Avruch J (1995) Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation. Proc Natl Acad Sci USA 92: 5744-5748
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5744-5748
    • Weng, Q.-P.1    Andrabi, K.2    Klippel, A.3    Kozlowski, M.T.4    Williams, L.T.5    Avruch, J.6
  • 134
    • 0028085078 scopus 로고
    • The insulin signaling system
    • White MF, Kahn CR (1994) The insulin signaling system. J Biol Chem 269: 1-4
    • (1994) J Biol Chem , vol.269 , pp. 1-4
    • White, M.F.1    Kahn, C.R.2
  • 135
    • 0026697169 scopus 로고
    • Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62
    • Wong G, Muller O, Clark R, Conroy L, Moran MF, Polakis P, McCormick F (1992) Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62. Cell 69: 551-558
    • (1992) Cell , vol.69 , pp. 551-558
    • Wong, G.1    Muller, O.2    Clark, R.3    Conroy, L.4    Moran, M.F.5    Polakis, P.6    McCormick, F.7
  • 136
    • 0027772672 scopus 로고
    • Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′,5′-monophosphate
    • Wu J, Dent P, Jelinek T, Wolfman A, Weber MJ, Sturgill TW (1993) Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′,5′-monophosphate. Science 262: 1065-1069
    • (1993) Science , vol.262 , pp. 1065-1069
    • Wu, J.1    Dent, P.2    Jelinek, T.3    Wolfman, A.4    Weber, M.J.5    Sturgill, T.W.6
  • 137
    • 0028326907 scopus 로고
    • Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts
    • Wymann M, Arcaro A (1994) Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts. Biochem J 298: 517-520
    • (1994) Biochem J , vol.298 , pp. 517-520
    • Wymann, M.1    Arcaro, A.2


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