Prostaglandin E2 up-regulates insulin-like growth factor binding protein-3 expression and synthesis in human articular chondrocytes by a c- AMP-independent pathway: Role of calcium and protein kinase A and C

Journal of Cellular Biochemistry

Volumn 63, Issue 3, 1996, Pages 320-333

  DiBattista, J A ^a,b   Dore S ^c   Morin, N ^b   Abribat, T ^a,b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b NOTRE DAME HOSPITAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

calcium; calphostin C; chondrocytes; gene expression; protein kinase C

Indexed keywords

CALCIUM; CALPHOSTIN C; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; PROSTAGLANDIN E2; PROTEIN KINASE C; SOMATOMEDIN BINDING PROTEIN 3;

ADULT; ARTICLE; CARTILAGE CELL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN SYNTHESIS; BIOSYNTHESIS; CARTILAGE; CELL CULTURE; DRUG EFFECT; SIGNAL TRANSDUCTION; UPREGULATION;

CALCIUM; CARTILAGE; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DINOPROSTONE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; PROTEIN KINASE C; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 0029657783     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19961201)63:3<320::AID-JCB7>3.0.CO;2-Z     Document Type: Article

References (68)

1. An S, Yang J, So SW, Zeng L, Goetzl EJ (1994): Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals. Biochemistry 33:14496-14502.
2. Beavo JA, Reifsnyder DH (1990): Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors. Trends Pharmacol Sci 11:150-155.
3. Bennett A, Chen TL, Feldman D, Hintz RI, Rosenfeld RG (1984): Characterization of insulin-like growth factor I receptors on cultured rat bone cells: regulation of receptor concentration by glucocorticoids. Endocrinology 115:1577-1583.
4. Bichell DP, Rotwein P, McCarthy TL (1993): Prostaglandin E2 rapidly stimulates insulin-like growth factor I gene expression in primary rat osteoblast cultures: Evidence for transcriptional control. Endocrinology 133:1020-1028.
5. Binoux M, Hossenlopp P, Lassare C, Segovia B (1991): Degradation of IGF binding protein-3 by proteases: physiological implications. In Spencer EM (ed.) "Modern Concepts of Insulin-Like Growth Factors." Proc. 2nd. Int. Symposium Insulin-like Growth Factors/Somatomedins, Elsevier, pp 329-336.
6. Bonin PD, Chiou WJ, McGee JE, Singh JP (1990): Two signal transduction pathways mediate interleukin-1 receptor expression in Balb/c3T3 fibroblasts. J Biol Chem 265:18643-18649.
7. Bunning RAD, Richardson HJ, Crawford A, Skjodt H, Hughes D, Evans DB, Gowen M, Dobson PR, Brown BL, Russell RG (1986): The effects of interleukin-1 on connective tissue metabolism and its relevance to arthritis. Agents Actions 18:131-152.
8. Burton K (1956): A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J 62:315-323.
9. Case JP, Lafyatis R, Kumkumian GK, Remmers EF, Wilder RL (1990): IL-1 regulation of transin/stromelysin transcription in rheumatoid synovial fibroblasts appears to involve two antagonistic transduction pathways, an inhibitory, and a stimulatory, protein kinase C dependent pathway. J Immunol 145:3755-3761.
10. 2 synthesis by a selective COX-2 inhibitor. Inflammation Res 44 (Suppl 3):S273.
11. Chen TL, Chang LY, Bates RL, Perlman AJ (1991): Dexamethasone and 1, 25-dihydroxyvitamin D3 modulation of insulin-like growth factor binding proteins in rat osteoblast-like cell cultures. Endocrinology 128:73-80.
12. Cohen P, Cohen PTW (1989): Protein phosphatases come of age. J Biol Chem 264:21435-21438.
13. Cohen P, Graves HCB, Peehl DM, Kamarei M, Giudice LC, Rosenfeld RG (1991) Prostate specific antigen (PSA) is an IGF binding protein-3 (IGFBP-3) protease found in seminal plasma. J Clin Endocrinol Metab 73:391-407.
14. Conca W, Kaplan PB, Krane SM (1989): Increase in levels of procollagenase messenger RNA in cultured fibroblasts induced by recombinant interleukin-1 beta or serum follow c-jun expression and are dependent on new protein synthesis. J Clin Invest 83:1753-1756.
15. Conti M, Catherine Jin SL, Monaco L, Repaske DR, Swinnen JV (1991): Hormonal regulation of cyclic nucleotide phosphodiesterases. Endocrine Rev 12:218-233.
16. Cubbage ML, Suwanichkul A, Powell DR (1990): Insulin-like growth factor binding protein-3: Organization of the human chromosomal gene and demonstration of promoter activity. J Biol Chem 265:12642-12649.
17. DeMellow JSM, Baxter RC (1988): Growth hormone dependent insulin-like growth factor binding protein both inhibits and potentiates IGF-1 stimulated DNA synthesis in skin fibroblasts. Biochem Biophys Res Commun 156:199-204.
18. DiBattista JA, Martel-Pelletier J, Wosu LO, Sandor T, Antakly T, Pelletier JP (1991a): Glucocorticoid receptor mediated inhibition of interleukin-1 stimulated neutral metalloprotease synthesis in normal human chondrocytes. J Clin Endocrinol Metab 72:316-326.
19. DiBattista JA, Martel-Pelletier J, Cloutier JM, Pelletier J-P (1991b): Modulation of glucocorticoid receptor expression in human articular chondrocytes by cAMP and prostaglandins. J Rheumatol 18:102-105.
20. DiBattista JA, Martel-Pelletier J, Antakly T, Tardif G, Cloutier J-M, Pelletier JP (1993): Reduced expression of glucocorticoid receptor levels in human osteoarthritic chondrocytes. Role in the suppression of metalloprotease synthesis. J Clin Endocrinol Metab 76:1128-1134.
21. 1 inhibit the cytokine-stimulated expression of metalloproteinases in normal human synovial fibroblasts: Mediation by cyclic AMP signalling pathway. Lab Invest 71:223-270.
22. 2 up-regulation of IGF-1 and IGFBP-3 expression and synthesis in human articular chondrocytes. In Transactions of the 41th Annual Meeting of the Orthopaedic Research Society, Orlando, FL, p 374.
23. DiBattista JA, Pelletier JP, Zafarullah M, Fujimoto N, Obata K, Martel-Pelletier J (1995b): Coordinate regulation of matrix metalloproteases and tissue inhibitor of metalloproteinase expression in human synovial fibroblasts. J Rheumatol 22:123-128.
24. 2 stimulated incorporation of proline into collagenase digestible proteins is mediated by insulin-like growth factor I in human articular chondrocytes. Mol Cell Endocrinol (in press).
25. Doré S, Pelletier JP, DiBattista JA, Tardif G, Brazeau P, Martel-Pelletier J (1994): Human OA chondrocytes possess an increased number of binding sites to IGF-1 but are irresponsive to its stimulation: Possible role of binding proteins. Arthritis Rheum 37:253-263.
26. Evans CH (1993): Cytokines: Molecular keys to homeostasis, development, and pathophysiology. J Cell Biochem 53:277-279.
27. Franchimont P, Bassler C (1991): Effects of hormones and local growth factors on articular chondrocyte metabolism. J Rheumatol 18(Suppl 27):68-70.
28. Goldring MB, Suen LF (1994): Immortalized human chondrocytes: A model of osteoarthritis. Osteoarthritis and Cartilage 2(Suppl 1):33.
29. Harris ED Jr (1990): Rheumatoid arthritis: Pathophysiology and implications for therapy. N Engl J Med 291:1285-1292.
30. Hossenlopp P, Seurin D, Segovia-Quinson B, Hardouin S, Binoux M (1986): Analysis of serum insulin-like growth factor binding proteins using Western blotting: Use of a method for titration of the binding proteins and competitive binding studies. Anal Biochem 154:138-143.
31. Inagaki M, Gonda Y, Nishizawa K, Kitamura S, Sato C, Ando S, Tanabe K, Kikuchi K, Tsuiki S, Nishi Y (1990): Phosphorylation sites linked to glial filament disassembly in vitro locate in a non-α-helical head domain. J Biol Chem 265:4722-4729.
32. Irie A, Segi E, Sugimoto Y, Ichikawa A, Negishi M (1994): Mouse prostaglandin E receptor EP3 subtype mediates calcium signals via Gi in cDNA transfected chinese hamster ovary cells. Biochem Biophys Res Commun 204:303-309.
33. Jones JI, Clemmons DR (1995) Insulin-like growth factors and their binding proteins: Biological actions. Endocrine Rev. 16:3-34.
34. Kiley SC, Jaken S (1994): Protein kinase C: Interactions and consequences. Trends Cell Biol 4:223-227.
35. Knudsen PJ, Dinarello CA, Strom TB (1986): Prostaglandins post-transcriptionally inhibit monocyte expression of interleukin-1 activity by increasing intracellular cyclic adenosine monophosphate. J Immunol 137:3189-3194.
36. Kream BE, Petersen DN, Raisz LG (1990): Cortisol enhances the anabolic effects of insulin-like growth factor I on collagen synthesis and procollagen messenger ribinucleic acid levels in cultured 21-day fetal rat calvariae. Endocrinology 126:1576-1583.
37. Lamson G, Cohen P, Giudice LC, Fielder PJ, OH Y, Hintz RL, Rosenfeld RG (1993): Proteolysis of IGF BP-3 may be a common regulatory mechanism of IGF-1 action in vivo. Growth Regul 3:91-95.
38. Lo YY, Cruz TF (1995): Involvement of reactive oxygen species in cytokine and growth factor induction of c-fos expression in chondrocytes. J Biol Chem 270:11727-11730.
39. Malemud CJ (1993): Role of growth factors in cartilage metabolism. In Moskowitz RW (ed): "Rheumatic Disease Clinics in North America." Philadelphia: W.B. Saunders Company, pp 569-580.
40. Mankin HJ (1974): The reaction of articular cartilage to injury and osteoarthritis. N Engl J Med 291:1285-1292.
41. Martel-Pelletier J, McCollum R, DiBattista JA, Faure MP, Chin J, Cloutier JM, Pelletier JP (1992): The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes: Identification as the type-1 receptor and analysis of binding kinetics and biologic function. Arthritis Rheum 35:530-540.
42. Mauviel A (1993): Cytokine regulation of metalloproteinase gene expression. J Cell Biochem 53:288-295.
43. 2 stimulates insulin-like growth factor I synthesis in osteoblast-enriched cultures from fetal rat bone. Endocrinology 128:2895-2900.
44. Morham SG, Langenbach R, Loftin CD, Tiano HF, Vouloumanos N, Jennette JC, Mahler JF, Kluckman KD, Ledford A, Lee CA, Smithies O (1995): Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell 83:473-482.
45. Munoz E, Beutner U, Zubiaga A, Huber BT (1990): II-1 activates two separate signal transduction pathways in T helper type II cells. J Immunol 144:964-969.
46. Nicholson CD, Challiss RAJ, Shahid M (1991): Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isenzymes. Trends Pharmacol Sci 12:19-27.
47. Oh Y, Muller HL, Lamson G, Rosenfeld RG (1993a): Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells. Cell surface binding, growth inhibition. J Biol Chem 268: 14964-14971.
48. Oh Y, Muller HL, Pham H, Rosenfeld RG (1993b): Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells. J Biol Chem 268:26045-26048.
49. Okazaki R, Riggs BL, Conover CA (1994): Glucocortioid regulation of insulin-like growth factor binding protein expression in normal human osteoblast-like cells. Endocrinology 134:126-132.
50. Olney RC, Wilson DM, Mohtai M, Fielder PJ, Smith RL (1995): Interleukin-1 and tumor necrosis factora increase insulin-like growth factor-binding protein-3 (IGFBP-3) production and IGFBP-3 protease activity in human articular chondrocytes. J Endocrinol 146:279-286.
51. Pelletier JP, Martel-Pelletier J (1989): Protective effects of corticosteroids on cartilage lesions and osteophyte formation in the Pond-Nuki dog model of osteoarthritis. Arthritis Rheum 2:181-193.
52. Pelletier JP, Roughley PJ, DiBattista JA, McCollum R, Martel-Pelletier J (1991): Are cytokines involved in osteoarthritic pathophysiology? Semin Arthritis Rheum 20:12-25.
53. 2 on bone formation in cultured fetal rat calvariae: Role of insulin-like growth factor I. Endocrinology 133:1504-1510.
54. Reboul P, Tavera C, Abribat T, Pelletier JP, Brazeau P, Martel-Pelletier J (1994): Variations of the IGF/IGF binding protein system in the synovial fluid of OA and RA patients. Osteoarthritis Cartilage 2(Suppl 1):33.
55. Robinson DR (1985): Low molecular weight mediators of inflammation: Prostaglandins, leukotrienes, and cyclic nucleotides. In Kelly WN, Harris ED Jr, Ruddy S, Sledge CB (eds): "Textbook of Rheumatology." Philadelphia: W.B. Saunders Company, pp 71-82.
56. Ryan MC, Sieraski M, Sandell L (1990): The human type II collagen gene: Identification of an additional protein-coding domain and location of potential regulatory sequences in the promoter and first intron. Genomics 8:41-48.
57. Sandell LJ, Dudek EJ (1988): Insulin-like growth factor I stimulates type II collagen gene expression in cultured chondrocytes. In Transactions of the 35th Annual Meeting of the Orthopaedic Research Society, Atlanta, p 300.
58. Schmidt KN, Britta-Mareen Traenckner E, Meier B, Baeuerle PA (1995): Induction of oxidative stress by Okadaic Acid is required for activation of transcription factor NF-κB. J Biol Chem 270:27136-27142.
59. Schonthal A (1992): Okadaic acid: A valuable new tool for the study of signal transduction and cell cycle regulation. New Biol 4:16-21.
60. Sette C, Iona S, Conti M (1994) The short-term activation of a rolipram-sensitive, cAMP specific phosphodiesterase by thyroid-stimulating hormone in thyroid FRTL-5 cells is mediated by a cAMP-dependent phosphorylation. J Biol Chem 269:9245-9252.
61. Tesch GH, Handley CJ, Cornell HJ, Herington AC (1992): Effects of free and bound insulin-like growth factors on proteoglycan metabolism in articular cartilage explants. J Orthop Res 10:14-22.
62. Thévenin C, Kim SJ, Rieckmann P, Fujiki H, Norcross MA, Spron MB, Fauci AS, Kehrl JH (1990): Induction of nuclear factor-KB and the human immunodeficiency virus long terminal repeat by okadaic acid, a specific inhibitor of phosphatases 1 and 2A. New Biol 2:793-800.
63. Thévenin C, Kim SJ, Kehrl JH (1991): Inhibition of protein phosphatases by okadaic acid induced API in human T cells. J Biol Chem 266:9363-9366.
64. Valentinis B, Bhala A, DeAngelis T, Baserga R, Cohen P (1995): The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-1 receptor gene. Mol Endocrinol 9:361-367.
65. Wang L, Balkir R, Horton WEJ (1991): Identification of a cis-acting sequence in the collagen II enhancer required for chondrocyte expression and the binding of a chondrocyte nuclear factor. J Biol Chem 266:19878-19881.
66. Westermarck J, Lohi J, Keski-Oja J, Kahari VM (1994): Okadaic acid-elicited transcriptional activation of collagenase expression in HT-1080 fibrosarcoma cells is mediated by JunB. Cell Growth Differ 5:1205-1213.
67. Wood WI, Cachianes G, Henzel WJ, Winslow GA, Spencer SA, Hellmiss R, Martin JL, Baxter RC (1988): Cloning and expression of the growth hormone-dependent insulin-like growth factor binding protein. Mol Endocrinol 2:1176-1185.
68. Yano T, Taura C, Shibata M, Hirono Y, Ando S, Kusubata M, Takahashi T, Inagaki M (1991): A monoclonal antibody to the phosphorylated form of glial fibrillary acidic protein: Application to a non-radioactive method for measuring protein kinase activities. Biochem Biophys Res Commun 175:1144-1151.