The source of brain adenosine outflow during ischemia and electrical stimulation

Neurochemistry International

Volumn 28, Issue 1, 1996, Pages 113-118

  Latini, S ^a   Corsi, C ^a   Pedata, F ^a   Pepeu, G ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE NUCLEOTIDE; ADENOSINE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENOSYLHOMOCYSTEINASE; HYDROLASE INHIBITOR; S ADENOSYLHOMOCYSTEINE;

ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DEPHOSPHORYLATION; ELECTROSTIMULATION; ENERGY; HIPPOCAMPUS; MALE; METHYLATION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION;

ADENINE NUCLEOTIDES; ADENOSINE; ANIMAL; BRAIN; BRAIN ISCHEMIA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTRIC STIMULATION; HIPPOCAMPUS; HYDROLASES; IN VITRO; MALE; RATS; RATS, WISTAR; S-ADENOSYLHOMOCYSTEINE; SUPPORT, NON-U.S. GOV'T;

EID: 0029656266     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/0197-0186(95)00062-D     Document Type: Article

References (25)

1. Atkinson D. E. (1968) The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers Biochemistry 7, 4030-4034.
2. Bartel R. L. and Borchardt R. T. (1984) Effects of adenosine dialdehyde on S-adenosylhomocysteine hydrolase and S-adenosylmethionine-dependent transmethylation in mouse L 929 cells. Molec. Pharmac. 25, 418-424.
3. Deussen A., Lloyd H. G. E. and Schrader J. (1989) Contribution of S-adenosylhomocysteine to cardiac adenosine formation. J. Molec. Cell. Cardiol. 21, 773-782.
4. Fredholm B. B., Dunwiddie T. V., Bergman B. and Lindström K. (1984) Levels of adenosine and adenine nucleotides in slices of rat hippocampus. Brain Res. 295, 127-136.
5. Hagberg H., Andersson P., Lacarewicz J., Jacobson I., Butcher S. and Sandberg M. (1987) Extracellular adenosine, inosine, hypoxanthine, and xanthine in relation to tissue nucleotides and purines in rat striatum during transient ischemia. J. Neurochem. 49, 227-231.
6. Jonzon B. and Fredholm B. B. (1985) Release of purines, noradrenaline, and GABA from rat hippocampal slices by field stimulation. J. Neurochem. 44, 217-224.
7. Lloyd H. G. E. and Schrader J. (1987) The importance of the transmethylation pathway for adenosine metabolism in the heart. In: Topics and Perspectives in Adenosine Research (Gerlach E. and Becker B. F., eds), pp. 199-208. Springer-Verlag, Berlin.
8. Lloyd H. G. E., Deussen A., Wuppermann H. and Schrader J. (1988) The transmethylation pathway as a source for adenosine in the isolated guinea-pig heart. Biochem. J. 252, 489-494.
9. Lloyd H. G. F., Lindström K. and Fredholm B. B. (1993) Intracellular formation and release of adenosine from rat hippocampal slices evoked by electrical stimulation or energy depletion. Neurochem. Int. 23, 173-185.
10. Lowry O. H., Rosebrough N. J., Farr A. L. and Randall R. J. (1951) Protein measurement with the folin phenol reagent. J. Biol. Chem. 193, 265-275.
11. Meghji P. (1993) Storage, release, uptake, and inactivation of purines, Drug Dev. Res. 28, 214-219.
12. Meghji P. and Newby A. C. (1990) Sites of adenosine formation, action, and inactivation in the brain. Neurochem. Int. 16, 227-232.
13. Newby A. C., Worku Y. and Meghji P. (1987) Critical evaluation of the role of ecto- and cytosolic 5′-nucleotidase in adenosine formation. In: Topics and Perspectives in Adenosine Research (Gerlach E. and Becker B. F., eds), pp 155-169. Springer-Verlag, Berlin.
14. Palmer J. L. and Abeles R. H. (1979) The mechanism of action of S-adenosylhomocysteinase. J. Biol. Chem. 254, 1217-1226.
15. Patel B. T. and Tudball N. (1986) Localization of S-adenosylhomocysteine hydrolase and adenosine deaminase immunoreactivities in rat brain. Brain Res. 370, 250-264.
16. Pedata F., Pazzagli M., Tilli S. and Pepeu G. (1990) Regional differences in the electrically stimulated release of endogenous and radioactive adenosine and purine derivatives from rat brain slices. Naunyn-Schmiedeberg's Arch. Pharmac. 342, 447-453.
17. Pedata F., Pazzagli M. and Pepeu G. (1991) Endogenous adenosine release from hippocampal slices: excitatory amino acid agonists stimulate release, antagonists reduce the electrically-evoked release. Naunyn-Schmiedeberg's Arch. Pharmac. 344, 538-543.
18. Pedata F., Latini S., Pugliese A. M. and Pepeu G. (1993) Investigations into the adenosine outflow from hippocampal slices evoked by ischemia-like conditions. J. Neurochem. 61, 284-289.
19. Phillis J. W., Walter G. A., O'Regan M. H. and Stair R. E. (1987) Increases in cerebral cortical perfusate adenosine and inosine concentrations during hypoxia and ischemia. J. Cereb. Blood Flow Metab. 7, 679-686.
20. 14C]adenine and derivatives by cerebral tissues, superfused and electrically stimulated. Biochem. J. 126, 965-972.
21. Pull I. and McIlwain H. (1972b) Adenine derivatives as neurohumoral agents in the brain. Biochem. J. 130, 975-981.
22. Pull I. and McIlwain H. (1977) Adenine mononucleotides and their metabolites liberated from and applied to isolated tissues of the mammalian brain. Neurochem. Res. 2, 203-216.
23. Schrader J., Schütz W. and Bardenheuer H. (1981) Role of S-adenosylhomocysteine hydrolase in adenosine metabolism in mammalian heart. Biochem. J. 196, 65-70.
24. Schweinsberg P. D. and Loo T. L. (1980) Simultaneous analysis of ATP, ADP, AMP, and other purines in human erythrocytes by high-performance liquid chromatography. J. Chromatogr. 181, 103-107.
25. Whittingham T. S., Lust W. D. and Passonneau J. V. (1984) An in vitro model of ischemia: metabolic and electrical alterations in the hippocampal slice. J. Neurosci. 4, 793-802.