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Volumn 52, Issue 1, 1996, Pages 319-330

Chiral interactions of the fluoroether anesthetics desflurane, isoflurane, enflurane, and analogues with modified cyclodextrins studied by capillary gas chromatography and nuclear magnetic resonance spectroscopy: A simple method for column-suitability screening

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; CYCLODEXTRIN DERIVATIVE; DESFLURANE; ENFLURANE; ISOFLURANE;

EID: 0029656092     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4020(95)00860-B     Document Type: Article
Times cited : (23)

References (49)
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    • 0001778667 scopus 로고
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    • Banks, R. E.; Smart, B. E.; Tatlow, J. C. Eds.; Plenum Press: New York
    • Review: Halpern, D. F. Fluorinated Inhalation Anesthetics. In Organofluorine Chemistry Principles and Commercial Applications; Banks, R. E.; Smart, B. E.; Tatlow, J. C. Eds.; Plenum Press: New York, 1994; pp. 543-554.
    • (1994) Organofluorine Chemistry Principles and Commercial Applications , pp. 543-554
    • Halpern, D.F.1
  • 2
    • 0001163782 scopus 로고
    • Recent Developments in Fluorine-Substituted Anesthetics
    • Filler, R.; Kobayashi, Y.; Yagopulskii, L. Eds.; Elsevier Science Publishers: Amsterdam
    • Review: Halpern, D. F. Recent Developments in Fluorine-Substituted Anesthetics. In Organofluorine Compounds in Medicinal Chemistry and Biomedical Applications; Filler, R.; Kobayashi, Y.; Yagopulskii, L. Eds.; Elsevier Science Publishers: Amsterdam, 1993; pp.101-133.
    • (1993) Organofluorine Compounds in Medicinal Chemistry and Biomedical Applications , pp. 101-133
    • Halpern, D.F.1
  • 3
    • 85030012921 scopus 로고
    • Ph.D. Dissertation, Cornell University
    • Pearson, D. L. Ph.D. Dissertation, Cornell University, 1990;
    • (1990)
    • Pearson, D.L.1
  • 7
    • 85030006889 scopus 로고    scopus 로고
    • US 5 114 714, 1992 and US 5 114 715, 1992; filing date 11/29/90
    • Two patents (Young, J. W.; Brandt, S. US 5 114 714, 1992 and US 5 114 715, 1992; filing date 11/29/90) have been issued to Sepracor (Marlborough, MA, USA) claiming the synthesis and use of optically enriched isoflurane and desflurane. These patents, both of which are entirely devoid of experimental detail, physical characterization, and pharmacological data, were filed after Anaquest's (now Ohmeda) patent application (USSN 07/550,417; filed 7/10/90) describing the synthesis, full physical characterization, and pharmacological testing of the enantiomers of isoflurane.
    • Young, J.W.1    Brandt, S.2
  • 11
    • 85030017977 scopus 로고    scopus 로고
    • US Patent 3 981 927, 1976 (Hoechst)
    • Compound 1b: Siegemund, G.; Muschaweck, R. US Patent 3 981 927, 1976 (Hoechst).
    • Siegemund, G.1    Muschaweck, R.2
  • 12
    • 85030024375 scopus 로고    scopus 로고
    • Ger. Offen. 2 361 058, 1975 (Hoechst)
    • Compound If: Siegemund, G.; Muschaweck, R. Ger. Offen. 2 361 058, 1975 (Hoechst).
    • Siegemund, G.1    Muschaweck, R.2
  • 16
    • 85030023752 scopus 로고    scopus 로고
    • Unpublished observations
    • (d) Unpublished observations of L. A. Rozov and C. G. Huang (Ohmeda Inc.).
    • Rozov, L.A.1    Huang, C.G.2
  • 40
    • 85030004067 scopus 로고    scopus 로고
    • US Patent 3 980 714, 1976 (Hoechst)
    • Siegemund, G.; Muschaweck, R. US Patent 3 980 714, 1976 (Hoechst).
    • Siegemund, G.1    Muschaweck, R.2
  • 47
    • 85030016210 scopus 로고    scopus 로고
    • note
    • 3-bearing chiral carbon atom, eluted before the components of the latter.
  • 48
    • 85030024234 scopus 로고    scopus 로고
    • note
    • 8a
  • 49
    • 85030023841 scopus 로고    scopus 로고
    • note
    • Significant broadening, possibly due to long-range interactions, of one of the signals of the two diastereotopic fluorines of 2a and 2c and the signal of the lone methoxy-group fluorine of 2d is seen. Why these fluorines do not follow the trend seen for the other nuclei remains unclear.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.