Antibodies directed at mouse IL-2-R α and βchains act in synergy to abolish T-cell proliferation in vitro and delayed type hypersensitivity reaction in vivo

Transplant International

Volumn 9, Issue 1, 1996, Pages 46-50

  François, Christine ^a   Dantal, Jacques ^a   Sorel, Michel ^a   Cherel, Michel ^a   Miyasaka, Masayuki ^b   Soulillou, Jean Paul ^a   Jacques, Yannick ^a  

^a INSTITUT DE BIOLOGIE   (France)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Interleukin 2 receptor, monoclonal antibodies, mouse; Monoclonal antibodies, mouse interleukin 2 receptor; Mouse, interleukin 2 receptor, monoclonal antibodies

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN RECEPTOR; MONOCLONAL ANTIBODY;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; BETA CHAIN; DELAYED HYPERSENSITIVITY; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; SHEEP; T LYMPHOCYTE;

ANIMAL; ANTIBODIES, BISPECIFIC; ANTIBODIES, MONOCLONAL; CELL LINE; FEMALE; HYPERSENSITIVITY, DELAYED; IN VITRO; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; RECEPTORS, INTERLEUKIN-2; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0029656072     PISSN: 09340874     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-2277.1996.tb00851.x     Document Type: Article

References (22)

1. Audrain M, Boeffard F, Soulillou JP, Jacques Y (1991) Synergistic action of monoclonal antibodies directed at p55 and p75 of the human IL2-receptor. J Immunol 146: 884-892
2. Dantal J, Jacques Y, Soulillou JP (1991) Cluster-function relationship of anti-p55 IL2 receptor monoclonal antibodies in mice. Transplant Proc 23:826-827
3. Dantal J, Jacques Y, Soulillou JP (1991) Cluster-function relationship of rat antimouse p55 IL2 receptor monoclonal antibodies. In vitro studies on the CTL-L2 mouse cell line and in vivo studies in a delayed type hypersensitivity model in mice. Transplantation 52: 110-115
4. François C, Boeffard F, Kaluza B, Weidle UH, Jacques Y (1993) Construction of a bispecific antibody reacting with the α and β chains of the human IL-2 receptor. J Immunol 150: 4610-4619
5. Hatakeyama M, Tsudo M, Minamoto S, Kono T, Doi T, Miyata T, Miyasaka M, Taniguchi T (1989) Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's. Science 244: 551-556
6. Kamio M, Uchiyama T, Arima N, Itoh K, Ishikawa T, Hori T, Uchino H (1990) Role of α chain-IL2 complex in the formation of the ternary complex of IL2 and high-affinity IL2 receptor. Int Immunol 2: 521-530
7. Kelley VE, Bacha P, Pankewycz O, Nichols JC, Murphy JR, Strom TB (1988) Interleukin 2-diphteria toxin fusion protein can abolish cell-mediated immunity in vivo. Proc Natl Acad Sci USA 85: 3980-3984
8. Kirkman RL, Shapiro ME, Carpenter CB, McKay DB, Milford EL, Ramos EL, Tilney NL, Waldmann TA, Zimmermann CE, Strom TB (1991) A randomized prospective trial of anti-Tac monoclonal antibody in human renal transplantation. Transplantation 51: 107-113
9. Le Mauff B, Cantarovich D, Jacques Y, Soulillou JP (1990) Monoclonal antibodies against interleukin-2 receptors in the immunosuppressive management of kidney graft recipients. Transplant Rev 4: 79-92
10. Minami Y, Kono T, Miyasaki T, Taniguchi T (1993) The IL-2 receptor complex: its structure, function and target genes. Annu Rev Immunol 11: 245-267
11. Nakamura Y, Russel SM, Mess SA, Friedmann M, Erdos M, Franois C, Jacques Y, Adelstein S, Leonard WJ (1994) Heterodimerization of the IL-2 receptor β and γ chain cytoplasmic domains is required for signaling. Nature 369: 330-333
12. Nikaido T, Shimizu A, Ishida N, Sabe H, Teshigawara K, Maeda M, Uchiyama T, Yodoi J, Honjo T (1984) Molecular cloning of cDNA encoding human interleukin-2 receptor. Nature 311: 631-635
13. Queen C, Schneider WP, Selick HE, Payne PW, Landolfi NF, Ducan JF, Avdalovic NM, Levitt M, Junghans RP, Waldmann TA (1989) A humanized antibody that binds to the interleukin 2 receptor. Proc Natl Acad Sci USA 84: 10029-10033
14. Soulillou JP, Jacques Y (1989) Monoclonal anti-IL2 receptor in organ transplantation. Transpl Int 2: 46-52
15. Soulillou JP, Peyronnet P, Le Mauff B, Hourmant M, Olive D, Mawas C, Dela-age M, Hirn M, Jacques Y (1987) Prevention of rejection of kidney transplants by monoclonal antibody directed against interleukin 2 receptor. Lancet I: 1339-1342
16. Souliliou JE, Cantarovich D, Le Mauff B, Giral M, Robillard N, Hourmant M, Hirn M, Jacques Y (1990) Randomized trial of an anti-interleukin 2 receptor monoclonal antibody (33B3.1) versus rabbit antithymocyte globulin (ATG) in prophylaxis of early rejection in human renal transplantation. N Engl J Med 322: 1175-1182
17. Takeshita T, Goto Y, Tada K, Nagata K, Asao H, Sugamura K (1989) Monoclonal antibody defining a molecule possibly identical to the p75 subunit of interleukin 2 receptor. J Exp Med 169: 1323-1332
18. Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, Munakata H, Nakamura M, Sugamura K (1992) Cloning of the gamma chain of the human IL-2 receptor. Science 257: 379-382
19. Tanaka T. Tsudo M, Karasuyama H, Kitamura F, Kono T, Hatakeyama M, Taniguchi T, Miyasaka M (1991) A novel monoclonal antibody against murine IL-2 receptor β-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells. J Immunol 147: 2222-2228
20. Tsudo M, Kitamura F, Miyasaka M (1989) Characterization of the interleukin 2 receptor b chain using three monoclonal antibodies. Proc Natl Acad Sci USA 86:1982-1986
21. Vie H, Gauthier T, Breathnach R, Bonneville M, Godard A, Dietrich J, Karam G, Gesnel MC, Peyrat MA, Jacques Y, Soulillou JP (1992) Human fusion protein between IL-2 and IgM heavy chain are cytotoxic for cells expressing the IL-2 receptor. Proc Natl Acad Sci USA 83: 11337-11341
22. Waldmann TA (1993) The IL-2/IL-2 receptor system: a target for rational immune intervention. Immunol Today 14: 264-270