Modulation of sensitivity to mitomycin C and a dithiol analogue by tempol in non-small-cell lung cancer cell lines under hypoxia

Journal of Cancer Research and Clinical Oncology

Volumn 122, Issue 1, 1996, Pages 21-26

  Bando, Takuma ^a   Kasahara, Kazuo ^a   Shibata, Kazuhiko ^a   Numata, Yuka ^a   Heki, Utako ^a   Shirasaki, Hiroki ^a   Iwasa, Kei Ichi ^a   Fujimura, Masaki ^a   Matsuda, Tamotsu ^a  

^a KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

7 N (2 2 ( L Glutamylamino)ethyl dithio ethyl)mitomycin C; MMC mitomycin C; NSCLC non small cell lung cancer; P 450 reductase NADPH cytochrome P 450 reductase; PBS calcium and magnesium free Dulbecco's phosphate buffered saline

Indexed keywords

7 N ((2 (GAMMA GLUTAMYLAMINO)ETHYL)DITHIO)MITOMYCIN C; 7 N [2 [[2 (GAMMA GLUTAMYLAMINO)ETHYL]DITHIO]ETHYL]MITOMYCIN C; MITOMYCIN C; MITOMYCIN DERIVATIVE; TEMPOL; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SENSITIVITY; HUMAN; HUMAN CELL; HYPOXIA; LUNG NON SMALL CELL CANCER; METABOLIC ACTIVATION; PRIORITY JOURNAL;

EID: 0029656023     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01203069     Document Type: Article

References (28)

1. Bando T, Kasahara K, Shibata K, Nakatsumi Y, Fujimura M, Matsuda T (1994) Role of DT-diaphorase as a determinant of sensitivity to mitomycin analogues in non-small cell lung cancer cell lines. Int J Oncol 5:819-825
2. Benson AM, Hunkeler MJ, Talalay P (1980) Increase of NAD(P)H: quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity. Proc Natl Acad Sci USA 77:5216-5220
3. Bligh HFJ, Bartoszek A, Robson CN, Hickson ID, Kasper CB, Beggs JD, Wolf CR (1990) Activation of mitomycin C by NADPH:P-450 reductase. Cancer Res 50:7789-7792
4. Crooke ST, Bradner W (1976) Mitomycin C: a review. Cancer Treat Rev 3:121-139
5. Dorr RT, Liddil JD (1991) Modulation of mitomycin C-induced multidrug resistance in vitro. Cancer Chemother Pharmacol 27:290-294
6. Dorr RT, Liddil JD, Trent JM, Dalton WS (1987) Mitomycin C resistant L1210 leukemia cells: association with pleiotropic drug resistance. Biochem Pharmacol 36:3115-3120
7. Dulhunty AM, Li M, Whitmore GF (1989) Isolation of Chinese hamster ovary cell mutants deficient in excision repair and mitomycin C bioactivation. Cancer Res 49:117-122
8. Dulhunty AM, Whitmore GF (1991) Chinese hamster ovary cell lines resistant to mitomycin C under aerobic but not hypoxic conditions are deficient in DT-diaphorase. Cancer Res 51:1860-1865
9. Ernster L (1967) DT diaphorase. Methods Enzymol 10:309-317
10. Gustafson DL, Pritsos CA (1992) Bioactivation of mitomycin C by xanthine dehydrogenase from EMT6 mouse mammary carcinoma tumors. J Natl Cancer Inst 84:1180-1185
11. Hoban PR, Walton MR, Robson CN, Godden J, Stratford IJ, Workman P, Harris AL, Hickson ID (1990) Decreased NADPH:P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions. Cancer Res 50:4692-4697
12. 5 reductase. Cancer Res 53:4907-4912
13. lyenger BS, Lin HJ, Remers WA (1981) Development of new mitomycin C and porfiromycin analogues. J Med Chem 24:975-981
14. lyenger BS, Sami SM, Remers WA, Bradner WT, Scurg JE (1983a) Mitomycin C and porfiromycin analogues with substitutes ethylamine at position 7. J Med Chem 26:16-20
15. lyenger BS, Sami SM, Tarnow SE, Remers WA, Bradner WT, Schurig JE (1983b) Mitomycin C analogues with secondary amines at position 7. J Med Chem 26:1453-1457
16. Iyer VN, Szybalski W (1963) A molecular mechanism of mitomycin action: linking of complementary DNA strains. Microbiology 50:355-362
17. Kasahara K, Shibata K, Bando T, Numata Y, Fujimura M, Matsuda T (1994) DT-diaphorase as a determinant of sensitivity to Adriamycin in non-small cell lung cancer cell lines. Int J Cancer 59:204-207
18. Kennedy KA, Rockwell S, Sartorelli AC (1980) Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells. Cancer Res 40:2356-2360
19. Keyes SR, Fracasso PM, Heimbrook DC, Rockwell S, Sugar SG, Sartorelli AC (1984) Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C. Cancer Res 44:5638-5643
20. Mitchell JB, Samuni A, Krishna MC, DeGraff WG, Ahn MS, Samuni U, Russo A (1990) Biologically active metal-independent Superoxide dismutase mimics. Biochemistry 29:2802-2807
21. Morimoto M, Ashizawa T, Ohno H, Azuma M, Kobayashi E, Kono M, Saitoh Y, Kanda Y, Arai H, Sato H, Kasai M, Tsuruo T (1991) Antitumor activity of 7-JV-[2-[[2-(γ-L-glutamylamino)ethyl]dithio]ethyl]mitomycin C. Cancer Res 51:110-115
22. Phillips AH, Langdon RG (1962) Hepatic triphosphopyridine nucleotide-cytochrome c reductase: isolation, characterization, and kinetic studies. J Biol Chem 237:2652-2660
23. Rockwell S (1983) Effects of mitomycin C alone and in combination with X-rays on EMT6 mouse mammary tumors in vivo. J Natl Cancer Inst 71:765-771
24. Rockwell S, Kennedy KA, Sartorelli AC (1982) Mitomycin C as a prototype hioreductic alkylating agent: in vitro studies of metabolism and cytotoxicity. Int J Radiat Oncol Biol Phys 8:753-755
25. Sami SM, lyengar BS, Tarnow SE, Remers WA, Bradner WT, Schurig JE (1984) Mitomycin C analogues with aryl substituents on the 7-amino group. J Med Chem 27:701-708
26. Shan XQ, Aw TY, Smith ER, Ingelman-Sundberg M, Mannervik B, Inagaki T, Jones DP (1992) Effect of chronic hypoxia on detoxification enzymes in rat liver. Biochem Pharmacol 43:2421-2426
27. Shibata K, Kasahara K, Nakatsumi Y, Bando T, Fujimura M, Matsuda T (1993) Establishment and characterization of mitomycin C-resistant non-small lung cancer cell lines with decreased DT-diaphorase activity. Proc Am Assoc Cancer Res 34:305
28. Siegel D, Gibson NW, Preusch PC, Ross D (1990) Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells. Cancer Res 50:7483-7489