Characterization of the expressed CIITA allele in the class II MHC transcriptional mutant RJ2.2.5

Immunogenetics

Volumn 43, Issue 1, 1995, Pages 88-91

  Brown, Jeffrey A ^a   He, Xiao Fei ^a   Westerheide, Sandra D ^a   Boss, Jeremy M ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ARTICLE; GENE EXPRESSION; GENE FREQUENCY; HISTOCOMPATIBILITY GENE; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALLELES; AMINO ACID SEQUENCE; BASE SEQUENCE; GENE EXPRESSION REGULATION; GENES, MHC CLASS II; HUMAN; MOLECULAR SEQUENCE DATA; REGULATORY SEQUENCES, NUCLEIC ACID; SEQUENCE DELETION; SUPPORT, U.S. GOV'T, P.H.S.; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 0029655910     PISSN: 00937711     EISSN: 14321211     Source Type: Journal    
DOI: 10.1007/BF00186611     Document Type: Article

References (23)

1. Detailed delineation of an interferon-gamma-responsive element important in human HLA-DRA gene expression in a glioblastoma multiform line
2. Regulation of a transfected human class II major histocompatibility complex gene in human fibroblasts
3. Molecular analysis of G1B and G3A IFN-γ mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene induction
4. A multiplicity of CCAAT box-binding proteins
5. Two distinct B cell factors bind the HLA-DRA X box region and recognize different subsets of MHC class II promoters
6. Protease treatment of nuclear extracts distinguishes between class II major histocompatibility complex X1 box DNA-binding proteins in wild type and class II deficient B cells
7. The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters
8. The same CCAAT box-binding factor binds to the promoter of two coordinately regulated major histocompatibility complex class II genes
9. MHC class II-deficient combined immunodeficiency: a disease of gene regulation
10. Purified X2BP cooperatively binds the class II MHC X box region in the presence of purified RFX the X box factor deficient in the bare lymphocyte syndrome
11. Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X
12. Cooperative binding between factors RFX and X2bp to the X and X2 boxes of MHC class II promoters
13. Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y
14. Class II MHC transcriptional mutants are defective in higher order complex formation
15. Activation of class II MHC genes requires both the X box region and the class II transactivator (CIITA)
16. Single base pair substitutions within the HLA-DRA gen promoter separate the functions of the X1 and X2 boxes
17. Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)
18. Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA
19. A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome)
20. Current concepts in DRA gene regulation
21. B-cell-specific and interferon-gamma-inducible regulation of the HLA-DR alpha gene
22. Stereospecific alignment of the X and Y elements is required for major histocompatibility complex class II DRA promoter function
23. Human MHC class II gene transcription directed by the carboxyl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency