Low serum interleukin-10 levels in multiple sclerosis: Further evidence for decreased systemic immunosuppression?

Journal of Neurology

Volumn 243, Issue 1, 1996, Pages 13-17

  Salmaggi, A ^a   Dufour, A ^a   Eoli, M ^a   Corsini, E ^a   La Mantia, L ^a   Massa, G ^a   Nespolo, A ^a   Milanese, C ^a  

^a DEPARTMENT OF NEUROSURGERY   (Italy)

Author keywords

Interleukin 10; Lymphocyte subsets; Multiple sclerosis

Indexed keywords

CYTOKINE; INTERLEUKIN 10; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; FEMALE; HUMAN; LYMPHOCYTE SUBPOPULATION; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; AGED; ANTIGENS, CD4; ANTIGENS, CD45; FEMALE; HUMAN; IMMUNE SYSTEM; INTERLEUKIN-10; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE SUBSETS; MALE; MIDDLE AGE; MULTIPLE SCLEROSIS; REFERENCE VALUES;

EID: 0029655892     PISSN: 03405354     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf00878525     Document Type: Article

References (37)

1. Adachi K, Kumamoto T, Araki S (1990) Elevated soluble interleukin-2 receptor levels in patients with active multiple sclerosis. Ann Neurol 28:687-691
2. Antel JP, Peeples DM, Reder AT, Arnason BGW (1984) Analysis of T regulator cell surface markers and functional properties in multiple sclerosis. J Neuroimmunol 6:93-103
3. Beck J, Rondot P, Jullien P, Wietzerbin J, Lawrence DA (1991) TGF-β-like activity produced during regression of exacerbations in multiple sclerosis. Acta Neurol Scand 84:452-455
4. Blay JY, Burdin N, Rousset F, Lenoir G, Biron P, Philip T, Banchereau J, Favrot MC (1993) Serum interleukin-10 in non-Hodgkin lymphoma: a prognostic factor. Blood 82:2169-2174
5. Cannella B, Gao YL, Brosnan CF, Raine CS (1994) IL10 enhances experimental allergic encephalomyelitis (EAE) (abstract). J Neuroimmunol 54:1-2
6. +) T cells in multiple sclerosis. Ann Neurol 24:185-191
7. Chofflon M, Juillard C, Juillard P, Gauthier G, Grau GE (1992) Tumor necrosis factor α production as a possible predictor of relapse in patients with multiple sclerosis. Eur Cytokine Netw 3:523-531
8. Del Prete G, De Carli M, Almerigogna F, Giudizi MG, Biagiotti R, Romagnani S (1993) Human IL-10 is produced by both Type 1 Helper (Th1) and Type 2 Helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. J Immunol 150:353-360
9. De Waal Maleyft R, Haanen J, Spits H, Roncarolo MG, Velde A, Figdor C, Johnson K, Kastelein R, Yssel H, Vries JE de (1991) Interleukin-10 (IL10) and viral IL10 strongly reduce antigen-specific human T-cell proliferation by diminishing the antigen presenting capacity of monocytes via downregulation of class II histocompatibility complex expression. J Exp Med 174:915-924
10. De Waal Maleyft R, Yssel H, De Vries JA (1993) Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. J Immunol 150:4754-4765
11. Florentino DF, Zlotnik A, Mosmann TR, Howard M, O'Garra A (1991) IL-10 inhibits cytokine production by activated macrophages. J Immunol 147:3815
12. Franciotta DM, Grimaldi LME, Mar-lino GV, Piccolo G, Bergamaschi R, Citterio A, Melzi d'Eril GV (1989) Tumor necrosis factor in serum and cerebrospinal fluid of patients with multiple sclerosis. Ann Neurol 26:787-789
13. Gallo P, Piccinno M, Pagni S, Argentiero V, Giometto B, Bozza F, Tavolato B (1989) Immune activation in multiple sclerosis: study of IL2, sIL2R and gamma-IFN levels in serum and cerebrospinal fluid. J Neurol Sci 92:9-15
14. Gallo P, Piccinno MG, Tavolato B, Sidèn A (1991) A longitudinal study on IL2, sIL2R, IL4 and IFN-gamma in multiple sclerosis CSF and serum. J Neurol Sci 101:227-232
15. Gallo P, Sivieri S, Rinaldi L, Yan X, Lolli F, De Rossi A, Tavolato B (1994) Intrathecal synthesis of interleukin-10 (IL-10) in viral and inflammatory diseases of the central nervous system. J Neurol Sci 126:49-53
16. Hartung HP, Michels M, Reiners K, Seeldrayers P, Archelos JJ, Toyka KV (1993) Soluble ICAM-1 serum levels in multiple sclerosis and viral encephalitis. Neurology 43:2331-2335
17. Jander S, Heidenreich F, Stoll G (1993) Serum and CSF levels of soluble Intercellular Adhesion Molecule-1 (ICAM-1) in inflammatory neurological disease. Neurology 43:1809-1813
18. Kennedy MK, Torrance MD, Picha KS, Mohler KM (1992) Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J Immunol 149:2496-2505
19. Kittur SD, Kittur DS, Soncraut TT, Rapoport SI, Tourtellotte WW, Nagel JE, Adler WH (1990) Soluble interleukin 2 receptors in cerebrospinal fluid from individuals with various neurological disorders. Ann Neurol 28:1668-1673
20. Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33:1444-1452
21. Link J, Fredrikson S, Soderstrom M, Ollson T, Hojeberg B, Ljungdahl A, Link H (1994) Organ-specific autoantigens induce transforming growth factor-β mRNA expression in mononuclear cells in multiple sclerosis and myasthenia gravis. Ann Neurol 35:197-203
22. May LT, Viguet H, Kenney JS, Ida N, Allison AC, Sehgal PB (1993) High levels of "complexed" interleukin-6 in human blood. J Biol Chem 267:19698-19704
23. McDonald WI, Halliday AM (1977) Diagnosis and classification of multiple sclerosis. Br Med Bull 33:4-8
24. Morimoto C, Hafler DA, Weiner HL, Letvin NL, Hagan M, Daley J, Schlossmann SF (1987) Selective loss of the suppressor inducer T-cell subset in progressive multiple sclerosis. N Engl J Med 316:67-72
25. Oger JF, Roos R, Antel JP (1983) Immunology of multiple sclerosis. Neurol Clin 1:655-679
26. Oger JF, Kastrukoff L, O'Gorman M, Paty DW (1986) Progressive multiple sclerosis: abnormal immune functions in vitro and aberrant correlation with enumeration of lymphocyte subpopulations. J Neuroimmunol 12:37-48
27. Oger JF, Kastrukoff LF, Li DKB, Paty DW (1988) Multiple sclerosis: in relapsing patients, immune functions vary with disease activity as assessed by MRI. Neurology 38:1739-1744
28. Peter JB, Boctor FN, Tourtellotte W (1991) Serum and CSF levels of IL-2, sIL-2R, TNF-α and IL-1β in chronic progressive multiple sclerosis. Expected lack of clinical utility. Neurology 41:121-123
29. Peyron F, Burdin N, Ringwald P, Vuillez JP, Rousset F, Banchereau J (1994) High levels of circulating IL-10 in human malaria. Clin Exp Immunol 95:300-303
30. Porrini AM, Dell'Arciprete L, Gambi D (1994) Rationale for the use of interleukin-10 to suppress multiple sclerosis exacerbations (abstract). J Neurol 241[Suppl 1]:S152
31. Racke MK, Sriram S, Carlino J, Cannella B, Raine CS, McFarlin DE (1993) Long term treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-β2. J Neuroimmunol 46:175-184
32. Rieckmann P, Albrecht M, Kitze B, Weber T, Tumani H, Broocks A, Luer W, Poser S (1994) Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis. Neurology 44:1523-1526
33. Rott O, Fleischer B, Cash E (1994) Interleukin-10 prevents experimental allergic encephalomyelitis in rats. Eur J Immunol 24: 1434-1440
34. Schumacher GA, Beebe G, Kibler RE, Kurland LT, Kurtzke JF, McDowell F, Nagler B, Sibley WA, Tourtellotte WW, Willmon TL (1965) Problems of experimental trials of therapy in multiple sclerosis. Ann NY Acad Sci 122:552-556
35. Trotter JI, Clifford DB, McInnis JE, Griffeth C, Bruns KA, Perlmutter MS, Anderson CB, Collins KG, Banks G, Hicks BC (1989) Correlation of immunological studies and disease progression in chronic progressive multiple sclerosis. Ann Neurol 25:172-178
36. Trotter JI, Collins KG, Veen RC van der (1991) Serum cytokine levels in chronic progressive multiple sclerosis: interleukin-2 levels parallel tumor necrosis factor-alpha levels. J Neuroimmunol 33:29-36
37. Tsukada N, Matsuda M, Miyagi K, Yanagisawa N (1993) Increased levels of intercellular adhesion molecule-1 (ICAM-1) and tumor necrosis factor receptor in the cerebrospinal fluid of patients with multiple sclerosis. Neurology 43:2679-2682