Evidence for the involvement of a nuclear NF-κB inhibitor in global down-regulation of the major histocompatibility complex class I enhancer in adenovirus type 12-transformed cells

Molecular and Cellular Biology

Volumn 16, Issue 1, 1996, Pages 398-404

  Liu, Xiaohong ^a,c   Ge, Ruowen ^a,d   Ricciardi, Robert P ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA SCHOOL OF DENTAL MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRIDAE; HUMAN ADENOVIRUS TYPE 12;

DETERGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEIN INHIBITOR;

ADENOVIRUS 12; ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; DOWN REGULATION; ENHANCER REGION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPRESSOR GENE; VIRUS CARCINOGENESIS; VIRUS TRANSCRIPTION;

ADENOVIRUSES, HUMAN; ANIMAL; BASE SEQUENCE; CELL LINE, TRANSFORMED; CELL NUCLEUS; COMPARATIVE STUDY; DNA; DOWN-REGULATION; ENHANCER ELEMENTS (GENETICS); GENES, MHC CLASS I; H-2 ANTIGENS; MICE; MOLECULAR SEQUENCE DATA; NF-KAPPA B; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0029655482     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.1.398     Document Type: Article

References (57)

1. Ackrill, A. M., and G. E. Blair. 1988 Regulation of major histocompatibility class I gene expression at the level of transcription in highly oncogenic adenovirus transformed rat cells. Oncogene 3:483-487.
2. Arenzana-Seisdedos, F., J. Thompson, M. S. Rodriguez, F. Bachelerie, D. Thomas, and R. T. Hay. 1995. Inducible nuclear expression of newly synthesized IκBα negatively regulates DNA-binding and transcriptional activities of NF-κB. Mol. Cell. Biol. 15:2689-2696.
3. Baeuerle, P. A., and D. Baltimore. 1988 Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor. Cell 53:211-217
4. Baeuerle, P. A., and D. Baltimore. 1988. IκB: a specific inhibitor of the NF-κB transcription factor. Science 242:540-546
5. Baldwin, A. S., Jr., and P. A. Sharp. 1988. Two transcription factors. NF-κB and H2TF1, interact with a single regulatory sequence in the class I major histocompatibility complex promoter Proc. Natl. Acad. Sci. USA 85:723-727.
6. Ballard, D. W., E. P. Dixon, N. J. Peifer, H. Bogerd, S. Doerre, B. Stein, and W. C. Greene. 1992 The 65-kDa subunit of human NF-κB functions as a potent transcriptional activator and a taraet for v-Rel-mediated repression. Proc. Natl. Acad Sci USA 89:1875-1879.
7. Beg, A. A., and A. S. Baldwin, Jr. 1993 The IκB proteins: multifunctional regulators of Rel/NF-κB transcription factors. Genes Dev. 7:2064-2070.
8. Bernards, R., P. I. Schrier, A. Houweling, J. L. Bos, and A. J. van der Eb. 1983. Tumorigenicity of cells transformed by adenovirus type 12 by evasion of T-cell immunity. Nature (London) 305:776-779
9. Bours, V., P. R. Burd, K. Brown, J. Villalobos, S. Park, R.-P. Ryseck, R. Bravo, K. Kelly, and U. Siebenlist. 1992 A novel mitogen-inducible gene product related to p50/p105-NF-κB participates in transactivation through a κB site. Mol. Cell Biol 12:685-695.
10. Bradford, M. M. 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem. 72:248-254.
11. Burke, P. A., S. Hirschfeld, Y. Shirayoshi, J. W. Kasik, K. Hamada, E. Appella, and K. Ozato. 1989. Developmental and tissue-specific expression of nuclear proteins that bind the regulatory element of the major histocompatibility complex class I gene. J. Exp Med 169:1309-1321.
12. Cressman, D. E., and R. Taub. 1993. IκBα can localize in the nucleus but shows no direct transactivation potential. Oncogene 8:2567-2573
13. David-Watine, B., A. Israel, and P. Kourilsky. 1990. The regulation and expression of MHC class I genes Immunol Today 11:286-292
14. Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983 Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489.
15. Dobrzanski, P., R.-P. Ryseck, and R. Bravo. 1994 Differential interactions of Rel-NF-κB complexes with IκBα determine pools of constitutive and inducible NF-αB activity. EMBO J. 13:4608-4616.
16. Eager, K. B., J. Williams, D. Breiding, S. Pan, B. Knowles, E. Appella, and R. P. Ricciardi. 1985 Expression of histocompatibility antigens H-2K, -D, and -L is reduced in adenovirus-12-transformed mouse cells and is restored by interferon-γ Proc. Natl. Acad. Sci. USA 82:5525-5520.
17. Franzoso, G., V. Bours, S. Park, M. Tomita-Yamaguchi, K. Kelly, and U. Siebenlist. 1992 The candidate oncoprotein Bcl-3 is an antagonist of p50/ NF-κB-mediated inhibition. Nature (London) 359:339-342.
18. Friedman, D. J., and R. P. Ricciardi. 1988. Adenovirus type 12 E1A gene represses accumulation of MHC class I mRNAs at the level of transcription. Virology 165:303-305.
19. Fugita, T., G. P. Nolan, S. Ghosh, and D. Baltimore. 1992 Independent modes of transcriptional activation by the p50 and p65 subunits of NF-κB. Genes Dev. 6:775-787.
20. Ge, R., A. Kralli, R. Weinmann, and R. P. Ricciardi. 1992. Down-regulation of the major histocompatibility complex class I enhancer in adenovirus type 12-transformed cells is accompanied by an increase in factor binding J Virol. 66:6969-6978.
21. Ge, R., X. Liu, and R. P. Ricciardi. 1994. E1A oncogene of adenovirus-12 mediates trans-repression of MHC class I transcription in Ad5/Ad12 somatic hybrid transformed cells Virology 203:389-392.
22. Israël, A., O. Le Bail, D. Hatat, J. Piette, M. Kieran, F. Logeat, D. Wallach, M. Fellous, and P. Kourilsky. 1989. TNF stimulates expression of mouse MHC class I genes by inducing an NF-κB-like enhancer binding activity which displaces constitutive factors. EMBO J. 8:3793-3800.
23. Kang, S.-M., A.-C. Tran, M. Grilli, and M. J. Lenardo. 1992 NF-κB subunit regulation in nontransformed CD4 T lymphocytes. Science 256:1452-1456.
24. Kieran, M., V. Blank, F. Logeat, J. Vandekerckhove, F. Lottspeich, O. Le Bail, M. B. Urban, P. Kourilsky, P. A. Baeuerle, and A. Israël. 1990. The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product. Cell 62:1007-1018.
25. Kralli, A. 1991. Ph.D. thesis University of Pennsylvania, Philadelphia
26. Kralli, A., R. Ge, U. Graeven, R. P. Ricciardi, and R. Weinmann. 1992. Negative regulation of the major histocompatibility complex class I enhancer in adenovirus type 12-transformed cells via a retinoic acid response element. J Virol. 66:6979-6988.
27. Kretzschmar, M., M. Meisterernst, C. Scheidereit, G. Li, R. G. Roeder. 1992. Transcriptional regulation of the HIV-1 promoter by NF-κB in vitro. Genes Dev. 6:761-774
28. Kunsch, C., S. M. Ruben, and C. A. Rosen. 1992. Selection of optimal κB/Rel DNA-binding motifs: interaction of both subunits of NF-κB with DNA is required for transcriptional activation Mol Cell. Biol. 12:4412-4421.
29. Kushner, D. B., D. S. Pereira, X. Liu, F. L. Graham, and R. P. Ricciardi. The first exon of Ad12 E1A excluding the transactivation domain mediates differential binding of COUP-TF and NF-κB to the MHC class I enhancer in transformed cells Oncogene, in press.
30. Liu, X., R. Ge, S. Westmoreland, A. J. Cooney, S. Y. Tsai, M.-J. Tsai, and R. P. Ricciardi. 1994. Negative regulation by the R2 element of the MHC class I enhancer in adenovirus-12 transformed cells correlates with high levels of COUP-TF binding. Oncogene 9:2183-2190.
31. Meijer, I., A. J. M. Boot, G. Mahabir, A. Zantema, A. J. van der Eb. 1992. Reduced binding activity of transcription factor NF-κB accounts for MHC class I repression in adenovirus type 12 E 1-transformed cells Cell. Immunol. 145:56-65
32. Miyamoto, S., and I. M. Verma. 1995. Rel/NF-κB/IκB story Adv Cancer Res. 66:255-292.
33. Neumann, M., K. Tsapos, J. A. Scheppler, J. Ross, and B. R. Franza, Jr. 1992. Identification of complex formation between two intracellular tyrosine kinase substrates, human c-Rel and the p105 precursor of p50 NF-κB. Oncogene 7:2095-2104.
34. Nielsch, U., S. G. Zimmer, and L. E. Babiss. 1991 Changes in NF-κB and ISGF3 DNA binding activities are responsible for differences in MHC and β-IFN gene expression in Ad5- versus Ad12-transformed cells. EMBO J. 10:4169-4175.
35. Pereira, D. S., D. B. Kushner, R. P. Ricciardi, and F. L. Graham. Testing NF-κB1-p50 antibody specificity using knockout mice Submitted for publication.
36. Perkins, N. D., R. M. Schmid, C. S. Duckett, K. Leung, N. R. Rice, and G. J. Nabel. 1992 Distinct combinations of NF-κB subunits determine the specificity of transcriptional activation. Proc. Natl Acad. Sci. USA 89:1529-1533.
37. b gene expression in metastatic tumor cells. J Exp. Med. 177:1651-1662
38. Raziuddin, J. A. Mikovits, I. Calvert, S. Ghosh, H.-F. Kung, and F. W. Ruscetti. 1991. Negative regulation of human immunodeficiency virus type 1 expression in monocytes role of the 65-kDa plus 50-kDa NF-κB dimer. Proc Natl. Acad Sci. USA 88:9426-9430.
39. Ricciardi, R. P. 1995. Transformation and tumorigenesis mediated by the adenovirus E1A and E1B oncogenes, p. 195-225. In G. Barbanti-Brodano, M. Bendinelli, and H Friedman (ed.). DNA tumor viruses: oncogenic mechanisms. Plenum Press, New York.
40. Rice, N. R. Unpublished data
41. Rice, N. R., and M. K. Ernst. 1993. In vivo control of NF-κB activation by IκBα EMBO J. 12:4685-4695
42. Rice, N. R., M. L. MacKichan, and A. Israël. 1992. The precursor of NF-κB p50 has IκB-like functions. Cell 71:243-253
43. Ruben, S. M., R. Narayanan, J. F. Klement, C.-H. Chen, and C. A. Rosen. 1992. Functional characterization of the NF-κB p65 transcriptional activator and an alternatively spliced derivative. Mol. Cell. Biol. 12:444-454.
44. Ryseck, R.-P., P. Bull, M. Takamiya, V. Bours, U. Siebenlist, P. Dobrzanski, and R. Bravo. 1992. RelB, a new Rel family transcription activator that can interact with p50-NF-κB. Mol. Cell. Biol. 12:674-684.
45. Scheinman, R. I., A. A. Beg, and A. S. Baldwin, Jr. 1993. NF-κB p100 (Lyt-10) is a component of H2TF1 and can function as an IκB-like molecule. Mol. Cell. Biol. 13:6089-6101.
46. Schmitz, M. L., and P. A. Baeuerle. 1991. The p65 subunit is responsible for the strong transcription activating potential of NF-κB. EMBO J. 10:3805-3817.
47. Scheoten, G. J., A. J. van der Eb, and A. Zantema. 1995 Downregulation of MHC class I expression due to interference with p105-NFκB1 processing by Ad12 E1A. EMBO J. 14:1498-1507.
48. Schrier, P. I., R. Bernards, R. T. M. J. Vaessen, A. Houweling, and A. J. van der Eb. 1983. Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells. Nature (London) 305:771-775.
49. Segars, J. H., T. Nagata, V. Hours, J. A. Medin, G. Franzoso, J. C. G. Blanco, P. D. Drew, K. G. Becker, J. An, T. Tang, D. A. Stephany, B. Neel, U. Siebenlist, and K. Ozato. 1993. Retinoic acid induction of major histocompalibility complex class I genes in NTcra-2 embryonal carcinoma cells involves induction of NF-κB (p50-p65) and retinoic acid receptor β-retinoid \ receptor β heterodimers. Mol. Cell. Biol. 13:6157-6169.
50. Shapiro, D. J., P. A. Sharp, W. W. Wahli, and M. J. Keller. 1988. A high-efficiency HeLa cell nuclear transcription extract. DNA 7:47-55.
51. Siebenlist, U., G. Franzoso, and K. Brown. 1994. Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol. 10:405-455
52. Tanaka, K., K. J. Isselbacher, G. Khoury, and G. Jay. 1985. Reversal of oncogenesis by the expression of a major histocompatibility complex class I gene. Science 228:26-30.
53. Thanos, D., and T. Maniatis. 1995. NF-κB: a lesson in family values. Cell 80:529-532.
54. Thompson, J. E., R. J. Phillips, H. Erdjument-Bromage, P. Tempst, S. Ghosh. 1994 IκB-β regulates the persistent response in a biphasic activation of NF-κB. Cell 80:573-582.
55. Vasavada, R., K. B. Eager, G. Barbanti-Brodano, A. Caputo, and R. P. Ricciardi. 1986. Adenovirus type 12 early region 1A proteins repress class I HLA expression in transformed human cells. Proc Natl. Acad. Sci. USA 83:5257-5261.
56. Yewdell, J. W., J. R. Bennink, K. B. Eager, and R. P. Ricciardi. 1988. CTL recognition of adenovirus-transformed cells infected with influenza virus lysis by anti-influenza CTL parallels adenovirus-12-induced suppression of class I MHC molecules. Virology 162:236-238.
57. Zabel, U., T. Henkel, M. dos Santos Silva, and P. A. Baeuerle. 1993. Nuclear uptake control of NF-κB by MAD-3. an IκB protein present in the nucleus EMBO J. 12:201-211.