Three classes of mutations in the A subunit of the CCAAT-binding factor CBF delineate functional domains involved in the three-step assembly of the CBF-DNA complex

Molecular and Cellular Biology

Volumn 16, Issue 1, 1996, Pages 328-337

  Sinha, Satrajit ^a   Kim, In San ^a   Sohn, Kun Young ^a,b   De Crombrugghe, Benoit ^a   Maity, Sankar N ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b Kyungpook National University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ARCHAEA; MAMMALIA; SACCHAROMYCES CEREVISIAE;

DNA BINDING PROTEIN; HISTONE; HISTONE H2A; HISTONE H2B; PROTEIN SUBUNIT; TRANSCRIPTION FACTOR;

ARTICLE; DNA CROSS LINKING; DNA PROTEIN COMPLEX; GENETIC CONSERVATION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; STOICHIOMETRY;

AMINO ACID SEQUENCE; ANIMAL; BINDING SITES; CCAAT-ENHANCER-BINDING PROTEINS; CONSERVED SEQUENCE; DNA; DNA-BINDING PROTEINS; HUMAN; IN VITRO; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN CONFORMATION; RATS; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0029655406     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.1.328     Document Type: Article

References (50)

1. Arents, G., R. W. Burlingame, B.-C. Wang, W. E. Love, and E. N. Moudrianakis. 1991. The nucleosomal core histone octamer at 3.1Å resolution a tripartite protein assembly and a left-handed superhelix. Proc. Natl. Acad Sci. USA 88:10148-10152.
2. Arents, G., and E. N. Moudrianakis. 1993. Topology of the histone octamer surface, repeating structural motifs utilized in the docking of nucleosomal DNA. Proc. Natl. Acad. Sci. USA 90:10489-10493.
3. Baxevanis, A. D., G. Arents, E. N. Moudrianakis, and D. Landsman. 1995 A variety of DNA-binding and multimeric proteins contain the histone told motif. Nucleic Acids Res. 23:2685-2691.
4. Becker, D. M., J. D. Fikes, and L. Guarente. 1991. A cDNA encoding a human CCAAT-binding protein cloned by functional complementation in yeast. Proc. Natl. Acad. Sci. USA 88:1968-1972.
5. Breeden, L., and K. Nasmyth. 1985. Regulation of the yeast HO gene. Cold Spring Harbor Symp. Quant. Biol. 50:643-650.
6. Bucher, P. 1990 Weight matrix description of four eukaryotic RNA polymerase II promoter elements derived from 502 unrelated promoter sequences. J. Mol Biol 212:563-578.
7. Chodosh, L. A., A. S. Baldwin, R. W. Carthew, and P. A. Sharp. 1988. Human CCAAT-binding proteins have heterologous subunits. Cell 53:11-24.
8. Cleary, M. A., S. Stern, M. Tanaka, and W. Herr. 1993. Differential positive control by Oct-1 and Oct-2: activation of a transcriptionally silent motif through Oct-1 and VP16 corecruitment. Genes Dev. 7:72-83.
9. Coustry, F. Personal communication.
10. Coustry, F., S. N. Maity, and B. de Crombrugghe. 1995. Studies on transcription activation by the multimeric CCAAT-binding factor. J. Biol. Chem. 270:468-475
11. Dorn, A., J. Bollekens, A. Staub, C. Benoist, and D. Mathis. 1987. A multiplicity of CCAAT box-binding proteins Cell 50:863-872.
12. Durfeee, T., K. Becherer, P.-L. Chen, S.-H. Yeh, Y. Yang, A. E. Kilburn, W. H. Lee, and S. J. Elledge. 1993. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit Genes Dev. 7:555-569.
13. Fields, S., and O. Song. 1989. A novel genetic system to detect protein-protein interactions Nature (London) 350:245-246.
14. Forsburg, S. L., and L. Guarente. 1988. Mutational analysis of upstream activation sequence 2 of the CYC1 gene of Saccharomyces cerevisiae: a HAP2-HAP3 responsive site. Mol. Cell. Biol. 8:647-654.
15. Fu, X. Y., S. A. Kessler, S. A. Veals, D. E. Levy, and J. Darnell. 1990. ISGF-3, the transcriptional activator induced by interferon α, consists of multiple interacting polypeptide chains Proc. Natl. Acad. Sci. USA 87:8555-8559.
16. Gietz, D., A.-S. Jean, R. A. Woods, and R. H. Schiestl. 1992. Improved method for high efficiency transformation of intact yeast cells Nucleic Acids Res. 20:1425.
17. Hahn, S., and L. Guarente. 1988. Yeast HAP2 and HAP3: transcriptional activators in a heteromeric complex. Science 240:317-321
18. Hahn, S., J. Pinkham, R. Wei, R. Miller, and L. Guarente. 1988. The HAP3 regulatory locus of Saccharomyces cerevisiae encodes divergent overlapping transcripts Mol. Cell. Biol. 8:655-663
19. Harper, J. W., G. R. Adami, N. Wei, K. Keyomarsi. and S. J. Elledge. 1993. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805-816.
20. Hatamochi, A., P. T. Golumbek, E. Van Schaftingen, and B. de Crombrugghe. 1988. A CCAAT binding factor consists of two different components that are both required for DNA binding. J. Biol. Chem. 263:5940-5947.
21. Inostroza, J. A., F. H. Mermelstein, I. Ha, W. S. Lane, and D. Reinberg. 1992 Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription. Cell 70:477-489.
22. Karsenty, G., P. T. Golumbek, and B. de Crombrugghe. 1988 Point mutations and small substitution mutations in three different upstream elements inhibit the activity of the mouse α2 (I) collagen promoter. J. Biol. Chem. 263:13909-13915.
23. Kessler, D. S., S. A. Veals, X. Y. Fu, and D. E. Levy. 1990. Interferon-α regulates nuclear translocation and DNA-binding affinity of ISGF-3, a multimeric transcriptional activator. Genes Dev. 4:1753-1765.
24. Kokubo, T., D.-W. Gong, J. C. Wootton, M. Horikoshi, R. Roeder, and Y. Nakatani. 1994. Molecular cloning of Drosophila TFIID subunits. Nature (London) 367:484-487.
25. Kristie, T. M., and P. A. Sharp. 1990. Interactions of the Oct-1 POU subdomains with specific DNA sequences and with the HSV α-trans-activator protein. Genes Dev. 4:2383-2396.
26. LaMarco, K. L., and S. L. McKnight. 1989 Purification of a set of cellular polypeptides that bind to the purine-rich cis-regulatory element of herpes simplex virus immediate early genes. Genes Dev. 3:1372-1383.
27. Li, X. Y., R. Mantovani, R. H. Van Huisjduijnen, I. Andre, C. Benoist, and D. Mathis. 1992. Evolutionary variation of the CCAAT-binding transcription factor NF-Y Nucleic Acids Res. 20:1087-1091.
28. Maire, P., J. Wuarin, and U. Schibler. 1989 The role of cis-acting promoter elements in tissue-specific albumin gene expression. Science 246:343-346.
29. Mairy, S. N., and B. de Crombrugghe. 1992. Biochemical analysis of the B subunit of the heteromeric CCAAT-binding factor. A DNA-binding domain and a subunit interaction domain are specified by two separate segments. J. Biol. Chem. 267:8286-8292.
30. Maity, S. N., P. T. Golumbek, G. Karsenty, and B. de Crombrugghe. 1988. Selective activation of transcription by a novel CCAAT binding factor. Science 241:582-585.
31. Maity, S. N., S. Sinha, E. C. Ruteshousher, and B. de Crombrugghe. 1992 Three different polypeptides are necessary for DNA binding of the mammalian heteromeric CCAAT binding factor. J. Biol. Chem. 267:16574-16580.
32. Maity, S. N., T. Vuorio, and B. de Crombrugghe. 1990. The B subunit of a rat heteromeric CCAAT-binding transcription factor shows a striking sequence identity with the yeast Hap2 transcription factor. Proc. Natl. Acad. Sci. USA 87:5378-5382
33. Mantovani, R., U. Pessara, F. Tronche, X. Y. Li, A. Knapp, J. Pasquali, C. Benoist, and D. Mathis. 1992. Monoclonal antibodies to NF-Y define its function in MHC class II and albumin gene transcription EMBO J 11:3315-3322.
34. McNabb, D. S., Y. Xing, and L. Guarente. 1995. Cloning of yeast HAP5: a novel subunit of a heterotrimeric complex required for CCAAT binding. Genes Dev 9:47-58.
35. Moudrianakis, E. N., and G. Arents. 1993. Structure of the histone octamer core of the nucleosome and its potential interactions with DNA. Cold Spring Harbor Symp Quant Biol. 58:273-279.
36. Olesen, J. T., and L. Guarente. 1990. The HAP2 subunit of yeast CCAAT transcriptional activator contains adjacent domains for subunit association and DNA recognition: model for the HAP2/3/4 complex. Genes Dev 4: 1714-1729.
37. Olesen, J. T., S. Hahn, and L. Guarente. 1987. Yeast HAP2 and HAP3 activators both bind to the CYC1 upstream activation site UAS2 in an interdependent manner. Cell 51:953-961.
38. Pabo, C. O., and R. T. Sauer. 1992. Transcription factors: structural families and principles of DNA recognition Annu. Rev. Biochem 61:1053-1095.
39. Pinkham, J. L., J. T. Olesen, and L. Guarente. 1987. Sequence and nuclear localization of the Saccharomyces cerevisiae HAP2 protein, a transcriptional activator. Mol. Cell. Biol. 7:578-585.
40. Sandman, K., J. A. Krzycki, B. Dobrinski, R. Lurz, and J. N. Reeve. 1990. HMf, a DNA-binding protein isolated from the hyperthermophilic archaeon Methanothermus fervidus, is most closely related to histones. Proc. Natl. Acad. Sci. USA 87:5788-5791
41. Sinha, S. Unpublished results.
42. Sinha, S., S. N. Maity, J. Lu, and B. de Crombrugghe. 1995 Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B, and with yeast HAP2 and HAP3. Proc. Natl. Acad. Sci. USA 92:1624-1628.
43. Thompson, C. C., T. A. Brown, and S. L. McKnight. 1991 Convergence of Ets- and Notch-related structural motifs in a heteromeric DNA binding complex. Science 253:762-768.
44. Tjian, R., and T. Maniatis. 1994. Transcriptional activation: a complex puzzle with few easy pieces. Cell 77:5-8
45. Van Huisjduijnen, R. H., X. Y. Li, D. Black, H. Matthes, C. Benoist, and D. Mathis. 1990. Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y (CP-1/CBF) subunits. EMBO J. 10:3119-3127.
46. Vuorin, T., S. N. Maity, and B. de Crombrugghe. 1990. Purification and molecular cloning of the "A" chain of a rat heteromeric CCAAT-binding protein. Sequence identity with the yeast Hap3 transcription factor J. Biol. Chem. 265:22480-22486.
47. Wells, D., and C. McBride. 1989. A comprehensive compilation and alignment of histories and histone genes. Nucleic Acids Res. 17(Suppl.):r311.
48. Wright, K. L., B. J. Vilen, Y. Itoh-Lindstrom, T. L. Moore, G. Li, M. Criscitiello, P. Cogswell, J. B. Clarke, and J. P. Y. Ting. 1994. CCAAT box binding protein NF-Y facilitates in vivo recruitment of upstream DNA binding transcription factors. EMBO J 13:4042-4053
49. Xing, Y., J. D. Fikes, and L. Guarente. 1993. Mutations in yeast HAP2/HAP3 define a hybrid CCAAT box binding domain. EMBO J. 12:4647-4655.
50. Xing, Y., S. Zhang, J. T. Olesen, A. Rich, and L. Guarente. 1994. Subunit interaction in the CCAAT-binding heteromeric complex is mediated by a very short α-helix in HAP2. Proc. Natl. Acad. Sci. USA 91:3009-3013.