Single amino acid substitution in constant region 1 or 4 of gp120 causes the phenotype of a human immunodeficiency virus type 1 variant with mutations in hypervariable regions 1 and 2 to revert

Journal of Virology

Volumn 70, Issue 1, 1996, Pages 607-611

  Wang, Wei Kung ^a   Essex, Max ^a   Lee, Tun Hou ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CYSTEINE; DNA; GLYCOPROTEIN GP 120; ISOLEUCINE; METHIONINE; RNA DIRECTED DNA POLYMERASE; VALINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GLYCOSYLATION; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOBLOTTING; MONKEY; MUTATION; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; VIRUS INFECTIVITY;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; BINDING SITES; CELL LINE; CLONING, MOLECULAR; DNA PRIMERS; GLYCOSYLATION; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMAN; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHENOTYPE; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; VARIATION (GENETICS);

EID: 0029655298     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.1.607-611.1996     Document Type: Article

References (43)

1. Alexander, S., and J. H. Elder. 1984. Carbohydrate dramatically influences immune reactivity of antisera to viral glycoprotein antigens. Science 226:1328-1330.
2. Andeweg, A. C., P. Leeflang, A. D. M. E. Osterhaus, and M. L. Bosch. 1993 Both the V2 and V3 regions of the human immunodeficiency virus type 1 surface glycoprotein functionally interact with other envelope regions in syncytium formation. J Virol. 67:3232-3239.
3. Benjouad, A., J.-C. Gluckman, L. Montagnier, and E. Bahraoui. 1993 Specificity of antibodies produced against native or desialylated human immunodeficiency virus type 1 recombinant gp160. J. Virol. 67:1693-1697.
4. Benjonad, A., J.-C. Gluckman, H. Rochat, L. Montagnier, and E. Bahraoui. 1992. Influence of carbohydrate moieties on the immunogenicity of human immunodeficiency virus type 1 recombinant gp160. J. Virol. 66:2473-2483.
5. Benn, S., R. Rutledge, T. Folks, J. Gold, L. Baker, J. McCormick, P. Feorino, P. Pint, T. Quinn, and M. Martin. 1985. Genomic heterogeneity of AIDS retroviral isolates from North America and Zaire. Science 230:949-951.
6. Bolmstedt, A., S. Olofsson, E. Sjogren-Jansson, S. Jeansson, I. Sjoblom, L. Akerblom, J.-E. S. Hansen, and S.-L. Hu. 1992 Carbohydrate determinant NeuAc-Galβ(1-4) of N-linked glycans modulates the antigenic activity of human immunodeficiency virus type 1 glycoprotein gp120. J. Gen. Viral. 73:3099-3105.
7. Boyd, M. T., G. R. Simpson, A. J. Cann, M. A. Johnson, and R. A. Weiss. 1993. A single amino acid substitution in the V1 loop of human immunodeficiency virus type 1 gp120 alters cellular tropism. J. Virol. 67:3649-3652.
8. Davis, D., M. Stephens, C. Willers, and P. J. Lachmann. 1990. Glycosylation governs the binding of antipeptide antibodies to regions of hypervariable amino acid sequence within recombinant gp120 of human immunodeficiency virus type 1 J. Gen. Virol. 71:2889-2898.
9. Fisher, A. G., E. Collalti, L. Ratner, R. C. Gallo, and F. Wong-Staal. 1985. A molecular clone of HTLV-III with biological activity. Nature (London) 316:262-265.
10. Freed, E. O., and M. A. Martin. 1994. Evidence for a functional interaction between the V1/V2 and C4 domains of human immunodeficiency virus type 1 envelope glycoprotein gp120. J Virol. 68:2503-2512.
11. Groenink, M., R. A. M. Fouchier, S. Broersen, C. H. Baker, M. Koot, A. B. van't Wout, H. G. Huisman, F. Miedema, M. Tersmette, and H. Schuitemaker. 1993. Relation of phenotype evolution of HIV-1 to envelope V2 configuration. Science 260:1513-1516.
12. Hahn, B. H., M. A. Gonda, G. M. Shaw, M. Popovic, J. A. Hoxie, R. C. Gallo, and F. Wong-Staal. 1985. Genomic diversity of the acquired immune deficiency syndrome virus HTLV-III: different viruses exhibit greatest divergence in their envelope genes. Proc. Natl. Acad. Sci. USA 82:4813-4817
13. Koito, A., G. Harrowe, J. A. Levy, and C. Cheng-Majer. 1994. Functional role of the V1/V2 region of human immunodeficiency virus type 1 envelope glycoprotein gp120 in infection of primary macrophages and soluble CD4 neutralization. J. Virol. 68:2253-2259
14. Koito, A., L. Stamatatos, and C. Cheng-Mayer. 1995. Small amino acid sequence changes within the V2 domain can affect the function of a T-cell line-tropic human immunodeficiency virus type 1 envelope gp120. Virology 206:878-884.
15. Kornfeld, H., N. Riedel, G. A. Viglianti, V. Hirsch, and J. I. Mullins. 1987. Cloning of HTLV-4 and its relation to simian and human immunodeficiency viruses. Nature (London) 326:610-613.
16. Kunkel, T. A. 1985. Rapid and efficient site-specific mutagenesis without phenotypic selection Proc Natl. Acad Sci USA 82:488-492
17. Lee, W. R., W. J. Syu, D. Bin, M. Matsuda, S. Tan, A. Wolf, M. Essex, and T. H. Lee. 1992 Non-random distribution of gp120 N-linked glycosylation sites critical for HIV-1 infectivity Proc. Natl Acad. Sci. USA 89:2213-2217
18. Leonard, C. K., M. W. Spellman, L. Riddle, R. Harris, J. N. Thomas, and T. J. Gregory. 1990. Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells. J Biol. Chem. 265:10373-10382.
19. Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982 Molecular cloning a laboratory manual Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
20. McKeating, J. A., C. Shotton, J. Cordell, S. Graham, P. Balfe, N. Sullivan, M. Charles, M. Page, A. Bolmstedt, S. Olofsson, S. C. Kayman, Z. Wu, A. Pinter, C. Dean, J. Sodroski, and R. A. Weiss. 1993. Characterization of neutralizing monoclonal antibodies to linear and conformation-dependent epitopes within the first and second variable domains of human immunodeficiency virus type I gp120. J. Virol. 67:4932-4944.
21. McNearney, T., Z. Hornickova, R. Markham, A. Birdwell, M. Arens, A. Saah, and L. Ratner. 1992. Relationship of human immunodeficiency virus type 1 sequence heterogeneity to stage of disease Proc. Natl. Acad. Sci. USA 89:10247-10251.
22. Modrow, S., B. H. Hahn, G. M. Shaw, R. C. Gallo, F. Wong-Staal, and H. Wolf. 1987 Computer-assisted analysis of envelope protein sequences of seven human immunodeficiency virus isolates: prediction of antigenic epitopes in conserved and variable regions. J Virol. 61:570-578
23. Moore, J. P., Q. J. Sattentau, H. Yoshiyama, M. Thali, M. Charles, N. Sullivan, S.-W. Poon, M. S. Fung, F. Traincard, M. Pinkus, G. Robey, J. E. Robinson, D. D. Ho, and J. Sodroski. 1993. Probing the structure of the V2 domain of human immunodeficiency virus type 1 surface glycoprotein gp120 with a panel of eight monoclonal antibodies: human immune response to the V1 and V2 domains. J Virol 67:6135-6151
24. Moore, J. P., M. Thali, B. A. Jameson, F. Vignaux, G. K. Lewis, S.-W. Poon, M. Charles, M. S. Fung, B. Sun, P. J. Durda, L. Åkerblom, B. Wahren, D. D. Ho, Q. J. Sattentau, and J. Sodroski. 1993 Immunochemical analysis of the gp120 surface glycoprotein of human immunodeficiency virus type 1: probing the structure of the C4 and V4 domains and the interaction of the C4 domain with the V3 loop. J. Virol. 67:4785-4796.
25. Moore, J. P., R. L. Willey, G. K. Lewis, J. Robinson, and J. Sodroski. 1994. Immunological evidence for interactions between the first, second, and fifth conserved domains of the gp120 surface glycoprotein of human immunodeficiency virus type 1. J. Virol. 68:6836-6847.
26. Myers, G., B. Korber, S. Wain-Hobson, R. F. Smith, and G. N. Pavlakis. 1994. Human retroviruses and AIDS: a compilation and analysis of nucleic acid and amino acid sequences. Los Alamos National Laboratory, Los Alamos, N.Mex.
27. Overbaugh, J., and L. M. Rudensey. 1992. Alterations in potential sites for glycosylation predominate during evolution of the simian immunodeficiency virus envelope gene in macaques J Virol. 66:5937-5948
28. Ratner, L., R. C. Gallo, and F. Wong-Staal. 1985. HTLV-III, LAV, ARV are variants of same AIDS virus. Nature (London) 313:636-637.
29. Sanger, F., and A. R. Conlson. 1975. A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase. J. Mol. Biol. 94:441-445.
30. Shaw, G. M., B. H. Hahn, S. K. Arya, J. E. Groopman, R. C. Gallo, and F. Wong-Staal. 1984 Molecular characterization of human T-cell leukemia (lymphotropic) virus type III in the acquired immune deficiency syndrome. Science 226:1165-1171.
31. Shioda, T., J. A. Levy, and C. Cheng-Majer. 1991. Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp120 gene. Nature (London) 349:167-169.
32. Simmonds, P., L. Q. Zhang, F. McOmish, P. Balfe, C. A. Ludlam, and A. J. L. Brown. 1991. Discontinuous sequence change of human immunodeficiency virus (HIV) type 1 env sequences in plasma viral and lymphocyte-associated proviral populations in vivo: implications for models of HIV pathogenesis. J. Virol 65:6266-6276.
33. Stamatatos, L., and C. Cheng-Mayer. 1993. Evidence that the structural conformation of envelope gp120 affects human immunodeficiency virus type 1 infectivity, host range, and syncytium-forming ability. J Virol 67:5635-5639.
34. Sullivan, N., M. Thali, C. Furman, D. D. Ho, and J. Sodroski. 1993 Effect of amino acid changes in the V1/V2 region of the human immunodeficiency virus type 1 gp120 glycoprotein on subunit association, syncytium formation, and recognition by a neutralizing antibody. J. Virol. 67:3674-3679
35. Wang, W.-K., M. Essex, and T.-H. Lee. 1995. The highly conserved aspartic acid residue between hypervanable regions 1 and 2 of human immunodeficiency virus type 1 gp120 is impurtarn for early stages of virus replication. J. Virol. 69:538-542.
36. Wang, W.-K., M. Essex, and T. H. Lee. 1995. Uncommon gp120 cysteine residues found in primary HIV-1 isolates AIDS Res. Hum. Retroviruses 11:185-188
37. Warrier, S. V., A. Pinter, W. J. Honnen, M. Girard, E. Muchmore, and S. A. Tilley. 1994. A novel, glycan-dependent epitope in the V2 domain of human immunodeficiency virus Type 1 gp120 is recognized by a highly potent, neutralizing chimpanzee monoclonal antibody J. Virol. 68:4636-4642.
38. Westervelt, P., D. B. Trowbridge, L. G. Epstein, B. M. Blumberg, Y. Li, B. H. Hahn, G. M. Shaw, R. W. Price, and L. Ratner. 1992. Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo J. Virol. 66:2577-2582.
39. Willey, R. L., E. K. Ross, A. J. Buckler-White, T. S. Theodore, and M. A. Martin. 1989. Functional interaction of constant and variable domains of human immunodeficiency virus type 1 gp120. J. Virol. 63:3595-3600.
40. Willey, R. L., D. H. Smith, L. A. Lasky, T. S. Theodore, P. L. Earl, B. Moss, D. J. Capon, and M. A. Martin. 1988 In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity. J. Virol. 62:139-147.
41. Wong-Staal, F., G. M. Shaw, B. H. Hahn, S. Z. Salahuddin, M. Popovic, P. Markham, R. Redfield, and R. C. Gallo. 1985 Genomic diversity of human T-lymphotropic virus type III (HTLV-III) Science 229:759-762.
42. Wyatt, R., M. Thali, S. Tilley, A. Pinter, M. Posner, D. Ho, J. Robinson, and J. Sodroski. 1992. Relationship of the human immunodeficiency virus type 1 gp120 third variable loop to a component of the CD4 binding site in the fourth conserved region J Virol. 66:6997-7004.
43. Yu, X.-F., S. Ito, M. Essex, and T. H. Lee. 1988. A naturally immunogenic virion-associated protein specific for HIV-2 and SIV. Nature (London) 335:262-265.