Temperature-sensitive phenotype of the human parainfluenza virus type 3 candidate vaccine strain (cp45) correlates with a defect in the L gene

Journal of Virology

Volumn 70, Issue 1, 1996, Pages 580-584

  Ray, Ranjit ^a   Galinski, Mark S ^b   Heminway, Beverly R ^b   Meyer, Keith ^a   Newman, Frances K ^a   Belshe, Robert B ^a  

^a SAINT LOUIS UNIVERSITY   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOPROTEIN; PROTEIN; RNA POLYMERASE;

ANIMAL CELL; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; ENZYME ACTIVITY; GENE; IMMUNOPRECIPITATION; NONHUMAN; PARAINFLUENZA VIRUS 3; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; TEMPERATURE SENSITIVITY; VIRUS GENOME; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

ANIMAL; CELL LINE; DNA, VIRAL; GENE DELETION; GENETIC COMPLEMENTATION TEST; HUMAN; PARAINFLUENZA VIRUS 3, HUMAN; PHENOTYPE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TEMPERATURE; TRANSFECTION; VIRAL PROTEINS; VIRAL VACCINES;

EID: 0029655276     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.1.580-584.1996     Document Type: Article

References (59)

1. Armstrong, K. M., R. Fairman, and R. L. Baldwin. 1993. The (i, i+4) Phe-His interaction in an alanine-based alpha-helix. J. Mol. Biol. 230:284-291.
2. 1a.Belshe, R. B. Submitted for publication
3. 1b.Belshe, R. B. Unpublished data
4. Belshe, R. B., and F. K. Hissom. 1982 Cold adaptation of parainfluenza virus type 3: induction of three phenotypic markers. J. Med. Virol. 10:235-242.
5. Belshe, R. B., R. Karron, F. K. Newman, E. L. Anderson, S. L. Nugent, M. Steinhoff, M. L. Clements, M. H. Wilson, S. L. Hall, E. L. Tierney, and B. R. Murphy. 1992. Evaluation of a live attenuated, cold-adapted parainfluenza virus type 3 vaccine in children. J. Clin Microbiol. 30:2064-2070.
6. Bouchard, M. J., D.-H. Lam, and V. Racaniello. 1995. Determinants of attenuation and temperature sensitivity in the type 1 poliovrrus Sabin vaccine. J. Virol. 69:4972-4978.
7. Calain, P., J. Curran, D. Kolakofsky, and L. Roux. 1993. Molecular cloning of natural parmyxovirus copy-back defective interfering RNAs and their expression from DNA Virology 191:62-71.
8. Calain, P., and L. Roux. 1993 The rule of six. a basic feature for efficient replication of Sendai virus defective interfering RNA. J. Virol 67:4822-4830
9. Clements, M. L., R. B. Belshe, J. King, F. Newman, T. U. Westblom, E. L. Tierney, W. T. London, and B. R. Murphy. 1991. Evaluation of bovine, cold-adapted human, and wild-type human parainfluenza type 3 viruses in adult volunteers and in chimpanzees J Clin. Microbiol 29:1175-1182
10. Coelingh, K. V., and E. I. Tierney. 1989 Antigenic and functional organization of human parainflueitza virus tvpe 3 fusion glycoprotein. J. Virol. 63:375-382.
11. Coelingh, K. V., C. C. Winter, and B. R. Murphy. 1985. Antigenic variation in the hemagglutinin-neurammidase protein of human parainfluenza type 3 virus. Virology 143:569-582.
12. Crookshanks-Newnian, F. K., and R. B. Belshe. 1986. Protection of weanling hamsters from experimental infection with wild-type parainfluenza virus type 3 (para 3) by cold-adapted mutants of para 3. J. Med. Virol 18:131-137.
13. De, B. P., and A. K. Banerjee. 1993 Rescue of synthetic analogs of genome RNA of human parinfluenza virus type 3 Virology 196:344-348.
14. De, B. P., M. S. Galinski, and A. K. Banerjee. 1990. Characterization of an in vitro system for the synthesis of mRNA from human parainfluenza virus type 3. J. Virol. 64:1135-1142.
15. Dimock, K., and P. L. Collins. 1993. Rescue of synthetic analogs of genomic RNA and replicative-intermediate RNA of human parainfluenza virus type 3. J Virol. 67:2772-2778
16. Enami, M., W. Luytjes, M. M. Krystal, and P. Palese. 1990. Introduction of site-specific mutations into the genome of influenza virus. Proc. Natl. Acad Sci USA 87:3802-3805
17. Fuerst, T. R., E. C. Niles, F. W. Studier, and B. Moss. 1986 Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesized bacteriophage T7 RNA polymerase. Proc. Natl. Acad. Sci. USA 83:8122-8126.
18. 15a Galinski, M. S., et al. Unpublished data.
19. Gatinski, M. S., M. A. Mink, D. M. Lambert, S. L. Wechsler, and M. W. Pons. 1986 Molecular cloning and sequence analysis of the human parainfiuenza 3 virus RNA encoding the nucleocapsid protein. Virology 149:139-151.
20. Galinski, M. S., M. A. Mink, D. M. Lambert, S. L. Wechsler, and M. W. Pons. 1986. Molecular cloning and sequence analysis of the human parainfluenza 3 virus mRNA encoding the P and C proteins Virology 154:46-60.
21. Galinski, M. S., M. A. Mink, and M. W. Pons. 1988. Molecular cloning and sequence analysis of the human parainfluenza 3 virus gene encoding the L protein. Virology 165:499-510.
22. Galinski, M. G., and S. L. Wechsler. 1991. The molecular biology of the paramyxovirus genus, p. 41-82. In D. W. Kingsbury (ed.). The paramyxoviruses. Plenum Press, New York.
23. Graber, M., C. Barry, J. Diapola, and A. Hasagawa. 1992. Intracellular pH in OK cells. II. Effects of temperature on cell pH. Am. J. Physiol 262:F723-F730
24. Hall, S. L., C. M. Sarris, E. L. Tierney, W. T. London, and B. R. Murphy. 1993. A cold-adapted mutant of parainfluenza virus type 3 is attenuated and protective in chimpanzees. J. Infect. Dis. 167:958-962.
25. Hall, S. L., A. Stokes, E. L. Tierney, W. T. London, R. B. Belshe, F. C. Newman, and B. R. Murphy. 1992. Cold-passaged human parainfluenza type 3 viruses contain ts and non-ts mutations leading to attenuation in rhesus monkeys. Virus Res. 22:173-184.
26. Harty, R. N., and P. Palese. 1995. Mutations within noncoding terminal sequences of model RNAs of Sendai virus: influence on reporter gene expression. J. Virol. 59:5128-5131.
27. Herlocher, M. L., H. N. Massab, and R. G. Webster. 1993. Molecular and biological changes in the cold-adapted "master strain" A/AA/6/60(H2N2) influenza virus. Proc. Natl. Acad. Sci. USA 90:6032-6036.
28. Horikami, S. M., J. Curran, D. Kolakofsky, and S. A. Moyer. 1992. Complexes of Sendai virus NP-P and P-L proteins are required for defective interfering particle genome replication in vitro. J. Virol. 66:4901-4908.
29. Hu, X., R. Ray, and R. W. Compans. 1992. Functional interactions between the fusion protein and hemagglutinin-neuraminidase of human parainfluenza viruses. J. Virol. 66:1528-1534
30. Krystal, M., R. Li, D. Lyles, G. Pavlakis, and P. Palese. 1986 Expression of the three influenza virus polymerase proteins in a single cell allows growth complementation of viral mutants. Proc. Natl. Acad Sci. USA 83:2709-2713
31. Lawson, N. D., E. A. Stillman, M. A. White, and J. K. Rose. 1995. Recombinant vesicular stomatitis viruses from DNA. Proc. Natl. Acad. Sci. USA 92:4477-4481.
32. Lefkowitz, E. J., A. K. Pattnaik, and L. A. Ball. 1990. Complementation of a vesicular stomatitis virus glycoprotein G mutant with wild-type protein expressed from either a bovine papilloma virus or a vaccinia virus vector system. Virology 178:373-383.
33. Li, R. A., P. Palese, and M. Krystal. 1989. Complementation and analysis of an NP mutant of influenza virus. Virus Res. 12:97-111.
34. Marks, M. D., J. Kennedy-Morrow, and J. A. Lesnaw. 1985. Assignment of the temperature-sensitive lesion in the replication mutant Al of vesicular stomatitis virus to the N gene. J. Virol. 53:44-51
35. Ongradi, J., C. Cunningham, and J. F. Szilagyi. 1985. Temperature sensitivity of the transcriptase of mutants tsB1 and tsF1 of vesicular stomatitis virus New Jersey is a consequence of mutation affecting polypeptide L. J Gen Virol 66:1507-1513.
36. Park, K. H., T. Huang, F. F. Correia, and M. Krystal. 1991. Rescue of a foreign gene by Sendai virus. Proc. Natl Acad Sci. USA 88:5537-5541.
37. Park, K. H., and M. Krystal. 1992. In vivo model for pseudo-templated transcription in Sendai virus. J. Virol 66:7033-7039.
38. Peden, K. W., S. L. Spence, L. C. Tack, C. A. Cartwright, A. Srinivasan, and J. M. Pipas. 1990. A DNA replication-positive mutant of simian virus 40 that is defective for transformation and the production of infectious virions. J. Virol. 64:2912-21.
39. - temper-ature-sensitive mutants of Newcastle disease virus. J. Virol. 42:440-446
40. Peeples, M. E., L. L. Rasenas, and M. A. Bratt. 1982 RNA synthesis by Newcastle disease virus temperature-sensitive mutants in two RNA-negative complementation groups. J. Virol. 42:996-1006.
41. Portner, A., R. A. Seroggs, P. A. Marx, and D. W. Kingsbury. 1975 A temperature-sensitive mutant of Sendai virus with an altered hemagglutinin-neuraminidase polypeptide: consequences for virus assembly and cytopathology. Virology 67:179-187.
42. Ray, R., V. E. Brown, and R. W. Compans. 1985. Glycoproteins of human parainfhienza virus type 3: characterization and evaluation as a subunit vaccine. J. Infect. Dis. 152:1219-1230.
43. Ray, R., and R. W. Compans. 1986. Monoclonal antibodies reveal extensive antigenic differences between the hemagglutinin-neuraminidase glycoproteins of human and bovine parainfluenza 3 viruses. Virology 148:232-236.
44. Ray, R., and R. W. Compans. 1987. Glycoproteins of human parainfruenza virus type 3: affinity purification, antigenic characterization and reconstitution into lipid vesicles. J. Gen. Virol. 68:409-418.
45. Ray, R., K. Meyer, F. Newman, and R. B. Belshe. 1995. Characterization of a live, attenuated human parainfluenza type 3 virus candidate vaccine strain. J. Virol. 69:1959-1963.
46. Sambrook, J., L. Rodgers, J. White, and M. J. Gething. 1985. Lines of BPV-transformed murine cells that constitutively express influenza virus hemagglutinin EMBO J. 4:91-103.
47. Sanchez, A., and A. K. Banerjee. 1985. Studies on human parainfluenza virus 3: characterization of the structural proteins and in vitro synthesized proteins coded by mRNAs isolated from infected cells. Virology 143:45-54.
48. Schnell, M. J., T. Mebatsion, and K. Conzelmann. 1994. Infectious rabies viruses from clone cDNA. EMBO J. 13:4195-4203.
49. Shibata, S., F. Yamamoto-Goshima, K. Maeno, T. Hanaichi, Y. Fujita, K. Nakajima, M. Imai, T. Komatsu, and S. Sugiura. 1993. Characterization of a temperature-sensitive influenza B virus mutant defective in neuraminidase J. Virol. 67:3264-3273.
50. Shoemaker, K. R., R. Fairman, D. A. Schultz, A. D. Robertson, E. J. York, J. M. Stewart, and R. L. Baldwin. 1990 Side-chain interactions in the C-peptide helix. Phe8 . .His12+ Biopolymers 29:1-11.
51. Spriggs, M. K., and P. L. Collins. 1986. Human parainfluenza virus type 3 messenger RNAs, polypeptide coding assignments, intergenic sequences, and genetic map J Virol. 59:646-654
52. Stokes, A., E. L. Tierney, C. M. Sarris, B. R. Murphy, and S. L. Hall. 1993. The complete nucleotide sequence of two-cold-adapted, temperature-sensitive attenuated mutant vaccine viruses (cp12 and cp45) derived from the JS strain of human parainfluenza virus type 3 (PIV3). Virus Res. 30:43-52
53. Storey, D. G., K. Dimock, and C. Y. Kang. 1984. Structural characterization of virion proteins and genomic RNA of human parainfluenza virus 3 J. Virol. 52:761-766.
54. Takebe, Y., M. Seiki, J. Fujisawa, P. Hoy, K. Yokota, K. Arai, M. Yoshida, and N. Arai. 1988 SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat 3. Mol. Cell. Biol. 8:466-472.
55. Thompson, S. D., and A. Portner. 1987. Localization of functional sites on the hemagglutinin-neuraminidase glycoprotein of Sendai virus by sequence analysis of antigenic and temperature-sensitive mutants. Virology 160:1-8
56. Tsipis, J. E., and M. A. Bratt. 1976. Isolation and primary characterization of temperature-sensitive mutants of Newcastle disease virus. J. Virol. 18:848-855.
57. Westrop, G. D., K. A. Wareham, D. M. A. Evans, G. Dunn, P. D. Minor, D. I. McGrath, F. Taffs, S. Marsden, M. A. Skinner, G. C. Schild, and J. W. Almond. 1989. Genetic basis of attenuation of the Sabin type 3 oral poliovirus vaccine J. Virol. 63:1338-1344.
58. Whitt, M. A., L. Chong, and J. K. Rose. 1989. Glycoprotein cytoplasmic domain sequences required for rescue of a vesicular stomatitis virus glycoprotein mutant J. Virol. 63:3569-3578.
59. Zhuu, H., and A. K. Banerjee. 1995. Interaction between the nucleocapsid protein and the phosphoprotein of human parainfluenza virus 3. J. Biol. Chem. 270:12485-12490.