Controlled Release of Lidocaine from Injectable Gels and Efficacy in Rat Sciatic Nerve Block

Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists

Volumn 12, Issue 12, 1995, Pages 1997-2002

  Paavola, Anne ^a   Yliruusi, Jouko ^a   Kajimoto, Yoji ^a   Kalso, Eija ^a   Wahlström, Torsten ^a   Rosenberg, Per ^a  

^a NONE

Author keywords

controlled release; gel; in vitro in vivo correlation; lidocaine HC1; nerve block

Indexed keywords

CARBOXYMETHYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; LIDOCAINE; LOCAL ANESTHETIC AGENT; METHOCEL A4M; METHOCEL E4M; METHYLCELLULOSE; POLOXAMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG RELEASE; FEMALE; GEL; NERVE BLOCK; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SUSTAINED RELEASE PREPARATION; TOPICAL DRUG ADMINISTRATION; VISCOSITY;

ANIMALS; DRUG DELIVERY SYSTEMS; FEMALE; GELS; LIDOCAINE; NERVE BLOCK; PAIN MEASUREMENT; RATS; RATS, WISTAR; SCIATIC NERVE; TIME FACTORS;

EID: 0029626640     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1023/A:1016264527738     Document Type: Article

References (20)

1. Neurokinetics of lidocaine in the infraorbital nerve of rat in vivo. Relation to sensory block
2. Dextran-local anesthetic interactions
3. Spinal anesthesia: Signifficant prolongation of the pharmacological effect of tetracaine with lipid solution of the agent
4. The utility of 2-hydroxypropyl-β-cyclodextrin as a vehicle for the intracerebral and intrathecal administration of drugs
5. Prolongation of canine epidural anesthesia by liposome encapsulation of lidocaine
6. The influence of solution viscosity on the dissolution rate of soluble salts, and the measurement of an effective viscosity
7. Influence of additives on (hydroxyethyl) methylcellulose properties: relation between gelation temperature change, compressed matrix integrity and drug release profile
8. Rheological synergism between ionic and non-ionic cellulose gum
9. Toxicological evaluation of poloxamer vehicles for intramuscular use
10. Artificial skin. I. Preparation and properties of Pluronic F-127 gels for treatment of burns
11. A method for measurement of analgesic activity on inflamed tissue
12. Chronic catheterization of the spinal subarachnoidal space
13. The effect of methylcellulose on the absorption of nitrofurantoin from gastrointestinal tract
14. Interaction between drugs and macromolecules
15. Ultrasonic velocity and light-scattering studies on the polyoxyethylene-polyoxypropylene copolymer Pluronic F 127 in aqueous solution
16. In vitro release of lidocaine from Pluronic F-127 gels
17. Myotoxicity of local anesthetics and regeneration of damaged muscle fibres
18. Effects of repeated bupivacaine administration on sciatic nerve and surrounding muscle tissue in rats
19. Fibrosarcomas induced by multiple subcutaneous injections of carboxymethylcellulose (CMC), polyvinylpyrrolidone (PVP), and polyoxyethylene sorbitane monostearate (Tween 60)