Both activators and inhibitors of protein kinase C promote the inhibition of phenylephrine-induced [Ca2+]i oscillations in single intact rat hepatocytes

Cell Calcium

Volumn 18, Issue 3, 1995, Pages 232-244

  Berrie, C P ^a   Cobbold, P H ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; CALCIUM; CHELERYTHRINE; DIACYLGLYCEROL; ENZYME ACTIVATOR; ENZYME INHIBITOR; PEPTIDE; PHENYLEPHRINE; PHORBOL ESTER; PROTEIN KINASE C; SPHINGOSINE; STAUROSPORINE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL METABOLISM; CONTROLLED STUDY; FEEDBACK SYSTEM; LIVER CELL; MALE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029621023     PISSN: 01434160     EISSN: None     Source Type: Journal    
DOI: 10.1016/0143-4160(95)90068-3     Document Type: Article

References (47)

1. Calcium oscillations
2. Repetitive transient rises in cytoplasmic free calcium in hormonestimulated hepatocytes
3. Agonistinduced oscillations in cytoplasmic free calcium concentration in single rat hepatocytes
4. Inositol trisphosphate and calcium signalling
5. Inhibitors of protein kinase C prolong the falling phase of each free-calcium transient in a hormone-stimulated hepatocyte
6. Spatial and temporal aspects of cell signalling
7. The generation of repetitive free calcium transients in a hormonestimulated hepatocyte
8. Receptor control of calcium transients
9. Phorbolester-induced alterations of free calcium ion transients in single rat hepatocytes
10. 2+ oscillations in single hepatocytes
11. A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro antiproliferative as well as in vivo anti-tumour activity
12. Staurosporine K-252 and UCN-01: potent but non-specific inhibitors of protein kinases
13. Potent selective inhibitors of protein kinase C
14. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C
15. Chelerythrine is a potent and specific inhibitor of protein kinase C
16. Protein kinase C contains a pseudosubstrate prototope in its regulatory domain
17. Protein kinase C pseudosubstrate prototope: structure-function relationships
18. A protein kinase C pseudosubstrate peptide inhibits phosphorylation of the CD3 antigen in streptolysin-O-permeabilised human T lymphocytes
19. A method for measuring protein kinase C activity in permeabilised T lymphocytes by using peptide substrates. Evidence for multiple pathways of kinase activation
20. A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor
21. Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP
22. Specific inhibitors of protein kinase C block transmitter-induced modulation of sensory neuron calcium current
23. Inhibition of IL-2 receptor induction and IL-2 production in the human leukaemic cell line Jurkat by a novel peptide inhibitor of protein kinase C
24. A novel N-myristoylated synthetic octapeptide inhibits protein kinase C activity and partially reverses murine fibrosarcoma cell resistance to adriamycin
25. Modulation of protein kinase C and diverse cell functions by sphingosine — a pharmacologically interesting compound linking sphingolipids and signal transduction
26. Role of co-factors in protein kinase C activation
27. The role of protein kinase C in cell surface signal transduction and tumour promotion
28. Metabolic rate of membrane permeant diacylglycerol and its relation to human resting T-lymphocyte activation
29. Intracellular signalling by hydrolysis of phospholipids and activation of protein kinase C
30. The regulation and cellular functions of phosphatidylcholine hydrolysis
31. Signalling through phosphatidylcholine breakdown
32. Hormonal stimulation of diacylglycerol formation in hepatocytes. Evidence for phosphatidylcholine breakdown
33. Diacylglycerol kinase: a key modulator of signal transduction?
34. Phosphorylation of diacylglycerol kinase in vitro by protein kinase C
35. Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-ϵ
36. Diacylglycerol kinase and phosphatidic acid phosphatase — enzymes metabolising lipid second messengers
37. Diacylglycerol kinase in receptor-stimulated cells converts its substrate in a topologically restricted manner
38. Effects of okadaic acid on the activities of two distinct phosphatidate phosphohydrolases in rat hepatocytes
39. Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans
40. Protein kinase C isozymes: divergence in signal transduction?
41. Protein kinase C — a question of specificity
42. Porcine diacylglycerol kinase sequence has zinc finger and E-F hand motifs
43. Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localises in neurons
44. Different effects of sphingosine, R59022 and anionic amphiphiles on two diacylglycerol kinase isozymes purified from porcine thymus cytosol
45. The different effects of sphingosine on diacylglycerol kinase isozymes in Jurkat cells a human T-cell line
46. Sphingosine inhibits phosphatidate phosphohydrolase in human neutrophils by a protein kinase C-independent mechanism
47. Sphingosinemediated phosphatidylinositol metabolism and calcium mobilisation