Mechanism of the antiproliferative action of leflunomide: A77 1726, the active metabolite of leflunomide, does not block T-cell receptor-mediated signal transduction but its antiproliferative effects are antagonized by pyrimidine nucleosides

Journal of Heart and Lung Transplantation

Volumn 14, Issue 6 I, 1995, Pages 1016-1030

  Cao, W W ^a   Kao, P N ^a   Chao, A C ^a   Gardner, P ^a   Ng, J ^a   Morris, R E ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; CALCIUM; CYTIDINE; DEOXYCYTIDINE; DEOXYURIDINE; DNA; DRUG METABOLITE; GUANOSINE; INDO 1; INTERLEUKIN 2; IONOMYCIN; LEFLUNOMIDE; LUCIFERASE; MONOCLONAL ANTIBODY CD3; PHORBOL 13 ACETATE 12 MYRISTATE; PHYTOHEMAGGLUTININ; PURINE NUCLEOSIDE; PYRIMIDINE NUCLEOSIDE; T LYMPHOCYTE RECEPTOR; TERIFLUNOMIDE; THYMIDINE; URIDINE;

ARTICLE; CALCIUM MOBILIZATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION;

ANILINE COMPOUNDS; CALCIUM; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROXYBUTYRATES; IMMUNOSUPPRESSIVE AGENTS; INTRACELLULAR FLUID; ISOXAZOLES; LYMPHOCYTE ACTIVATION; NUCLEOTIDES; PYRIMIDINE NUCLEOSIDES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION;

EID: 0029620896     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (0)