In vivo pharmacology of an angiotensin AT1 receptor antagonist with balanced affinity for angiotensin AT2 receptors

European Journal of Pharmacology

Volumn 294, Issue 2-3, 1995, Pages 439-450

  Kivlighn, Salah D ^a   Zingaro, Gloria J ^a   Gabel, Robert A ^a   Broten, Theodore P ^a   Chang, Raymond S L ^a   Ondeyka, Debra L ^a   Mantlo, Nathan B ^a   Gibson, Raymond E ^a   Greenlee, William J ^a   Siegl, Peter K S ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Angiotensin converting enzyme inhibitor; Angiotensin II; Angiotensin receptor antagonist; Antihypertensive; L 163,017

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN A1 RECEPTOR; ANGIOTENSIN A1 RECEPTOR ANTAGONIST; ANGIOTENSIN A2 RECEPTOR; ANGIOTENSIN II [1 SARCOSINE 8 ISOLEUCINE]; BRADYKININ; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; GLYCERYL TRINITRATE; IODINE 125; L 163017; N [[4' [(2 ETHYL 5,7 DIMETHYL 3H IMIDAZO[4,5 B]PYRIDIN 3 YL)METHYL] 2 BIPHENYLYL]SULFONYL]BENZAMIDE; NORADRENALIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BIOEQUIVALENCE; BLOOD PRESSURE; CONTROLLED STUDY; DOG; DRUG ANTAGONISM; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; FEMALE; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR OCCUPANCY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RHESUS MONKEY; SPECIES DIFFERENCE;

ANGIOTENSIN II; ANIMALS; ANTIHYPERTENSIVE AGENTS; BIOLOGICAL AVAILABILITY; BLOOD PRESSURE; DOGS; FEMALE; IMIDAZOLES; MACACA MULATTA; MALE; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANGIOTENSIN;

EID: 0029619525     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00564-1     Document Type: Article

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