Selective inhibitors of 5-lipoxygenase reduce CML blast cell proliferation and induce limited differentiation and apoptosis

Leukemia Research

Volumn 19, Issue 11, 1995, Pages 789-801

  Anderson, K M ^a   Seed, T ^b   Plate, J M D ^a   Jajeh, A ^c   Meng, J ^a   Harris, J E ^a  

^a RUSH MEDICAL COLLEGE   (United States)

^b ARGONNE NATIONAL LABORATORY   (United States)

^c Jr Hospital of Cook County   (United States)

Author keywords

5 lipoxygenase inhibitors; apoptosis; CML blast cells

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 5,8,11,14 ICOSATETRAYNOIC ACID; ANTILEUKEMIC AGENT; ARACHIDONATE 5 LIPOXYGENASE; DNA; LEUKOTRIENE; LIPOXYGENASE INHIBITOR; N [1 (4 BENZYLOXYPHENYL)ETHYL]ACETOHYDROXAMIC ACID; SC 41661A; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLAST CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRUCTURE; CELL ULTRASTRUCTURE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DNA DEGRADATION; DRUG MECHANISM; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROMYELOCYTE;

5,8,11,14-EICOSATETRAYNOIC ACID; ACETAMIDES; AMIDES; ANTINEOPLASTIC AGENTS; APOPTOSIS; ARACHIDONATE 5-LIPOXYGENASE; BLAST CRISIS; CELL DIFFERENTIATION; CELL DIVISION; DNA, NEOPLASM; HUMANS; INDOLES; LEUKEMIA, MYELOID, CHRONIC; LIPOXYGENASE INHIBITORS; PYRIDINES; TUMOR CELLS, CULTURED;

EID: 0029619314     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/0145-2126(95)00043-7     Document Type: Article

References (57)

1. Participation of lipoxygenase products in lymphohematopoietic and other cell proliferation and differentiation
2. Induction of apoptosis in blood cells from a patient with acute myelocytic leukemia by SC41661A a selective inhibitor of 5-lipoxygenase
3. Inhibition of leukotriene biosynthesis with A53162, a selective and orally active inhibitor of 5-lipoxygenase (5-LO)
4. Novel 5-lipoxygenase inhibitor (SC41661A) reduced human ovarian cancer cell invasion and ascitic tumor growth
5. Novel 5-lipoxygenase inhibitor (SC41661A) reduced human ovarian cancer cell invasion and ascitic tumor growth
6. MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane-association of 5-lipoxygenase in ionophorechallenged leukocytes
7. Evidence that endogenous generation of leukotrienes does not regulate proliferation of malignant haematopoietic cell lines
8. MK886, an antagonist against leukotriene generation inhibits DNA synthesis in a subset of acute myeloid leukemia cells
9. Elevated white blood cell synthesis of leukotriene C4 in chronic myelogenous leukemia but not in polycythemia vera
10. Deficient lipoxin synthesis: a novel disfunction in myeloproliferative disorders with special reference to blast crisis of chronic myelogenous leukemia
11. Mechanisms of apoptosis: integration of genetic, biochemical and cellular indicators
12. Apoptosis or programmed cell death?
13. Apoptosis; the biochemistry and molecular biology of programmed cell death
14. Apoptosis: a different type of cell death
15. Inhibition of U937 eicosanoid and DNA synthesis by 5,8,11,14-eicosatetraynoic acid, an inhibitor of arachidonic acid metabolism and its partial reversal by leukotriene C4
16. Five 8,11,14-eicosatetraynoic acid-induced destruction of mitochondria in human prostate cells (PC3)
17. Gel electrophoresis of DNA
18. The effect of 5,8,11,14-eicosatetraynoic acid on lipid metabolism
19. ETYA, a pleotrophic membrane-active arachidonic acid analogue affects multiple signal transduction pathways in cultured transformed mammalian cells
20. 5,8,11,14-eicosatetraynoic acid-induced differentiation of U937 cells
21. Proliferation, differentiation arrest and survival in leukemic blast cells
22. The role of apoptosis (programmed cell death) in haemopoiesis and the immune system
23. Apoptosis. Its significance in cancer and cancer therapy
24. TNF-induced c-fos via a novel pathway requiring conversion of arachidonic acid to a lipoxygenase metabolite
25. Activation of NF-kb and oncogene mRNA by 12(R)-hydroxyeicosatrienoic acid (12(R)-HETrE)in microvessel endothelial cells
26. Contrasting effects of two arachidonate 5-lipoxygenase inhibitors on formyl methionyl-leucyl-phenylalanine (fMPL) and complement fragment 5a induced human neutrophil superoxide generation
27. Delayed ribonucleosomal DNA fragmentation in programmed cell death
28. Drug-induced apoptosis: relationship between DNA fragmentation and cell death
29. Detection of the initial stages of DNA fragmentation in apoptosis
30. Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis
31. Necrosis and apoptosis induced by oxidized low density lipoproteins occur through two calcium-dependent pathways in lymphoblastoid cells
32. Blood and bone marrow
33. Bc1–2 functions in antioxidant pathway to prevent apoptosis
34. Oxidative stress as a mediator of apoptosis
35. Invited commentary. Is apoptosis mediated by reactive oxygen species?
36. Bcl 2 inhibition of neural death. Decreased generation of reactive oxygen species
37. Inflammation and oxidative stress in carcinogenesis
38. Identification, purification and characterization of a calcium-dependent endonuclease (NUC 18) from apoptotic rat thymocytes
39. Premature p34cdc2 activation required for apoptosis
40. Specific proteolytic cleavage of poly(ADP) ribose polymerase: an early marker of chemotherapy-induced apoptosis
41. Continuous c-fos expression precedes programmed cell death in vivo
42. Induction of DNA replication and expression of protooncogenes c-myc and c-fos in quiescent BALb/3T3 cells by xanthine oxidase
43. Oxidant stress induces the protooncogenes c-fos and c-myc in mouse epidermal cells
44. Spontaneous chemiluminescence of ETYA (581114-eicosatetraynoic acid) is inhibited by catalase or peroxidase
45. Nuclear factor kB: an oxidative stress-responsive transcription factor of eukaryotic cells (a review)
46. Involvement of oxygen radicals in the differentiation of rat myelomonocytic leukemia cells in vitro and in vivo
47. Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli
48. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells
49. Cell killing and induction of manganous superoxide dismutase by tumor necrosis factor-α is mediated by lipoxygenase metabolites of arachidonic 20 acid
50. Induction of c-fos and c-jun gene expression by phenolic antioxidants
51. Bcl-2 heterodimerizes in vivo with a conserved homologue, BAX that accelerates programmed cell death
52. Induction of apoptosis in fibroblasts by IL-1B-converting enzyme, a mammalian homolog of the C. elegans cell death gene, ced-3
53. Nafazatron (Bay g 6575) inhibition of tumor cell lipoxygenase activity and cellular proliferation
54. Propagation of human blastic myeloid leukemias in the SCID mouse
55. Control of programmed cell death in normal and leukemic cells. New implications for therapy
56. Control of sensitivity to induction of apoptosis in myeloid leukemic cells by differentiation and bcl-2 dependent and independent pathways