Interferon Treatment Inhibits Virus Replication in HIV-1- and SIV-Infected CD4+ T-Cell Lines by Distinct Mechanisms: Evidence for Decreased Stability and Aberrant Processing of HIV-1 Proteins

Virology

Volumn 214, Issue 2, 1995, Pages 379-386

  Agy, Michael B ^a   Acker, Randy L ^a   Sherbert, Cynthia H ^a   Katze, Michael G ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; RNA;

ARTICLE; CELL CULTURE; GENE EXPRESSION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOBLOTTING; PRIORITY JOURNAL; VIRUS INFECTION; VIRUS REPLICATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; GENE EXPRESSION; GENES, VIRAL; HIV ANTIGENS; HIV-1; HUMANS; INTERFERON-ALPHA; INTERFERON-BETA; SIMIAN IMMUNODEFICIENCY VIRUS; VIRAL PROTEINS; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MIRIDAE; RNA VIRUSES; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0029619153     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1006/viro.1995.0047     Document Type: Article

References (40)

1. Agy, M. B., Wambach, M., Foy, K., and Katze, M. G. (1990). Expression of cellular genes in CD-4 positive lymphoid cells infected by the human immunodeficiency virus, HIV-1: Evidence for a host protein synthesis shutoff induced by cellular mRNA degradation. Virology 177, 251-258.
2. Agy, M. B., Foy, K., Gale, M. J., Benveniste, R. E., Clark, E. A., and Katze, M. G. (1991). Viral and cellular gene expression in CD4+ human lymphoid cell lines infected by the simian immunodeficiency virus, SIV/Mne. Virology 183, 170-180.
3. Baca-Regen, L., Heinzinger, N., Stevenson, M., and Gendelman, H. E. (1995). Alpha interferon-induced antiretroviral activities: Restriction of viral nucleic acid synthesis and progeny virion production in human immunodeficiency virus type 1-infected monocytes. J. Virol. 68, 7559-7565.
4. Barre-Sinoussi, F., Chermann, J. C., Rey, F., Nugeyre, M. T., Chamaret, S., Gruest, J., Dauguet, C., Axler-Blin, C., Vezinet-Brun, F., Rouzioux, R., Rozenbaum, W., and Montagnier, L. (1983). Isolation of a T-lym-photropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 220, 868-871.
5. Chomczynski, P., and Sacchi, N. (1987). Single-step method of RNA isolation by guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
6. Coccia, E. M., Krust, B., and Hovanessian, A. G. (1994). Specific inhibition of viral protein synthesis in HIV-infected cells in response to interferon treatment. J. Biol. Chem. 269, 23087-23094.
7. Daniel, M. D., Letvin, N. L., King, N. W., Kannagi, M., Sehgal, P. K., Kanki, P. J., Essex, M., and Desoriers, R. C. (1985). Isolation of a T-cell tropic HTLV-III-like retrovirus from macaques. Science 228, 1201-1204.
8. Feinberg, A. P., and Voglestein, B. (1983). A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132, 6-13.
9. Fernie, B. F., Poli, G., and Fauci, A. S. (1991). Alpha interferon suppresses virion but not soluble human immunodeficiency virus antigen production in chronically infected T-lymphocytic cells. J. Virol. 65, 3968-3971.
10. Hansen, B. D., Nara, P. L., Maheshwari, R. K., Sidhu, G. S., Bernbaum, J. G., Hoekzema, D., Meltzer, M. S., and Gendelman, H. E. (1995). Loss of infectivity by progeny virus from alpha interferon-treated human immunodeficiency virus type 1-infected T cells is associated with defective assembly of envelope gp120. J. Virol. 66, 7543-7548.
11. Harada, S., Koyanagi, Y., and Yamamoto, N. (1985). Infection of HTLV-III/LAV in HTLV-1-carrying cells MT-2 and MT-4 and application in plaque assay. Science 229, 563-566.
12. Hovanessian, A. G. (1991). Interferon-induced and ds RNA activated enzymes: A specific protein kinase and 2'-5' oligodenylate synthetases. J. Interferon Res. 1, 199-205.
13. Katze, M. G. (1992). The war against the interferon-induced dsRNA activated protein kinase: can viruses win? J. Interferon Res. 12, 241-248.
14. r protein kinase. Semin. Virol. 4, 259-268.
15. Katze, M. G. (1995). Regulation of the interferon-induced PKR: Can viruses cope? Trends Microbiol. 3, 75-78.
16. Kootstra, N. A., van't Wout, A. B., Huisman, H. G., Miedema, F., and Schuitemaker, H. (1994). Interference of interleukin-10 with human immunodeficiency virus type 1 replication in primary monocyte-derived macrophages. J. Virol. 68, 6967-6975.
17. Lairmore, M. D., Post, A. A., Goldsmith, C. S., and Folks, T. M. (1991). Cytokine enhancement of simian immunodeficiency virus (SIV/mac) from a chronically infected cloned T-cell line (HuT-78). Arch. Virol. 121, 43-53.
18. Laurence, J. (1990). Immunology of HIV infection, I: Biology of interferons. AIDS Res. Hum. Retroviruses 6, 1149-1156.
19. Maitra, R. K., McMillan, N., Desai, S., McSwiggen, J., Hovanessian, A. G., Sen, G., Williams, B. R. G., and Silverman, R. H. (1994). Activation of two interferon-inducible enzymes by chemically-synthesized HIV-1 TAR RNA. Virology 204, 823-827.
20. Meylan, P. R. A., Guatelli, J. C., Munis, J. R., Richman, D. D., and Korn-bluth, R. S. (1993). Mechanisms for the inhibition of HIV replication by interferons-alpha,-beta, and-gamma in primary human macrophages. Virology 193, 138-148.
21. Perno, C.-F., Bergamini, A., Pesce, C. D., Milanese, G., Capozzi, M., Aquaro, S., Thaisrivongs, S., Tarpley, W. G., Zon, G., D'Agostini, C., Rocchi, G., Garaci, E., and Calio, R. (1993). Inhibition of the protease of human immunodeficiency virus blocks replication and infectivity of the virus in chronically infected macrophages. J. Infect. Dis. 168, 1148-1156.
22. Pettit, S. C., Moody, M. D., Wehbie, R. S., Kaplan, A. H., Nantermet, P. V., Klein, C. A., and Swanstrom, R. (1994). The p2 domain of human immunodeficiency virus type 1 Gag regulates sequential proteolytic processing and is required to produce fully infectious virions. J. Virol. 68, 8017-8027.
23. Pitha, P. (1991). Multiple effects of interferon on HIV-1 replication. J. Interferon Res. 11, 313-318.
24. Pitha, P. M. (1994). Multiple effects of interferon on the replication of human immunodeficiency virus type 1. Antiviral Res. 24, 205-219.
25. Poli, G., Orenstein, J. M., Kinter, A., Folks, T. M., and Fauci, A. S. (1989). Interferon-alpha but not AZT suppresses HIV expression in chronically infected cell lines. Science 244, 575-577.
26. Roy, S., Katze, M. G., Parkin, N. T., Edery, I., Hovanessian, A. G., and Sonenberg, N. (1990). Control of the interferon-induced 68-kilodalton protein kinase by HIV-1 tat gene product. Science 247, 1216-1219.
27. Roy, S., Agy, M. B., Hovanessian, A. G., Sonenberg, N., and Katze, M. G. (1991). The integrity of the stem structure of human immunodeficiency virus type 1 Tat-responsive sequence RNA is required for interaction with the interferon-induced 68, 000-Mr protein kinase. J. Virol. 65, 632-640.
28. Salahuddin, S. Z., Markham, P. D., Wong-Staal, F., Franchini, G., Kalya-naraman, V. S., and Gallo, R. C. (1983). Restricted expression of human T-cell leukemia-lymphoma virus (HTLV) in transformed human umbilical cord lymphocytes. Virology 129, 51-64.
29. Samuel, C. E. (1991). Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities. Virology 183, 1-11.
30. Samuel, C. E. (1993). The eIF-2 a protein kinases, regulators of translation in eukaryotes from yeasts to humans. J. Biol. Chem. 268, 7603-7606.
31. Sen, G. C., and Lengyel, P. (1992). The interferon system-A bird's eye view of its biochemistry. J. Biol. Chem. 267, 5017-5020.
32. Shirazi, Y., and Pitha, P. M. (1993). Interferon alpha-mediated inhibition of human immunodeficiency virus type 1 provirus synthesis in T-cells. Virology 193, 303-312.
33. Shirazi, Y., and Pitha, P. M. (1995). Alpha interferon inhibits early stages of the human immunodeficiency virus type 1 replication cycle. J. Virol. 66, 1321-1328.
34. Simm, M., Shahabuddin, M., Chao, W., Allan, J. S., and Volsky, D. J. (1995). Aberrant Gag protein composition of a human immunodeficiency virus type 1 vif mutant produced in primary lymphocytes. J. Virol. 69, 4582-4586.
35. Smith, M. S., Thresher, R. J., and Pagano, J. S. (1991). Inhibition of human immunodeficiency virus type 1 morphogenesis in T cells by alpha interferon. Antimicrob. Agents Chemother. 35, 62-67.
36. Staehli, P. (1990). Interferon induced proteins and the antiviral state. Adv. Virus Res. 38, 147-200.
37. Thomas, P. S. (1980). Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc. Natl. Acad. Sci. USA 77, 5201-5205.
38. Wain-Hobson, S., Vartanian, J. P., Henry, M., Chenciner, N., Cheynier, R., Delassus, S., Martins, L. P., Sala, M., Nugeure, M. T., and Gu'etard, G. (1991). LAV revisited: Origins of the early HIV-1 isolates from Institut Pasteur. Science 252, 961-965.
39. Walsh, D. G., Horvath, C. J., Hansen-Moosa, A., MacKey, J. J., Sehgal, P. K., Daniel, M. D., Desrosiers, R. C., and Ringler, D. J. (1991). Cytokine influence on simian immunodeficiency virus replication within primary macrophages: TFN-alpha, but not GMCSF, enhances viral replication on a per-cell basis. Am. J. Pathol. 139, 877-887.
40. Zhou, A., Hassel, B. A., and Silverman, R. H. (1993). Expression cloning of a 2-5A-dependent RNAse: a uniquely regulated mediator of interferon action. Cell 72, 753-765.