Activity of IL12 as adjuvant in promoting Th1 and Th2 recall responses

Research in Immunology

Volumn 146, Issue 7-8, 1995, Pages 486-493

  Wolf, S F ^a   Bliss, J ^a   Stokes, K ^a   Sypek, J ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADJUVANT; ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; HELPER CELL; IMMUNE RESPONSE; IMMUNIZATION; INFECTION; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECALL; SPLEEN;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CELLS, CULTURED; IMMUNOLOGIC MEMORY; INTERLEUKIN-12; TH1 CELLS; TH2 CELLS;

EID: 0029613248     PISSN: 09232494     EISSN: None     Source Type: Journal    
DOI: 10.1016/0923-2494(96)83021-5     Document Type: Article

References (26)

1. The adjuvant effect of IL-12 in a vaccine against Leishmania major
2. Interleukin 12 as an adjuvant promotes a Th1 but does not suppress a Th2 recall response
3. Longterm CD4+ memory T cells from the spleen lack Mel-14, the lymph node horning receptor
4. T-cell memory: new perspectives
5. Requirements and basis for efficacious vaccination by a low antigen dose regimen against intracellular pathogens uniquely susceptible to a cell-mediated attack
6. Effects of interleukin-12 on immune responses and host protection in mice infected with intestinal nematode parasites
7. Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo
8. Recombinant IL12 cures mice infected with Leishmania major
9. Development of TH1 CD4+ T cells through IL12 produced by Listeria-induced macrophages
10. The B7 and CD28 receptor families
11. Immunological memory
12. Effects of IL-12 on helper T cell-dependent immune responses in vivo
13. Heterogeneity of cytokine secretion patterns and functions of helper T cells
14. Th1 and Th2 cells : different patterns of lymphokine secretion lead to different functional properties
15. Cell contact-mediated macrophage activation for anti-leishmanial defense. I. Lymphocyte effector mechanism that is contact-dependent and noncytotoxic
16. Stability of Th1 and Th2 populations
17. IL12 acts directly on CD4+ T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming
18. Generation and in vivo persistence of polarized Th1 and Th2 memory
19. IL-4 directs the development of Th2-like helper effectors
20. Resolution of cutaneous leishmaniasis: EL 12 initiates a protective T helper Type 1 immune response
21. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling
22. Interleukin-12 A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
23. Interferon gamma-independent effects of interleukin-12 administered during acute or established infection due to Leishmania major
24. The effects of IL-12 on B cell subset function
25. Natural killer cells induce activated murice B cells to secrete lg
26. Interleukin-12 alters the isotype-restricted antibody response of mice to hen eggwhite lysozyme