Effects of metrifonate and tacrine in the spatial morris task and modified irwin test: Evaluation of the efficacy/safety profile in rats

Drug Development Research

Volumn 36, Issue 4, 1995, Pages 166-179

  Blokland, Arjan ^a   Hinz, Volker ^a   Schmidt, Bernard H ^a  

^a Institute for Neurobiology   (Germany)

Author keywords

Alzheimer's disease; cholinesterase; cognition; metrifonate; Morris task; safety; side effect; tacrine

Indexed keywords

CHOLINESTERASE INHIBITOR; METRIFONATE; TACRINE;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG SAFETY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SALIVATION; SEIZURE; SPATIAL DISCRIMINATION; TREMOR;

EID: 0029610697     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.430360403     Document Type: Article

References (55)

1. Pharmacokinetics of metrifonate and its rearrangement product dichlorvos in whole blood
2. Excitatory amino acids and memory: Evidence from research on Alzheimer's disease and behavioral pharmacology
3. Working memory in aged rats
4. Temporally graded, age‐related impairments in spatial memory in the rat
5. The cholinergic hypothesis of geriatric memory dysfunction
6. Effect of metrifonate, a long‐acting cholinesterase inhibitor in Alzheimer's disease
7. Age‐related changes in spatial discrimination learning performance in Lewis rats
8. Choline acetyltransferase activity and histopathology of frontal cortex from biopsies of demented patients
9. Critical appraisal of behavioral tests for evaluation of age‐related memory deficits in animals
10. A double‐blind, placebo‐controlled multi‐center study of tacrine for Alzheimer's disease
11. Post‐train administration of 9‐amino‐1,2,3,4‐tetrahydroacredine enhances passive avoidance retention and decreases b‐adrenoceptor‐linked cyclic AMP formation in middle‐aged rats
12. Tacrine in Alzheimer's disease
13. A controlled trial of tacrine in Alzheimer's disease
14. Clinical experience with metrifonate
15. Hypersensitivity to scopolamine in the elderly
16. Effect of acute arecoline, tacrine and arecoline + tacrine post‐training administration on retention in old mice
17. Animal and drug modeling for Alzheimer synaptic pathology
18. Acute effects of physostigmine on complex operant behavior in rhesus monkeys
19. Spatial learning deficits in old rats: A model for memory decline in the aged
20. Ethological study of the effects of tetrahydroaminoacridine (THA) on social recognition in rats
21. Inhibition of cholinesterase by tetrahydroaminoacridine
22. Cholinergic enzymes in neocortex, hippocampus and basal forebrain of non‐neurological and senile dementia of Alzheimer‐type patients
23. Metrifonate: Summary of toxicological and pharmacological information available
24. Muscarinic subtype selectivity of tetrahydroaminoacridine: Possible relationship to its capricious efficacy
25. A 30‐week randomized controlled trial of high‐dose tacrine in patients with Alzheimer's disease
26. Effect of pesticides on central and peripheral nervous system function in rats
27. Biochemistry of Alzheimer's dementia
28. 3H]THA (tetrahydroaminoacridine) binding sites in rat brain
29. Increased cognitive sensitivity to scopolamine with age and a perspective on the scopolamine model
30. Animal models of Alzheimer's disease: Glutamatergic denervation as an alternative approach to cholinergic denervation
31. Anticholinergic sensitivty in the aging rat septohippocampal system as assessed in a spatial memory task
32. Paeniflorin attenuates learning impairment of aged rats in an operant brightness discrimination task
33. Aging and spatial cognition
34. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia
35. Effect of life‐long hypocaloric diet on age‐related changes in motor and cognitive behavior in a rat population
36. Spatial discrimination learning in rats as an animal model of cognitive ageing
37. An evaluation of spatial information processing in aged rats
38. Central anticholinergic hypersensitivity in aging
39. Effects of tetrahydroaminoacridine and nicotine in nucleus basalis and serotonin‐lesioned rats
40. Effects of tetrahydroaminoacridine on spatial navigation of nucleus‐basalis‐ and frontal‐cortex‐lesioned rats
41. Serotonin depletion decreases the therapeutic effect of nicotin, but not THA, in medial septal‐lesioned rats
42. Pitfalls in behavioural ageing research in animals
43. Effect of age and strain on working memory in mice as measured by win‐shift paradigm
44. Measurement of cognitive abilities in senescent animals
45. Blood cholinesterase inhibition as a guide to the efficacy of putative therapies for Alzheimer's dementia: Comparison of tacrine and physostigmine
46. Comparative effects of alpha‐2 receptor agents and THA on the performance of adult and aged rats in the delayed nonmatching to position task
47. Effect of acute and chronic cholinesterase inhibition on biogenic amines in rat brain
48. Effects of age on water escape behavior and on repeated acquisition in rats
49. Different time course for age‐related changes of behavior in a complex spatial discrimination task in Lewis rats
50. The effects of aging in rats on working and reference memory performance in a spatial hole board discrimination task
51. Characterisation of a novel muscarinic receptor agonist, YM796: Comparison with cholinesterase inhibitors in in vivo pharmacological studies
52. Antiamnesic and cholinomimetic side‐effects of the cholinesterase inhibitors, physostigmine, tacrine and NIK‐247 in rats