Chromatin Domains and Prediction of MAR Sequences

International Review of Cytology

Volumn 162, Issue C, 1996, Pages 279-388

  Boulikas, Teni ^a  

^a Inst of Molecular Medical Sciences   (United States)

Author keywords

Development; DNA distortion; DNA polymorphism; DNase l hypersensitive sites; Enhancer; Initiator protein; Intrinsic curvature; Inverted repeat; Nucleosome; Replication origins; Replicon; Torsional strain; Transcription factor

Indexed keywords

DEOXYRIBONUCLEASE I; DNA TOPOISOMERASE (ATP HYDROLYSING); HISTONE H1; LAMIN; MATRIX PROTEIN; REPETITIVE DNA;

CELL NUCLEUS MATRIX; CHROMATIN STRUCTURE; DNA REPAIR; DNA REPLICATION ORIGIN; DNA TRANSCRIPTION; NUCLEOSOME; PRIORITY JOURNAL; REVIEW;

ANIMALS; ANTIGENS, NUCLEAR; BASE SEQUENCE; CHROMATIN; DNA REPLICATION; ENHANCER ELEMENTS (GENETICS); HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR MATRIX; NUCLEAR PROTEINS; NUCLEIC ACID CONFORMATION; PROTEIN STRUCTURE, TERTIARY;

EID: 0029610541     PISSN: 00747696     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0074-7696(08)61234-6     Document Type: Article

References (449)

1. Adachi, Y., Käs, E., Laemmli, U.K., Preferential, cooperative binding of DNA toposiomerase II to scaffold-associated regions. EMBO J. 8 (1989), 3997–4006.
2. Adachi, Y., Luke, M., Laemmli, U.K., Chromosome assembly in vitro: Topoisomerase II is required for condensation. Cell (Cambridge, Mass.) 64 (1991), 137–148.
3. Adom, J.N., Richard-Foy, H., A region immediately adjacent to the origin of replication of bovine papilloma virus type 1 interacts in vitro with the nuclear matrix. Biochem. Biophys. Res. Commun. 176 (1991), 479–485.
4. Aelen, J.M.A., Opstelten, R.J.G., Walka, F., Organization of DNA replication in Physarum polycephalum. Attachement of origins of replicons and replication forks to the nuclear matrix. Nucleic Acids Res. 11 (1983), 1181–1195.
5. Agard, D.A., Sedat, J.W., Three-dimensional architecture of a polytene nucleus. Nature (London) 302 (1983), 676–681.
6. Aharoni, A., Baran, N., Manor, H., Characterization of a multisubunit human protein which selectively binds single stranded d(GA)n and d(GT)n sequence repeats in DNA. Nucleic Acids Res. 21 (1993), 5221–5228.
7. Allen, G.C., Hall, G.E. Jr., Childs, L.C., Weissinger, A.K., Spiker, S., Thompson, W.F., Scaffold attachment regions increase reporter gene expression in stably transformed plant cells. Plant Cell 5 (1993), 603–613.
8. Altieri, F., Maras, B., Eufemi, M., Ferraro, A., Turano, C., Purification of a 57 kDa nuclear matrix protein associated with thiol:protein—disulfide oxidoreductase and phospholipase C activities. Biochem. Biophys. Res. Commun. 194 (1993), 992–1000.
9. Amati, B.B., Gasser, S.M., Chromosomal ARS and CEN elements bind specifically to the yeast nuclear scaffold. Cell (Cambridge, Mass.) 54 (1988), 967–978.
10. Amati, B.B., Gasser, S.M., Drosophila scaffold-attached regions bind nuclear scaffolds and can function as ARS elements in both budding and fission yeasts. Mol. Cell. Biol. 10 (1990), 5442–5454.
11. Pick, B.B., Amati, L., Laroche, T., Gasser, S.M., Nuclear scaffold attachment stimulates, but is not essential for ARS activity in Saccharomyces cerevisiae: Analysis of the Drosophila ftz SAR. EMBRO J. 9 (1990), 4007–4016.
12. Anderson, J.N., Detection, sequence patterns and function of unusual DNA structures. Nucleic Acids Res. 14 (1986), 8513–8533.
13. Archer, T.K., Cordingley, M.G., Wolford, R.G., Hager, G.L., Transcription factor access is mediated by accurately positioned nucleosomes on the mouse mammary tumor virus promoter. Mol. Cell. Biol. 11 (1991), 688–698.
14. Aronow, B.J., Ebert, C.A., Valerious, M.T., Potter, S.S., Wiginton, D.A., Witte, D.P., Hutton, J.J., Dissecting a locus control region: Facilitation of enhancer function by extended enhancer-flanking sequences. Mol. Cell. Biol. 15 (1995), 1123–1135.
15. Avramova, Z., Bennetzen, J.L., Isolation of matrices from maize leaf nuclei: Identification of a matrix-binding site adjacent to the Adh 1 gene. Plant Mol. Biol. 22 (1993), 1135–1143.
16. Avramova, Z., Paneva, E., Matrix attachment sites in the murine α-globin gene. Biochem. Biophys. Res. Commun. 182 (1992), 78–85.
17. Bachs, O., Lanini, L., Serratosa, J., Coll, M.J., Bastos, R., Aligue, R., Rius, E., Carafoli, E., Calmodulin-binding proteins in the nuclei of quiescent and proliferatively activated rat liver cells. J. Biol. Chem. 265 (1990), 18595–18600.
18. Banerji, J., Olson, L., Schaffner, W., A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Cell (Cambridge, Mass.) 33 (1983), 729–740.
19. Barrack, E.R., Coffey, D.S., The specific binding of estrogens and androgens to the nuclear matrix of sex hormone responsive tissues. J. Biol. Chem. 255 (1980), 7265–7275.
20. Baru, M., Shlissel, M., Manor, H., The yeast GAL4 protein transactivates the polyomavirus origin of DNA replication in mouse cells. J. Virol. 65 (1991), 3496–3503.
21. Basler, J., Hastie, N.D., Pietras, D., Matsui, S.-I., Sandberg, A.A., Berezney, R., Hybridization of nuclear matrix attached deoxyribonucleic acid fragments. Biochemistry 20 (1981), 6921–6929.
22. Beggs, A.H., Migeon, B.R., Chromatin loop structure of the human X chromosome: Relevance to X inactivation and CpG clusters. Mol. Cell. Biol. 9 (1989), 2322–2331.
23. Belgrader, P., Dey, R., Berezney, R., Molecular cloning of matrin 3. A 125-kiloDalton protein of the nuclear matrix contains an extensive acidic domain. J. Biol. Chem. 266 (1991), 9893–9899.
24. Bell, S.P., Stillman, B., ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature (London) 357 (1992), 128–134.
25. Bell, S.P., Kobayashi, R., Stillman, B., Yeast origin recognition complex functions in transcription silencing and DNA replication. Science 262 (1993), 1844–1849.
26. Benyajati, C., Worcel, A., Isolation, characterization, and structure of the folded interphase genome of Drosophila melanogaster. Cell (Cambridge, Mass.) 9 (1976), 393–407.
27. Berezney, R., The nuclear matrix: A heuristic model for investigating genomic organization and function in the cell nucleus. J. Cell. Biochem. 47 (1991), 109–123.
28. Berezney, R., Bucholtz, L.A., Dynamic association of replicating DNA fragments with the nuclear matrix of regenerating liver. Exp. Cell Res. 132 (1981), 1–13.
29. Berezney, R., Coffey, D.S., Identification of a nuclear protein matrix. Biochem. Biophys. Res. Commun. 60 (1974), 1410–1417.
30. Berezney, R., Coffey, D.S., Nuclear protein matrix: Association with newly synthesized DNA. Science 189 (1975), 291–293.
31. Bergemann, A.D., Johnson, E.M., The HeLa Pur factor binds single-stranded DNA at a specific element conserved in gene flanking regions and origins of DNA replication. Mol. Cell. Biol. 12 (1992), 1257–1265.
32. Bergemann, A.D., Ma, Z.-W., Johnson, E.M., Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein. Mol. Cell. Biol. 12 (1992), 5673–5682.
33. Berrios, M., Osheroff, N., Fisher, P.A., In situ localization of DNA topoisomerase II, a major polypeptide component of the Drosophila nuclear matrix fraction. Proc. Natl. Acad. Sci. U.S.A. 82 (1985), 4142–4146.
34. Betz, A.G., Neuberger, M.S., Milstein, C., Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol. Today 14 (1993), 405–411.
35. Betz, A.G., Rada, C., Pannell, R., Milstein, C., Neuberger, M.S., Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: Clustering, polarity, and specific hot spots. Proc. Natl. Acad. Sci. U.S.A. 90 (1993), 2385–2388.
36. Betz, A.G., Milstein, C., González-Fernández, A., Pannell, R., Larson, T., Neuberger, M.S., Elements regulating somatic hypermutation of an immunoglobulin k gene: Critical role for the intron enhancer/matrix attachment region. Cell (Cambridge, Mass.) 77 (1994), 239–248.
37. Beven, A., Guan, Y., Peart, J., Cooper, C., Shaw, P., Monoclonal antibodies to plant nuclear matrix reveal intermediate filament-related components within the nucleus. J. Cell Sci. 98 (1991), 293–302.
38. Bianchi, M.E., Beltrame, M., Paonessa, G., Specific recognition of cruciform DNA by nuclear protein HMG1. Science 243 (1989), 1056–1059.
39. Bianchi, M.E., Falciola, L., Ferrari, S., Lilley, D.M.J., The DNA binding site of HMG1 protein is composed of two similar segments (HMG boxes), both of which have counterparts in other eukaryotic regulatory proteins. EMBO J. 11 (1992), 1055–1063.
40. Bidwell, J.P., van Wijnen, A.J., Fey, E.G., Dworetzky, S., Penman, S., Stein, J.L., Lian, J.B., Stein, G.S., Osteocalcin gene promoter-binding factors are tissue-specific nuclear matrix components. Proc. Natl. Acad. Sci. U.S.A. 90 (1993), 3162–3166.
41. Bidwell, J.P., Fey, E.G., van Wijnen, A.J., Pennman, S., Stein, J.L., Lian, J.B., Stein, G.S., Nuclear matrix proteins distinguish normal diploid osteoblasts from osteosarcoma cells. Cancer Res. 54 (1994), 28–32.
42. Björkroth, B., Ericsson, C., Lamb, M.M., Daneholt, B., Structure of the chromatin axis during transcription. Chromosoma 96 (1988), 333–340.
43. Blasquez, V.C., Xu, M., Moses, S.C., Garrard, W.T., Immunoglobulin k gene expression after stable integration. I. Role of the intronic MAR and enhancer in plasmacytoma cells. J. Biol. Chem. 264 (1989), 21183–21189.
44. Blasquez, V.C., Sperry, A.O., Cockerill, P.N., Garrard, W.T., Protein:DNA interactions at chromosomal loop attachement sites. Genome 31 (1989), 503–509.
45. Blasquez, V.C., Hale, M.A., Trevorrow, K.W., Garrard, W.T., Immunoglobulin k gene enhancers synergistically activate gene expression but independently determine chromatin structure. J. Biol. Chem. 267 (1992), 23888–23893.
46. Blencowe, B.J., Nickerson, J.A., Issner, R., Penman, S., Sharp, P.A., Association of nuclear matrix antigens with exon-containing splicing complexes. J. Cell Biol. 127 (1994), 593–607.
47. Bode, J., Maass, K., Chromatin domain surrounding the human interferon-β gene as defined by scaffold-attached regions. Biochemistry 27 (1988), 4706–4711.
48. Bode, J., Pucher, H.-J., Maass, K., Chromatin structure and induction-dependent conformational changes in human interferon-β genes in a mouse host cell. Eur. J. Biochem. 158 (1986), 393–401.
49. Bode, J., Kohwi, Y., Dickinson, L., Joh, T., Klehr, D., Mielke, C., Kohwi-Shigematsu, T., Biological significance of unwinding capability of nuclear matrix-associating DNAs. Science 255 (1992), 195–197.
50. Bodnar, J.W., A domain model for eukaryotic DNA organization: A molecular basis for cell differentiation and chromosome evolution. J. Theor. Biol. 132 (1988), 479–507.
51. Bodnar, J.W., Hanson, P.I., Polvino-Bodnar, M., Zempsky, W., Ward, D.C., The terminal regions of adenovirus and minute virus of mice DNAs are preferentially associated with the nuclear matrix in infected cells. J. Virol. 63 (1989), 4344–4353.
52. Boerwinkle, E., Xiong, W., Fourest, E., Chan, L., Rapid typing of tandemly repeated hypervariable loci by the polymerase chain reaction: Application to the apolipoprotein B 3′ hypervariable region. Proc. Natl. Acad. Sci U.S.A. 86 (1989), 212–216.
53. Bohr, V.A., Smith, C.A., Okumoto, D.S., Hanawalt, P.C., DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall. Cell (Cambridge, Mass.) 40 (1985), 359–369.
54. Boiteux, S., de Oliveira, R.C., Laval, J., The Escherichia coli O6-methylguanine-DNA methyltransferase does not repair promutagenic O6-methylguanine residues when present in Z-DNA. J. Biol. Chem. 260 (1985), 8711–8715.
55. Bolshoy, A., McNamara, P., Harrington, R.E., Trifonov, E.N., Curved DNA without A-A: Experimental estimation of all 16 DNA wedge angles. Proc. Natl. Acad. Sci. U.S.A. 88 (1991), 2312–2316.
56. Bonifer, C., Hecht, A., Saueressig, H., Winter, D.M., Sippel, A.E., Dynamic chromatin: The regulatory domain organization of eukaryotic gene loci. J. Cell. Biochem. 47 (1991), 99–108.
57. Bonifer, C., Yannoustsos, N., Kruger, G., Grosveld, F., Sippel, A.E., Dissection of the locus control function located on the chicken lysozyme gene domain in transgenic mice. Nucleic Acids Res. 22 (1994), 4202–4210.
58. Bonven, B.J., Gocke, E., Westergaard, O., A high affinity topoisomerase I binding sequence is clustered at DNAase I hypersensitive sites in Tetrahymena R-Chromatin. Cell (Cambridge, Mass.) 41 (1985), 541–551.
59. Borowiec, J.A., Hurwitz, J., Localized melting and structural changes in the SV40 origin of replication induced by T-antigen. EMBO J. 7 (1988), 3149–3158.
60. Bossi, L., Smith, D.M., Conformational change in the DNA associated with an unusual promoter mutation in a tRNA operon of Salmonella. Cell (Cambridge, Mass.) 39 (1984), 643–652.
61. Both, G.W., Taylor, L., Pollard, J.W., Steele, E.J., Distribution of mutations around rearranged heavy-chain antibody variable-region genes. Mol. Cell. Biol. 10 (1990), 5187–5196.
62. Boulikas, T., Nucleosomes are assembled into discrete size structures by histone H1 in vitro. Biochem. Cell. Biol. 64 (1986), 463–473.
63. Boulikas, T., Protein-protein and protein-DNA interactions in calf thymus nuclear matrix using cross-linking by ultraviolet irradiation. Biochem. Cell. Biol. 64 (1986), 474–484.
64. Boulikas, T., Nuclear envelope and chromatin structure. Int. Rev. Cytol., Suppl. 17 (1987), 493–571.
65. Boulikas, T., Functions of chromatin and the expression of genes. Int. Rev. Cytol. Suppl. 17 (1987), 599–684.
66. Boulikas, T., At least sixty ADP-ribosylated histones are present in nuclei from dimethylsulfate-treated and untreated cells. EMBO J. 7 (1988), 57–67.
67. Boulikas, T., Evolutionary consequences of preferential damage and repair of chromatin domains. J. Mol. Evol. 35 (1992), 156–180.
68. Boulikas, T., Chromatin and nuclear matrix in development and in carcinogenesis: A theory. Int. J. Oncol. 1 (1992), 357–372.
69. Boulikas, T., Homeotic protein binding sites, origins of replication and nuclear matrix anchorage sites share the ATTA and ATTTA motifs. J. Cell. Biochem. 50 (1992), 1–13.
70. Boulikas, T., Poly(ADP-ribosyl)ation, repair, chromatin and cancer. Curr. Perspect. Mol. Cell. Oncol. 1 (1992), 1–109.
71. Boulikas, T., Nature of DNA sequences at the attachment regions of chromatin loops to the nuclear matrix. J. Cell. Biochem. 52 (1993), 14–22.
72. Boulikas, T., Homeodomain protein binding sites, inverted repeats, and nuclear matrix attachment regions along the human β-globin gene complex. J. Cell. Biochem. 52 (1993), 23–36.
73. Boulikas, T., Poly(ADP-ribosyl)ation, DNA strand breaks, chromatin and cancer. Toxicol. Lett. 67 (1993), 129–150.
74. Boulikas, T., A compilation and classification of DNA binding sites for protein transcription factors from vertebrates. CRC Crit. Rev. Eukaryotic Gene Express. 4 (1994), 117–321.
75. Boulikas, T., Transcription factor binding sites in the matrix attachment region of the chicken α-globin gene. J. Cell. Biochem. 55 (1994), 513–529.
76. T. Boulikas (1995a). Common structural features in origins of replication among all life forms J. Cell. Biochem. (in press).
77. Boulikas, T., How enhancers work: Juxtapositioning of DNA control elements by synergistic interaction of MARs. Int. J. Oncol. 6 (1995), 1313–1318.
78. Boulikas, T., A model of transcription/replication enhancer. Oncol. Rep. 2 (1995), 171–181.
79. Boulikas, T., Phosphorylation of transcription factors and control of the cell cycle. CRC Crit. Rev. Eukaryotic Gene Express. 5 (1995), 1–77.
80. T. Boulikas (1995e). Interaction of histone H1 and HMG1,2 with supercoiled plasmids. In preparation.
81. Boulikas, T., Kong, C.F., Multitude of inverted repeats characterize a class of anchorage sites of chromatin loops to the nuclear matrix. J. Cell. Biochem. 53 (1993), 1–12.
82. Boulikas, T., Kong, C.F., A novel class of matrix attached regions (MARs) identified by random cloning and their implications in differentiation and carcinogenesis. Int. J. Oncol. 2 (1993), 325–330.
83. T. Boulikas C.F. Kong (1995). The 3′ untranslated region of the human poly(ADP-ribose) polymerase gene is a matrix attached region. In preparation.
84. Boulikas, T., Wiseman, J.M., Garrard, W.T., Points of contact between histone H1 and the histone octamer. Proc. Natl. Acad. Sci. U.S.A. 71 (1980), 127–131.
85. T. Boulikas L. Xie C.F. Kong A. Todd M. Zannis-Hadjopoulos (1995). The 5′ flanking region of the human choline acetyltransferase gene displays enhancer, nuclear matrix attachment, and bipartite origin of replication activities separated by an origin silencer. In preparation.
86. Breyne, P., Van Montagu, M., Depicker, A., Gheysen, G., Characterization of a plant scaffold attachment region in a DNA fragment that normalizes transgene expression in tobacco. Plant Cell 4 (1992), 463–471.
87. Brooks, A.R., Nagy, B.P., Taylor, S., Simonet, W.S., Taylor, J.M., Levy-Wilson, B., Sequences containing the second-intron enhancer are essential for transcription of the human apolipoprotein B gene in the livers of transgenic mice. Mol. Cell. Biol. 14 (1994), 2243–2256.
88. Brotherton, T., Zenk, D., Kahanic, S., Reneker, J., Avian nuclear matrix proteins bind very tightly to cellular DNA of the β-globin gene enhancer in a tissue-specific fashion. Biochemistry 30 (1991), 5845–5850.
89. Brown, E.H., Iqbal, M.A., Stuart, S., Hatton, K.S., Valinsky, J., Schildkraut, C.L., Rate of replication of the murine immunoglobulin heady-chain locus: Evidence that the region is part of a single replicon. Mol. Cell. Biol. 7 (1987), 450–457.
90. Brukner, I., Jurukovski, V., Konstantinović, M., Savić, A., Curved DNA without AA/TT dinucleotide step. Nucleic Acids Res. 19 (1991), 3549–3551.
91. Brun, C., Dang, Q., Miassod, R., Studies of an 800-kilobase DNA stretch of the Drosophila X chromosome: Comapping of a subclass of scaffold-attached regions with sequences able to replicate autonomously in Saccharomyces cerevisiae. Mol. Cell. Biol. 10 (1990), 5455–5463.
92. Buchman, A.R., Kimmerly, W.J., Rine, J., Kornberg, R.D., Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences, and telomeres in Saccaromyces cerevisiae. Mol. Cell. Biol. 8 (1988), 210–225.
93. Buckler-White, A.J., Humphrey, G.W., Pigiet, V., Association of polyoma T antigen and DNA with the nuclear matrix from lytically infected 3T6 cells. Cell (Cambridge, Mass.) 22 (1980), 37–46.
94. Buongiorno-Nardelli, M., Micheli, G., Carr, M.T., Marilley, M., A relationship between replicon size and supercoiled loop domains in the eukaryotic genome. Nature (London) 298 (1982), 100–102.
95. Caddle, M.S., Dailey, L., Heintz, N.H., RIP60, a mammalian origin-binding protein, enhances DNA bending near the dihydrofolate reductase origin of replication. Mol. Cell. Biol. 10 (1990), 6236–6243.
96. Caddle, M.S., Lussier, R.H., Heintz, N.H., Intramolecular DNA triplexes, bent DNA and DNA unwinding elements in the initiation region of an amplified dihydrofolate reductase replicon. J. Mol. Biol. 211 (1990), 19–33.
97. Callan, H.G., DNA replication in the chromosomes of eukaryotes. Cold Spring Harbor Symp. Quant. Biol. 38 (1974), 195–203.
98. Callan, H.G., Lampbrush chromosomes. Proc. R. Soc. London, Ser. B 214 (1982), 417–448.
99. Capco, D.G., Wan, K.M., Penman, S., The nuclear matrix: Three-dimensional architecture and protein composition. Cell (Cambridge, Mass.) 29 (1982), 847–858.
100. Carri, M.T., Micheli, G., Graziano, E., Pace, T., Buongiorno-Nardelli, M., The relationship between chromosomal origins of replication and the nuclear matrix during the cell cycle. Exp. Cell Res. 164 (1986), 426–436.
101. Chao, M.V., Gralla, J.D., Martinson, H.G., lac operator nucleosomes, 1. Repressor binds specifically to operator within the nucleosome core. Biochemistry 19 (1980), 3254–3260.
102. Chatterjee, P.K., Flint, S.J., Partition of E1A proteins between soluble and structural fractions of adenovirus-infected and -transformed cells. J. Virol. 60 (1986), 1018–1026.
103. Chimera, J.A., Musich, P.R., The association of the interspersed repetitive KpnI sequences with the nuclear matrix. J. Biol. Chem. 260 (1985), 9373–9379.
104. Chiu, S.-M., Xue, L.-Y., Friedman, L.R., Oleinick, N.L., Cooper ion-mediated sensitization of nuclear matrix attachment sites to ionizing radiation. Biochemistry 32 (1993), 6214–6219.
105. Chiu, S.-M., Friedman Sokany, N.M., Xue, L.-Y., Oleinick, N.L., Nuclear matrix proteins are crosslinked to transcriptionally active gene sequences by ionizing radiation. Radiat. Res. 107 (1986), 24–38.
106. Chou, R.H., Churchill, J.R., Mapstone, D.E., Flubacher, M.M., Sequence-specific binding of a c-myc nuclear-matrix-associated region shows increased nuclear matrix retention after leukemic cell (HL-60) differentiation. Am. J. Anat. 191 (1991), 312–320.
107. Christ, C., Tye, B.-K., Functional domains of the yeast transcription/replication factor MCM1. Genes Dev. 5 (1991), 751–763.
108. Chung, J.H., Whiteley, M., Felsenfeld, G., A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell (Cambridge, Mass.) 74 (1993), 505–514.
109. Chuprina, V.P., Fedoroff, O.Y., Reid, B.R., New insights into the structure of An tracts and B'-B' bends in DNA. Biochemistry 30 (1991), 561–568.
110. Ciejek, E.M., Nordström, J.L., Tsai, M.-J., O'Malley, B.W., Ribonucleic acid precursors are associated with the chick oviduct nuclear matrix. Biochemistry 21 (1982), 4945–4953.
111. Ciejek, E.M., Tsai, M.-J., O'Malley, B.W., Actively transcribed genes are associated with the nuclear matrix. Nature (London) 306 (1983), 607–609.
112. Classon, M., Henriksson, M., Sümegi, J., Klein, G., Hammaskjöld, M.-L., Elevated c-myc expression facilitates the replication of SV40 DNA in human lymphoma cells. Nature (London) 330 (1987), 272–274.
113. Cockell, M., Frutiger, S., Hughes, G.J., Gasser, S.M., The yeast protein encoded by PUB1 binds T-rich single stranded DNA. Nucleic Acids Res. 22 (1994), 32–40.
114. Cockerill, P.N., Nuclear matrix attachment occurs in several regions of the IgH locus. Nucleic Acids Res. 18 (1990), 2643–2648.
115. Cockerill, P.N., Garrard, W.T., Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites. Cell (Cambridge, Mass.) 44 (1986), 273–282.
116. Cockerill, P.N., Garrard, W.T., Chromosomal loop anchorage sites appear to be evolutionarily conserved. FEBS Lett. 204 (1986), 5–7.
117. Cockerill, P.N., Yuen, M.-H., Garrard, W.T., The enhancer of the immunogloblin heavy chain locus is flanked by presumptive chromosomal loop anchorage elements. J. Biol. Chem. 262 (1987), 5394–5397.
118. Collins, J.M., Transient structure of replicative DNA in normal and transformed human fibroblasts. J. Biol. Chem. 254 (1979), 10167–10172.
119. Collins, J.M., Glock, M.S., Chu, A.K., Nuclease S1 sensitive sites in parental deoxyribonucleic acid of cold- and temperature-sensitive mammalian cells. Biochemistry 21 (1982), 3414–3419.
120. Colvard, D.S., Wilson, E.M., Androgen receptor binding to nuclear matrix in vitro and its inhibition by 8S androgen receptor promoting factor. Biochemistry 23 (1984), 3479–3486.
121. Comings, D.E., Wallack, A.S., DNA-binding properties of nuclear matrix proteins. J. Cell Sci. 34 (1978), 233–246.
122. Cook, P.R., The nucleoskeleton and the topology of transcription. Eur. J. Biochem. 185 (1989), 487–501.
123. Cook, P.R., Brazell, I.A., Supercoils in human DNA. J. Cell Sci. 19 (1975), 261–279.
124. Cook, P.R., Lang, J., Hayday, A., Lania, L., Fried, M., Chiswell, D.J., Wyke, J.A., Active viral genes in transformed cells lie close to the nuclear cage. EMBO J. 1 (1982), 447–452.
125. Croston, G.E., Kerrigan, L.A., Lira, L.M., Marshak, D.R., Kadonaga, J.T., Sequence-specific antirepression of histone H1-mediated inhibition of basal RNA polymerase II transcription. Science 251 (1991), 643–649.
126. Crothers, D.M., Haran, T.E., Nadeau, J.G., Intrinsically bent DNA. J. Biol. Chem. 265 (1990), 7093–7096.
127. Cunningham, J.M., Purucker, M.E., Jane, S.M., Safer, B., Vanin, E.F., Ney, P.A., Lowrey, C.H., Nienhuis, A.W., The regulatory element 3′ to the Aγ-globin gene binds to the nuclear matrix and interacts with special A-T-rich binding protein 1 (SATB1), an SAR/MAR-associating region DNA binding protein. Blood 84 (1994), 1298–1308.
128. Dailey, L., Caddle, M.S., Heintz, N., Heinz, N.H., Purification of RIP60 and RIP100, mammalian proteins with origin-specific DNA-binding and ATP-dependent DNA helicase activities. Mol. Cell. Biol. 10 (1990), 6225–6235.
129. Dean, F.B., Hurwitz, J., Simian virus 40 large T antigen untwists DNA at the origin of DNA replication. J. Biol. Chem. 266 (1991), 5062–5071.
130. Deb, S., DeLucia, A.L., Koff, A., Tsue, S., Tegtmeyer, P., The adenine-thymine domain of the simian virus 40 core origin directs DNA bending and coordinately regulates DNA replication. Mol. Cell. Biol. 6 (1986), 4578–4584.
131. de Jong, L., van Driel, R., Stuurman, N., Meijne, A.M.L., van Renswoude, J., Principles of nuclear organization. Cell Biol. Int. Rep. 14 (1990), 1051–1074.
132. de Lange, T., Human telomeres are attached to the nuclear matrix. EMBO J. 11 (1992), 717–724.
133. Deppert, W., von der Weth, A., Functional interaction of nuclear transport-defective simian virus 40 large T antigen with chromatin and nuclear matrix. J. Virol. 64 (1990), 838–846.
134. Dickinson, L.A., Joh, T., Kohwi, Y., Kohwi-Shigematsu, T., A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition. Cell (Cambridge, Mass.) 70 (1992), 631–645.
135. Dietz, A., Kay, V., Schlake, T., Landsmann, J., Bode, J., A plant scaffold attached region detected close to a T-DNA integration site is active in mammalian cells. Nucleic Acids Res. 22 (1994), 2744–2751.
136. Diffley, J.F.X., Cocker, J.H., Protein-DNA interactions at a yeast replication origin. Nature (London) 357 (1992), 169–172.
137. Dijkwel, P.A., Hamlin, J.L., Matrix attachment regions are positioned near replication initiation sites, genes, and an interamplicon junction in the amplified dihydrofolate reductase domain of Chinese hamster ovary cells. Mol. Cell. Biol. 8 (1988), 5398–5409.
138. Dijkwel, P.A., Wenink, P.W., Poddighe, J., Permanet attachment of replication origins to the nuclar matrix in BHK-cells. Nucleic Acids Res. 14 (1986), 3241–3249.
139. Di Leonardo, A.D., Linke, S.P., Clarkin, K., Wahl, G.M., DNA damage triggers a prolonged p53–dependent G1 arrest and long-term induction of Cip 1 in normal human fibroblasts. Genes Dev. 8 (1994), 2540–2551.
140. Drapkin, R., Reardon, J.T., Ansari, A., Huang, J.-C., Zawel, L., Ahn, K., Sancar, A., Reinberg, D., Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II. Nature (London) 368 (1994), 769–772.
141. Dunaway, M., Ostrander, E.A., Local domains of supercoiling activate a eukaryotic promoter in vivo. Nature (London) 361 (1993), 746–748.
142. DuPraw, E.J., Macromolecular organization of nuclei and chromosomes: a folded fibre model based on whole-mount electron microscopy. Nature (London) 206 (1965), 338–343.
143. Durfee, T., Mancini, M.A., Jones, D., Elledge, S.J., Lee, W-H., The amino terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localized to centers for RNA processing. J. Cell Biol. 127 (1994), 609–622.
144. Dworetzky, S.I., Fey, E.G., Penman, S., Lian, J.B., Stein, J.L., Stein, G.S., Progressive changes in the protein composition of the nuclear matrix during rat osteoblast differentiation. Proc. Natl. Acad. Sci. U.S.A. 87 (1990), 4605–4609.
145. Dworetzky, S.I., Wright, K.L., Fey, E.G., Pennman, S., Lian, J.B., Stein, J.L., Stein, G.S., Sequence-specfic DNA-binding proteins are components of a nuclear matrix-attachment site. Proc. Natl. Acad. Sci. U.S.A. 89 (1992), 4178–4182.
146. Earnshaw, W.C., Halligan, B., Cooker, C.A., Heck, M.M.S., Liu, L.F., Topoisomerase II is a structural component of mitotic chromosome scaffolds. J. Cell Biol. 100 (1985), 1706–1715.
147. Grabher, A., Eberharter, A., Gstraunthaler, G., Loidl, P., Nuclear matrix of the lower eukaryote Physarum polycerphalum and the mammalian epithelial LLC-PK1 cell line. A comprehensive investigation of different preparation procedures. Eur. J. Biochem. 212 (1993), 573–580.
148. Eggert, H., Jack, R.S., An ectopic copy of the Drosophila fiz associated SAR neither reorganizes local chromatin structure nor hinders elution of a chromatin fragment from isolated nuclei. EMBO J. 10 (1991), 1237–1243.
149. Elias, P., Gustafsson, C.M., Hammarsten, O., The origin binding protein of herpes simplex virus 1 binds cooperatively to the viral origin of replication oris. J. Biol. Chem. 265 (1990), 17167–17173.
150. Elias, P., Gustafsson, C.M., Hammarsten, O., Stow, N.D., Structural elements required for the cooperative binding of the herpes simplex virus origin binding protein to oriS reside in the N-terminal part of the protein. J. Biol. Chem. 267 (1992), 17424–17429.
151. Ellis, G.C., Grobler-Rabie, A.F., Hough, F.S., Bester, A.J., Location and methylation pattern of a nuclear matrix associated region in the human PROa2(I) collagen gene. Biochem. Biophys. Res. Commun. 157 (1988), 500–506.
152. Ellison, J.R., Howard, G.C., Non-random position of the satellite A-T rich DNA sequences within nuclei in early embryos of Drosophila virilis. Chromosoma 83 (1981), 555–561.
153. Erdile, L.F., Heyers, W.-D., Kolodners, R., Kelly, T.J., Characterization of cDNA encoding the 70-kDa single-stranded DNA-binding subunit of human replication protein A and the role of the protein in DNA replication. J. Biol. Chem. 266 (1991), 12090–12098.
154. Fackelmayer, F.O., Dahm, K., Renz, A., Ramsperger, U., Richter, A., Nucleic-acid-binding properties of hnRNP-U/SAF-A, a nuclear-matrix protein which binds DNA and RNA in vivo and in vitro. Eur. J. Biochem. 221 (1994), 749–757.
155. Fakan, S., Puvion, E., The ultrastructural visualization of nucleolar and extranucleolar RNA synthesis and distribution. Int. Rev. Cytol. 65 (1980), 255–299.
156. Fakan, S., Leduc, Y., Lamarre, D., Brunet, G., Poirier, G.G., Immunoelectron microscopical distribution of poly(ADP-ribose) polymerase in the mammalian cell nucleus. Exp. Cell Res. 179 (1988), 517–526.
157. Farache, G., Razin, S.V., Targa, F.R., Scherrer, K., Organization of the 3′-boundary of the chicken α globin gene domain and characterization of CR 1-specific protein binding site. Nucleic Acids Res. 18 (1990), 401–409.
158. Farache, G., Razin, S.V., Rzeszowska-Wolny, J., Moreau, J., Targa, F.R., Scherrer, K., Mapping of structural and transcription-related matrix attachment sites in the α-globin gene domain of avian erythroblasts and erythrocytes. Mol. Cell. Biol. 10 (1990), 5349–5358.
159. Fernandes, D.J., Catapano, C.V., Nuclear matrix targets for anticancer agents. Cancer Cells 3 (1991), 134–140.
160. Ferraro, A., Grandi, P., Eufemi, M., Altieri, F., Turano, C., Crosslinking of nuclear proteins to DNA by cis-diammminedichloroplatinum in intact cells. FEBS Lett. 307 (1992), 383–385.
161. Feuerstein, N., Chan, P.K., Mond, J.J., Identification of numatrin, the nuclear matrix protein associated with induction of mitogenesis, as the nucleolar protein B23. Implication for the role of the nucleolus in early transduction of mitogenic signals. J. Biol. Chem. 263 (1988), 10608–10612.
162. Fey, E.G., Penmann, S., Nuclear matrix proteins reflect cell type of origin in cultured human cells. Proc. Natl. Acad. Sci. U.S.A. 85 (1988), 121–125.
163. Fey, E.G., Wan, K.M., Penman, S., Epithelial cytoskeletal framework and nuclear matrix-intermediate filament scaffold: Three-dimensional organization and protein composition. J. Cell Biol. 98 (1984), 1973–1984.
164. Fey, E.G., Krochmalnic, G., Penman, S., The nonchromatin substructures of the nucleus: The ribonucleoprotein containing and RNP-deleted matrices analyzed by sequential fractionation and resinless section electron microscopy. J. Cell Biol. 102 (1986), 1654–1665.
165. Fey, E.G., Bangs, P., Sparks, C., Odgren, P., The nuclear matrix: Defining structural and functional roles. CRC Crit. Rev. Eukaryotic Express. 1 (1991), 127–143.
166. Fishel, B.R., Sperry, A.O., Garrad, W.T., Yeast calmodulin and a conserved nuclear protein participate in the in vivo binding of a matrix association region. Proc. Natl. Acad. Sci. U.S.A. 90 (1993), 5623–5627.
167. Fisher, D.Z., Chaudhary, N., Blobel, B., cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins. Proc. Natl. Acad. Sci. U.S.A. 83 (1986), 6450–6464.
168. Foisner, R., Gerace, L., Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation. Cell (Cambridge, Mass.) 73 (1993), 1267–1279.
169. Forrester, W.C., van Genderen, C., Jenuwein, T., Grosschedl, R., Dependence of enhancer-mediated transcription of the immunoglobulin gene of nuclear matrix attachment regions. Science 265 (1994), 1221–1225.
170. Frappier, L., O'Donnell, M., EBNA1 distorts oriP, the Epstein-Barr virus latent replication origin. J. Virol. 66 (1992), 1786–1790.
171. Frappier, L., Zannis-Hadjopoulos, M., Autonomous replication of plasmids bearing monkey DNA origin-enriched sequences. Proc. Natl. Acad. Sci. U.S.A. 84 (1987), 6668–6672.
172. Fredman, J.N., Engler, J.A., Adenovirus precursor to terminal protein interacts with the nuclear matrix in vivo and in vitro. J. Virol. 67 (1993), 3384–3395.
173. Garrard, W.T., Chromosomal loop organization in eukaryotic genomes. Nucleic Acids Mol. Biol. 4 (1990), 163–175.
174. Gasser, S.M., Laemmli, U.K., Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of Dmelanogaster. Cell (Cambridge, Mass.) 46 (1986), 521–530.
175. Gasser, S.M., Laemmli, U.K., The organization of chromatin loops: Characterization of a scaffold attachment site. EMBO J. 5 (1986), 511–518.
176. Gasser, S.M., Amati, B.B., Cardenas, M.E., Hofmann, J.F.-X., Studies on scaffold attachment sites and their relation to genome function. Int. Rev. Cytol. 119 (1989), 57–96.
177. Georgiev, G.P., Vassetzky, Y.S. Jr., Luchinik, A.N., Chernokhvostov, V.V., Razin, S.V., Nuclear skeleton, DNA domains and control of replication and transcription. Eur. J. Biochem. 200 (1991), 613–624.
178. Getzenberg, R.H., Nuclear matrix and the regulation of gene expression: Tissue specificity. J. Cell. Biochem. 55 (1994), 22–31.
179. Giaever, G.N., Wang, J.C., Supercoiling of intracellular DNA can occur in eukaryotic cells. Cell (Cambridge, Mass.) 55 (1988), 849–856.
180. Gillies, S.D., Morrison, S.L., Oi, V.T., Tonegawa, S., A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. Cell (Cambridge, Mass.) 33 (1983), 717–728.
181. Gilmour, D.S., Elgin, S.C.R., Association of topoisomerase I with transcriptionally active loci in Drosophila. NCI Monogr. 4 (1987), 17–21.
182. Gilmour, D.S., Pflugfelder, G., Wang, J.C., Lis, J.T., Topoisomerase I interacts with transcribed regions in Drosophila cells. Cell (Cambridge, Mass.) 44 (1986), 401–407.
183. Giusti, A.M., Manser, T., Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: Implications for the location of cis-acting elements require for somatic mutation. J. Exp. Med. 177 (1993), 797–809.
184. Glass, C.A., Glass, J.R., Taniura, H., Hasel, K.W., Blevitt, J.M., Gerace, L., The α-helical rod domain of human lamins A and C contains a chromatin binding site. EMBO J 12 (1993), 4413–4424.
185. Goldman, M.A., The chromatin domain as a unit of gene regulation. BioEssays 9 (1988), 50–55.
186. Gourdon, G., Sharpe, J.A., Wells, D., Wood, W.G., Higgs, D.R., Analysis of a 70 kb segment of DNA containing the human and α-globin genes linked to their regulatory element (HS-40) in transgenic mice. Nucleic Acids Res. 22 (1994), 4139–4147.
187. Greenfield, I., Nickerson, J., Penman, S., Stanley, M., Human papillomavirus 16 E7 protein is associated with the nuclear matrix. Proc. Natl. Acad. Sci. U.S.A. 88 (1991), 11217–11221.
188. Greenstein, R.J., Constitutive attachment of murine erythroleukemia cell histone-depleted DNA loops to nuclear scaffolding is found in the β-major but not the α1-globin gene. DNA 7 (1988), 601–607.
189. Gromova, I., Thomsen, B., Razin, R.V., Different topoisomerase II antitumor drugs direct similar specific long-range fragmentation of an amplified c-MYC gene locus in living cells and in high salt-extracted nuclei. Proc. Natl. Acad. Sci. U.S.A. 92 (1995), 102–106.
190. Grossbach, E.R., Björkroth, B., Daneholt, B., Presence of histone H1 on an active Balbiani ring gene. Cell (Cambridge, Mass.) 60 (1990), 78–83.
191. Grosveld, F., van Assendelft, G.B., Greaves, D.R., Kollias, G., Position-independent, high-level expression of the human β-globin gene in transgenic mice. Cell (Cambridge, Mass.) 51 (1987), 975–985.
192. Guo, Z.-S., De Pamphilis, M.L., Specific transcription factors stimulate simian virus 40 and polyomavirus origins of DNA replication. Mol. Cell. Biol. 12 (1992), 2514–2524.
193. Hakes, D.J., Berezney, R., Molecular cloning of matrin F/G: A DNA binding protein of the nuclear matrix that contains putative zinc finger motifs. Proc. Natl. Acad. Sci. U.S.A. 88 (1991), 6186–6190.
194. Hall, G. Jr., Allen, G.C., Loer, D.S., Thompson, W.F., Spiker, S., Nuclear scaffolds and scaffold-attachment regions in higher plants. Proc. Natl. Acad. Sci. U.S.A. 88 (1991), 9320–9324.
195. Hancock, R., Topological organisation of interphase DNA: The nuclear matrix and other skeletal strucures. Biol. Cell 46 (1982), 105–122.
196. Hancock, R., Boulikas, T., Functional organization in the nucleus. Int. Rev. Cytol. 79 (1982), 165–214.
197. Hancock, R., Hughes, M.E., Organisation of DNA in the interphase nucleus. Biol. Cell 44 (1982), 201–212.
198. Hanna, Z., Simard, C., Laperriere, A., Jolicoeur, P., Specific expression of the human CD4 gene in mature CD4+ CD8- and immature CD4+ CD4+ T cells and in macrophages of transgenic mice. Mol. Cell. Biol. 14 (1993), 1084–1094.
199. Harless, J., Hewitt, R.R., Intranuclear localization of UV-induced DNA repair in human VA13 cells. Mutat. Res. 183 (1987), 177–184.
200. Hatfull, G.F., Noble, S.M., Grindley, N.D.F., The γδ resolvase induces an unusual DNA structure at the recombinational crossover point. Cell (Cambridge, Mass.) 49 (1987), 103–110.
201. Hay, R.T., DePamphilis, M.L., Initiation of SV40 DNA replication in vivo: Location and structure of 5′ ends of DNA synthesized in the ori region. Cell (Cambridge, Mass.) 28 (1982), 767–779.
202. He, D., Nickerson, J.A., Penman, S., Core filaments of the nuclear matrix. J. Cell Biol. 110 (1990), 569–580.
203. Hendrickson, E.A., Fritze, C.E., Folk, W.R., DePamphilis, M.L., The origin of bidirectional DNA replication in polyoma virus. EMBO J. 6 (1987), 2011–2018.
204. Hendzel, M.J., Delcuve, G.P., Davie, J.R., Histone deacetylase is a component of the internal nuclear matrix. J. Biol. Chem. 266 (1991), 21936–21942.
205. Hendzel, M.J., Sun, J.M., Chen, H.Y., Rattner, J.B., Davie, J.R., Histone acetyltransferase is associated with the nuclear matrix. J. Biol. Chem. 269 (1994), 22894–22901.
206. Herman, R., Weymouth, L., Penman, S., Heterogeneous nuclear RNA-protein fibers in chromatin-depleted nuclei. J. Cell Biol. 78 (1978), 663–674.
207. Hirano, T., Hiraoka, Y., Yanakida, M., A temperature-sensitive mutation of the Schizosaccharomyces pombe gene nuc2+ that encodes a nuclear-scaffold protein blocks spindle elongation in mitotic anaphase. J. Cell Biol. 106 (1988), 1171–1183.
208. Hirano, T., Kinoshita, N., Morikawa, K., Yanakida, M., Snap helix with knob and hole: Essential repeats in S. pombe nuclear protein nuc2+. Cell (Cambridge, Mass.) 60 (1990), 319–328.
209. Hochstrasser, M., Mathog, D., Gruenbaum, Y., Saumweber, H., Sedat, J.W., Spatial organization of chromosomes in the salivary gland nuclei of Drosophila melanogaster. J. Cell Biol. 102 (1986), 112–123.
210. Hofmann, J.F.-X., Gasser, S.M., Identification and purification of a protein that binds the yeast ARS consensus sequence. Cell (Cambridge, Mass.) 64 (1991), 951–960.
211. Hofmann, J.F.-X., Laroche, T., Brand, A.H., Gasser, S.M., RAP-1 factor is necessary for DNA loop formation in vitro at the silent mating type locus HML. Cell (Cambridge, Mass.) 57 (1989), 725–737.
212. Homberger, H.P., Bent DNA is a structural feature of scaffold-attached regions in Drosophila melanogaster interphase nuclei. Chromosoma 98 (1989), 99–104.
213. Hsieh, D.-J., Camiolo, S.M., Yates, J.L., Constitutive binding of EBNA1 protein to the Epstein-Barr virus replication origin, oriP, with distortion of DNA structure during latent infection. EMBO J. 12 (1993), 4933–4944.
214. Huber, M.C., Bosch, F.X., Sippel, A.E., Bonifer, C., Chromosomal position effects in chicken lysozyme gene transgenic mice are correlated with suppression of DNase I hypersensitive site formation. Nucleic Acids Res. 22 (1994), 4195–4201.
215. Iguchi-Ariga, S.M.M., Itani, T., Yamaguchi, M., Ariga, H., c-myc protein can be substituted for SV40 T antigen in SV40 DNA replication. Nucleic Acids Res. 15 (1987), 4889–4899.
216. Iguchi-Ariga, S.M.M., Okazaki, T., Itani, T., Ogata, M., Sato, Y., Ariga, H., An initiation site of DNA replication with transcriptional enhancer activity present upstream of the c-myc gene. EMBO J. 7 (1988), 3135–3142.
217. Imler, J.L., Lemaire, C., Wasylyk, C., Wasylyk, B., Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer. Mol. Cell. Biol. 7 (1987), 2558–2567.
218. Ioshikhes, I., Bolshoy, A., Trifonov, E.N., Preferred positions of AA and TT dinucleotides in aligned nucleosomal DNA sequences. J. Biomol. Struct. Dyn. 9 (1992), 1111–1117.
219. Isomura, T., Tamiya-Koizumi, K., Suzuki, M., Yoshida, S., Taniguchi, M., Matsuyama, M., Ishigaki, T., Sakuma, S., Takahashi, M., RFP is a binding protein associated with the nuclear matrix. Nucleic Acids Res. 20 (1992), 5305–5310.
220. Ito, T., Sakaki, Y., Nuclear matrix association regions of rat α2-macroglobulin gene. Biochem. Biophys. Res. Commun. 149 (1987), 449–454.
221. Ivanchenko, M., Avramova, Z., Interaction of MAR-sequences with nuclear matrix proteins. J. Cell. Biochem. 50 (1992), 190–200.
222. Izaurralde, E., Mirkovitch, J., Laemmli, U.K., Interaction of DNA with nuclear scaffolds in vitro. J. Mol. Biol. 200 (1988), 111–125.
223. Izaurralde, E., Käs, E., Laemmli, U.K., Highly preferential nucleation of histone H1 assembly on scaffold-associated regions. J. Mol. Biol. 210 (1989), 573–585.
224. Jackson, D.A., Structure-function relationships in eukaryotic nuclei. BioEssays 13 (1991), 1–10.
225. Jackson, D.A., McCready, S.J., Cook, P.R., RNA is synthesized at the nuclear cage. Nature (London) 292 (1981), 552–555.
226. Jackson, D.A., Dickinson, P., Cook, P.R., The size of chromatin loops in HeLa cells. EMBO J. 9 (1990), 567–571.
227. Jacquemin-Sablon, H., Triqueneaux, G., Deschamps, S., le Maire, M., Doniger, J., Dautry, F., Nucleic acid binding and intracellular localization of unr, a protein with five cold shock domains. Nucleic Acids Res. 22 (1994), 2643–2650.
228. Jarman, A.P., Higgs, D.R., Nuclear scaffold attachment sites in the human globin gene complexes. EMBO J. 7 (1988), 3337–3344.
229. Jenuwein, T., Forrester, W.O., Qiu, R.-G., Grosschedl, R., The immunoglobulin enhancer core establishes local factor access in nuclear chromatin independent of transcriptional stimulation. Genes Dev. 7 (1993), 2016–2032.
230. Jeppensen, P.G.N., Bankier, A.T., A partial characterization of DNA fragments protected from nuclease degradation in histone-depleted metaphase chromosomes of the Chinese hamster. Nucleic Acids Res. 7 (1979), 49–67.
231. Johnson, E.M., Jelinek, W.R., Replication of a plasmid bearing a human Alu-family repeat in monkey COS-7 cells. Proc. Natl. Acad. Sci. U.S.A. 83 (1986), 4660–4664.
232. Johnston, B.H., The S1-sensitive form of d(C-T)n-d(A-G)n: Chemical evidence for a three-standard structure in plasmids. Science 241 (1988), 1800–1804.
233. Johnston, B.H., Rich, A., Chemical probes of DNA conformation: Detection of Z-DNA at nucleotide resolution. Cell (Cambridge, Mass.) 42 (1985), 713–724.
234. Johnston, B.H., Quigley, G.J., Ellison, M.J., Rich, A., The Z-Z Junction: The boundary between two out-of-phase Z-DNA regions. Biochemistry 30 (1991), 5257–5263.
235. Jones, C., Su, R.T., Association of viral and plasmid DNA with the nuclear matrix during productive infection. Biochim. Biophys. Acta 910 (1987), 52–62.
236. Jost, J.-P., Seldran, M., Association of transcriptionally active vitellogenin II gene with the nuclear matrix of chicken liver. EMBO J. 3 (1984), 2005–2008.
237. Juan, L., Utley, R.T., Adams, C.C., Vettese-Dadey, M., Workman, J.L., Differential repression of transcription factor binding by histone H1 is regulated by the core histone amino termini. EMBO J. 13 (1994), 6031–6040.
238. Kamakaka, R.T., Thomas, J.O., Chromatin structure of transcriptionally competent and repressed genes. EMBO J. 9 (1990), 3997–4006.
239. Käs, E., Chasin, L.A., Anchorage of the Chinese hamster dihydrofolate reductase gene to the nuclear scaffold occurs in an intragenic region. J. Mol. Biol. 198 (1987), 677–692.
240. Käs, E., Laemmli, U.K., In vivo topoisomerase II cleavage of the Drosophila histone and satellite III repeats: DNA sequence and structural characteristics. EMBO J. 11 (1992), 705–716.
241. Käs, E., Izaurralde, E., Laemmli, U.K., Specific inhibition of DNA binding to nuclear scaffolds and histone H1 by distamycin: The role of oligo(dA) oligo(dT) tracts. J. Mol. Biol. 210 (1989), 587–599.
242. Käs, E., Adachi, L., Poljak, Y., Laemmli, U.K., A model for chromatin opening: Stimulation of topoisomerase II and restriction enzyme cleavage of chromatin by distamycin. EMBO J. 12 (1993), 115–126.
243. Kaufmann, S.H., Brunet, G., Talbot, B., Lamarr, D., Dumas, C., Shaper, J.H., Poirier, G., Association of poly(ADP-ribose) polymerase with the nuclear matrix: The role of intermolecular disulfide bond formation, RNA retention, and cell type. Exp. Cell. Res. 192 (1991), 524–535.
244. Kay, V., Bode, J., Binding-specificity of a nuclear scaffold: Supercoiled, single-stranded, and scaffold-attached-region DNA. Biochemistry 33 (1994), 367–374.
245. Keesee, S.K., Meneghini, M.D., Szaro, R.P., Wu, Y.-J., Nuclear matrix proteins in human colon cancer. Proc. Natl. Acad. Sci. U.S.A. 91 (1994), 1913–1916.
246. Kellum, R., Schedl, P., A position-effect assay for boundaries of higher order chromosomal domains. Cell 64 (1991), 941–950.
247. Khanuja, P.S., Lehr, J.E., Soule, H.D., Gehani, S.K., Noto, A.C., Choudhury, S., Chen, R., Pienta, K.J., Nuclear matrix proteins in normal and breast cancer cells. Cancer Res. 53 (1993), 3394–3398.
248. Kim, J.L., Nikolov, D.B., Burley, S.K., Co-crystal structure of TBP recognizing the minor groove of a TATA element. Nature (London) 365 (1993), 520–527.
249. Kimmerly, W., Buchman, A., Kornberg, R., Rine, J., Roles of two DNA-binding factors in replication, segregation and transcriptional repression mediated by a yeast silencer. EMBO J. 7 (1988), 2241–2253.
250. Kitsberg, D., Selig, S., Keshet, I., Cedar, H., Replication structure of the human β-globin gene domain. Nature (London) 366 (1993), 588–590.
251. Klehr, D., Maass, K., Bode, J., Scaffold-attached regions from the human interferon β domain can be used to enhance the stable expression of genes under the control of various promoters. Biochemistry 30 (1991), 1264–1270.
252. Klehr, D., Schlake, T., Maass, K., Bode, J., Scaffold-attached regions (SAR elements) mediate transcriptional effects due to butyrate. Biochemistry 31 (1992), 3222–3229.
253. Klempnauer, K.-H., Interaction of myb proteins with the nuclear matrix in vitro. Oncogene 2 (1988), 545–551.
254. Koepsel, R.R., Khan, S.A., Statid and initiator protein-enhanced bending of DNA at a replication origin. Science 233 (1986), 1316–1318.
255. Koff, A., Schwedes, J.F., Tegtmeyer, P., Herpes simplex virus origin-binding protein (UL9) loops and distorts the viral replication origin. J. Virol. 65 (1991), 3284–3292.
256. Kohwi, Y., Non-B-DNA structure: Preferential target for the chemical carcinogen glycidaldehyde. Carcinogenesis (London) 10 (1989), 2035–2042.
257. Kohwi-Shigematsu, T., Kohwi, Y., Torsional stress stabilizes extended base unpairing in suppressor sites flanking immunoglobulin heavy chain enhancer. Biochemistry 29 (1990), 9551–9560.
258. Kolluri, R., Torrey, T.A., Kinniburgh, A.J., A CT promoter element binding protein: Definition of a double-strand and a novel single-strand DNA-binding motif. Nucleic Acids Res. 20 (1992), 111–116.
259. Koo, H.-S., Wu, H.-M., Crothers, D.M., DNA bending at adenine thymidine tracts. Nature (London) 320 (1986), 501–506.
260. Kowalski, D., Eddy, M.J., The DNA unwinding element: A novel, cis-acting component that facilitates opening of the Escherichia coli replication origin. EMBO J. 8 (1989), 4335–4344.
261. Krogh, S., Mortensen, U.H., Westergaard, O., Bonven, B.J., Eukaryotic topoisomerase I-DNA interaction is stabilized by helix curvature. Nucleic Acids Res. 19 (1991), 1235–1241.
262. Kumara-Siri, M.H., Shapiro, L.E., Surks, M.I., Association of the 3,5,3′-triiodo-L-thyronine nuclear receptor with the nuclear matrix of cultured growth hormone-producing rat pituitary tumor cells (GC cells). J. Biol. Chem. 261 (1986), 2844–2852.
263. Kuo, M.-H., Grayhack, E., A library of yeast genomic MCM1 binding sites contains genes involved in cell cycle control, cell wall and membrane structure, and metabolism. Mol. Cell. Biol. 14 (1994), 348–359.
264. Laybourn, P.J., Kadonaga, J.T., Role of nucleosomal cores and histone H1 in regulation of transcription by RNA polymerase II. Science 254 (1991), 238–245.
265. Lebécque, S.G., Gearhart, P.J., Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is ~1kb from V(D)J gene. J. Exp. Med. 172 (1990), 1717–1727.
266. Leibovitch, S.A., Leibovitch, M.P., Hillion, H., Krug, J., Harel, J., A destabilized DNA conformation associated with tightly bound nuclear proteins in active genes of rat myoblast. Nucleic Acids Res. 11 (1983), 4035–4047.
267. Levy-Wilson, B., Fortier, C., The limits of the DNase I-sensitive domain of the human apolipoprotein B gene coincide with the locations of chromosomal anchorage loops and define the 5′ and 3′ boundaries of the gene. J. Biol. Chem. 264 (1989), 21196–21204.
268. Lichtenstein, M., Keini, G., Cedar, H., Bergman, Y., B cell-specific demethylation: A novel role for the intronic k chain enhancer sequence. Cell (Cambridge, Mass.) 76 (1994), 913–923.
269. Li, H., Roux, S.J., Casein kinase II protein kinase is bound to lamina-matrix and phosphorylates lamin-like protein in isolated pea nuclei. Proc. Natl. Acad. Sci. U.S.A. 849 (1992), 8434–8438.
270. Lin, L.-S., Meyer, R.J., DNA synthesis is initiated at two positions within the origin of replication of plasmid R1162. Nucleic Acids Res. 15 (1987), 8319–8331.
271. Lothstein, L., Arenstorf, H.P., Chung, S.-Y., Walker, B.W., Wooley, J.C., LeStourgeon, W.M., General organization of protein in HeLa 40S nuclear ribonucleoprotein particles. J. Cell Biol. 100 (1985), 1570–1581.
272. Ludérus, M.E.E., de Graaf, A., Mattia, E., den Blaauwen, J.L., Grande, M.A., de Jong, L., van Driel, R., Binding of matrix attachment regions to lamin B1. Cell (Cambridge, Mass.) 70 (1992), 949–959.
273. Ludérus, M.E.E., den Blaauwen, J.L., de Smith, O.J.B., Compton, D.A., van Driel, R., Binding of matrix attachment regions to lamin polymers involves single-stranded regions and the minor groove. Mol. Cell. Biol. 14 (1994), 6297–6305.
274. Mancini, M.A., Shan, B., Nickerson, J.A., Penman, S., Lee, W.-H., The retinoblastoma gene product is a cell cycle-dependent, nuclear matrix associated protein. Proc. Natl. Acad. Sci. U.S.A. 91 (1994), 418–422.
275. Marilley, M., Gassend-Bonnet, G., Supercoiled loop organization of genomic DNA: A close relationship between loop domains, expression units and replicon organization in rDNA in Xenopus laevis. Exp. Cell Res. 180 (1989), 475–489.
276. Marsden, M.P.F., Laemmli, U.K., Metaphase chromosome structure: Evidence for a radial loop model. Cell (Cambridge, Mass.) 17 (1979), 849–858.
277. Martelli, A.M., Gilmour, R.S., Bareggi, R., Cocco, L., The effect of in vitro heat exposure on the recovery of nuclear matrix-bound DNA polymerase α activity during the different phases of the cell cycle in synchronized HeLa S3 cells. Exp. Cell Res. 201 (1992), 470–476.
278. Martin, R.G., Oppenheim, A., Initiation points for DNA replication in nontransformed and simian virus 40-transformed Chinese hamster lung cells. Cell (Cambridge, Mass.) 11 (1977), 859–869.
279. Mastrangelo, I.A., Hough, P.V.C., Wall, J.S., Dodson, M., Dean, F.B., Hurwitz, J., ATP-dependent assembly of double hexamers of SV40 T antigen at the viral origin of DNA replication. Nature (London) 38 (1989), 658–662.
280. Matsumoto, L.H., Enrichment of satellite DNA on the nuclear matrix of bovine cells. Nature (London) 294 (1981), 481–482.
281. McCready, S.J., Cook, P.R., Lesions induced in DNA by ultraviolet light are repaired at the nuclear cage. J. Cell Sci. 70 (1984), 189–196.
282. McCready, S.J., Godwin, J., Mason, D.W., Brazell, I.A., Cook, P.R., DNA is replicated at the nuclear cage. J. Cell Sci. 46 (1980), 365–386.
283. McKeon, F.D., Kirschner, M.W., Caput, D., Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins. Nature (London) 319 (1986), 463–468.
284. McKnight, R.A., Shamay, A., Sankaran, L., Wall, R.J., Henninghausen, L., Matrix-attachment regions can impart position-independent regulation of a tissue-specific gene in transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 89 (1992), 6943–6947.
285. McNamara, P.T., Bolshoy, A., Trifonov, E.N., Harrington, R.E., Sequence-dependent kinks induced in curved DNA. J. Biomol. Struct. Dyn. 8 (1990), 529–538.
286. McPherson, C.E., Shim, E.Y., Friedman, D.S., Zaret, K.S., An active tissue-specific enhancer and bound transcription factor existing in a precisely positioned nucleosomal array. Cell (Cambridge, Mass.) 75 (1993), 387–398.
287. Metzger, D.A., Curtis, S., Korach, K.S., Dicthylstilbestrol metabolites and analogs: Differential ligand effects on estrogen receptor interactions with nuclear matrix sites. Endocrinology (Baltimore) 128 (1991), 1785–1791.
288. Mielke, C., Kohwi, Y., Kohwi-Shigematsu, T., Bode, J., Hierarchical binding of DNA fragments derived from scaffold-attached regions: Correlation of properties in vitro and function in vivo. Biochemistry 29 (1990), 7475–7485.
289. Miller, T.E., Huang, C.-Y., Pogo, A.O., Rat liver nuclear skeleton and ribonucleo-protein complexes containing HnRNA. J. Cell Biol. 76 (1978), 675–691.
290. Milner, A.E., Gordon, D.J., Turner, B.M., Vaughan, A.T.M., A correlation between DNA-nuclear matrix binding and relative radiosensitivity in two human squamous cell carcinoma cell lines. Int. J. Radiat. Res. 63 (1993), 13–20.
291. Mirkovitch, J., Mirault, M.-E., Laemmli, U.K., Organization of the higher-order chromatin loop: Specific DNA attachment sites on nuclear scaffold. Cell (Cambridge, Mass.) 39 (1984), 223–232.
292. Mirkovitch, J., Spierer, P., Laemmli, U.K., Genes and loops in 320,000 base-pairs of the Drosophila melanogaster chromosome. J. Mol. Biol. 190 (1986), 255–258.
293. Mirkovitch, J., Gasser, S.M., Laemmli, U.K., Relation of chromosome structure and gene expression. Philos. Trans. R. Soc. London, Ser. B 317 (1987), 563–574.
294. Mirkovitch, J., Gasser, S.M., Laemmli, U.K., Scaffold attachment of DNA loops in metaphase chromosomes. J. Mol. Biol. 200 (1988), 101–109.
295. Mirzayan, C, Copeland, C.S., Snyder, M., The NUF1 gene encodes an essential coiled-coil related protein that is a potential component of the yeast nucleoskeleton. J. Cell Biol. 116 (1992), 1319–1332.
296. Moreau, J., Marcaud, L., Maschat, F., Kejzlarova-Lepesant, J., Lepesant, J.-A., Scherrer, K., A + T-rich linkers define functional domains in eukaryotic DNA. Nature (London) 295 (1982), 260–262.
297. Mukherjee, S., Patel, I., Bastia, D., Conformational changes in a replication origin induced by an initiator protein. Cell (Cambridge, Mass.) 43 (1985), 189–197.
298. Mullenders, L.H.F., van Zeeland, A.A., Natarajan, A.T., Analysis of the distribution of DNA repair patches in the DNA-nuclear matrix complex from human cells. Biochim. Biophys. Acta 740 (1983), 428–435.
299. Mullenders, L.H.F., van Kasteran-van Leeuwen, A.C., van Zeeland, A.A., Natarajan, A.T., Nuclear matrix associated DNA is preferentially repaired in normal human fibroblasts, exposed to a low dose of ultraviolet light but not in Cockayne's syndrome fibroblasts. Nucleic Acids Res. 16 (1988), 10607–10623.
300. Müller, H.-P., Sogo, J.M., Schaffner, W., An enhancer stimulates transcription in trans when attached to the promoter via a protein bridge. Cell (Cambridge, Mass.) 58 (1989), 767–777.
301. Müller, W.E.G., Okamoto, T., Reuter, P., Ugarkovic, D., Schröder, H.C., Functional characterization of Tat protein from human immunodeficiency virus. Evidence that Tat links viral RNAs to nuclear matrix. J. Biol. Chem. 265 (1990), 3803–3808.
302. Murakami, Y., Satake, M., Yamaguchi-Iwai, Y., Sakai, M., Maramatsu, M., Ito, Y., The nuclear protooncogenes c-jun and c-fos as regulators of DNA replication. Proc. Natl. Acad. Sci. U.S.A. 88 (1991), 3947–3951.
303. Nagagomi, K., Kohwi, Y., Dickinson, L.A., Kohwi-Shigematsu, T., A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1. Mol. Cell. Biol. 14 (1994), 1852–1860.
304. Nakayasu, H., Ueda, K., Preferential association of acidic actin with nuclei and nuclear matrix from mouse leukemia L5178Y cells. Exp. Cell Res. 163 (1986), 327–336.
305. Naylor, L.H., Lilley, D.M.J., van de Sande, J.H., Stress-induced cruciform formation in a cloned d(CATG)10 sequence. EMBO J. 5 (1986), 2407–2413.
306. Nejedly, K., Kwinkowski, M., Galazka, G., Klysik, J., Palecek, E., Recognition of the structural distortions at the junctions between B and Z segments in negatively supercoiled DNA by osmium tetroxide. J. Biomol. Struct. Dyn. 3 (1985), 467–478.
307. Neuer-Nitsche, B., Lu, X., Werner, D., Functional role of a highly repetitive DNA sequence in anchorage of the mouse genome. Nucleic Acids Res. 16 (1988), 8351–8360.
308. Nishizawa, M., Tanabe, K., Takahashi, T., DNA polymerases and DNA topoisomerases solubilized from nuclear matrices of regenerating rat livers. Biochem. Biophys. Res. Commun. 124 (1984), 917–924.
309. Obi, F.O., Billett, M.A., Preferential binding of the carcinogen benzo[a]pyrene to proteins of the nuclear matrix. Carcinogenesis (London) 12 (1991), 481–486.
310. F.O. Obi A.J. Ryan M.A. Billett (1986). Preferential binding of the carcinogen benzo[a]pyrene to DNA in active chromatin and the nuclear matrix. Carcinogenesis (London) 907–913.
311. O'Neill, E.A., Fletcher, C., Burrow, C.R., Heintz, N., Roeder, R.G., Kelly, T.J., Transcription factor OTF-1 is functionally identical to the DNA replication factor NF-III. Science 241 (1988), 1210–1213.
312. Paz, M., Osman, M., Landesman, Y., Fainsod, A., Gruenbaum, Y., Molecular analysis of the Drosophila nuclear lamin gene. Genomics 8 (1990), 217–224.
313. Panayotatos, N., Wells, R.D., Cruciform structures in supercoiled DNA. Nature (London) 289 (1981), 466–470.
314. Pardoll, D.M., Vogelstein, B., Sequence analysis of nuclear matrix associated DNA from rat liver. Exp. Cell Res. 128 (1980), 466–470.
315. Pardoll, D.M., Vogelstein, B., Coffey, D.S., A fixed site of DNA replication in eucaryotic cells. Cell (Cambridge, Mass.) 19 (1980), 527–536.
316. Parsons, R., Anderson, M.E., Tegtmeyer, P., Three domains in the simian virus 40 core origin orchestrate the binding, melting and DNA helicase activities of T antigen. J. Virol. 64 (1990), 509–518.
317. Parvari, R., Ziv, E., Lantner, F., Heller, D., Schechter, I., Somatic diversification of chicken immunoglobulin light chains by point mutations. Proc. Natl. Acad. Sci. U.S.A. 87 (1990), 3072–3076.
318. Paul, A.-N., Ferl, R.J., Osmium tetroxide footprinting of a scaffold attachment region in the maize Adh1 promoter. Plant Mol. Biol. 22 (1993), 1145–1151.
319. Paulson, J.R., Laemmli, U.K., The structure of histone-depleted metaphase chromosomes. Cell (Cambridge, Mass.) 12 (1977), 817–828.
320. Pearson, C.E., Ruiz, M.T., Price, G.B., Zannis-Hadjopoulos, M., Cruciform DNA-binding protein in HeLa cell extracts. Biochemistry 33 (1994), 14185–14196.
321. Pearson, C.E., Zannis-Hadjopoulos, M., Price, G.B., Zorbas, H., A novel type of interaction between cruciform DNA and a cruciform binding protein from HeLa cells. EMBO J 14 (1995), 1571–1580.
322. Igo-Kemenes, M., Pech, T., Zachau, H.G., Nucleotide sequence of a highly repetitive component of rat DNA. Nucleic Acids. Res. 7 (1979), 417–432.
323. Peterson, C.L., Orth, K., Calame, K.L., Binding in vitro of multiple cellular proteins to immunoglobulin heavy-chain enhancer DNA. Mol. Cell Biol. 6 (1986), 4168–4178.
324. Phi-Van, L., Strätling, W.H., The matrix attachment regions of the chicken lysozyme gene co-map with the boundaries of the chromatin domain. EMBO J. 7 (1988), 655–664.
325. Phi-Van, L., von Kries, J.P., Ostertag, W., Strätling, W.H., The chicken lysozyme 5′ matrix attachment region increases transcription from a heterologous promoter in heterologous cells and dampens position effects on the expression of transfected genes. Mol. Cell. Biol. 10 (1990), 2302–2307.
326. Pienta, K.J., Ward, W.S., An unstable nuclear matrix may contribute to genetic instability. Med. Hypotheses 42 (1994), 45–52.
327. Pienta, K.J., Getzenberg, R.H., Coffey, D.S., Cell structure and DNA organization. CRC Crit. Rev. Eukaryotic Gene Express. 1 (1991), 355–385.
328. Poljak, L., Seum, C., Mattioni, T., Laemmli, U.K., SARs stimulate but do not confer position independent gene expression. Nucleic Acids Res. 22 (1994), 4386–4394.
329. Pommier, Y., Cockerill, P.N., Kohn, K.W., Garrard, W.T., Identification within the simian virus 40 genome of a chromosomal loop attachment site that contains topoisomerase II cleavage sites. J. Virol. 64 (1990), 419–423.
330. Postnikov, Y.V., Shick, V.V., Belyavsky, A.V., Khrapko, K.R., Brodolin, K.L., Nikolskaya, T.A., Mirzabekov, A.D., Distribution of high mobility group proteins 1/2E and 14/17 and linker histones H1 and H5 on transcribed and non-transcribed regions of chicken erythrocyte chromatin. Nucleic Acids Res. 19 (1991), 717–725.
331. Pruijn, G.J.M., van Driel, W., van der Vliet, P.C., Nuclear factor III, a novel sequence-specific DNA-binding protein from HeLa cells stimulating adenovirus DNA replication. Nature (London) 322 (1986), 656–659.
332. Ptashne, M., How eukaryotic transcriptional activators work. Nature (London) 335 (1988), 683–689.
333. Ptashne, M., Gann, A.A.F., Activators and targets. Nature (London) 346 (1990), 329–331.
334. Rao, B.S., Zannis-Hadjopoulos, M., Price, G.B., Reitman, M., Martin, R.G., Sequence similarities among monkey ori-enriched (ors) fragments. Gene 87 (1990), 233–242.
335. Razin, S.V., Mantieva, V.L., Georgiev, G.P., DNA adjacent to attachment points of deoxyribonucleoprotein fibril to chromosomal axial structure is enriched in reiterated base sequences. Nucleic Acids Res. 5 (1978), 4737–4751.
336. Razin, S.V., Kekelidze, M.G., Lukanidin, E.M., Scherrer, K., Georgiev, G.P., Replication origins are attached to the nuclear skeleton. Nucleic Acids Res. 14 (1986), 8189–8207.
337. Razin, S.V., Vassetzky, Y.S., Hancock, R., Nuclear matrix attachment regions and topoisomerase II binding and reaction sites in the vicinity of a chicken DNA replication origin. Biochem. Biophys. Res. Commun. 177 (1991), 265–270.
338. Razin, S.V., Petrov, P., Hancock, R., Precise localization of the α-globin gene cluster within one of the 20- to 300-kilobase DNA fragments released by cleavage of chicken chromosomal DNA at topoisomerase II sites in vivo: Evidence that the fragments are DNA loops or domains. Proc. Natl. Acad. Sci. U.S.A. 88 (1991), 8515–8519.
339. Reeves, R., Nissen, M.S., The AT-DNA-binding domain of mammalian high mobility group I chromosomal proteins: A novel peptide motif for recognizing DNA structure. J. Biol. Chem. 265 (1990), 8573–8582.
340. Reeves, R., Langan, T.A., Nissen, M.S., Phosphorylation of the DNA-binding domain of nonhistone high-mobility group I protein by cdc2 kinase: Reduction of binding affinity. Proc. Natl. Acad. Sci. U.S.A. 88 (1991), 1671–1675.
341. Robinson, S.I., Nelkin, B.D., Vogelstein, B., The ovalbumin gene is associated with the nuclear matrix of chicken oviduct cells. Cell (Cambridge, Mass.) 28 (1982), 99–106.
342. Romig, H., Fackelmayer, F.O., Renz, A., Ramsperger, U., Richter, A., Characterization of SAF-A, a novel nuclear DNA binding protein from HeLa cells with high affinity for nuclear matrix/scaffold attachment DNA elements. EMBO J. 11 (1992), 3431–3440.
343. Romig, H., Ruff, J., Fackelmayer, F.O., Patil, M.S., Richter, A., Characterization of two intronic nuclear-matrix-attachment regions in the human DNA topoisomerase I gene. Eur. J. Biochem. 221 (1994), 411–419.
344. Ross, W., Shulman, M., Landy, A., Biochemical analysis of att-defective mutants of the phage lambda site-specific recombination system. J. Mol. Biol. 156 (1982), 505–529.
345. Roth, S.Y., Dean, A., Simpson, R.T., Yeast a2 repressor positions nucleosomes in TRP1/ARS1 chromatin. Mol. Cell. Biol. 10 (1990), 2247–2260.
346. Russev, G., Boulikas, T., Repair of transcriptionally active and inactive genes during S and G2 phases of the cell cycle. Eur. J. Biochem. 204 (1992), 267–272.
347. Ryder, K., Silver, S., DeLucia, A.L., Fanning, E., Tegtmeyer, P., An altered DNA conformation in origin region I is a determinant for the binding of SV40 large T antigen. Cell (Cambridge, Mass.) 44 (1986), 719–725.
348. Saigo, K., Yaginuma, K., Hayashi, H., Isono, K., Takada, S., Koike, K., Enhanced expression of c-myc gene and binding protein to the 2.3 kb upstream region of the P1 promoter in human liver and colon cancers. Int. J. Oncol. 5 (1994), 1099–1104.
349. Saragosti, S., Moyne, G., Yaniv, M., Absence of nucleosomes in a fraction of SV40 chromatin between the origin of replication and the region coding for the late leader RNA. Cell (Cambridge, Mass.) 20 (1980), 65–73.
350. Schaack, J., Ho, W.Y.-W., Freimuth, P., Shenk, T., Adenovirus terminal protein mediates both nuclear matrix association and efficient transcription of adenovirus DNA. Genes Dev. 4 (1990), 1197–1208.
351. Scheuermann, R.H., Chen, U., A developmental-specific factor binds to suppressor sites flanking the immunoglobulin heavy-chain enhancer. Genes Dev. 3 (1989), 1255–1266.
352. Schirmbeck, R., Deppert, W., Specific interaction of simian virus 40 large T antigen with cellular chromatin and nuclear matrix during the course of infection. J. Virol. 61 (1987), 3561–3569.
353. Schirmbeck, R., Deppert, W., Nuclear subcompartmentalization of simian virus 40 large T antigen: Evidence for in vitro regulation of biochemical activities. J. Virol. 63 (1989), 2308–2316.
354. Schirmbeck, R., Deppert, W., Structural topography of simian virus 40 DNA replication. J. Virology, 65, 1991, 2588.
355. Schnos, M., Zahn, K., Inman, R.B., Blattner, F.R., Initiation protein induced helix destabilization at the 1 origin: A prepriming step in DNA replication. Cell (Cambridge, Mass.) 52 (1988), 385–395.
356. Schnos, M., Zahn, K., Blattner, F.R., Inman, R.B., DNA looping induced by bacteriophage I O protein: Implications for formation of higher order structures at the origin of replication. Virology 168 (1989), 370–377.
357. Schuchard, M., Subramaniam, M., Ruesink, T., Spelsberg, T.C., Nuclear matrix localization and specific matrix DNA binding by receptor binding factor I of the avian oviduct progesterone receptor. Biochemistry 30 (1991), 9516–9522.
358. Scott, M.P., Tamkun, J.W., Hartzell, G.W., The structure and function of the homeodomain. Biochim. Biophys. Acta 989 (1989), 25–48.
359. Shpigelman, E.S., Trifonov, E.N., Bolshoy, A., Curvature: Software for the analysis of curved DNA. Comput. Appl. Biosci. 9 (1993), 435–440.
360. Shrader, T.E., Crothers, D.M., Artificial nucleosome positioning sequences. Proc. Natl. Acad. Sci. U.S.A. 86 (1989), 7418–7422.
361. Slatter, R.E., Dupree, P., Gray, G., A scaffold-associated region is located downstream of the pea plastocyanin gene. Plant Cell 3 (1991), 1239–1250.
362. Small, D., Vogelstein, B., The anatomy of supercoiled loops in the Drosophila 7F locus. Nucleic Acids Res. 13 (1985), 7704–7713.
363. Small, D., Nelkin, B., Vogelstein, B., Nonrandom distribution of repeated DNA sequences with respect to supercoiled loops and the nuclear matrix. Proc. Natl. Acad. Sci. U.S.A. 70 (1982), 5911–5915.
364. Small, D., Nelkin, B., Vogelstein, B., The association of transcribed genes with the nuclear matrix of Drosophila cells during heat shock. Nucleic Acids Res. 13 (1985), 2413–2431.
365. Smith, H.C., Berezney, R., DNA polymerase α is tightly bound to the nuclear matrix of actively replicating liver. Biochem. Biophys. Res. Commun. 97 (1980), 1541–1547.
366. Smith, H.C., Berezney, R., Nuclear matrix-bound deoxyribonucleic acid synthesis: An in vitro system. Biochemistry 21 (1982), 6751–6761.
367. Smith, H.C., Berezney, R., Dynamic domains of DNA polymerase α in regenerating rat liver. Biochemistry 22 (1983), 3042–3046.
368. Smith, H.C., Puvion, E., Buchholtz, L.A., Berezney, R., Spatial distribution of DNA loop attachment and replicational sites in the nuclear matrix. J. Cell Biol. 99 (1984), 1794–1802.
369. Smith, H.C., Ochs, R.L., Lin, D., Chinault, A.C., Ultrastructural and biochemical comparisons of nuclear matrices prepared by high salt or LIS extraction. Mol. Cell. Biol. 77 (1987), 49–61.
370. Snyder, M., Buchman, A.R., Davis, R.W., Bent DNA at a yeast autonomously replicating sequence. Nature (London) 324 (1986), 87–89.
371. Sohn, J., Gerstein, R.M., Hsieh, C., Lerner, M., Selsing, E., Somatic hypermutation of an immunoglobulin heavy chain transgene. J. Exp. Med. 77 (1993), 493–504.
372. Sperry, A.O., Blasquez, V.C., Garrard, W.T., Dysfunction of chromosomal loop attachment sites: Illegitimate recombination linked to matrix association regions and topoisomerase II. Proc. Natl. Acad. Sci. U.S.A. 86 (1989), 5497–5501.
373. Spradling, A., Orr-Weaver, T., Regulation of DNA replication during Drosophila development. Annu. Rev. Genet. 21 (1987), 373–403.
374. Stein, G.S., Lian, J.B., Dworetzky, S.I., Owen, T.A., Bortell, R., Bidwell, J.P., van Wijnen, A.J., Regulation of transcription-factor activity during growth and differentiation: Involvement of the nuclear matrix in concentration and localization of promoter binding proteins. J. Cell. Biochem. 47 (1991), 300–305.
375. Stief, A., Winter, D.M., Strätling, W.H., Sippel, A.E., A nuclear DNA attachment element mediates elevated and position-independent gene activity. Nature (London) 341 (1989), 343–345.
376. Stuurman, N., Floore, A., Colen, A., de Jong, L., van Driel, R., Stabilization of the nuclear matrix by disulfide bridges: Identification of matrix polypeptides that form disulfides. Exp. Cell Res. 200 (1992), 285–294.
377. Sun, J.-M., Chen, H.Y., Davie, J.R., Nuclear factor 1 is a component of the nuclear matrix. J. Cell. Biochem. 55 (1994), 252–263.
378. Sung, P., Prakash, L., Matson, S.W., Prakash, S., RAD3 protein of Saccharomyces cerevisiae is a DNA helicase. Proc. Natl. Acad. Sci. U.S.A. 84 (1987), 8951–8955.
379. Surdej, P., Got, C., Rosset, R., Miassod, R., Supragenic loop organization: Mapping in Drosophila embryos, of scaffold-associated regions on a 800 kilobase DNA continuum cloned from the 14B–15B first chromosome region. Nucleic Acids Res. 18 (1990), 3713–3722.
380. Swaneck, G.E., Fishman, J., Covalent binding of the endogenous estrogen 16α- hydroxyestrone to estradiol receptor in human breast cancer cells: Characterization and intranuclear localization. Proc. Natl. Acad. Sci. U.S.A. 85 (1988), 7831–7835.
381. Sykes, R.C., Lin, D., Hwang, S.J., Framson, P.E., Chinault, A.C., Yeast ARS function and nuclear matrix association coincide in a short sequence from the human HPRT locus. Mol. Gen. Genet. 212 (1988), 301–309.
382. Taira, T., Iguchi-Ariga, S.M.M., Ariga, H., A novel DNA replication origin identified in the human heat shock protein 70 gene promoter. Mol. Cell. Biol. 14 (1994), 6386–6397.
383. Takai, T., Nishita, Y., Iguchi-Ariga, S.M.M., Ariga, H., Molecular cloning of MSSP-2, a c-myc gene single-strand binding protein: Characterization of binding specificity and DNA replication activity. Nucleic Acids Res. 22 (1994), 5576–5581.
384. Takeda, S., Zou, Y.-R., Bluethmann, H., Kitamura, D., Muller, U., Rajewsky, K., Deletion of the immunoglobulin k chain intron enhancer abolishes k chain gene rearrangement in cis but not λ chain gene rearrangement in trans. EMBO J 12 (1993), 2329–2336.
385. Tartier, L., Michalik, V., Spotheim-Maurizot, M., Rahmouni, A.R., Sabatter, R., Charlier, M., Radiolytic signature of Z-DNA. Nucleic Acids Res. 22 (1994), 5565–5570.
386. Tasheva, E.S., Roufa, D.J., Densely methylated DNA islands in mammalian chromosomal replication origins. Mol. Cell. Biol. 14 (1994), 5636–5644.
387. Tawfic, S., Ahmed, K., Growth stimulus-mediated differential translocation of casein kinase 2 to the nuclear matrix. Evidence based on androgen action in the prostate. J. Biol. Chem. 269 (1994), 24615–24620.
388. Teschke, C., Solleder, G., Moritz, K.B., The highly variable pentameric repeats of the AT-rich germline limited DNA in Parascaris univalens are the telomeric repeats of somatic chromosomes. Nucleic Acids Res. 19 (1991), 2677–2684.
389. Tew, K.D., Wang, A.L., Schein, P.S., Alkylating agent interactions with the nuclear matrix. Biochem. Pharmacol. 32 (1983), 3509–3516.
390. Thanos, D., Maniatis, T., The high mobility group protein HMGI(Y) is required for NF-kB-dependent virus induction of the human IFN-b gene. Cell (Cambridge, Mass.) 71 (1992), 777–789.
391. Thoma, F., Nucleosome positioning. Biochim. Biophys. Acta 1130 (1992), 1–19.
392. Thoma, F., Koller, T., Klug, A., Involvement of histone H1 in the organization of the nucleosome and of the salt-dependent superstructures of chromatin. J. Cell Biol. 83 (1979), 403–427.
393. Thompson, E.M., Christians, E., Stinnakre, M.G., Renard, J.P., Scaffold attachment regions stimulate HSP70.1 expression in mouse preimplantation embryos but not in differentiated tissues. Mol. Cell. Biol. 14 (1994), 4694–4703.
394. Thukral, S.K., Blain, G.C., Chang, K.K.H., Fields, S., Distinct residues of human p53 implicated in binding to DNA simian virus 40 large T antigen, 53BP1, and 53BP2. Mol. Cell. Biol. 14 (1994), 8315–8321.
395. Todd, A., Landry, S., Pearson, C.E., Khoury, V., Zannis-Hadjopoulos, M., Deletion analysis of minimal sequence requirements for autonomous replication of ors8, a monkey early-replicating DNA sequence. J. Cell. Biochem. 57 (1995), 280–289.
396. Travers, A.A., DNA bending and nucleosome positioning. Trends Biochem. Sci. 12 (1987), 108–112.
397. Trifonov, E.N., Sequence-dependent deformational anistropy of chromatin DNA. Nucleic Acids Res. 8 (1980), 4041–4053.
398. Trifonov, E.N., Curved DNA. CRC Crit. Rev. Biochem. 19 (1986), 89–106.
399. Trifonov, E.N., The multiple codes of nucleotide sequences. Bull. Math. Biol. 51 (1989), 417–432.
400. Trifonov, E.N., DNA in profile. Trends Biochem. Sci. 16 (1991), 467–470.
401. Trifonov, E.N., Brendel, V., “Gnomic: A Dictionary of Genetic Codes”, 1987, Springer-Verlag, Berlin.
402. Trifonov, E.N., Sussman, J.J., The pitch of chromatin DNA is reflected in its nucleotide sequence. Proc. Natl. Acad. Sci. U.S.A. 77 (1980), 3816–3820.
403. Tsurimoto, T., Stillman, B., Multiple replication factors augment DNA synthesis by the two eukaryotic DNA polymerases, α and δ. EMBO J. 8 (1989), 3883–3889.
404. Tsutsui, K., Tsutsui, K., Muller, M.T., The nuclear scaffold exhibits DNA-binding sites selective for supercoiled DNA. J. Biol. Chem. 263 (1988), 7235–7241.
405. Tsutsui, K., Tsutsui, K., Okada, S., Watarai, S., Seki, S., Yasuda, T., Shohmori, T., Identification and characterization of a nuclear scaffold protein that binds the matrix attachment region DNA. J. Biol. Chem. 268 (1993), 12886–12894.
406. Umek, R.M., Kowalsky, D., The ease of DNA unwinding as a determinant of initiation at yeast replication origins. Cell (Cambridge, Mass.) 52 (1988), 559–567.
407. Umthun, A.R., Hou, Z., Sibenaller, Z.A., Shaiu, W.-L., Dobbs, D.L., Identification of DNA-binding proteins that recognize a conserved type I repeat sequence in the replication origin region of Tetrahymena rDNA. Nucleic Acids Res. 22 (1994), 4432–4440.
408. Valenzuela, M.S., Mueller, G.C., Dasgupta, S., Nuclear matrix-DNA complex resulting from EcoR1 digestion of HeLa nucleoids is enriched for DNA replicating forks. Nucleic Acids Res. 11 (1983), 2155–2164.
409. van Belkum, A., Blommers, M.J.J., van den Elst, H., van Boom, J.H., Hilbers, C.W., Biochemical and biophysical studies on the folding of the core region of the origin of replication of bacteriophage M13. Nucleic Acids Res. 18 (1990), 4703–4710.
410. van Driel, R., Humbel, B., de Jong, L., The nucleus: A black box being opened. J. Cell. Biochem. 47 (1991), 311–316.
411. van Steensel, B., van Haarst, A.D., de Kloet, E., van Driel, R., Binding of corticosteroid receptors to rat hippocampus nuclear matrix. FEBS Lett. 292 (1991), 229–231.
412. van Wijnen, A.J., Fey, J.P., Bidwell, E.G., Penman, S., Lian, J.B., Stein, J.L., Stein, G.S., Nuclear matrix association of multiple sequence-specific DNA binding activities related to SP-1, ATF, CCAAT, C/EBP, OCT-1, and AP-1. Biochemistry 32 (1993), 8397–8402.
413. Varshavsky, A.J., Sundin, O., Bohn, M., A stretch of “late” SV40 viral DNA about 400 bp long which includes the origin of replication is specifically exposed in SV40 minichromosomes. Cell (Cambridge, Mass.) 16 (1979), 453–466.
414. Vaughn, J.P., Dijkwel, P.A., Mullenders, L.H.F., Hamlin, J.L., Replication forks are associated with the nuclear matrix. Nucleic Acids Res. 18 (1990), 1965–1969.
415. Vazquez, J., Schedl, P., Sequences required for enhancer blocking activity of scs are located within two nuclease-hypersensitive regions. EMBO J. 13 (1994), 5984–5993.
416. Venter, U., Svaren, J., Schmitz, J., Schmid, A., Horz, W., A nucleosome precludes binding of the transcription factor Pho4 in vivo to a critical target site in the PH05 promoter. EMBO J. 13 (1994), 4848–4855.
417. Verheijen, R., van Venrooij, W., Ramaekers, F., The nuclear matrix: Structure and composition. J. Cell Sci. 90 (1988), 11–36.
418. Verheijen, R., Kuijpers, H.J.H., Schlingemann, R.O., Boehmer, A.L.M., van Driel, R., Brakenhoff, G.J., Ramaekers, F.C.S., Ki-67 detects a nuclear matrix-associated proliferation-related antigen. J. Cell Sci. 92 (1989), 123–130.
419. Virta-Pearlman, V.J., Gunaratne, P.H., Chinault, A.C., Analysis of a replication initiation sequence from the adenosine deaminase region of the mouse genome. Mol. Cell. Biol. 13 (1993), 5931–5942.
420. von Kries, J.P., Buhrmester, H., Strätling, W.H., A matrix/scaffold attachment region binding protein: Identification, purification and mode of binding. Cell (Cambridge, Mass.) 64 (1991), 123–135.
421. Wagner, A.J., Kokontis, J.M., Hay, N., Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p2waf1/cip1. Genes Dev 8 (1994), 2817–2830.
422. Waitz, W., Loidl, P., Cell cycle dependent association of c-myc protein with the nuclear matrix. Oncogene 6 (1991), 29–35.
423. Wan, K.M., Nickerson, J.A., Krockmalnic, G., Penman, S., The B1C8 protein is in the dense assemblies of the nuclear matrix and relocates to the spindle and perinucleolar filaments at mitosis. Proc. Natl. Acad. Sci. U.S.A. 91 (1994), 594–598.
424. Wang, Z.-Y., Lin, X.-H., Nobuyoshi, M., Deuel, T.F., Identification of a single-stranded DNA-binding protein that interacts with an S1 nuclease-sensitive region in the platelet-derived growth factor A-chain gene promoter. J. Biol. Chem. 268 (1993), 10681–10685.
425. Ward, G.K., McKenzie, R., Zannis-Hadjopoulos, M., Price, G.B., The dynamic distribution and quantification of DNA cruciforms in eukaryotic nuclei. Exp. Cell Res. 188 (1990), 235–246.
426. Ward, G.K., Shihab-el-Deen, A., Zannis-Hadjopoulos, M., Price, G.B., DNA cruciforms and the nuclear supporting structure. Exp. Cell Res. 195 (1991), 92–98.
427. Warters, R.L., Childers, T.J., Radiation-induced thymine base damage in replicating chromatin. Radiat. Res. 90 (1982), 564–574.
428. Wasylyk, C., Wasylyk, B., The immunoglobulin heavy-chain B-lymphocyte enhancer efficiently stimulates transcription in non-lymphoid cells. EMBO J. 5 (1986), 553–560.
429. Webb, C.F., Das, C., Eneff, K.L., Tucker, P.W., Identification of a matrix-associated region 5′ of an immunoglobulin heavy chain variable region gene. Mol. Cell. Biol. 11 (1991), 5206–5211.
430. Wegner, M., Zastrow, G., Klavinius, A., Schwender, S., Muller, F., Luksza, H., Hoppe, J., Wienberg, J., Grummt, F., Cis-acting sequences from mouse rDNA promote plasmid DNA amplification and persistence in mouse cells: Implication of HMG-I in their function. Nucleic Acids Res. 17 (1989), 9909–9932.
431. Weintraub, H., Larsen, A., Groudine, M., α-globin-gene switching during the development of chicken embryos: Expression and chromosome structure. Cell (Cambridge, Mass.) 24 (1981), 333–344.
432. Whitehurst, C., Henney, H.R., Max, E.E., Schroeder, H.W. Jr., Stüber, F., Siminovitch, K.A., Garrard, W.T., Nucleotide sequence of the intron of the germline human k immunoglobulin gene connecting the J and C regions reveals a matrix association region (MAR) next to the enhancer. Nucleic Acids Res. 20 (1992), 4929–4930.
433. Wittig, B., Wölfl, S., Dorbic, T., Vahrson, W., Rich, A., Transcription of human c-myc in permeabilized nuclei is associated with formation of Z-DNA in three discrete regions of the gene. EMBO J. 11 (1992), 4653–4663.
434. Wu, C., Zannis-Hadjopoulos, M., Price, G.B., In vivo activity for initiation of DNA replication resides in a transcribed region of the human genome. Biochim. Biophys. Acta 1174 (1993), 258–266.
435. Wu, H.-M., Crothers, D.M., The locus of sequence-directed and protein-induced DNA bending. Nature (London) 308 (1984), 509–513.
436. L. Xie T. Boulikas (1995). A potential replication initiator protein interacts with one strand of a cruciform within the putative origin of replication/MAR/enhancer of the human choline acetyltransferase gene. In preparation.
437. Xu, J., Manning, F.C.R., Patierno, S.R., Preferential formation and repair of chromium-induced DNA adducts and DNA-protein crosslinks in nuclear matrix DNA. Carcinogenesis 15 (1994), 1443–1450.
438. Xu, M., Hammer, R.E., Blasquez, V.C., Jones, S.L., Garrard, W.T., Immunoglobulin k gene expression after stable integration. II. Role of the intronic MAR and enhancer in transgenic mice. J. Biol. Chem. 264 (1989), 21190–21195.
439. Yalkinoglu, A.O., Zentgraf, H., Hübscher, U., Origin of adeno-associated virus DNA replication is a target of carcinogen-inducible DNA amplification. J. Virol. 65 (1991), 3175–3184.
440. Yamamoto, T., Takahashi, T., Matsukage, A., Tight association of DNA polymerase α with granular structures in the nuclear matrix of chick embryo cell: Immunocytochemical detection with monoclonal antibody against DNA polymerase α. Cell Struct. Funct. 9 (1984), 83–90.
441. Yee, H.A., Wong, A.K.C., van de Sande, J.H., Rattner, J.B., Identification of novel single-stranded d(TC)n binding proteins in several mammalian species. Nucleic Acids Res. 19 (1991), 949–953.
442. Yuan, J., Simos, G., Blobel, G., Georgatos, S.D., Binding of lamin A to polynucleosomes. J. Biol. Chem. 266 (1991), 9211–9215.
443. Zahn, K., Blattner, F.R., Sequence-induced DNA curvature at the bacteriophage λ origin of replication. Nature (London) 317 (1985), 451–453.
444. Zahn, K., Blattner, F.R., Direct evidence for DNA bending at the lambda replication origin. Science 236 (1987), 416–422.
445. Zannis-Hadjopoulos, M., Frappier, L., Khoury, M., Price, G.B., Effect of anti-cruciform DNA monoclonal antibodies on DNA replication. EMBO J. 7 (1988), 1837–1844.
446. Zeitlin, S., Parent, A., Silverstein, S., Efstratiadis, A., Pre-mRNA splicing and the nuclear matrix. Mol. Cell. Biol. 7 (1987), 111–120.
447. Zenk, D.W., Ginder, G.D., Brotherton, T.W., A nuclear matrix protein binds very tightly to DNA in the avian β-globin gene enhancer. Biochemistry 29 (1990), 5221–5226.
448. Zhao, K., Käs, E., Gonzalez, E., Laemmli, U.K., SAR-dependent mobilization of histone H1 by HMG-I/Y in vitro: HMG-I/Y is enriched in H1-depleted chromatin. EMBO J. 12 (1993), 3237–3247.
449. Zhao, Y., Tsutsumi, R., Yamaki, M., Nagatsuka, Y., Ejiri, S., Tsutsumi, K., Initiation zone of DNA replication at the aldolase B locus encompasses transcription promoter region. Nucleic Acids Res. 22 (1994), 5385–5390.