PPAR: a mediator of peroxisome proliferator action

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 333, Issue 1-2, 1995, Pages 101-109

  Green, Stephen ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Non genotoxic carcinogen; Nuclear receptor; Peroxisome proliferator; PPAR

Indexed keywords

ANTILIPEMIC AGENT; CARCINOGEN; CELL NUCLEUS RECEPTOR; CLOFIBRATE; FATTY ACID; PEROXISOME PROLIFERATOR RECEPTOR; PIRINIXIC ACID; UNCLASSIFIED DRUG;

CARCINOGENESIS; CONFERENCE PAPER; CONTROLLED STUDY; LIVER CANCER; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; RAT;

ANIMALS; ANTILIPEMIC AGENTS; CARCINOGENS; FATTY ACIDS; HUMANS; LIVER NEOPLASMS; MICE; MICROBODIES; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SPECIES SPECIFICITY; TRANSCRIPTION FACTORS;

EID: 0029609755     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/0027-5107(95)00136-0     Document Type: Article

References (65)

1. Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis
2. PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene
3. Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin
4. The ontogeny of peroxisome proliferator activated receptor gene expression in the mouse and rat
5. Calcium as a permissive factor but not an initiation factor in DNA synthesis induction in cultured rat hepatocytes by the peroxisome proliferator ciprofibrate
6. Influence of fenofibrate on cellular and subcellular liver structure in hyperlipidemic patients
7. Peroxisomal proliferaotrs inhibit acyl CoA synthetase and stimulate protein kinase C in vivo
8. RXRa a promiscuous partner of retinoic acid and thyroid hormone receptors
9. Interaction of LY171883 and other peroxisome proliferators with fatty acid binding protein isolated from rat liver
10. Differences between the promoting activities of the peroxisome proliferator WY-14643 and phenobarbital in rat liver
11. Failure of the peroxisome proliferator Wy-14643 to initiate growth-selectable foci in rat liver
12. Age-related susceptibility to the carcinogenic effect of the peroxisome proliferator Wy-14643 in rat liver
13. Identification of two mPPAR related receptors and evidence for the existence of five subfamily members
14. Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors
15. Hepatic peroxisomal changes induced by a tetrazole-substituted alkoxyacetophenone in rats and comparison with other species
16. Peroxisome proliferation due to di(2-ethylhexyl) phthalate (DEHP) species differences and possible mechanisms
17. The steroid and thyroid hormone receptor superfamily
18. Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor.
19. Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid)
20. Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.
21. Nuclear receptors enhance our understanding of transcription regulation
22. Relationship between morphological changes and lipid lowering action of p-chlorophenoxyisobutyric acid (CPIB) on hepatic mitochondria and peroxisomes in man
23. Isolation complementary DNA sequence, and regulation of rat hepatic lauric acid omega-hydroxylase (cytochrome P-450LA omega) Identification of a new cytochrome P-450 gene family
24. Nature of the hepatomegalic effect produced by ethylchlorophenoxy-isobutyrate in the rat
25. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
26. Cloning of novel members of the steroid hormone receptor superfamily
27. The peroxisome proliferator activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs
28. Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.
29. Retinoid X receptors interact with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling
30. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
31. Differential expression and activation of a family of murine peroxisome proliferator activated receptors
32. The carcinogenicity of dietary di(2-ethylhexyl) phthalate (DEHP) in Fischer 344 rats and B6C3F1 mice
33. Increased susceptibility of aged rats to hepatocarcinogenesis by the peroxisome proliferator nafenopin and the possible involvement of altered liver foci occurring spontaneously
34. Comparative studies on nafenopin induced hepatic peroxisome proliferation in the rat syrian hamster, guinea-pig and marmoset
35. A fatty acyl-CoA oxidizing system in rat liver peroxisomes: enhancement by clofibrate, a hypolipidemic drug
36. Targeted disruption of the alpha isoform of the peroxisome proliferator activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
37. Purification, cloning and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently
38. Biochemical mechanisms of induction of hepatic peroxisome proliferation
39. Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element
40. H-2RIIBP (RXR β) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes
41. Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl) phthalate and (4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio)acetic acid (Wy-14,643) in rats
42. Chicken ovalbumin upstream promoter transcription factor (COUP-TF) binds to a peroxisome proliferator responsive element and antagonises peroxisome proliferator mediated signaling
43. Peroxisome proliferation and nongenotoxic carcinogenesis: Commentary on a symposium*1
44. The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid ω-hydroxylase, by clofibric acid
45. Comparison of constitutive and inducible levels of expression of peroxisomal beta-oxidation and catalase genes in liver and extrahepatic tissues of rat
46. The effect of hypolipidemic agents on the hepatic microsomal drug-metabolizing enzyme system of the rat. Induction of cytochrome(s) P-450 with specificity toward terminal hydroxylation of lauric acid
47. Metabolic aspects of peroxisomal β-oxidation
48. Two cis-acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of the rat acyl CoA oxidase gene
49. Experimental studies on the toxicity of Atromid with particular reference to fine structural changes in the liver of rodents
50. Carcinogenesis by hepatic peroxisome proliferators: Evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans
51. Peroxisome proliferators and cancer: mechanisms and implications
52. Mitogenic and carcinogenic effects of a hypolipidemic peroxisome proliferator, (4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio)acetic acid (Wy-14,643), in rat and mouse liver
53. Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens
54. Transcription regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators
55. Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids
56. cDNA cloning chromosomal mapping and functional characterisation of the human peroxisome proliferator activated receptor
57. A species comparison of acute hyperplasia induced by the peroxisome proliferator methylclofenapate: involvement of the binucleated hepatocyte
58. The mouse peroxisome proliferator activated receptor recognises a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene
59. Determinants of target gene specificity for steroid/thyroid hormone receptors
60. 3 receptors
61. RXRb: a coregulator that enhances binding of retinoic acid thyroid hormone and vitamin D receptors to their cognate response elements
62. 3H)thymidine and Salmonella mutagenesis assays
63. Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase
64. Retinoid X receptor is an auxiallary protein for thyroid hormone and retinoic acid receptors
65. Cloning of a new member of the peroxisome proliferator activated receptor gene family from mouse liver