The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis

Journal of Pharmacology and Experimental Therapeutics

Volumn 275, Issue 2, 1995, Pages 1043-1049

  Cherwinski, H M ^a   Cohn, R G ^a   Cheung, P ^a   Webster, D J ^a   Xu, Y Z ^a   Caulfield, J P ^a   Young, J M ^a   Nakano, G ^a   Ransom, J T ^a  

^a Cadus Pharmaceutical Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREQUINAR; CELL ANTIGEN; CYCLINE; CYTIDINE; DIHYDROOROTATE DEHYDROGENASE; DIHYDROOROTIC ACID DERIVATIVE; DNA; IMMUNOSUPPRESSIVE AGENT; LEFLUNOMIDE; MITOGENIC AGENT; NUCLEAR PROTEIN; RNA; TERIFLUNOMIDE; UNCLASSIFIED DRUG; URIDINE;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL CYCLE; CELL STIMULATION; CONTROLLED STUDY; DNA CONTENT; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; METABOLIC INHIBITION; MONONUCLEAR CELL; NONHUMAN; NUCLEOLUS; PRIORITY JOURNAL; PYRIMIDINE SYNTHESIS; RAT; RNA ANALYSIS; RNA SYNTHESIS; SPLEEN CELL;

ANIMALS; CELL CYCLE; CELL NUCLEOLUS; CELLS, CULTURED; DNA; ENZYME INHIBITORS; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; ISOXAZOLES; KI-67 ANTIGEN; LYMPHOCYTE ACTIVATION; NEOPLASM PROTEINS; NUCLEAR PROTEINS; OXIDOREDUCTASES; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PROLIFERATING CELL NUCLEAR ANTIGEN; PYRIMIDINES; RATS; RNA; T-LYMPHOCYTES; URIDINE;

EID: 0029591467     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (0)