Infrequent MDM2 gene amplification and absence of gross WAF1 gene alterations in nasopharyngeal carcinoma

European Journal of Cancer. Part B: Oral Oncology

Volumn 31, Issue 5, 1995, Pages 328-332

  Qian, Wang ^a   Hu, Li Fu ^a   Chen, Fu ^a   Wang, Yisong ^a   Magnusson, K P ^a   Kashuba, E ^a   Klein, G ^a   Wiman, K G ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

MDM2 amplification; NPC; WAF1

Indexed keywords

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE AMPLIFICATION; HUMAN; HUMAN TISSUE; NASOPHARYNX CARCINOMA; ONCOGENE; PRIORITY JOURNAL;

BLOTTING, SOUTHERN; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA, NEOPLASM; ENZYME INHIBITORS; GENE AMPLIFICATION; HUMANS; NASOPHARYNGEAL NEOPLASMS; NUCLEAR PROTEINS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2;

EID: 0029590026     PISSN: 09641955     EISSN: None     Source Type: Journal    
DOI: 10.1016/0964-1955(95)00034-8     Document Type: Article

References (31)

1. The Epidemiology of Epstein-Barr virus and associated diseases in man
2. Epidemiology of nasopharyngeal carcinoma
3. Direct evidence for the presence of Epstein-Barr virus DNA and nuclear antigen in malignant epithelial cells from patients with poorly differential carcinoma of the nasopharynx
4. Seroepidemiological studies on nasopharyngeal carcinoma in China
5. In viral infections of humans
6. Epstein-Barr virus and human malignancies
7. p53 overexpression and Epstein-Barr virus infection in undifferentiated and squamous cell nasopharyngeal carcinomas
8. p53 protein detected by immunohistochemical statining is not always mutant
9. Detection of the tumor suppressor gene p53 in nasopharyngeal carcinoma in Hong Kong Chinese
10. An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma
11. Absence of p53 gene mutations in primary nasopharyngeal carcinomas
12. p53 mutation in human nasopharyngeal carcinomas
13. Alterations of the p53 gene in nasopharyngeal carcinoma
14. Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line
15. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
16. Enhanced binding of a 95 KDa protein to p53 in cells undergoing p53-mediated growth arrest
17. Oncoprotein MDM2 conceals the activation domain of tumor suppressor p53
18. Amplification of a gene encoding a p53-associated protein in human sarcomas
19. MDM2 gene amplification in metastatic osteosarcomas
20. p53 mutation and MDM2 amplification in human soft tissue sarcomas
21. Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
22. The p53-binding protein MDM2 gene is differentially expressed in human breast carcinoma
23. WAF1, a potential mediator of p53 tumor suppression
24. The p21 cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
25. p21 is a universal inhibitor of cyclin kinases
26. Histopathology of nasopharyngeal carcinoma
27. The transcriptional transactivation function of wild type p53 is inhibited by SV40 large T antigen and by HPV-16 E6 oncoprotein
28. Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53
29. EBNA-5, an Epstein-Barr virus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins
30. Epstein-Barr virus gene expression in nasopharyngeal carcinoma