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of special interest, The authors show that in vitro, TGF-β induces apoptosis in T-cell lines. In comparison to apoptosis induces by IL-2 deprivation, apoptosis triggered by TGFβ is delayed. Furthermore, TBF-β induced apoptosis of T cells was not associated with a decreased expresion of the proto-oncogenes bcl-2 or c-myc.
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of special interest, It is shown that in vitro, T cells die by apoptosis during IL-2 stimulated cell cycling and TCR engagement at high doses of antigens (including MBP and peptide Ac1-11). In vivo, repeated treatment with soluble MBP is seen to improve the clinical course of EAE probably due to eradication of disease-causing T cells.
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