Effect of penetration enhancers on flurbiprofen permeation through rat skin

International Journal of Pharmaceutics

Volumn 126, Issue 1-2, 1995, Pages 267-274

  Chi, Sang Cheol ^a   Park, Eun Seok ^a   Kim, Hyun ^a  

^a Sungkyunkwan University   (South Korea)

Author keywords

Fatty acids; Flurbiprofen; Pharmacokinetics; Skin permeation; Urea

Indexed keywords

DECANOIC ACID; FATTY ACID; FLURBIPROFEN; LAURIC ACID; LINOLEIC ACID; LINOLENIC ACID; MYRISTIC ACID; PALMITOLEIC ACID; PENETRATION ENHANCING AGENT; PROPYLENE GLYCOL; UNSATURATED FATTY ACID; UREA;

ANIMAL TISSUE; ARTICLE; DIFFUSION; DRUG BLOOD LEVEL; DRUG MIXTURE; MALE; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; RAT; SKIN PENETRATION; SKIN PERMEABILITY; STRATUM CORNEUM;

EID: 0029587302     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(95)04137-0     Document Type: Article

References (28)

1. Absorption through human skin of ibuprofen and flurbiprofen; effect of dose variation, deposited drug films, occlusion and the penetration enhancer N-methyl-2-pyrrolidone
2. Enhancement of naloxone penetration through human skin in vitro using fatty acids, fatty alcohols, surfactants, sulfoxides and amides
3. Mode of action of penetration enhancers in human skin
4. The influence of urea on percutaneous absorption
5. Flurbiprofen: A review of its pharmacological properties and therapeutic use in rheumatic diseases
6. Effect of various adjuvants on the transdermal delivery of indomethacin
7. High performance liquid chromatographic analysis of flurbiprofen in rat plasma
8. Increased skin permeability for lipophilic molecules
9. Effect of fatty acids and alcohols on the penetration of acyclovir across human skin in vitro
10. Effect of vehicle composition on percutaneous absorption of nicardipine and ketorolac in rhesus monkeys
11. In vitro and in vivo enhancement of skin permeation with oleic and lauric acids
12. Penetration enhancers in percutaneous absorption
13. Effect of fatty acid and urea on the penetration of ketoprofen through rat skin
14. Anti-inflammatory and analgesic actions and skin irritation of flurbiprofen by dermal application
15. Anti-inflammatory effect of flurbiprofen for dermal application (FP-A)
16. Anti-inflammatory effect of flurbiprofen by topical application
17. Influence of oleic acid and other permeation promoters on transdermal delivery of dihydroergotamine through rabbit skin
18. Mechanism for the enhancement effect of fatty acids on the percutaneous absorption of propranolol
19. Sorption promoters for topically applied substances
20. Evaluation of the primary skin irritation and allergic contact sensitization potential of transdermal triprolidine
21. Enhancing effect of pyrrolidone derivatives on transdermal penetration of 5-fluorouracil, triamcinolone acetonide, indomethacin, and flurbiprofen
22. Effect of several penetration enhancers on the percutaneous absorption of indomethacin in hairless rats
23. Study of the gastric mucosa in rheumatic patients before and after the administration of flurbiprofen
24. Urea analogues in propylene glycol as penetration enhancers in human skin
25. Enhancement of percutaneous absorption of molsidomine
26. Skin permeability of various non-steroidal antiinflammatory drugs