Tamoxifen inhibits hepatoma cell growth through an estrogen receptor independent mechanism

Journal of Hepatology

Volumn 23, Issue 6, 1995, Pages 712-719

  Jiang, Shun Yuan ^a   Shyu, Rong Yaun ^a   Yeh, Ming Yang ^a   Jordan, V Craig ^b  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Antiestrogen; Estrogen; Estrogen receptor; Growth regulation; Hepatoma; Tamoxifen

Indexed keywords

ESTROGEN RECEPTOR; MESTRANOL; TAMOXIFEN;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL; TUMOR GROWTH;

ANTINEOPLASTIC AGENTS, HORMONAL; CARCINOMA, HEPATOCELLULAR; CELL DIVISION; ESTROGEN ANTAGONISTS; HUMANS; LIVER NEOPLASMS; MESTRANOL; RECEPTORS, ESTROGEN; TAMOXIFEN; TUMOR CELLS, CULTURED;

EID: 0029587220     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-8278(95)80038-7     Document Type: Article

References (42)

1. Steroid receptor family: structure and functions
2. The biochemical pharmacology of antiestrogen action
3. Inhibition of protein kinase C by tamoxifen
4. Calmodulin antagonism and growth-inhibiting activity of triphenylethylene antiestrogens in MCF-7 human breast cancer cells
5. Modulation of natural killer cells activity by tamoxifen in stage one postmenopausal breast cancer
6. Nonviral risk factors for hepatocellular carcinoma in a low-risk population, the non-Asians of Los Angeles county, California
7. Female hormone utilisation and risk of hepatocellular carcinoma
8. Contraceptive steroids as a risk factor for hepatocellular carcinoma: a case/control study in South African black women
9. Carcinogenic effects of diethylstylbestrol in male Syrian hamster and European hamster
10. High incidence of hepatocellular carcinomas after synthetic estrogen administration in Syrian gold hamster fed alpha-naphthoflavone: a new tumor model
11. The effect of estrogen and tamoxifen on hepatocyte proliferation in vivo and in vitro
12. Hepatomas: hormone receptors and therapy
13. Estrogen receptors in hepatocellular carcinoma
14. Sex hormone receptors in hepatocellular carcinoma: is there a rationale for hormonal treatment?
15. Androgen and estrogen receptors in hepatocellular carcinoma and in the surrounding noncancerous liver tissue
16. Androgen and estrogen receptors in hepatocellular carcinoma and the surrounding liver in women
17. Quantitation of estrogen and androgen receptors in hepatocellular carcinoma and adjacent normal human liver
18. Unresectable hepatocellular carcinoma: a prospective controlled trial with tamoxifen
19. Controlled trial of tamoxifen in patients with advanced hepatocellular carcinoma
20. Agonistic and antagonistic effects of antiestrogens in different target organs
21. An initiation-promotion assay in rat liver as a potential complement to the 2-year carcinogenesis bioassay
22. Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats
23. Adjuvant tamoxifen in early breast cancer: occurrence of new primary cancers
24. The incidence of hepatocellular carcinoma in US white women with breast cancer after the introduction of tamoxifen in 1977
25. Effect of mestranol on cell proliferation and angiotensinogen production in Hep G2 cells: relation with the cell cycle and action of tamoxifen
26. Human hepatocellular carcinoma cell lines that secrete the major plasma proteins and hepatitis B surface antigens
27. A new human hepatoma cell line: establishment and characterization
28. Molecular analysis of the p53 alleles in primary hepatocellular carcinomas and cell lines
29. Growth regulation of estrogen receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor
30. A simple, rapid, and sensitive DNA assay procedure
31. + RNA
32. The actin genes of Drosophila: a dispersed multigene family
33. The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties
34. Biochemical transfer of single-copy eukaryotic genes using total cellular DNA as donor
35. Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture
36. Anti-oestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts
37. Effect of tamoxifen on DNA synthesis and proliferation of human malignant glioma lines in vitro
38. Phenotypic characterization, karyotype analysis and in vitro tamoxifen sensitivity if new ER-negative vulvar carcinoma cell lines. UM-SCV-1A and UM-SCV-1B
39. Growth inhibition of laryngeal UM-SCC cell lines by tamoxifen
40. The unliganded estrogen receptor (ER) transduces growth factor signals
41. Tamoxifen metabolites in patients on long-term adjuvant therapy for breast cancer
42. Distribution of tamoxifen and its metabolites in rat and human tissues during steady-state treatment