Biology of Membrane Transport Proteins

Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists

Volumn 12, Issue 12, 1995, Pages 1823-1837

  Sadée, Wolfgang ^a   Drübbisch, Volkmar ^a   Amidon, Gordon L ^a  

^a NONE

Author keywords

genetic transporter defects; glucose; membrane transporters; multidrug resistance; peptides; transporter gene families; transporter regulation

Indexed keywords

ABC TRANSPORTER; CARRIER PROTEIN; GLUCOSE TRANSPORTER; ION CHANNEL; MEMBRANE PROTEIN; PEPTIDES AND PROTEINS;

AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CLASSIFICATION; DRUG TRANSPORT; FEMALE; GENE CONTROL; GENETIC DISORDER; HUMAN; ION TRANSPORT; MALE; MOLECULAR BIOLOGY; MOLECULAR CLONING; MULTIDRUG RESISTANCE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CLONING, MOLECULAR; DOPAMINE; MOLECULAR STRUCTURE; SEQUENCE ANALYSIS;

EID: 0029584879     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1023/A:1016211015926     Document Type: Review

References (105)

1. A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport
2. Membrane transport proteins: implications of sequence comparisons
3. Transport proteins in bacteria: common themes in their design
4. Sodium cotransport proteins
5. The MIP family of integral membrane channel proteins: sequence comparisons, evolutionary relationships, reconstructed pathway of evolution and proposed functional differentiation of the two repeated halves of the proteins
6. Molecular biology of carrier proteins
7. Transport of cationic amino acids by the mouse ecotropic retrovirus receptor
8. Molecular biology of mammalian glucose transporters
9. Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid
10. +-independent neutral amino acid transporter from rat kidney
11. Expression cloning of a mammalian proton-coupled oligopeptide transporter
12. +/peptide cotransporter
13. +/peptide cotransporter family, from human kidney
14. +/nucleoside cotransporter. A member of the SGLT family
15. Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein
16. −-dependent taurine transporter that is regulated by hypertonicity
17. Cloning and expression of a high affinity taurine transporter from rat brain
18. Identification and characterization of a prostaglandin transporter
19. + antiporter
20. + exchanger
21. Cloning and expression of cDNA for a Na/Pi cotransport system of kidney cortex
22. 2− cotransport
23. Expression of rat renal sulfate transport systems in Xenopus laevis oocytes
24. Expression cloning of a cocaine-and antidepressant-sensitive human noradreline transporter
25. Cloning and Expression of a cocaine sensitive dopamine transporter complementary DNA
26. Cloning and expression of a cocaine-sensitive rat dopamine transporter
27. Cloning of a serotonin transporter affected by antidepressants
28. Cloning and expression of a rat brain GABA transporter
29. Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes
30. Cloning and expression of a rat brain L-glutamate transporter
31. + toxicity encodes a vesicular amine transporter
32. N. Kartner and V. Ling. Multidrug resistance in cancer. Scientific Amer. 44–51 (1989).
33. Cystic fibrosis transmembrane conductance regulator: nucleotide binding to a synthetic peptide
34. A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway
35. Transport protein genes in the murine MHC: possible implications for antigen processing
36. Delivering peptides to the central nervous system: dilemma's and strategies
37. In vivo transport of a dynorphin-like analgesic peptide, E-2078, through blood-brain barrier: an application of brain microdialysis
38. +-coupled primary transport systems in bacteria
39. Fishy tales of kidney function
40. Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine
41. Cloning and characterization of the vasopressin-regulated urea transporter
42. Cystinuria caused by mutations in rBAT, a gene involved in the transport of cystine
43. Mutations in the sulfonylurea receptor gene in familial persistant hyperinsulinemic hypoglycemia of infancy
44. + exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis
45. Structure and function of hexose transporters
46. +/glucose co-transporter
47. Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney and β-pancreatic islet cells
48. Perinatal hypothyroidism impairs the normal transition of GLUT4 and GLUT1 glucose transporters from fetal to neonatal levels in heart and brown adipose tissue
49. Insulinsensitive association of GLUT4 with endocytic clathrin-coated vesicles revealed with the use of brefeldin A
50. Comparison of GLUT4 and GLUT1 subcellular trafficking in basal and insulin-stimulated 3T3-L1 cells
51. Domains that confer intracellular sequestration of the GLUT4 glucose transporter in xenopus oocytes
52. Characterization of a major protein in GLUT4 vesicles
53. Regulation of receptor internalization by the major histocompatibility complex class I molecule
54. +/glucose cotransporter
55. Causes of insulin resistance
56. Expression and regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice
57. + co-transport system in the Caco-2 human colon carcinoma cell line
58. Identification of identical polypeptides for cephalosporins and dipeptides in intestinal brush-border membrane vesicles by photoaffinity labeling
59. Functional expression of the intestinal peptide-protein co-transporter in Xenopus laevis oocytes
60. Functional expression of endogenous dipeptide transporter and exogenous proton/peptide cotransporter in Xenopus oocytes
61. Association of intestinal peptide transport with a protein related to the cadherin superfamily
62. Drug excretion mediated by a new prototype of polyspecific transporter
63. Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter
64. Hepatocellular transport of bile acids
65. Utilizing bile acid carrier mechanisms to enhance liver and small intestinal absorption
66. Liver specific drug targeting by coupling to bile acids
67. Expression of a human renal sodium nucleoside cotransporter in Xenopus laevis oocytes
68. Molecular characterization of the dopamine transporter
69. +; uptake and toxicity in nonneuronal COS cells expressing dopamine transporter cDNA
70. Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding
71. Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium
72. Chimeric human and rat serotonin transporters reveal domains involved in recognition of transporter ligands
73. Dopamine-accumulating retinal neurons revealed by in vitro fluorescence display a unique morphology
74. 131I-meta-iodobenzylaguanidine
75. The Caenorhabditis elegans uns-17 gene: a putative vesicular acetylcholine transporter
76. A kinetic and allosteric model for the acetylcholine transporter-vesamicol receptor in synaptic vesicles
77. A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic Taq I RFLPs
78. Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport
79. Mutagenesis of the C-terminal nucleotide-binding site of an anion-translocating ATPase
80. Arsenical-resistant trypanosomes lack an unusual adenosine transporter
81. Sickly channels in mild disease
82. A bacterial system for investigating transport effects of cystic fibrosis-associated mutations
83. Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy
84. Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells
85. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
86. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
87. The multidrug resistance gene (MDR1) represents a potential target for reversing drug resistance in human malignancies
88. Multidrug resistance is not an important factor in therapeutic outcome in human malignancies
89. Localization of the forskolin labeling sites to both halves of p-glycoprotein: similarity of the sites labeled by forskolin and prazosin
90. An altered pattern of cross-resistance in multi-drug resistant human cells results from spontaneous mutations in the mdr 1 (p-glycoprotein) gene
91. Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1
92. Cellular localization of the multidrug resistance gene product p-glycoprotein in normal human tissues
93. Drug absorption limited by p-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers
94. Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter
95. Interaction of MHC class I molecules with the transporter associated with antigen processing
96. Selectivity of MHC-encoded peptide transporters from human mouse and rat
97. Homozygous human TAP peptide transporter mutation in HLA class I deficiency