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Conservation of solvent-binding sites in 10 crystal forms of T4 lysozyme
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of special interest, Solvent binding sites were compared in 10 different crystal forms of phage T4 lysozyme. Despite differences in cystallization conditions, crystal contacts, residues due to mutations and varying attention to solvent during refinement, 60% of the 20 most frequently occupied sites were conserved. Distribution of these sites on the surface of the protein is discussed.
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20
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0028916599
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A hot spot of binding energy in a hormone-receptor interface
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of outstanding interest, The crystal structure of the complex between human growth hormone and the extracellular domain of its first bound receptor shows that about 30 side chains from each protein make contact. More than three-quarters of the binding energy is due to a central hydrophobic region.
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