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Volumn 5, Issue 6, 1995, Pages 825-829

What makes a binding site a binding site?

Author keywords

[No Author keywords available]

Indexed keywords

ORGANIC COMPOUND; WATER;

EID: 0029584688     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0959-440X(95)80017-4     Document Type: Article
Times cited : (132)

References (22)
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    • Ordered water in macromolecular structure
    • of outstanding interest, This review summarizes recent progress in experimental and theoretical approaches on how and why water is ordered at protein surfaces. Most importantly the author discusses issues related to the reliability of experimental results.
    • (1994) Curr Biol , vol.4 , pp. 770-776
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    • of special interest, Solvent binding sites were compared in 10 different crystal forms of phage T4 lysozyme. Despite differences in cystallization conditions, crystal contacts, residues due to mutations and varying attention to solvent during refinement, 60% of the 20 most frequently occupied sites were conserved. Distribution of these sites on the surface of the protein is discussed.
    • (1994) Protein Sci , vol.3 , pp. 1031-1039
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  • 20
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    • A hot spot of binding energy in a hormone-receptor interface
    • of outstanding interest, The crystal structure of the complex between human growth hormone and the extracellular domain of its first bound receptor shows that about 30 side chains from each protein make contact. More than three-quarters of the binding energy is due to a central hydrophobic region.
    • (1995) Science , vol.267 , pp. 383-386
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    • Atlas1
  • 22
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    • A direct measure of the contribution of solvent reorganization to the enthalpy of ligand binding
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.