메뉴 건너뛰기




Volumn 7, Issue 12, 1995, Pages 1995-2003

Promotion of V(D)J recombinational accessibility by the intronic Ek element: Role of the κB motif

Author keywords

Accessibility; K enhancer; KB motif; Methylation; Transcription; V(D)J recombination

Indexed keywords

RECOMBINASE; TRANSCRIPTION FACTOR;

EID: 0029584058     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/7.12.1995     Document Type: Article
Times cited : (27)

References (50)
  • 2
    • 0027221908 scopus 로고
    • Gene rearrangement and B-cell development
    • Chen, J. and Alt, F. W. 1993. Gene rearrangement and B-cell development. Curr. Opin. Immunol. 5:194.
    • (1993) Curr. Opin. Immunol , vol.5 , pp. 194
    • Chen, J.1    Alt, F.W.2
  • 4
    • 0025301095 scopus 로고
    • RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
    • Oettinger, M. A., Schatz, D. G., Gorka, C. and Baltimore, D. 1990. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248:1517.
    • (1990) Science , vol.248 , pp. 1517
    • Oettinger, M.A.1    Schatz, D.G.2    Gorka, C.3    Baltimore, D.4
  • 7
    • 0023002697 scopus 로고
    • Recombination between immunoglobulin variable region gene segments is enhanced by transcription
    • Blackwell, T. K., Moore, M. W., Yancopoulos, G. D., Suh, H., Lutzker, S., Seising, E. and Alt, F. W. 1986. Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature 324:585.
    • (1986) Nature , vol.324 , pp. 585
    • Blackwell, T.K.1    Moore, M.W.2    Yancopoulos, G.D.3    Suh, H.4    Lutzker, S.5    Seising, E.6    Alt, F.W.7
  • 8
    • 0027396509 scopus 로고
    • Influence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate
    • Engler, P., Weng, A. and Storb, U. 1993. Influence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate. Mot. Cell. Biol. 13:571.
    • (1993) Mot. Cell. Biol , vol.13 , pp. 571
    • Engler, P.1    Weng, A.2    Storb, U.3
  • 9
    • 0028352076 scopus 로고
    • Sequences affecting the V(D)J recombinational activity of the IgH intronic enhancer in a transgenic substrate
    • Fernex, C., Caillol, D., Capone, M., Krippl, B. and Ferrier, P. 1994. Sequences affecting the V(D)J recombinational activity of the IgH intronic enhancer in a transgenic substrate. Nucleic Acids Res. 22:792.
    • (1994) Nucleic Acids Res , vol.22 , pp. 792
    • Fernex, C.1    Caillol, D.2    Capone, M.3    Krippl, B.4    Ferrier, P.5
  • 10
    • 0026504462 scopus 로고
    • Transcription of germ line V alpha segments correlates with ongoing T-cell receptor alpha-chain rearrangement
    • Fondell, J. D. and Marcu, K. B. 1992. Transcription of germ line V alpha segments correlates with ongoing T-cell receptor alpha-chain rearrangement. Mol. Cell. Biol. 12:1480.
    • (1992) Mol. Cell. Biol , vol.12 , pp. 1480
    • Fondell, J.D.1    Marcu, K.B.2
  • 11
    • 0027301927 scopus 로고
    • Methylation status of immunoglobulin K gene segments correlates with their recombination potential
    • Goodhardt, M., Cavelier, P., Doyen, N., Kallenbach, S., Babinet, C. and Rougeon, F. 1993. Methylation status of immunoglobulin K gene segments correlates with their recombination potential. Eur. J. Immunol. 23:1789.
    • (1993) Eur. J. Immunol , vol.23 , pp. 1789
    • Goodhardt, M.1    Cavelier, P.2    Doyen, N.3    Kallenbach, S.4    Babinet, C.5    Rougeon, F.6
  • 12
    • 0026507505 scopus 로고
    • CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication
    • Hsieh, C. L. and Lieber, M. R. 1992. CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication. EMBO J. 11:315.
    • (1992) EMBO J , vol.11 , pp. 315
    • Hsieh, C.L.1    Lieber, M.R.2
  • 13
    • 0023854305 scopus 로고
    • The coupling between enhancer activity and hypomethylation of kappa immunoglobulin genes is developmentally regulated
    • Kelley, D. E., Pollock, B. A., Atchison, M. L. and Perry, R. P. 1988. The coupling between enhancer activity and hypomethylation of kappa immunoglobulin genes is developmentally regulated. Mol. Cell. Biol. 8:930.
    • (1988) Mol. Cell. Biol , vol.8 , pp. 930
    • Kelley, D.E.1    Pollock, B.A.2    Atchison, M.L.3    Perry, R.P.4
  • 14
    • 0020960251 scopus 로고
    • Methylation status and DNasel sensitivity of immunoglobulin genes: Changes associated with rearrangement
    • Mather, E. L. and Perry, R. P. 1983. Methylation status and DNasel sensitivity of immunoglobulin genes: changes associated with rearrangement. Proc. Natl Acad. Sci. USA 80:4689.
    • (1983) Proc. Natl Acad. Sci. USA , vol.80 , pp. 4689
    • Mather, E.L.1    Perry, R.P.2
  • 15
    • 0028068082 scopus 로고
    • Ig heavy chain protein control B cell development by regulating germ-line transcription and retargeting V(D)J recombination
    • Schlissel, M. S. and Morrow, T. 1994. Ig heavy chain protein control B cell development by regulating germ-line transcription and retargeting V(D)J recombination. J. Immunol. 153:1645.
    • (1994) J. Immunol , vol.153 , pp. 1645
    • Schlissel, M.S.1    Morrow, T.2
  • 16
    • 0027282297 scopus 로고
    • Stimulation of K light-chain gene rearrangement by the immunoglobulin n heavy chain in a pre-B-cell line
    • Shapiro, A. M., Schlissel, M. S., Baltimore, D. and DeFranco, A. L. 1993. Stimulation of K light-chain gene rearrangement by the immunoglobulin n heavy chain in a pre-B-cell line. Mol. Cell. Biol. 13:5679.
    • (1993) Mol. Cell. Biol , vol.13 , pp. 5679
    • Shapiro, A.M.1    Schlissel, M.S.2    Baltimore, D.3    DeFranco, A.L.4
  • 17
    • 0022565521 scopus 로고
    • Regulation of the assembly and expression of variable-region genes
    • Yancopoulos, G. D. and Alt, F. W. 1986. Regulation of the assembly and expression of variable-region genes. Annu. Rev. Immunol. 4:339.
    • (1986) Annu. Rev. Immunol , vol.4 , pp. 339
    • Yancopoulos, G.D.1    Alt, F.W.2
  • 18
    • 0027521610 scopus 로고
    • Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the Jh locus
    • Chen, J., Young, F., Bottaro, A., Stewart, V., Smith, R. K. and Alt, F. W. 1993. Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the Jh locus. EMBO J. 12:4365.
    • (1993) EMBO J , vol.12 , pp. 4365
    • Chen, J.1    Young, F.2    Bottaro, A.3    Stewart, V.4    Smith, R.K.5    Alt, F.W.6
  • 19
    • 0027192988 scopus 로고
    • V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer
    • Serwe, M. and Sablitzky, F. 1993. V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer. EMBO J. 12:2321.
    • (1993) EMBO J , vol.12 , pp. 2321
    • Serwe, M.1    Sablitzky, F.2
  • 20
    • 0027189754 scopus 로고
    • Deletion of the immunoglobulin K chain intron enhancer abolishes K chain gene rearrangement in c/‘s but not X chain gene rearrangement in trans
    • Takeda, S., Zou, Y.-R., Bluethmann, H., Kitamura, D., Muller, U. and Rajewsky, K. 1993. Deletion of the immunoglobulin K chain intron enhancer abolishes K chain gene rearrangement in c/‘s but not X chain gene rearrangement in trans. EMBO J. 12:2329.
    • (1993) EMBO J , vol.12 , pp. 2329
    • Takeda, S.1    Zou, Y.-R.2    Bluethmann, H.3    Kitamura, D.4    Muller, U.5    Rajewsky, K.6
  • 21
    • 0027508340 scopus 로고
    • TCRp and TCRa gene enhancers confer tissue-and stage-specificity on V(D)J recombination events
    • Capone, M., Watrin, F., Fernex, C., Horvat, B., Krippl, B., Wu, L., Scollay, R. and Ferrier, P. 1993. TCRp and TCRa gene enhancers confer tissue-and stage-specificity on V(D)J recombination events. EMBO J. 12:4335.
    • (1993) EMBO J , vol.12 , pp. 4335
    • Capone, M.1    Watrin, F.2    Fernex, C.3    Horvat, B.4    Krippl, B.5    Wu, L.6    Scollay, R.7    Ferrier, P.8
  • 22
    • 0025803543 scopus 로고
    • Factors affecting the rearrangement efficiency of an Ig test gene
    • Engler, P., Roth, P., Kim, J. Y. and Storb, U. 1991. Factors affecting the rearrangement efficiency of an Ig test gene. J. Immunol. 146:2826.
    • (1991) J. Immunol , vol.146 , pp. 2826
    • Engler, P.1    Roth, P.2    Kim, J.Y.3    Storb, U.4
  • 24
    • 0028223482 scopus 로고
    • Differential activation of transcription versus recombination of transgenic TCRp variable region gene segments in B and T lineage cells
    • Okada, A., Mendelsohn, M. and Alt, F. W. 1994. Differential activation of transcription versus recombination of transgenic TCRp variable region gene segments in B and T lineage cells. J. Exp. Med. 180:261.
    • (1994) J. Exp. Med , vol.180 , pp. 261
    • Okada, A.1    Mendelsohn, M.2    Alt, F.W.3
  • 25
    • 0028270307 scopus 로고
    • Elements regulating somatic hypermutation of an immunoglobulin k gene: Critical role for the intron enhancer/matrix attachment region
    • Betz, A. G., Milstein, C., Gonzalez-Fernandez, A., Pannell, R., Larson, T. and Neuberger, M. S. 1995. Elements regulating somatic hypermutation of an immunoglobulin k gene: critical role for the intron enhancer/matrix attachment region. Cell 77:239.
    • (1995) Cell , vol.77 , pp. 239
    • Betz, A.G.1    Milstein, C.2    Gonzalez-Fernandez, A.3    Pannell, R.4    Larson, T.5    Neuberger, M.S.6
  • 26
    • 0027103172 scopus 로고
    • Immunoglobulin K gene enhancers synergistically activate gene expression but independently determine chromatin structure
    • Blasquez, V. C., Hale, M. A., Trevorrow, K. W. and Garrard, W. T. 1992. Immunoglobulin K gene enhancers synergistically activate gene expression but independently determine chromatin structure. J. Biol. Chem. 267:23888.
    • (1992) J. Biol. Chem , vol.267 , pp. 23888
    • Blasquez, V.C.1    Hale, M.A.2    Trevorrow, K.W.3    Garrard, W.T.4
  • 27
    • 0027501312 scopus 로고
    • Kappa immunoglobulin promoters and enhancers display developmentally controlled interactions
    • Fulton, R. and Ven Ness, B. 1993. Kappa immunoglobulin promoters and enhancers display developmentally controlled interactions. Nucleic Acids Res. 21:4941.
    • (1993) Nucleic Acids Res , vol.21 , pp. 4941
    • Fulton, R.1    Ven Ness, B.2
  • 28
    • 0027984287 scopus 로고
    • Selective synergy of immunoglobulin enhancer elements in B-cell development: A characteristic of kappa light chain enhancers, but not heavy chain enhancers
    • Fulton, R. and Van Ness, B. 1994. Selective synergy of immunoglobulin enhancer elements in B-cell development: a characteristic of kappa light chain enhancers, but not heavy chain enhancers. Nucleic Acids Res. 22:4216.
    • (1994) Nucleic Acids Res , vol.22 , pp. 4216
    • Fulton, R.1    Ven Ness, B.2
  • 29
    • 0024293488 scopus 로고
    • Complementation between two cell lines lacking K enhancer activity: Implications for the developmental control of immunoglobulin transcription
    • Atchison, M. L. and Perry, R. P. 1988. Complementation between two cell lines lacking K enhancer activity: implications for the developmental control of immunoglobulin transcription. EMBO J. 7:4213.
    • (1988) EMBO J , vol.7 , pp. 4213
    • Atchison, M.L.1    Perry, R.P.2
  • 30
    • 0023280348 scopus 로고
    • Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility
    • Lenardo, M., Pierce, J. W. and Baltimore, D. 1987. Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility. Science 236:1573.
    • (1987) Science , vol.236 , pp. 1573
    • Lenardo, M.1    Pierce, J.W.2    Baltimore, D.3
  • 31
    • 0028079737 scopus 로고
    • Organization of transcription factor binding sites in the K intron enhancer
    • Schanke, J. T. and Ven Ness, B. G. 1994. Organization of transcription factor binding sites in the K intron enhancer. J. Immunol. 153:4565.
    • (1994) J. Immunol , vol.153 , pp. 4565
    • Schanke, J.T.1    Ven Ness, B.G.2
  • 32
    • 0028966511 scopus 로고
    • Nucleoprotein structure influences the response of the mouse mammary tumor virus promoter to activation of the cyclic AMP signalling pathway
    • Pennie, W., Hager, G. H. and Smith, C. L. 1995. Nucleoprotein structure influences the response of the mouse mammary tumor virus promoter to activation of the cyclic AMP signalling pathway. Mol. Cell. Biol. 15:2125.
    • (1995) Mol. Cell. Biol , vol.15 , pp. 2125
    • Pennie, W.1    Hager, G.H.2    Smith, C.L.3
  • 33
    • 0022930702 scopus 로고
    • Inducibility of k immunoglobulin enhancer binding protein NF-kB by a posttranslational mechanism
    • Sen, R. and Baltimore, D. 1986. Inducibility of k immunoglobulin enhancer binding protein NF-kB by a posttranslational mechanism. Cell 47:921.
    • (1986) Cell , vol.47 , pp. 921
    • Sen, R.1    Baltimore, D.2
  • 34
    • 0021769678 scopus 로고
    • Lipopolysaccharide-induced transcription of the kappa immunoglobulin locus occurs on both alleles and is independant of méthylation status
    • Nelson, K. J., L., M. E. and Perry, R. P. 1984. Lipopolysaccharide-induced transcription of the kappa immunoglobulin locus occurs on both alleles and is independant of méthylation status. Nucleic Acids Res. 12:1911.
    • (1984) Nucleic Acids Res , vol.12 , pp. 1911
    • Nelson, K.J.1    Nelson, L.2    Nelson, M.E.3    Perry, R.P.4
  • 35
    • 0021876471 scopus 로고
    • Inducible transcription of the unrearranged K constant region locus is a common feature of pre-B cells and does not require DNA or protein synthesis
    • Nelson, K. J., Kelley, D. E. and Perry, R. P. 1985. Inducible transcription of the unrearranged K constant region locus is a common feature of pre-B cells and does not require DNA or protein synthesis. Proc. Natl Acad. Sci. USA 82:5305.
    • (1985) Proc. Natl Acad. Sci. USA , vol.82 , pp. 5305
    • Nelson, K.J.1    Kelley, D.E.2    Perry, R.P.3
  • 36
    • 0024435908 scopus 로고
    • Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription
    • Schlissel, M. S. and Baltimore, D. 1989. Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription. Cell 58:1001.
    • (1989) Cell , vol.58 , pp. 1001
    • Schlissel, M.S.1    Baltimore, D.2
  • 37
    • 0027508368 scopus 로고
    • A V(D)J recombinase inducible B-cell line: Role of transcriptional enhancer elements in directing V(D)J recombination
    • Oltz, E. M., Alt, F. W., Lin, W. C., Chen, J., Taccioli, G., Desiderio, S. and Rathbun, G. 1993. A V(D)J recombinase inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination. Mol. Cell. Biol. 13:6223.
    • (1993) Mol. Cell. Biol , vol.13 , pp. 6223
    • Oltz, E.M.1    Alt, F.W.2    Lin, W.C.3    Chen, J.4    Taccioli, G.5    Desiderio, S.6    Rathbun, G.7
  • 38
    • 0022423216 scopus 로고
    • Various rat adult tissues express only one major mRNA species from glyceraldehyde-3-phosphate-dehydrogenase multigene family
    • Fort, P. L., Piechczyk, M., El Sabrouty, S., Dani, P., Jeantuer, P. and Blanchard, J. M. 1982. Various rat adult tissues express only one major mRNA species from glyceraldehyde-3-phosphate-dehydrogenase multigene family. Nucleic Acids Res. 13:1431.
    • (1982) Nucleic Acids Res , vol.13 , pp. 1431
    • Fort, P.L.1    Piechczyk, M.2    El Sabrouty, S.3    Dani, P.4    Jeantuer, P.5    Blanchard, J.M.6
  • 39
    • 0344627945 scopus 로고
    • Oligonucleotide that binds nuclear factor NF-kappa B acts as a lymphoid-specific and inducible enhancer element
    • Pierce, J. W., Lenardo, M. and Baltimore, D. 1988. Oligonucleotide that binds nuclear factor NF-kappa B acts as a lymphoid-specific and inducible enhancer element. Proc. Natl Acad. Sci. USA 85:1482.
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 1482
    • Pierce, J.W.1    Lenardo, M.2    Baltimore, D.3
  • 40
    • 0028328632 scopus 로고
    • B cell-specific demethyiation: A novel role for the intronic k chain enhancer sequence
    • Lichtenstein, M., Keini, G., Cedar, H. and Bergman, Y. 1994. B cell-specific demethyiation: a novel role for the intronic k chain enhancer sequence. Cell 76:913.
    • (1994) Cell , vol.76 , pp. 913
    • Lichtenstein, M.1    Keini, G.2    Cedar, H.3    Bergman, Y.4
  • 42
    • 0029030481 scopus 로고
    • The V(D)J recombinational and transcriptional activities of the IgH intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate
    • Fernex, C., Capone, M. and Ferrier, P. 1995. The V(D)J recombinational and transcriptional activities of the IgH intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate. Mol. Cell. Biol. 15:3217.
    • (1995) Mol. Cell. Biol , vol.15 , pp. 3217
    • Fernex, C.1    Capone, M.2    Ferrier, P.3
  • 43
    • 0021086610 scopus 로고
    • Two DNA methyltransferases from murine erythroleukemia cells: Purification, sequence specificity, and mode of interaction with DNA
    • Bestor, T. H. and Ingram, V. M. 1983. Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA. Proc. Natl Acad. Sci. USA 80:5559.
    • (1983) Proc. Natl Acad. Sci. USA , vol.80 , pp. 5559
    • Bestor, T.H.1    Ingram, V.M.2
  • 44
    • 0020486108 scopus 로고
    • Substrate and sequence specificity of a eukaryotic DNA methylase
    • Gruenbaum, Y., Cedar, H. and Razin, A. 1982. Substrate and sequence specificity of a eukaryotic DNA methylase. Nature 295:620.
    • (1982) Nature , vol.295 , pp. 620
    • Gruenbaum, Y.1    Cedar, H.2    Razin, A.3
  • 45
    • 0026653420 scopus 로고
    • The essential of DNA methylation
    • Bird, A. 1992. The essential of DNA methylation. Cell 70:5.
    • (1992) Cell , vol.70 , pp. 5
    • Bird, A.1
  • 46
    • 0027495467 scopus 로고
    • Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2
    • Nan, X., Meehan, R. and Bird, A. 1993. Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2. Nucleic Acids Res. 21:4886.
    • (1993) Nucleic Acids Res , vol.21 , pp. 4886
    • Nan, X.1    Meehan, R.2    Bird, A.3
  • 47
    • 0028938555 scopus 로고
    • The bulk chromatin structure of a murine transgene does not vary with its transcriptional or DNA methylation status
    • Weng, A., Engler, P. and Storb, U. 1995. The bulk chromatin structure of a murine transgene does not vary with its transcriptional or DNA methylation status. Mol. Cell. Biol. 15:572.
    • (1995) Mol. Cell. Biol , vol.15 , pp. 572
    • Weng, A.1    Engler, P.2    Storb, U.3
  • 48
    • 0027487392 scopus 로고
    • The immunoglobulin ji enhancer core establishes local factor access in nuclear chromatin independent of transcriptional stimulation
    • Jenuwein, T., Forrester, W. C., Qiu, R.-G. and Grosschedl, R. 1993. The immunoglobulin ji enhancer core establishes local factor access in nuclear chromatin independent of transcriptional stimulation. Genes Dev. 7:2016.
    • (1993) Genes Dev , vol.7 , pp. 2016
    • Jenuwein, T.1    Forrester, W.C.2    Qiu, R.-G.3    Grosschedl, R.4
  • 49
    • 84968433140 scopus 로고
    • Regulation of lymphocyte-specific immunogloblin µ heavy chain enhancer by ETS-domain proteins
    • Nelsen, B., Tian, G., Erman, B., Gregoire, J., Maki, R., Graves, B. and Sen, R. 1993. Regulation of lymphocyte-specific immunogloblin µ heavy chain enhancer by ETS-domain proteins. Science 261-82.
    • (1993) Science , pp. 261-282
    • Nelsen, B.1    Tian, G.2    Erman, B.3    Gregoire, J.4    Maki, R.5    Graves, B.6    Sen, R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.