Variable region cDNA sequences and characterization of murine anti-human interferon γ receptor monoclonal antibodies that inhibit receptor binding by interferon γ

Molecular Immunology

Volumn 32, Issue 17-18, 1995, Pages 1329-1338

  Bridges, Angela ^a   Birch, Ashley ^a   Williams, Geoffrey ^a   Aguet, Michel ^a   Schlatter, Daniel ^b   Huber, Walter ^b   Garotta, Gianni ^b   Robinson, John A ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b Preclinical Research   (Switzerland)

Author keywords

biosensor; cytokine; epitopes; gene family; immunoassay; immunoglobulin; structure

Indexed keywords

COMPLEMENTARY DNA; GAMMA INTERFERON; INTERFERON RECEPTOR; MONOCLONAL ANTIBODY;

ARTICLE; CELL LINE; CONTROLLED STUDY; DNA SEQUENCE; HUMAN; HUMAN CELL; IMMUNOASSAY; IMMUNOGLOBULIN VARIABLE REGION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; BASE SEQUENCE; BINDING SITES, ANTIBODY; BINDING, COMPETITIVE; DNA, COMPLEMENTARY; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; INTERFERON TYPE II; MICE; MOLECULAR SEQUENCE DATA; RECEPTORS, INTERFERON; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029583305     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/0161-5890(95)00114-X     Document Type: Article

References (45)

1. Purification of human γ interferon receptors by sequential affinity chromatography on immobilized monoclonal antireceptor antibodies and human γ interferon
2. Structural conservation of hypervariable regions in immunoglobulins evolution
3. Signaling steps involving the cytoplasmic domain of the interferon-gamma receptor alpha-subunit are not species-specific
4. Hybridoma fusion cell lines contain an aberrant kappa transcript
5. H segments
6. Conformations of immunoglobulin hypervariable regions
7. Making antibody fragments using phage display libraries
8. Crystallizing proteins—a rational approach
9. Human growth hormone and extracellular domain of its receptor: crystal structure of the complex
10. Functional and silent rearranged immunoglobulin genes in hybridoma genome
11. Stoichiometry of interaction between interferon γ and its receptor
12. Human interferon-γ receptor. Mapping of epitopes recognized by neutralizing antibodies using native and recombinant receptor proteins
13. Analysis of soluble human and mouse interferon-γ receptors expressed in eukaryotic cells
14. The extracellular domain of the human interferon gamma receptor interacts with a species-specific signal transducer
15. Interferon-gamma induces receptor dimerization in solution and on cells
16. Crystal structure of the extracellular region of human tissue factor
17. A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells
18. Functional characterization of a hybrid human-mouse interferon γ receptor: Evidence for species-specific interaction of the extracellular receptor domain with a putative signal transducer
19. Chimeric interferon-γ receptors demonstrate that an accessory factor required for activity interacts with the extracellular domain
20. Signaling by the cytokine receptor superfamily: JAKs and STATs
21. Sequences of Proteins of Immunological Interest
22. Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system
23. Optimization of primers for cloning libraries of mouse immunoglobulin genes using the polymerase chain reaction
24. Mouse variable-region gene families: Complexity, polymorphism and use in non-autoimmune responses
25. Interferon γ signals via a high-affinity multisubunit receptor complex that contains two types of polypeptide chain
26. Structure of the extracellular domain of human tissue factor: Location of the factor VIIa binding site
27. Monoclonal antibodies to the human interferon-γ receptor: blocking of the biological activities of interferon-γ and purification of the receptor
28. The human interferon-γ receptor. Purification, characterization, and preparation of antibodies
29. Cloning immunoglobulin variable domains for expression by the polymerase chain reaction
30. Early events in signalling by interferons
31. Crystal structure of a human immunodeficiency virus type 1 neutralising antibody, 50.1, in complex with its V3 loop peptide antigen
32. Mutagenesis of immunoglobulin-like domains from the extracellular human interferon γ receptor a chain and their recognition by neutralizing antibodies monitored by surface plasmon resonance technology
33. DNA sequencing with chain-terminating inhibitors
34. Generation and characterization of monoclonal antibodies specific for the human IFN-γ receptor
35. Identification and sequence of an accessory factor required for activation of the human interferon γ receptor
36. Complete variable region sequence of a nonfunctionally rearranged kappa light chain transcribed in the non-secretor P3-X63-Ag8653 myeloma cell line
37. Alignment of disulfide bonds of the extracellular domain of the interferon γ receptor and investigation of their role in biological activity
38. H domains of immunoglobulins
39. Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor
40. Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli
41. Sequences of the Lym-1 antibody heavy chain and light chain variable regions
42. Structural and functional basis for hormone binding and receptor oligomerization
43. Dissection of the extracellular human interferon γ receptor α chain into two immunoglobulin-like domains. Production in an Escherichia coli thioredoxin gene fusion expression system and recognition by neutralizing antibodies
44. Length distribution of CDRH3 in antibodies
45. Improved M13 phage cloning vectors and host strains: nucleotide sequence of the M13mp18 and pUC19 vectors