Celiprolol double-peak occurrence and gastric motility: Nonlinear mixed effects modeling of bioavailability data obtained in dogs

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 23, Issue 3, 1995, Pages 267-286

  Lipka, Elke ^a,b   Lee, I Der ^a   Langguth, Peter ^a,c   Spahn Langguth, Hildegard ^b   Mutschler, Ernst ^b   Amidon, Gordon L ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b GOETHE UNIVERSITY   (Germany)

^c ETH ZURICH   (Switzerland)

Author keywords

celiprolol; double peak phenomenon; gastric emptying; gastric motility; nonlinear oral bioavailability; NONMEM; variable oral pharmacokinetics

Indexed keywords

CELIPROLOL;

ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; DOG; DRUG BLOOD LEVEL; DRUG STRUCTURE; ENANTIOMER; FEMALE; GASTROINTESTINAL MOTILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; STEREOSPECIFICITY; STOMACH EMPTYING; STOMACH MOTILITY;

NON-PROGRAMMATIC;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BIOLOGICAL AVAILABILITY; CELIPROLOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; FEMALE; GASTRIC EMPTYING; GASTROINTESTINAL MOTILITY; INJECTIONS, INTRAVENOUS; INTESTINAL ABSORPTION; MALE; MODELS, BIOLOGICAL;

EID: 0029583114     PISSN: 0090466X     EISSN: 15738744     Source Type: Journal    
DOI: 10.1007/BF02354285     Document Type: Article

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