Role of IL12 in HIV disease/AIDS

Research in Immunology

Volumn 146, Issue 7-8, 1995, Pages 615-622

  Chougnet, C ^a   Clerici, M ^b   Shearer, G M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; TRANSFORMING GROWTH FACTOR BETA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL EXPERIMENT; APOPTOSIS; CONFERENCE PAPER; CONTROLLED STUDY; GENE EXPRESSION; HELPER CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; NATURAL KILLER CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

ACQUIRED IMMUNODEFICIENCY SYNDROME; HIV INFECTIONS; HUMANS; INTERLEUKIN-12;

EID: 0029583069     PISSN: 09232494     EISSN: None     Source Type: Journal    
DOI: 10.1016/0923-2494(96)83039-2     Document Type: Article

References (56)

1. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major
2. IL-10 is induced during HTV1 infection and is capable of decreasing viral replication in human macrophages
3. Programmed cell death and AIDS: from hypothesis to experiment
4. Th1 and Th2 cytokine production by peripheral blood mononuclear cells from HTV-infected patients
5. Functional studies of epidermal Langerhans cells and blood monocytes in HTV-infected persons
6. Antitumor and antimetastatic activity of interleukin 12 against murine tumors
7. Impaired IL-12 production in human immunodeficiency virus-infected patients
8. Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors an dhuman immunodeficiency virus-infected patients
9. A TH1 → TH2 switch is a critical step in the etiology of HIV infection
10. The Th1-Th2 hypothesis of HTV infection ; new insights
11. Restoration of HIV-specific cell-mediated immune responses by Interleukin-12 in vitro
12. Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis
13. Role of Interleukin-10 in T cell helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus
14. Interleukin 10 (EL-10) inhibits human lymphocyte interferon-γ production by suppressing natural killer cell stimulatory factor IL-12 synthesis in accessory cells
15. Stimulatory and inhibitory effects of IL-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells : priming for IL-12 and TNF-α production
16. Dysregulation of interleukin 8, interleukin 10, and interleukin 12 release by alveolar macrophages from HTV type 1-infected subjects
17. Indirect mechanisms of HIV pathogenesis: how does HIV kill T cells?
18. Early interleukin-12 production by macrophages in response to mycobacterial infection depends on interferon-γ and TNF-α
19. HIV infection suppresses type l lymphokine and IL-12 responses to Toxoplasma gondii but fails to inhibit the synthesis of other parasite-induced monokines
20. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts
21. Apoptosis in AIDS
22. Lack of evidence for the dichotomy of Th1 and Th2 predominance in HIV-infected individuals
23. Regulation of Interleukin-12 expression in human monocytes : selective priming by interferon-γ of lipolysaccbaride-inducible p35 and p40 genes
24. Infection of dendritic cells with HIV1 : virus load regulates stimulation and suppression of T-cell activity
25. Differential regulation of IL-12, TNF-α, and IL-1β production in human myeloid leukemia cell lines and peripheral blood mononuclear cells
26. Ability of HIV to promote a Th1 to Th0 shift and to replicate preferentially in Th2 and Th0 clones
27. IL-12 inhibits the production of IL-4 and IL-10 in allergen-specific human CD4+ T lymphocytes
28. IL-10 inhibits HIV-1 replication and is induced by Tat
29. Programmed death of T cells in HTV-1 infection
30. T-cell dysfunction in HIV infection: anergy due to defective antigen-presenting cell function?
31. Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production
32. Increased levels of IFN-gamma, IL-4 and TGF-beta mRNA expressing blood mononuclear cells in human HIV infection
33. Effects of IL-12 on the response and susceptibility to experimental viral infections
34. Dendritic cells from HTV-1 infected individuals show reduced capacity to stimulate autologous T-cell proliferation
35. IL-12 is both required and prognostic in vivo for T helper type 1 differentiation in murine candidiasis
36. Antitumor effects of interleukin-12 (IL-12) : applications for the immunotherapy and gene therapy of cancer
37. Interleukin-12 a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-Helper cells type 1 and cytotoxic lymphocytes
38. Endogenous IL-12 regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology
39. The multiple nature of peptide growth factors, transforming growth factors-betas
40. Dissociation between interleukin-1 beta mRIMA and protein synthesis in human peripheral blood mononuclear cells
41. Recombinant C5a stimulates transcription rather than translation of interleukin-1 (IL-1) and tumor necrosis factor: translational signal provided by lipopolysaccaride or IL-1 itself
42. Transforming growth factor-β expression and natural killer cell responses during virus infection of normal, nude, and SCID mice
43. Impaired interleukin-12 production in human immunodeficiency virus-infected patients
44. Role of lnterleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the immunodeficiency virus
45. Impaired interleukin-12 production in human immunodeficiency virus-infected patients
46. Role of Th1/Th2 cytokines in HIV infection
47. Cytokine regulation of acute and chronic HIV infection in vitro: from cell lines to primary mononuclear cells
48. Impaired interleukin-12 production in human immunodeficiency virus-infected patients
49. Stimulatory and inhibitory effects of IL-4 and IL-13 on production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and TNF-α production
50. Th1 and Th2 cytokine production by peripheral blood mononuclear cells from HTV-infected patients
51. Dysregulation of Interleukin 8, Interleukin 10 and Interleukin 12 release by alveolar macrophages from HIV Type 1-infected subjects
52. Cytokines from lymphoid organs of HTV-infected patients : production and role in the immune disequilibrium of the disease
53. Lack of evidence for the dichotomy of Thl and Th2 predominance in HTV-infected individuals
54. Differential regulation of IL-12, TNF-α, and IL-1β production in human myeloid leukemia cell lines and peripheral blood mononuclear cells
55. Up-regulation of monocytic IL-10 by tumor necrosis factor-a and cAMP elevating drugs
56. Immunologic characterization of children vertically infected with human immunodeficiency virus with slow and rapid disease progression