Clinical phase I and pharmacokinetic trial of the new titanium complex budotitane

Investigational New Drugs

Volumn 13, Issue 4, 1995, Pages 327-332

  Schilling, T ^a   Keppler, K B ^b   Heim, M E ^c   Niebch, G ^d   Dietzfelbinger, H ^a   Rastetter, J ^a   Hanauske, A R ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c Sonnenberg Klinik gGmbH   (Germany)

^d ASTA MEDICA AG   (Germany)

Author keywords

budotitane; metal complex; phase I; titanium

Indexed keywords

BUDOTITANE;

ADULT; AGED; AGEUSIA; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BLEEDING; BLOOD TOXICITY; CANCER CHEMOTHERAPY; CARDIOTOXICITY; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG TOXICITY; FEMALE; HEART ARRHYTHMIA; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE TACHYCARDIA; HEMOLYSIS; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; LEUKOPENIA; MALE; MAXIMUM PERMISSIBLE DOSE; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RETICULOCYTE; SOLID TUMOR; THROMBOCYTOPENIA;

ADULT; AGED; ANTINEOPLASTIC AGENTS; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; ORGANOMETALLIC COMPOUNDS;

EID: 0029582820     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/BF00873139     Document Type: Article

References (13)

1. Antitumor activity of cis-dihalogenobis(1-phenyl-1,3-butane-dionato)titanium(IV) compounds against Walker carcinosarcoma
2. Antitumor-active bis-β-diketonato metal complexes: budotitane — a new anticancer agent
3. Antitumor activity of 1,3-diketonato zirconium (IV) and hafnium (IV) complexes
4. Preclinical evaluation of dichlorbis(1-phenylbutane-1,3-dionato)titanium (IV) and budotitane
5. Efficacy of β-diketonato complexes of titanium, zirconim and hafnium against chemically induced autochtonous colonic tumors in rats
6. Assessment of preclinical activity of budotitane in three different transplantable tumor systems, its mutagenicity, and first results of clinical phase I studies
7. Clinical studies with budotitane, a new non-platinum metal complex for cancer therapy
8. Cardiac arrhythmia: possible complication from treatment with cisplatin
9. A case of second-degree atrioventricular block caused by high dose cisplatin treatment
10. High-frequency atrial arrhythmia induced by a cisplatin-etoposide combination
11. In vitro studies on the cardiotoxicity of chemotherapeutics