The clinical significance of malfunction of the CD44 locus in malignancy

Journal of Neuro-Oncology

Volumn 26, Issue 3, 1995, Pages 209-219

  Tarin, D ^a   Bolodeoku, J ^a   Hatfill, S J ^a   Sugino, T ^a   Woodman, A C ^a   Yoshida, K ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

CD44s; CD44v; metastasis; RT PCR

Indexed keywords

HERMES ANTIGEN;

ALTERNATIVE RNA SPLICING; ANTIGEN EXPRESSION; ANTIGENIC VARIATION; ARTICLE; BREAST CANCER; CANCER INVASION; CARCINOGENESIS; DIGESTIVE SYSTEM CANCER; GENE EXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG TUMOR; LYMPHOID TISSUE; LYMPHOPROLIFERATIVE DISEASE; METASTASIS; TUMOR IMMUNOLOGY; URINARY TRACT CANCER; UTERINE CERVIX CANCER;

ANIMALS; ANTIGENS, CD44; BREAST NEOPLASMS; EXONS; FEMALE; GASTROINTESTINAL NEOPLASMS; GENE EXPRESSION; HUMANS; LUNG NEOPLASMS; LYMPHOID TISSUE; LYMPHOPROLIFERATIVE DISORDERS; NEOPLASM METASTASIS; NEOPLASMS; POLYMERASE CHAIN REACTION; UROLOGIC NEOPLASMS; UTERINE CERVICAL NEOPLASMS;

EID: 0029561886     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/BF01052624     Document Type: Article

References (59)

1. Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons
2. CD44 splice variants confer metastatic behaviour in rats: Homologous sequences are expressed in human tumor cell lines
3. Molecular cloning of CD44R1 and CD44R2, two novel isoforms of the human CD44 lymphocytes ‘homing’ receptor expressed by hemopoietic cells
4. Biochemical properties of glycoproteins involved in lymphocyte recognition of high endothelial venules in man
5. Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons
6. A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family
7. CD44 and its interaction with the extracellular matrix
8. The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronatebearing cells
9. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells
10. Multiple variants of the human lymphocyte homing receptor CD44 generated by insertions at a single site in the extracellular domain
11. Significance of CD44 gene products for cancer diagnosis and disease evaluation
12. Non-invasive detection of malignancy by identification of unusual CD44 gene activity in exfoliated cancer cells
13. CD44 variant exon epitopes in primary breast cancer and length of survival
14. Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms
15. Glycoprotein CD44 expression and its association with survival in breast cancer
16. Novel variants of CD44 arising from alternative splicing: Changes in the CD44 alternative splicing pattern of MCF-7 breast carcinoma cells treated with hyaluronidase
17. CD44 expression and oestrogen receptor status in breast cancer
18. Binding and degradation of hyaluronan by human breast cancer cell lines expressing different forms of CD44: Correlation with invasive potential
19. CD44 is associated with proliferation in normal and neoplastic human colorectal epithelial cells
20. Expression of CD44R1 adhesion molecule in colon carcinomas and metastases
21. CD44 alternative splicing in human colon carcinomas
22. A human homologue of the rat metastasis-associated variant of CD44 is expressed in colorectal carcinomas and adenomatous polyps
23. Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression
24. Expression of CD44 splice variant isoforms is an early event in colorectal neoplasia
25. Expression of CD44 abnormal transcripts in human gastric carcinomas
26. Differential expression of CD44 splice variants in intestinal- and diffusetype human gastric carcinomas and normal gastric mucosa
27. Molecular mechanisms of stomach carcinogenesis
28. Different splice variants of CD44 are expressed in gastrinomas but not in other subtypes of endocrine pancreatic tumors
29. Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins
30. Potential use of soluble CD44 in serum as indicator of tumor burden and metastasis in patients with gastric or colon cancer
31. Expression of integrins and CD44 isoforms in non-Hodgkins lymphoma: CD44 variant isoforms are preferentially expressed in high-grade malignant lymphomas
32. Venular endothelium binding molecules CD44 and LECAM-1 in normal and malignant B-cell populations
33. Participation in normal immune responses of a metastasis-inducing splice variant of CD44
34. CD44-a molecule involved in leukocyte adherence and T cell activation
35. Antibody which defines a subset of BM cells that can migrate to thymus
36. The CD44 expressed on the earliest thymic precursor population functions as a thymus homing molecule but does not bind to hyaluronate
37. Expression of adhesion structures during B-cell development in man
38. Expression of lymphocyte homing receptor antigen in non-Hodgkin's lymphoma
39. Serum CD44 in malignant lymphoma: an association with treatment response
40. Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44
41. Surface protein expression and messenger RNA-splicing analysis of CD44 in uterine cervical cancer and normal cervical epithelium
42. Expression of CD44 in prostate cancer cells
43. Expression of CD44 in human lung tumors
44. Expression of alternatively spliced forms of the CD44 extracellular-matrix receptor on human lung carcinomas
45. Isolation and characterization of human melanoma cell variants expressing high and low levels of CD44
46. Distinct effects of two CD44 isoforms on tumor growth in vivo
47. Expression of the cell adhesion molecule CD44 in gastric adenocarcinomas
48. Expression of the CD44 adhesion molecule in primary and metastatic gynecologic malignancies and their cell lines
49. Regulated expression of exon v6 containing isoforms of CD44 in man: Downregulation during malignant transformation of tumors of squamocellular origin
50. CD44H expression by human neuroblastoma cells: relation to MYCN amplification and lineage differentiation
51. Expression of CD44 in normal human versus tumor endometrial tissues: Possible implication of reduced expression of CD44 in lymph-vascular space involvement of cancer cells
52. Expression of CD44 is repressed in neuroblastoma cells