Dose-rate effect on induction and repair rate of radiation-induced DNA double-strand breaks in a normal and an ataxia telangiectasia human fibroblast cell line

Biochimie

Volumn 77, Issue 11, 1995, Pages 900-905

  Foray, N ^a   Arlett, C F ^b   Malaise, E P ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

ataxia telangiectasia; DNA double strand breaks; DNA repair; dose rate effect

Indexed keywords

DOUBLE STRANDED DNA;

ARTICLE; ATAXIA TELANGIECTASIA; CELL LINE; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; FIBROBLAST; HUMAN; HUMAN CELL; IONIZING RADIATION; PULSED FIELD GEL ELECTROPHORESIS; RADIATION DOSE; TEMPERATURE;

ATAXIA TELANGIECTASIA; CELL LINE; CELL SURVIVAL; DNA; DNA REPAIR; FIBROBLASTS; HUMANS; RADIATION DOSAGE; TEMPERATURE; TIME FACTORS;

ATAXIA; ATAXIA TELANGIECTASIA;

EID: 0029559791     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/0300-9084(95)90010-1     Document Type: Article

References (38)

1. Defective repair of DNA double-strand breaks and chromosomes; damage in fibroblasts from a eurosensitive leukemia patient
2. Induction and rejoining of DNA double-strand breaks interphase chromosome breaks after exposure to X-rays in one normal and two hypersensitive human fibroblast cell lines
3. In CHEF electrophoresis a linear induction of DSB corresponds to a nonlinear fraction of extracted DNA with dose
4. DNA double-strand break analysis by CHEF electrophoresis
5. 0ibroblasts from ataxia telangiectasia (AT) and AT heterozygotes show and enhanced level of residual DNA double-strand breaks after low dose-rate γ-irradiation as assayed by pulsed field gel electrophoresis
6. Use of restriction endonucleases to study relationships between DNA double-strand breaks, chromosomal aberrations and other end-points in mammalian cells
7. Randomly distributed DNA double-strand breaks as measured by pulsed field gel electrophoresis — A series of explanatory calculations
8. On the nature of a defect in cells from individuals with Ataxia-Telangiectasia
9. A quantitative comparison of potentially lethal damage repair and the rejoining of interphase chromosome breaks in low passage normal human fibroblasts
10. 241Am α-particles or bleomycin
11. The induction of DNA double-strand breaks in CHO cells by Pvu II: kinetics using neutral elution (pH 9.6)
12. 3H thymidine
13. Comparative human cellular radiosensitivity: III. γ-Radiation survival of cultured skin fibroblasts and testing T-lymphocytes from the peripheral blood of the same individual
14. The nature of ataxia-telangiectasia: problems and perspectives
15. The role of DNA double-strand breaks in ionizing radiation induced killing of eukaryotics cells
16. A component of DNA double-strand break repair is dependent on the spatial orientation of the lesions within the higher-order structures of chromatine
17. Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line
18. The production and repair of double strand breaks in cells from normal humans and from patients with ataxia telangiectasia
19. The spectrum of in vitro radiosensitivity in four human melanoma cell lines is not accounted for by differential induction or rejoining of DNA double strand breaks
20. Molecular determinants of radiosensitivity in mammalian cells
21. Initial damage or repair as the major determinant of cellular radiosensitivity
22. Ataxia telangiectasia: an investigation of the repair in the cell line AT5BIVA by plasmid reconstitution
23. Use of radiation quality as a probe for DNA lesion complexity
24. A comparison of the induction of DNA double-strand breakage and lethal lesions by γ-ray irradiation in Ataxis Telangiectasia and normal fibroblasts
25. A comparison of methods for calculating DNA double-strand break induction frequency in mammalian cells by pulsed-field gel electrophoresis
26. Initial radiation-induced DNA damage in human tumour cell lines: a correlation with intrinsic cellular radiosenstivity
27. Prediction of human cell radiosensitivity comparison of clonogenic assay with chromosome abrrations scored using premature chromosome condensation with fluorescence in situ hybridization
28. A single Ataxia Telangiectasia gene with a product similar to PI-3 kinase
29. Analysis of mutations caused by DNA double-strand breaks produced by a restriction enzyme in shuttle vector plasmids propagated in ataxia telangiectasia cells
30. Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity
31. Cellular radiosensitivity in ataxia-telangiectasia
32. DNA strand break and rejoining in cultured human fibroblasts exposed to fast neutrons or gamma rays
33. DNA damage produced by ionizing radiation in mammalian cells: identifies, mechanisms of formation and reparability
34. Saturation of a DNA repair process in dividing and nondividing mammalian cells
35. Oxygen effect for DNA double-strand break induction determined by pulsed-field gel electrophoresis
36. DNA double-strand break induction and rejoining as determinants of human tumour cell radiosensitivity. A pulsed-field gel electrophoresis study
37. Cellular radiosensitivity and DNA damage in primary human fibroblasts